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8664426 Functionalized amino acids and absorbable polymers therefrom  
The present invention relates to compounds of formula I and II, which are functionalized amino acids, and polymers formed from the same. Polymers formed from the functionalized amino acids are...
8575385 Process of making optically pure melphalan  
This invention provides a process of making optically pure melphalan of the formula by hydroxyethylation, in a regioselective manner, of the aromatic amino group rather than the glycinic amino group.
8519175 Functionalized amino acids and absorbable polymers therefrom  
The present invention relates to compounds of formula I and II, which are functionalized amino acids, and polymers formed from the same. Polymers formed from the functionalized amino acids are...
8507715 Method for producing β-aminocarbonyl compound  
An optically active β-aminocarbonyl compound is obtained by a Mannich reaction between an aldimine in which: nitrogen is protected and a malonic acid diester, in the presence of optically active...
8435562 Pharmaceutical compositions and oral dosage forms of a levodopa prodrug and methods of use  
Pharmaceutical compositions and oral dosage forms of (2R)-2-phenylcarbonyloxypropyl (2S)-2-amino-3-(3,4-dihydroxyphenyl)propanoate mesylate and methods of treating diseases comprising orally...
8399513 Levodopa prodrug mesylate hydrate  
Crystalline (2R)-2-phenylcarbonyloxypropyl (2S)-2-amino-3-(3,4-dihydroxyphenyl)propanoate mesylate, hydrate, methods of making the hydrate, pharmaceutical compositions containing the hydrate, and...
8324272 Levodopa dimethyl-substituted diester prodrugs, compositions, and methods of use  
Levodopa dimethyl-substituted diester prodrugs pharmaceutical, compositions comprising levodopa dimethyl-substituted diester prodrugs, and methods of using such prodrugs and pharmaceutical...
8323627 Monoester of N-undecylenoyl phenylalanine and polyol, method for preparing same, and use of said esters as a skin lightening agent  
A compound of the formula (I): where m is an integer equal to 0 or 1, and p is an integer equal to 0, 1, 2 or 3. A method for preparing the compound of the formula (I), and the use thereof as a...
8324273 Catechol protected levodopa diester prodrugs, compositions, and methods of use  
Catechol protected levodopa diester prodrugs pharmaceutical, compositions comprising catechol protected levodopa diester prodrugs, and methods of using such prodrugs and pharmaceutical...
8309754 Functionalized amino acids and absorbable polymers therefrom  
The present invention relates to compounds of formula I and II, which are functionalized amino acids, and polymers formed from the same. Polymers formed from the functionalized amino acids are...
8268884 Derivatives of substituted tartaric acid and usage for preparing beta-secretase inhibitors  
The present invention relates to compounds represented by formula (I), or isomers, prodrugs, pharmaceutically acceptable salts, solvates or hydrates thereof: in which each substituent of formula...
8247603 Deuterated catecholamine derivatives and medicaments comprising said compounds  
The present invention concerns deuterated catecholamine derivatives as well as pharmaceuticals containing these compounds. In addition, the invention concerns the use of deuterated catecholamine...
8168820 Deuterated catecholamine derivatives and medicaments comprising said compounds  
The present invention concerns deuterated catecholamine derivatives as well as pharmaceuticals containing these compounds. In addition, the invention concerns the use of deuterated catecholamine...
8093420 Functionalized amino acids and absorbable polymers therefrom  
The present invention relates to compounds of formula I and II, which are functionalized amino acids, and polymers formed from the same. Polymers formed from the functionalized amino acids are...
7968597 Levodopa prodrug mesylate, compositions thereof, and uses thereof  
(2R)-2-Phenylcarbonyloxypropyl (2S)-2-amino-3-(3,4-dihydroxyphenyl)propanoate mesylate and crystalline form thereof, methods of making the same, pharmaceutical compositions thereof, and methods of...
7935843 Functionalized diphenolics and absorbable polymers therefrom  
The present invention relates to dephenolic compounds, an example of which is shown below, which are functionalized, and polymers formed from the same. Polymers formed from the functionalized...
7709527 Levodopa dimethyl-substituted diester prodrugs compositions, and methods of use  
Levodopa dimethyl-substituted diester prodrugs pharmaceutical, compositions comprising levodopa dimethyl-substituted diester prodrugs, and methods of using such prodrugs and pharmaceutical...
7247724 Method for the production of phenylalanine derivatives  
The invention relates to an improved method for the production of 3-amidinophenylalanine derivatives, especially triisopropylphenyl-sulfonyl-substituted 3-amidinophenylalanine derivatives.
7183425 Diastereoselective reductive amination process  
This invention describes a reductive amination process whereby perfluorinated ketones or ketals are combined with α-aminoesters under basic conditions to form metal carboxylates....
7141263 Process for producing cinnamaldehyde derivatives, use thereof and the like  
A process for conveniently and efficiently producing a highly pure cinnamaldehyde derivative, for example, (2E)-(3-hydroxy-4-methoxy)cinnamaldehyde, which comprises reacting a benzaldehyde...
7115296 N-alkylaspartyl amide derivative and sweetening agent  
The present invention relates to a novel N-alkylaspartyl amide derivative, a salt form thereof, a sweetening agent containing the same and a sweetened food or drink containing the N-alkylaspartyl...
7057038 Kinetic resolutions of chiral 2- and 3-substituted carboxylic acids  
One aspect of the present invention relates to a method for the kinetic resolution of racemic and diastereomeric mixtures of chiral compounds. The critical elements of the method are: a...
RE39088 Amide compounds and use of the same  
An amide compound of the formula (I): wherein R is amino and the like, A is alkylene and the like, X is O, S and the like, M is arylene and the like, R1, R2, R3 and R4 are H, hydroxy and the like,...
7026003 Processes for preparing an aspartame slurry  
The present invention provides processes for preparing a slurry containing aspartame, which is stable and is useful as a sweetener; as well as methods of assessing the stability of an aspartame...
6989461 Catalyst for asymmetric (transfer) hydrogenation  
Catalyst for the asymmetric (transfer) hydrogenation represented by the formula MLaXbSc, where M is a transition metal, to be chosen from rhodium and ruthenium, and X is a counter ion and S is a...
6939987 Method for producing Aspartame derivative, method for purifying the same, crystals thereof and uses of the same  
N-[N-[3-(3-methoxy-4-hydroxyphenyl)propyl]-L-α-aspartyl]-L-p henylalanine 1-methyl ester is prepared by a process comprising: subjecting Aspartame and 3-(3-methoxy-4-hydroxyphenyl)propionaldehyde...
6930200 Multicomponent synthesis of amino acids and derivatives thereof  
Mono-substituted and di-substituted alpha-amino acids and derivatives thereof, substituted at the alpha positon with one (mono-) or two (di-) substituents (R2 and/or R3) as shown in Formula 1:...
6919380 Derivatives of C2-substituted indan-1-ol systems for the prophylaxis or treatment of obesity  
Derivatives of C2-substituted indan-1-ol compounds of formula I: its physiologically acceptable salts, and its physiologically functional derivatives for the prophylaxis or treatment of obesity...
6914151 Crystallization processes for the formation of stable crystals of aspartame derivative  
A crystallization process for forming a stable crystal of N-(3,3-dimethylbutyl)-APM, which comprises using either water or a mixture of water with a lower alcohol as the crystallizing solvent and...
6855843 Inhibitors of α4 mediated cell adhesion  
The present invention relates to a pharmaceutical composition comprising as an active ingredient a compound of formula (I), wherein Ring A is an aromatic or a heterocyclic ring; Q is a bond,...
6844465 Method for preparing highly stable crystals of aspartame derivative  
Disclosed in the present application are a method for preparing highly-stable A-type crystals by controlling and maintaining the product temperature of B-type N-(3,3-dimethylbutyl)-APM crystals at...
6841183 Process for producing aspartame derivatives, process for purifying aspartame derivatives, production intermediates, and process for producing production intermediates  
N-[N-[3-(2-hydroxy-substituted phenyl)propyl]-L-α-aspartyl]-L-phenylalanine 1-methyl ester derivatives, which are useful as sweeteners, may be conveniently produced by subjecting a...
6822111 Process for production of aspartyl dipeptide ester derivatives  
N-[N-[3-(phenyl having various substituent group(s) on the benzene ring)propyl]-L-α-aspartyl]-L-phenylalanine 1-methyl ester derivatives, which are useful as sweeteners, may be conveniently...
6818243 Crystals of aspartame derivative  
N-[N-[3-(3-hydroxy-4-methoxyphenyl)propyl]-L-α-aspartyl]-L-p henylalanine 1-methyl ester useful as a sweetener with a high potency of sweetness, is provided in the crystalline form having a high...
6794531 Process for production of aspartyl dipeptide ester derivative, novel production intermediate therefor, and process for production thereof  
The present invention relates to a method of manufacturing aspartyl dipeptide ester compounds, which can be used as sweeteners, and aldehydes that can be used in the manufacturing processes.
6790470 Aspartame derivative crystal and process for producing the same  
For example, N-[N-(3,3-dimethylbutyl)-L-α-aspartyl]-L-phenylalanine methyl ester (A-type crystal) showing characteristic peaks in diffractive X-ray at diffraction angles (2θ, CuKα ray) of at least...
6784309 Method for the purification of N-&lsqb N-(3,3-dimethylbutyl)-L-α-aspartyl&rsqb -L-phenylalanine 1-methyl ester  
This invention relates to the purification of N-[N-(3,3-dimethylbutyl)-L-α-aspartyl]-L-phenylalanine 1-methyl ester by slurrying a mixture containing...
6720446 Catalyst modification to enhance neotame production  
Processes for using modified catalysts with improved functionality in the production of neotame are disclosed. The modified catalysts surprisingly have been found to improve the selectivity over...
6689902 Arylpropyl aldehyde derivatives, processes for producing the same, and methods of using the same  
3-(3-Methyl-4-hydroxyphenyl)-3-methylbutyl aldehyde may be produced from 3-(3-methyl-4-hydroxyphenyl)-3-methylbutyric acid by converting the carboxyl group into a formyl group....
6657073 Crystallization of α-L-aspartyl-L-phenylalanine methyl ester  
The present invention provides a novel process for the crystallization of α-L-aspartyl-L-phenylalanine methyl ester crystals wherein initial nucleation and initial crystal growth is conducted in a...
6642406 Synthesis of N-&lsqb N-(3,3-dimethylbutyl)-L-α-aspartyl&rsqb -L-phenylalanine 1-methyl ester using L-α-aspartyl-L-phenylalanine 1-methyl ester precursors  
N-[N-(3,3-dimethylbutyl)-L-α-aspartyl]-L-phenylalanine 1-methyl ester is produced by hydrogenation of a mixture of 3,3-dimethylbutyraldehyde and a precursor of L-α-aspartyl-L-phenylalanine...
6627431 Chemoenzymatic synthesis of neotame  
A chemoenzymatic method is disclosed for preparing N-[N-(3,3-dimethylbutyl)-L-α-aspartyl]-L-phenylalanine 1-methyl ester via the enzymatic regioselective hydrolysis of neotame esters using lipases...
6613933 Process for separating and purifying aspartame and a derivative thereof  
A process for easily and efficiently separating aspartame (APM) from N-[N-(3,3-dimethylbutyl)-L-(α-aspartyl]-L-phenylalanine methyl ester (APM derivative), and thus separating and purifying the...
6562782 Oligocycloalkanoid compounds and methods of use  
The present invention related to an oligocycloalkanoid compound comprising formula (I) wherein m, n, and o are independently an integer from 0 to 2; A1 through A10 are independently a direct link,...
6552061 Amino acid derivatives and anti-inflammatory agents  
Provided are an anti-inflammatory agent containing, as an active ingredient, at least one selected from amino acid derivatives represented by formula (I) wherein Ar represents an optionally...
6506434 Process for coating N-&lsqb N-(3,3-dimethylbutyl)-L-α-aspartyl&rsqb -L-phenylalanine 1-methyl ester onto a carrier  
The present invention relates to a process for coating N-[N-(3,3-dimethylbutyl)-L-α-aspartyl]-L-phenylalanine 1-methyl ester onto a carrier. The invention also relates to...
6495597 Cytostatic agents  
Compounds of formula (I) wherein R4 is an ester or thioester group and R, R1, R2 and R3 are as defined in the specification, inhibit proliferation of tumor cells.
6465677 Method for the preparation of N-neohexyl-α-aspartyl-L-phenylalanine methyl ester from imidazolidin-4-one intermediates  
The synthesis of N-[N-(3,3-dimethylbutyl)-L-α-aspartyl]-L-phenylalanine 1-methyl ester via conversion under reducing conditions of novel imidazolidinone(s) is disclosed.
6444251 Sweetener compositions containing aspartame and aspartame derivative  
A homogeneous sweetener composition containing aspartame (APM) and N-[N-(3,3-dimethylbutyl)-L-α-aspartyl]-L-phenylalanine methyl ester having tasting properties similar to sucrose, can be...
6423864 Purification of N-&lsqb N-(3,3-dimethylbutyl)-L-α-aspartyl&rsqb -L-phenylalanine 1-methyl ester via crystallization  
N-[N-(3,3-dimethylbutyl)-L-α-aspartyl]-L-phenylalanine 1-methyl ester is crystallized in order to give highly pure product in high yield. In a preferred embodiment of the present invention,...

Matches 1 - 50 out of 276 1 2 3 4 5 6 >