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9035085 Aryl ketone compounds and compositions for delivering active agents  
The present invention provides aryl ketone compounds and compositions containing them which facilitate the delivery of active agents. The aryl ketone compounds have the formula or a salt thereof,...
9023974 Ester group-containing tetracarboxylic acid dianhydride, novel polyesterimide precursor derived therefrom, and polyesterimide  
A polyimide demonstrates low coefficient of hygroscopic expansion and low water absorption coefficient when used as an insulation film. The polyimide is derived from a tetracarboxylic acid...
9018255 Esters of (acyloxymethyl)acrylamide, a pharmaceutical composition containing them, and their use as inhibitors of the thioredoxin—thioredoxin reductase system  
The subject of the present invention are novel esters of (acyloxymethyl)acrylamide, a pharmaceutical composition containing them and their use in the production of drugs for the prophylaxis or...
9012677 Amino acid derivatives and absorbable polymers therefrom  
The present invention relates to the discovery of new class of hydrolysable amino acid derivatives and absorbable polyester amides, polyamides, polyepoxides, polyureas and polyurethanes prepared...
8901341 Amino acid derivatives and absorbable polymers therefrom  
The present invention relates to the discovery of new class of hydrolysable amino acid derivatives and absorbable polyester amides, polyamides, polyepoxides, polyureas and polyurethanes prepared...
8822534 Substituted aminopropionic derivatives as neprilysin inhibitors  
The present invention provides a compound of formula I′; or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R5, B1, X and n are defined herein. The invention also relates a method...
8822679 Quaternary heteroatom containing compounds  
A compound useful as a building block for the manufacture of various compounds is represented by Formula A or D. In Formula A and D, z is 0 or 1; Q is a heteroatom; R1 through R11 and Ra through...
8703990 Process for manufacture and resolution of 2-acylamino-3-diphenylpropanoic acid  
The invention relates to a novel process, novel process steps and novel intermediates useful in the synthesis of pharmaceutically active compounds, in particular neutral endopeptidase (NEP)...
8673974 Substituted amino bisphenyl pentanoic acid derivatives as NEP inhibitors  
The present invention provides a compound of formula I; or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, A1, X, X1, s and n are defined herein. The invention also relates to a...
8664391 Amide compounds as boosters of antivirals  
The present invention relates to compounds of formula (I) that have CYP450 inhibiting properties and are useful as boosting agents when used with HIV treatments. These compounds are represented by...
8664426 Functionalized amino acids and absorbable polymers therefrom  
The present invention relates to compounds of formula I and II, which are functionalized amino acids, and polymers formed from the same. Polymers formed from the functionalized amino acids are...
8637696 Methods for preparing amides and amino acids  
The invention provides novel compounds and methods to carry out organocatalytic Michael additions of aldehydes to nitroethylene catalyzed by a proline derivative to provide...
8558023 Enantioselective process for cycloalkenyl β-substituted alanines  
A process for preparing an enantiomerically enriched cycloalkene-substituted alanine compound having the structure: by asymmetrically hydrogenating a dehydro amino acid compound having the...
8552204 Zinc cluster  
Disclosed is a novel zinc cluster compound represented by general formula (1): Zn4O (OCOR)6 (RCOOH)n, wherein R represents an alkyl group which has 1 to 4 carbon atoms and may be substituted with...
8519175 Functionalized amino acids and absorbable polymers therefrom  
The present invention relates to compounds of formula I and II, which are functionalized amino acids, and polymers formed from the same. Polymers formed from the functionalized amino acids are...
8487109 Process for the palladium-catalyzed coupling of terminal alkynes with aryl tosylates  
The present invention relates to a process for the regioselective synthesis of compounds of the formula (I), wherein R1; R2; R3; R4; R5; J and W have the meanings indicated in the claims. The...
8466081 Halogenated amide ester and internal electron donor with same  
Disclosed are halogenated amide esters that are suitable as internal electron donors in procatalyst compositions. Ziegler-Natta catalyst compositions containing the present procatalyst...
8461372 Amino acid derivatives and absorbable polymers therefrom  
The present invention relates to the discovery of new class of hydrolysable amino acid derivatives and absorbable polyester amides, polyamides, polyepoxides, polyureas and polyurethanes prepared...
8415501 Methods and compositions for making and using polymorphs of cinacalcet  
The present invention is directed to methods and compositions for making and using a new polymorph of cinacalcet hydrochloride.
8394853 Substituted aminopropionic derivatives as neprilysin inhibitors  
The present invention provides a compound of formula I′; or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R5, B1, X and n are defined herein. The invention also relates a method...
8350076 Sodium channel blockers  
The present invention is directed to novel phenyloin derivative compounds and the use of such compounds as sodium channel blockers. Such compositions have utility as anti-cancer agents and can be...
8309766 Phenyl-containing n-acyl amine and aminoacid derivatives, methods for the production thereof, a pharmaceutical composition and the use thereof  
The present invention relates to novel phenyl-N-acyl derivatives of biogenic amines and amino acids of general formula (I) as cyclooxynease inhibitors, possessing analgetic and anti-inflammatory...
8309754 Functionalized amino acids and absorbable polymers therefrom  
The present invention relates to compounds of formula I and II, which are functionalized amino acids, and polymers formed from the same. Polymers formed from the functionalized amino acids are...
8119375 Method for the production of ramipril  
An improved method for preparing ramipril is disclosed, and also an intermediate for use in the method.
8106230 Succinic acid diester derivative, process for production thereof, and use of the derivative in the production of pharmaceutical preparation  
The present invention provides with a process of preparing an optically active succinimide derivative, which is a key intermediate for production of ranirestat. A compound (3) is easily prepared...
8034969 Synthesis of N-[N-(3,3-dimethylbutyl)-L-α-aspartyl]-L-phenylalanine 1-methyl ester using 3,3-dimethylbutyraldehyde precursors  
N—[N-(3,3-dimethylbutyl)-L-α-aspartyl]-L-phenylalanine 1-methyl ester is produced by hydrogenation of L-α-aspartyl-L-phenylalanine 1-methyl ester and 3,3-dimethylbutyraldehyde produced in situ by...
7998933 Process for treating the skin comprising applying to the skin at least one composition comprising at least one N-aminoacylamide  
The invention concerns novel compounds of the N-acylamino-amide family, compositions, in particular cosmetic or pharmaceutical, containing them, and their use for treating body or face skin...
7960578 Method for the synthesis of peptides without solvent  
The disclosure relates to a method for the synthesis of a compound of the formula (I) in which: n is an integer higher than or equal to 1; Rb and each Rn are independently a hydrogen atom, a C1-C6...
7902281 Thermoplastic resin composition and molded article thereof  
An object of the present invention is to provide a resin composition which is increased in heat resistance (high crystallinity) and transparency without impairing rigidity which a thermoplastic...
7846949 Compounds and compositions as LXR modulators  
The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity...
7786046 Benzoyl-substituted serineamides  
The present invention relates to benzoyl-substituted serinamides of the formula I in which the variables R1 to R11 are as defined in the description,and to their agriculturally useful salts,to...
7569720 Compounds  
This invention relates to newly identified ester-linked gemini surfactant compounds, to the use of such compounds and to their production. The invention also relates to the use of the ester-linked...
7563930 Crystal forms of Cinacalcet HCI and processes for their preparation  
Provided are crystalline forms of Cinacalet HCl and processes for their preparation.
7473796 Cytotoxic agents comprising new maytansinoids  
New thiol and disulfide-containing maytansinoids bearing a mono or di-alkyl substitution on the α-carbon atom bearing the sulfur atom are disclosed. Also disclosed are methods for the synthesis of...
7439383 Sodium channel blockers  
The present invention is directed to novel phenytoin derivative compounds and the use of such compounds as sodium channel blockers. Such compositions have utility as anti-cancer agents and can be...
7419970 Cosmetic compositions comprising N-acylamino amides  
The invention concerns novel compounds of the N-acylamino-amide family, compositions, in particular cosmetic or pharmaceutical, containing them, and their use for treating body or face skin...
7405320 Therapeutic and diagnostic conjugates for use with multispecific antibodies  
Disclosed are compounds that include two or more haptens conjugated by a spacer or a carrier. The haptens may include diethylenetriaminepentaacetate (DTPA), histimine-succinyl-glutamine (HSG), or...
7393967 Process for the preparation of cinacalcet base  
Provided is a process for preparing cinacalcet, (R)-α-methyl-N-[3-[3-(trifluoromethyl)phenyl]propyl]-1-napht halenemethane amine.
7294735 Purification of cinacalcet  
Isolated cinacalcet carbamate, processes for the preparation thereof, and processes for the use of cinacalcet carbamate as a reference marker and standard are provided. Also provided are...
7288670 Synthesis of N-[N-(3,3-dimethylbutyl)-L-α-aspartyl]-L-phenylalanine 1-methyl ester using 3,3-dimethylbutyraldehyde precursors  
N-[N-(3,3-dimethylbutyl)-L-α-aspartyl]-L-phenylalanine 1-methyl ester is produced by hydrogenation of L-α-aspartyl-L-phenylalanine 1-methyl ester and 3,3-dimethylbutyraldehyde produced in situ by...
7253299 Process for purifying n2-(1(s)-ethoxycarbonyl-3-phenylpropyl)-n6-thifluoroacetyl-l-lysine  
A process for purifying N2-(1(S)-ethoxycarbonyl-3-phenylpropyl)-N6-trifluoroacetyl-L -lysine which comprises subjecting N2-(1(S)-ethoxycarbonyl-3-phenylpropyl)-N6-trifluoroacetyl-L -lysine...
7183317 Compounds and methods to increase plasma HDL cholesterol levels and improve HDL functionality  
It has been discovered that certain selected ethers of probucol, and their pharmaceutically acceptable salts or prodrugs, are useful for increasing circulating HDL cholesterol. These compounds may...
7135587 Urea and urethane derivatives as integrin inhibitors  
Novel urea and urethane derivatives of general formula (I) in which R1, R2, R3, R5, R5′, X, Y, B, m, n and o are as defined in Patent Claim 1, and physiologically acceptable salts or solvates...
7115296 N-alkylaspartyl amide derivative and sweetening agent  
The present invention relates to a novel N-alkylaspartyl amide derivative, a salt form thereof, a sweetening agent containing the same and a sweetened food or drink containing the N-alkylaspartyl...
7037939 Compound and derivative of gabapentin  
The present invention relates to a compound represented as formula (I): wherein A is R2-N(R3R4), wherein Ar is a substituted or unsubstituted phenyl group, m is an integer between 0 to 4, Het is a...
6992207 Melphalan derivatives and their use as cancer chemotherapeutic drugs  
The invention refers to new alkylating di- and tripeptides based on a melphalan unit, and one or two additional amino acids or amino acid derivatives, which can be used in the treatment of...
6989384 Antipicornaviral compounds and compositions, their pharmaceutical uses, and materials for their synthesis  
Compounds of the formula: where the formula variables are as defined in the disclosure, advantageously inhibit or block the biological activity of the picomaviral 3C protease. These compounds, as...
6989461 Catalyst for asymmetric (transfer) hydrogenation  
Catalyst for the asymmetric (transfer) hydrogenation represented by the formula MLaXbSc, where M is a transition metal, to be chosen from rhodium and ruthenium, and X is a counter ion and S is a...
6972340 Selective protein tyrosine phosphatatase inhibitors  
Compounds of formula (I) or therapeutically acceptable salts thereof, are selective protein tyrosine kinase-B (PTP1B) inhibitors. Preparation of the compounds, compositions containing the...
6949557 Hydroanthracene based compounds as anticancer agents  
The invention relates to the use of novel anthracene based compounds for the inhibition or prevention of the growth or multiplication of cancer cells, and to therapeutic compositions containing...