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7625948 |
Ester compound and medicinal use thereof
A novel therapeutic agent for hyperlipidemia, which is an ester compound represented by the formula (1″)
(wherein
R 1 and R 2 are each hydrogen atom or optionally substituted aryl,...
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7538140 |
Ester compound and medicinal use thereof
A novel therapeutic agent for hyperlipidemia, which is an ester compound represented by the formula (1″)
(wherein
R 1 and R 2 are each hydrogen atom or optionally substituted aryl,...
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7408076 |
2-Bromoanaline and 2-chloroaniline compounds
Disclosed are 2-bromoaniline or 2-chloroaniline compounds of formula (I):
wherein R, R 1 and X are as defined. The compounds are useful as intermediates for preparing indole compounds.
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7408078 |
Anthranilic acid derivatives useful in treating infection with hepatitis C virus
The present invention provides pharmaceutical compositions useful in treating hepatitis C infection. The present invention also provides methods of treating hepatitis C infection by administering...
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7371867 |
Non-racemic trifluoroleucine, and methods of making and using
One aspect of the invention relates to hexafluoroleucine and congeners thereof, and methods of making the compounds. Another aspect of the invention relates to the synthesis of protein cores...
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7262209 |
Carbonyloxy-cyanomethyl compounds as antiparasitic agents
The invention relates to compounds of the general formula
wherein Ar 1 , Ar 2 , R 4 , R 5 , R 6 , R 7 , R 8 , W, X, a and b have the significances given in the specification, and optionally the...
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7132559 |
Non-racemic hexafluoroleucine, and methods of making and using it
One aspect of the invention relates to hexafluoroleucine and congeners thereof, and methods of making the compounds. Another aspect of the nvention relates to the synthesis of protein cores...
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7115662 |
Certain 5-alkyl-2-arylaminophenylacetic acids and derivatives
Disclosed are the compounds of formula I
wherein R is methyl or ethyl; R 1 is chloro or fluoro; R 2 is hydrogen or fluoro; R 3 is hydrogen, fluoro, chloro, methyl, ethyl, methoxy, ethoxy or...
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7084281 |
Synthesis of dihalohydrins and tri- and tetra-substituted olefins
A novel synthesis reaction for highly stereospecific tri- and tetra-substituted olefins is described. A single stereoisomer of stable α-halo-α,β-ester is produced in high yield by the reaction...
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7034015 |
Aminobenzoephenones
The invention relates to a novel class of aminobenzophenones derivatives, to pharmaceutical preparations comprising said compounds, to dosage units of such preparations, to methods of treating...
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6974595 |
Pharmaceutical compositions based on Diclofenae
New pharmaceutical compositions for oral use containing Diclofenac together with alkali metal bicarbonates in amounts of from 20 to 80 by weight with respect to Diclofenac are described. These...
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6930200 |
Multicomponent synthesis of amino acids and derivatives thereof
Mono-substituted and di-substituted alpha-amino acids and derivatives thereof, substituted at the alpha positon with one (mono-) or two (di-) substituents (R 2 and/or R 3 ) as shown in Formula 1:...
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6924082 |
Double-bond shifts of substituted (4n)-annulenes for information storage and data processing
The present application describes a method for information storage and data processing comprising the steps of thermo inducing or photo inducing double-bond shifts (DBS) in substituted (4 n...
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6835848 |
One-pot synthesis of alkyl 3-cyclopropylamino-2-&lsqb 2,4-dibromo-3-(difluromethoxy) benzoyl&rsqb -2-propenoate as a useful intermediate for antibacterial quinolone medicaments
The present invention relates to a new and industrially advantageous one-pot process for the preparation of alkyl 3-cyclopropyl amino-2-[2,4-dibromo-3-(difluoromethoxy) benzoyl]-2-propenoates of in...
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6727281 |
Certain 5-alkyl-2-arylaminophenylacetic acids and derivatives
Disclosed are the compounds of formula I wherein R is methyl or ethyl; R 1 is chloro or fluoro; R 2 is hydrogen or fluoro; R 3 is hydrogen, fluoro, chloro, methyl, ethyl, methoxy, ethoxy or...
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6667413 |
Uracil compounds and use thereof
The present invention relates to an uracil compound of the formula [I]: wherein W represents oxygen, sulfur, imino or C 1 to C 3 alkylimino; Y represents oxygen, sulfur, imino or C 1 to C 3 ...
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6653500 |
Method for the manufacture of Anagrelide
Methods are provided for making Anagrelide base from 2,3-dichlorobenzaldehyde. A method is also provided for making an intermediate compound ethyl N-(2,3-dichloro-6-nitrobenzyl)glycine from...
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6620962 |
Method for producing n-butyryl-4-amino-3-methyl-methyl benzoate and the novel compound n-(4-bromine-2-methylphenyl)-butanamide
According to the invention, N-butyryl-4-amino-3-methyl-methyl benzoate is obtained in a particularly advantageous manner by, initially, reacting o-toluidine with butyric acid chloride, by...
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6590119 |
Methods for the synthesis of dioxoalkanoic acid compounds
The invention relates to improved methods of producing aryl dioxoalkanoic acid compounds and derivatives useful as intermediates for diarylpyrrole therapeutic agents by the alcoholysis of...
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6358431 |
Calixarenes
A method of imparting a water repellent surface to a hydrophilic substrate which comprises contacting the substrate with a solution or dispersion of a suitable calixarene in a liquid medium.
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6258982 |
Process for the preparation of substituted aromatic amino compounds
The present invention relates to a hydrogenation process for the preparation of aromatic amino compounds containing directly on the aryl ring or in a side chain one or more entities that may also...
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6242634 |
Pyrimidin-4-one derivatives, their use, intermediates for their production, and processes for producing these intermediates
Novel pyrimidin-4-one derivatives of formula [1] are provided, which are useful as active ingredients of herbicides, wherein R 1 is hydrogen or alkyl; R 2 is alkyl optionally substituted with...
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6143734 |
Nitroso esters of β-oxo-amides and aryl propionic acid derivatives of non-steroidal antiinflammatory drugs
A compound comprising a non-steroidal antiinflammatory agent to which is directly or indirectly linked an NO group, a compound comprising an enolic anilide non-steroidal antiinflammatory agent to...
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6137003 |
Bis (haloethyl) aminobenzene derivatives
The present invention relates to bis(haloethyl)aminobenzene derivatives featured by having carboxyl-containing moiety and one other moiety at the ortho position with respect to the...
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6127392 |
Anthranilic acid analogs
Compounds of the formula: wherein: R 1 , R 2 , R 3 , R 4 ,R 5 , R 6 , R 7 and R 8 are, independently, hydrogen, COOR 15 , halogen, nitro, cyano, C 1 -10 alkoxy, C 1 -10 haloalkoxy, sulfonic...
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6110955 |
Metabolically stabilized oxyalkylene esters and uses thereof
This invention relates to compositions for and methods of treating, preventing or ameliorating cancer and other proliferative diseases as well as methods of inducing wound healing, treating...
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6043232 |
Nitroso esters of beta-oxo-amides and aryl propionic acid derivatives of non-steroidal antiinflammatory drugs
A compound comprising a non-steroidal antiinflammatory agent to which is directly or indirectly linked an NO group, a compound comprising an enolic anilide non-steroidal antiinflammatory agent to...
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5985919 |
(Het)aryloxy-, -thio- , aminocrotonates, methods of preparing them and their use as insecticides and fungicides
(Het)aryloxy-, -thio- and -aminocrotonates of the formula I ##STR1## where the substituents have the following meanings: U is oxygen, sulfur or amino; V is oxygen, sulfur, amino or alkylamino; ...
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5969133 |
Bioreductive cytotoxic agents
A compound which consists of a proactive alkylating moiety containing an electron-withdrawing group, a bioreductive moiety containing at least two double bonds, and a linker joining the proactive...
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5908955 |
Process for producing alkyl 3-amino-4-substituted benzoates
A process for producing an alkyl 3-amino-4-substituted benzoate represented by the following formula (II) is described, in which a 3-amino-4-substituted benzoic acid or an alkali metal salt thereof...
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5874608 |
Process for the preparation of esters of aromatic carboxylic acid
The present invention relates to a process for the preparation of compounds of the formula (1) R 1 R 2 R 3 R 4 R 5 ArCOOR (1) in which R 1 , R 2 , R 3 , R 4 and R 5 are...
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5874180 |
Electroluminescent arrangements and their use
The invention relates to electroluminescent arrangements (layers) containing special styrenes and to their use.
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5817862 |
Process for the preparation of cinnamic acid derivatives
The invention relates to a process for the preparation of cinnamic acid derivatives which involves reacting chlorinated aromatic compounds and acrylic acid derivatives in the presence of palladium...
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5763481 |
Vinylcarboxylic acid derivatives
Compounds of the formula ##STR1## wherein R 1 is C 3 -C 8 cycloalkyl, halo-C 3 -C 8 cycloalkyl, C 3 -C 8 cycloalkyl-C 1 -C 6 alkyl, halo-C 3 -C 8 cycloalkyl-C 1 -C 6 alkyl, --Si(R 3 )...
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5717109 |
Excitatory amino acid receptor antagonists
The present invention provides compounds of formula ##STR1## in which R represents an organic group, or a pharmaceutically acceptable metabolically labile ester or amide thereof, or a...
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5693617 |
Inhibitors of the 26s proteolytic complex and the 20s proteasome contained therein
Disclosed herein is a method for reducing the rate of degradation of proteins in an animal comprising contacting cells of the animal with certain proteasome inhibitors. The structure of the...
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5670136 |
2,4,6-triiodo-5-substituted-amino-isophthalate esters useful as x-ray contrast agents for medical diagnostics imaging
Compounds having the structure: ##STR1## wherein Q is ##STR2## n is an integer from 0 to 20; R 1 is H, alkyl, fluoroalkyl, cycloalkyl, aryl, aralkyl, alkoxyalkyl or acetamidoalkyl; R 2 , R 3 ,...
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5654452 |
Lipophilic contrast agents for use in hepatocyte-selective oil-in-water emulsions
Aromatic acid-derived lipophilic polyhalogenated compounds are provided for use as contrast agents in diagnostic imaging or as therapeutic agents. These compounds are particularly useful when...
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5633400 |
Process for the preparation of biphenyl derivatives
The invention relates to a process for the preparation of a compound of the formula (I) ##STR1## in which X is an optionally protected formyl group and R is a group which is itself inert to the...
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5616615 |
Enaminone esters
The present invention concerns enaminones having the formula: ##STR1## wherein R is COOCH 3 ; R 1 is CH 3 ; R 2 is H; and R 3 is selected from the group consisting of C 6 H 4 (p-Cl) and CH 2...
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5616810 |
Process for the preparation of deactivated anilines
The present invention is directed to a process for the preparation of deactivated anilines, which comprises the step of reacting a compound of formula ( I ) ##STR1## with a dialkylamide in the...
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5616805 |
Methods for preparing pyrenylamine derivatives and intermediates
A pyrenylamine derivative having an unsaturated bond formula (I), which can be employed as an organic photoconductive material for use in electrophotography: ##STR1## wherein R 1 , R 2 , R 3 , R 4...
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5603916 |
3 5-bis alkanoyl amino-2 4 6-triiodobenzyl esters
This invention relates to methods of x-ray diagnostic imaging the blood pool, liver, spleen and/or lymph system of a mammal comprising administering a contrast effective amount of a contrast agent...
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5557005 |
Process for preparing 3-chloroanthranilic alkyl esters of high purity from 3-chloroanthranilic acid
Process for preparing 3-chloroanthranilic alkyl esters by reacting 3-chloroanthranilic acid, in an inert solvent, with from 0.8 to 5 parts by weight of phosgene, and reacting the 3-chloroisatoic...
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5543550 |
Process for the preparation of 5-fluoroanthranilic alkyl esters and/or 5-fluoroanthranilic acid
The present invention relates to a process for the preparation of 5-fluoroanthranilic alkyl esters and/or 5-fluoroanthranilic acid, which comprises dissolving a 3-fluorobenzoic alkyl ester in...
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5530014 |
Cyclohexadiene derivatives
The cyclohexadiene derivatives are prepared by reaction of cyclohexanones with amines and subsequent dehydration. The compounds are suitable as active compounds in medicaments on account of their...
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5525328 |
Nanoparticulate diagnostic diatrizoxy ester X-ray contrast agents for blood pool and lymphatic system imaging
This invention relates to methods of x-ray diagnostic imaging the blood pool and/or lymph system of a mammal comprising administering a contrast effective amount of a particulate iodinated aroyloxy...
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5521218 |
Nanoparticulate iodipamide derivatives for use as x-ray contrast agents
This invention relates to methods of x-ray diagnostic imaging the blood pool, liver, spleen and/or lymph system of a mammal comprising administering a contrast effective amount of a contrast agent...
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5500204 |
Nanoparticulate diagnostic dimers as x-ray contrast agents for blood pool and lymphatic system imaging
This invention relates to methods of x-ray diagnostic imaging the blood pool, liver, spleen and/or lymph system of a mammal comprising administering a contrast effective amount of a succinic acid...
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5488133 |
Iodinated aroyloxy ketones
Compounds having the structure ##STR1## wherein (Z--COO is the residue of an iodinated aromatic acid; n is an integer from 0 to 20; R 1 , R 2 , R 3 and R 4 are independently H, alkyl,...
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