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8940919 Compound, method for producing the same, and method for producing oseltamivir phosphate  
A compound represented by the following general formula (1), and a method for producing the compound represented by the general formula (1), the method comprising: reacting together a compound...
8927659 Resorbable phenolic polymers  
The invention provides biocompatible resorbable polymers, comprising monomer units having formula (I), formula (II), formula (III) or formula (IV). The polymers degrade over time when implanted in...
8900796 Acid generator, chemically amplified resist composition, and patterning process  
The present invention provides an acid generator generates a sulfonic acid represented by the following general formula (1) in response to high-energy beam or heat: To provide a novel acid...
8901169 Neprilysin inhibitors  
In one aspect, the invention relates to compounds having the formula: where R1-R5 and X are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have...
8822527 Substituted biaryl alkyl amides  
Disclosed herein are substituted biaryl alkyl amide compounds, methods of synthesizing substituted biaryl alkyl amide compounds and methods of treating diseases and/or conditions with substituted...
8809571 Process for the production of 2-amino-2-[2-(4-C2-20-alkyl-phenyl)ethyl]propane-1,3-diols, and to compounds for use therein  
The present invention relates to improved processes for the production of 2-amino-2-[2-(4-C2-20-alkyl-phenyl)ethyl]propane-1,3-diols, and to compounds for use therein.
8802659 Bicyclic aryl sphingosine 1-phosphate analogs  
Compounds that have agonist activity at one or more of the S1P receptors are provided. The compounds are sphingosine analogs that, after phosphorylation, can behave as agonists at S1P receptors.
8802704 Oxadiazole derivatives  
The invention relates to oxadiazole compounds of formula I. The compounds are useful e.g. in the treatment of autoimmune disorders, such as multiple sclerosis.
8791159 Compound capable of binding S1P receptor and pharmaceutical use thereof  
A compound having an ability to bind to an SIP receptor and represented by formula (I), a salt thereof, a solvate thereof or a prodrug thereof is useful for prevention and/or treatment of...
8729257 Hybrid lipid compounds based on pentaerythritol, intermediates, preparation methods and use thereof  
This invention relates to a novel class of hybrid lipid compound based on pentaerythritol, their intermediates, preparation methods and uses thereof. Different kinds of functional groups such as...
8686184 Neprilysin inhibitors  
In one aspect, the invention relates to compounds having the formula: where R1, R2, R3, a, R4, R5, and R6 are as defined in the specification, or a pharmaceutically acceptable salt thereof. These...
8669285 Synthesis, methods of using, and compositions of cycloalkylmethylamines  
The present invention provides novel cycloalkylmethylamine analogs, and methods of preparing cycloalkylmethylamine analogs. The present invention also provides methods of using...
8664426 Functionalized amino acids and absorbable polymers therefrom  
The present invention relates to compounds of formula I and II, which are functionalized amino acids, and polymers formed from the same. Polymers formed from the functionalized amino acids are...
8637547 Compounds which inhibit members of the histone deacetylase family of enzymes and their use in the treatment of cell proliferative diseases  
Compounds of formula (I) inhibit HDAC activity, wherein A, B and D independently represent ═C— or ═N—; W is a divalent radical —CH═CH— or CH2CH2—; R1 is a carboxylic acid group (—COOH), or an...
8624051 Process for the preparation of isoserine derivatives  
This invention relates to a “one pot” process for the preparation of isoserine derivatives in high diastereoselective way. The process according to the invention includes the steps of reacting a...
8586536 Neprilysin inhibitors  
In one aspect, the invention relates to compounds having the formula: where R1-R6, a, b, and X are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds...
8563714 Bridged spiro [2.4] heptane derivatives as ALX receptor and/or FPRL2 agonists  
The present invention relates to bridged spiro[2.4]heptane derivatives of formula (I), wherein W, Y, Z, R1 and R2 are as defined in the description, their preparation and their use as...
8558023 Enantioselective process for cycloalkenyl β-substituted alanines  
A process for preparing an enantiomerically enriched cycloalkene-substituted alanine compound having the structure: by asymmetrically hydrogenating a dehydro amino acid compound having the...
8519175 Functionalized amino acids and absorbable polymers therefrom  
The present invention relates to compounds of formula I and II, which are functionalized amino acids, and polymers formed from the same. Polymers formed from the functionalized amino acids are...
8501809 Inhibitors of α4 mediated cell adhesion  
The present invention relates to a phenylalanine derivative of Formula (I) wherein X1 is a halogen atom, X2 is a halogen atom, Q is a CH2R— is a carboxyl group which may be esterified; or a...
8481044 Neprilysin inhibitors  
In one aspect, the invention relates to compounds having the formula: where R1-R6, a, b, Z, and X are as defined in the specification, or a pharmaceutically acceptable salt thereof. These...
8471054 Resorbable phenolic polymers  
The invention provides biocompatible resorbable polymers, comprising monomer units having formula (I), formula (II), formula (III) or formula (IV). The polymers degrade over time when implanted in...
8435562 Pharmaceutical compositions and oral dosage forms of a levodopa prodrug and methods of use  
Pharmaceutical compositions and oral dosage forms of (2R)-2-phenylcarbonyloxypropyl (2S)-2-amino-3-(3,4-dihydroxyphenyl)propanoate mesylate and methods of treating diseases comprising orally...
8399513 Levodopa prodrug mesylate hydrate  
Crystalline (2R)-2-phenylcarbonyloxypropyl (2S)-2-amino-3-(3,4-dihydroxyphenyl)propanoate mesylate, hydrate, methods of making the hydrate, pharmaceutical compositions containing the hydrate, and...
8389769 Polymerizable type II photoinitiators and curable compositions  
A polymerizable Type II photoinitiator according to Formula (I): wherein:A represents a Norrish Type II initiating group;L represents a divalent linking group positioning the Norrish Type II...
8367108 Functionalized non-phenolic amino acids and absorbable polymers therefrom  
The present invention relates to compound of formula I, which are functionalized, non-phenolic amino acids, and polymers formed from the same. Polymers formed from the functionalized amino acids...
8350076 Sodium channel blockers  
The present invention is directed to novel phenyloin derivative compounds and the use of such compounds as sodium channel blockers. Such compositions have utility as anti-cancer agents and can be...
8338478 Derivatives of 3,3-diphenylpropylamines  
The invention concerns novel derivatives of 3,3-diphenyl-propylamines, methods for their preparation, pharmaceutical compositions containing the novel compounds, and the use of the compounds for...
8309610 Crystalline forms of (1RS,3RS,6RS)-6-dimethylaminomethyl-1-(3-methoxyphenyl)cyclohexane-1,3-diol hydrochloride  
This invention relates to solid crystalline forms of (1RS,3RS,6RS)-6-Dimethylaminomethyl-1-(3-methoxy-phenyl)cycl ohexane-1,3-diol hydrochloride (1), methods of producing 1, methods of use of 1,...
8309754 Functionalized amino acids and absorbable polymers therefrom  
The present invention relates to compounds of formula I and II, which are functionalized amino acids, and polymers formed from the same. Polymers formed from the functionalized amino acids are...
8293948 Reagent for organic synthesis and method of organic synthesis reaction with the reagent  
A reagent for organic synthesis with which a chemical reaction can be conducted in a liquid phase and unnecessary compound(s) can be easily separated at low cost from the liquid phase after...
8247603 Deuterated catecholamine derivatives and medicaments comprising said compounds  
The present invention concerns deuterated catecholamine derivatives as well as pharmaceuticals containing these compounds. In addition, the invention concerns the use of deuterated catecholamine...
8178675 Compounds for the treatment of metabolic disorders  
Agents useful for the treatment of various metabolic disorders, such as insulin resistance syndrome, diabetes, hyper-lipidemia, fatty liver disease, cachexia, obesity, atherosclerosis and...
8168820 Deuterated catecholamine derivatives and medicaments comprising said compounds  
The present invention concerns deuterated catecholamine derivatives as well as pharmaceuticals containing these compounds. In addition, the invention concerns the use of deuterated catecholamine...
8153801 Process and intermediates for preparing integrase inhibitors  
The invention provides synthetic processes and synthetic intermediates that can be used to prepare 4-oxoquinolone compounds having useful integrase inhibiting properties.
8153837 Resorbable phenolic polymers  
The invention provides biocompatible resorbable polymers, comprising monomer units having formula (I), formula (II), formula (III) or formula (IV). The polymers degrade over time when implanted in...
8063105 Renin inhibitors  
The present invention relates to novel renin inhibitors of the general Formula (I), and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also...
7973181 Hydroxamic acid derivatives as inhibitors of HDAC enzymatic activity  
Compounds of formula (I) are inhibitors of histone deacetylase activity, and are useful in the treatment of, for example, cancers: wherein Y1 is a bond, —(C═O)—, —S(O2)—, —C(═O)O—, —OC(═O)—,...
7968597 Levodopa prodrug mesylate, compositions thereof, and uses thereof  
(2R)-2-Phenylcarbonyloxypropyl (2S)-2-amino-3-(3,4-dihydroxyphenyl)propanoate mesylate and crystalline form thereof, methods of making the same, pharmaceutical compositions thereof, and methods of...
7956212 Levodopa prodrugs, and compositions and uses thereof  
Prodrugs of levodopa, methods of making prodrugs of levodopa, methods of using prodrugs of levodopa, and compositions of prodrugs of levodopa are disclosed.
7906675 Compounds for the treatment of metabolic disorders  
A biologically active agent, wherein the agent is a compound of the formula: Wherein A, R5, R9, X, Q and n, m, q are defined herein below.
7902394 Calcilytic compounds  
Novel calcilytic compounds of Formula (I), pharmaceutical compositions, methods of synthesis, and methods of using them are provided.
7872151 Inhibitors of α4 mediated cell adhesion  
The present invention relates to a phenylalanine derivative of Formula (I) wherein X1 is a halogen atom, X2 is a halogen atom, Q is a CH2R— is a carboxyl group which may be esterified; or a...
7671090 Inhibitors of α4 mediated cell adhesion  
The present invention relates to a phenylalanine derivative of Formula (I) wherein X1 is a halogen atom, X2 is a halogen atom, Q is a CH2R— is a carboxyl group which may be esterified; or a...
7666906 β-Benzyloxyaspartate derivatives with amino group on benzene ring  
L-threo-β-benzyloxyaspartate derivatives having a substituent on the benzene ring, represented by the following formula (1): wherein R is hydrogen, a linear or branched lower aliphatic acyl group...
7652144 Compounds as PDE IV and TNF inhibitors  
A compound of formula XIX wherein R1, R2, Z1, Z2, Q1, Q2 and Q3 as defined in the specification.
7618999 Process of obtaining taxosteroids and precursors thereof  
The present invention relates to a process of obtaining taxosteroids and precursors thereof from the hydrindane bicyclic ring system. The compounds have a tetracyclic system which combines the...
7544833 Methods for producing N-(8-[2-hydroxybenzoyl]-amino) caprylic acid  
Disclosed are improved methods for the synthesis of N-(8-[2-hydroxybenzoyl]-amino)caprylic acid. Certain compounds have been found useful for preventing the formation of a colored impurity when...
7514578 Method for producing enantiomeric form of 2,3-diaminopropionic acid derivatives  
The invention relates to a method for producing enantiomeris form of 2, 3-diaminopropionic acid derivatives of formula (I) by asymetric hydrogenation from compounds of formula (II).
7456217 Inhibitors of alpha4 mediated cell adhesion  
The present invention relates to a phenylalanine derivative of Formula (I) wherein X1 is a halogen atom, X2 is a halogen atom, Q is a CH2R— is a carboxyl group which may be esterified; or a...