|
Match
|
Document |
Document Title |
|
|
7576209 |
Inhibitors of Akt activity
The instant invention provides for substituted naphthyridine compounds that inhibit Akt activity. In particular, the compounds disclosed selectively inhibit one or two of the Akt isoforms. The...
|
|
|
7560483 |
Methods for synthesis of prodrugs from 1-acyl-alkyl derivatives and compositions thereof
The present invention provides a method for synthesizing 1-(acyloxy)-alkyl derivatives from 1-acyl-alkyl derivatives, which typically proceeds stereospecifically, in high yield, does not require...
|
|
|
7432389 |
Compounds for the treatment of Alzheimer's disease
The present invention is substituted amine s of formula (XV)
useful in treating Alzheimer's ease and other similar disease.
|
|
|
7393873 |
Arylsulfonamide derivatives
N-aryl arylsulfonamide derivatives are bradykinin B1 antagonists or inverse agonists useful in the treatment or prevention of symptoms such as pain and inflammation associated with the bradykinin...
|
|
|
7365085 |
Compounds and methods
Disclosed is a compound having the formula:
pharmaceutically acceptable salts or solvates thereof and pharmaceutical compositions containing the same, wherein the structural variables are...
|
|
|
7361782 |
Process for preparing fluorochemical monoisocyanates
A process for preparing fluorochemical monoisocyanates comprises reacting at least one fluorochemical alcohol represented by the formula C n F 2n+1 SO 2 NCH 3 (CH 2 ) m OH, wherein n=2 to 5, and...
|
|
|
7312360 |
Substituted hydroxyethylamines
Disclosed are compounds of the formula
and the pharmaceutically acceptable salts thereof wherein the variables G, L, A, W, E, R2, R3, R4, R5, R N , and R c are defined herein. These compounds...
|
|
|
7282575 |
Functional peptide nucleic acid monomer and process for producing the same
A compound represented by the general formula (I) below:
In the formula, A is as defined in the specification and B denotes
where n is an integer of 1 to 4, and a process for producing the...
|
|
|
7247654 |
3,4-disubstituted benzamidines and benzylamines, and analogues thereof, useful as serine protease inhibitors
The present invention relates generally to compounds that inhibit serine proteases. In particular it is directed to novel 3,4-disubstituted benzamidines and benzylamines, or a stereoisomer or...
|
|
|
7244845 |
Process for preparing cyclic N-substituted alpha-imino carboxylic acids
The present invention relates to the novel methods of making matrix metalloproteinase inhibitors of Formula (I):
|
|
|
7170089 |
(4,5,9,10-Tetrahydro-pyren-2-yl)-carbamic acid 4-(2-methylsulfanyl-alkyl)-3,5-dinitro-benzyl ester, method of synthesizing thereof, and molecular electronic device using the same
A new compound derivative that can be used to form a unit molecular film as a rectifier in a molecular electronic device, a new rectifying compound (4,5,9,10-tetrahydro-pyren-2-yl)-carbamic acid...
|
|
|
7138540 |
Convenient method for the preparation of new precursor of no-carrier-added O-(2-[18F]fluoroethyl)-L-Tyrosine)
This is a new precursor and new method for the synthesis of no-carrier-added O-(2-[ 18 F]fluoroethyl)-L-Tyrosine which has been proved a suitable PET (position emission tomography) probe for tumor...
|
|
|
7132563 |
Convenient method for the preparation of no-carrier-added O-(2-[18F]fluoroethyl)-L-tyrosine)
This is a novel method for production of no-carrier-added O-(2-[ 18 F]fluoroethyl)-L-Tyrosine, which has been proved a suitable PET (position emission tomography) probe for tumor diagnosis imaging,...
|
|
|
7115767 |
Tetraline derivatives as ghrelin receptor modulators
The present invention is related to compounds of formula (I),
or a therapeutically suitable salt or prodrug thereof, the preparation of the compounds, compositions containing the compounds and...
|
|
|
7087642 |
Inhibitors of IMPDH enzyme
The present invention relates to compounds which inhibit IMPDH. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions...
|
|
|
7081545 |
Process for preparing fluorochemical monoisocyanates
A process for preparing fluorochemical monoisocyanates comprises reacting at least one fluorochemical alcohol represented by the formula C n F 2n+1 SO 2 NCH 3 (CH 2 ) m OH, wherein n=2 to 5, and...
|
|
|
7053235 |
(4,5,9,10-Tetrahydro-pyren-2-yl)-carbamic acid 4-(2-methylsulfanyl-alkyl)-3,5-dinitro-benzyl ester, method of synthesizing thereof, and molecular electronic device using the same
A new compound derivative that can be used to form a unit molecular film as a rectifier in a molecular electronic device, a new rectifying compound (4,5,9,10-tetrahydro-pyren-2-yl)-carbamic acid...
|
|
|
7034015 |
Aminobenzoephenones
The invention relates to a novel class of aminobenzophenones derivatives, to pharmaceutical preparations comprising said compounds, to dosage units of such preparations, to methods of treating...
|
|
|
7026515 |
Optically active amine derivatives and preparation process therefor
A readily available and inexpensive natural α-amino acid is converted into a compound represented by formula (1), which is then reacted with an organometallic reagent represented by formula (2) to...
|
|
|
7002037 |
Process for the preparation on enantiomerically enriched compounds
The present invention relates to novel resolution methods, which are useful in the preparation of enantiomerically enriched intermediates which in their turn are useful in the prepartion of...
|
|
|
6972340 |
Selective protein tyrosine phosphatatase inhibitors
Compounds of formula (I)
or therapeutically acceptable salts thereof, are selective protein tyrosine kinase-B (PTP1B) inhibitors. Preparation of the compounds, compositions containing the...
|
|
|
6924392 |
Ortho, meta-substituted bisaryl compounds, processes for their preparation, their use as medicaments, and pharmaceutical preparations comprising them
Ortho, meta-substituted bisaryl compounds, processes for their preparation, their use as medicaments, and pharmaceutical preparations including their use as antiarrhythmic active compounds, for...
|
|
|
6900213 |
Bisaryl derivatives having FSH modulatory activity
The invention relates to bisaryl derivatives of the formula I,
wherein (R,R) is selected from (H,H), O, (H,CH 3 ), (H,OH) and (H,CN); Ar is substituted phenyl
and A is a group of formula II,...
|
|
|
6897236 |
Aminobenzophenones as inhibitors of IL-1β and TNF-α
The present invention relates to compounds of formula (I) wherein R 1 , R 2 and R 3 independently represent one or more, same or different substituents selected from the group consisting of...
|
|
|
6870065 |
Bifunctional boronic compound complexing reagents and complexes
A reagent having the general formula of General Formula I:
wherein group R is an electrophilic or a nucleophilic moiety suitable for reaction of the reagent with a biologically active species;...
|
|
|
6861547 |
Process for preparing aryl-iminomethyl-carbamino acid esters
The invention relates to a process suitable for large-scale industrial use for preparing compounds of general formula (I)
wherein:
R 1 denotes a group selected from among methyl,...
|
|
|
6809126 |
Solid, radiation-curing powder coating binders and a process for preparing the same
The present invention relates to powder coating binders containing polyurethanes having (meth)acryloyl groups which are applied onto a substrate, fused with heat and cured by electromagnetic...
|
|
|
6737547 |
Compositions containing and methods of using N-acyl-1H-aminoindenes
The present invention provides novel aminoindenes having the structure: wherein n is 1 or 2, R 1 is hydrogen, linear or branched chain C 1 -C 8 alkyl or linear or branched chain C 1 -C 8 ...
|
|
|
6696487 |
Fungicidal phenyl(thio)urea and phenyl(thio)carbamate derivatives
The invention relates to compounds of formula (I), and also to salts thereof, which have fungicidal activities: in which the various radicals and substituents are as defined in the description,...
|
|
|
6670400 |
Phenoxyethylamine derivatives having high affinity for the 5-HT1A receptor, preparation thereof, use thereof as drugs, and pharmaceutical compositions containing said derivatives
Phenoxyethylamine derivatives of general formula (I) having high affinity for the 5-HT 1A receptor, methods for preparing same, pharmaceutical compositions containing said derivatives, and their...
|
|
|
6642180 |
Biphenyl-substituted cyclic ketoenols as pesticides
The present invention relates to novel biphenyl-substituted cyclic ketoenols of the formula (I) in which W represents hydrogen, halogen, alkyl, alkoxy, alkenyloxy, halogenoalkyl, halogenoalkoxy,...
|
|
|
6639040 |
Continuous process for the production of MDI allophanates
This invention relates to a continuous process for the production of allophanate modified diphenylmethane diisocyanates having an NCO group content of 19 to 32% and an urethane content of less than...
|
|
|
6610715 |
Cathecol hydrazone derivatives, process for preparing the same and pharmaceutical composition containing the same
The present invention provides novel cathecol hydrazone derivatives of formula (I) or pharmaceutically acceptable salts thereof, wherein R 1 is C 1-7 alkyl or C 3-7 cycloalkyl; R 2 is hydrogen,...
|
|
|
6610747 |
Phenoxybenzylamine derivatives as SSRIs
A compound of general formula (I) wherein R 1 and R 2 are H, C 1 -C 6 alkyl or (CH 2 ) d (C 3 -C 6 cycloalkyl) wherein d=0, 1, 2 or 3; or R 1 and R 2 together with the nitrogen to which they...
|
|
|
6589986 |
Methods of treating anxiety disorders
This invention provides methods for treating, preventing or inhibiting anxiety, anxiety-related conditions and phobias in a mammal using compounds of the formula: wherein: R 1 is H, alkyl,...
|
|
|
6583180 |
Glucocorticoid receptor modulators
Compounds of formula (I) or pharmaceutically acceptable salts thereof are novel glucocorticoid receptor modulators and are useful for treating type II diabetes in a mammal.
|
|
|
6538151 |
Modifications of 2-amino-4-(4-fluorobenzylamino)-1-ethoxycarbonylaminobenzene, and processes for their preparation
The invention relates to novel modifications of the compound 2-amino-4-(4-fluorobenzylamino)-1-ethoxy-carbonylaminobenzen
e of the processes for their preparation and their use in pharmaceutical...
|
|
|
6528609 |
Allophanates of polymeric MDI
This invention relates to a process for forming an allophanate-modified polymethylene poly(phenylisocyanate) comprising the steps of reacting a small amount of epoxide, along with alcohol, to...
|
|
|
6515023 |
Thrombin receptor antagonists
A thrombin receptor antagonist having the formula useful for inhibiting the aggregation of blood platelets. The compounds can be used in a method of acting upon a thrombin receptor which...
|
|
|
6492553 |
Methods for preparing N-&lsqb (aliphatic or aromatic)carbonyl)&rsqb -2-aminoaetamide compounds and for cyclizing such compounds
A method for preparing a N-[(aliphatic or aromatic)carbonyl)]-2-aminoacetamide compound, and for preparing a cyclized compound therefrom, as well as novel resin bound intermediate compounds that...
|
|
|
6489503 |
Storage stable methylene bis(phenylisocyanate) compositions
The present invention provides a liquid methylene bis(phenylisocyanate) composition including a high concentration of methylene bis(phenylisocyanate) which has an improved storage stability. The...
|
|
|
6486350 |
Biological reagents and methods for determining the mechanism in the generation of β-amyloid peptide
Disclosed are biological reagents which comprise compounds that inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in determining the cellular mechanism...
|
|
|
6469121 |
Process for the production of allophanate modified isocyanates
A method for the preparation of a storage stable organic polyisocyanate having allophanate linkages prepared by reacting a urethane containing organic polyisocyanate with a reactive hydroxyl...
|
|
|
6458781 |
Substituted diarylalkyl amides as calcium channel antagonists
The present invention provides compounds that block calcium channels and have the Formula I: The present invention also provides pharmaceutical compositions containing the compounds of Formula I...
|
|
|
6437169 |
1-naphthol compound and method for preparing compound having acidic proton using the same
1. A 1-naphthol compound represented by formula (I) below: wherein A represents the moiety of a compound having an acidic proton the pKa of a corresponding protonated form (AH) of which is 0 to...
|
|
|
6420603 |
Process for the preparation of n,n'-bis&lsqb 2,3-dihydroxypropyl&rsqb -5-&lsqb (hydroxyacetyl) methylamino&rsqb -2, 4,6-triiodo-1, 3-benzenedi carboxamide
A novel process for the preparation of N,N′-bis[2,3-dihydroxypropyl]-5-[(hydroxyacetyl) methylamino]-2,4,6-triiodo-1, 3-benzenedi carboxamide of formula (I), commonly known as lomeprol, a novel...
|
|
|
6416686 |
Polyisocyanates
Polyisocyanates are prepared by a process which comprises (i) preparation of an addition product (A) which contains one group which is reactive toward isocyanate and one isocyanate group by...
|
|
|
6399809 |
Process for the preparation of amino acid derivatives
Process for the preparation of amino acid derivatives of the general formula I where R 1 -R 4 are as defined herein, from the corresponding malonic acid monoester amides of the general formula...
|
|
|
6392001 |
Process for the production of light-stable polyisocyanates containing allophanate groups
The present invention relates to a process for the production of polyisocyanates containing allophanate groups and having aliphatically and/or cycloaliphatically bound isocyanate groups by reacting...
|
|
|
6376698 |
Prepolymers
A prepolymer is provided having an NCO value of 5-30% by weight which is the reaction product obtained by reacting an excessive amount of a diphenylmethane diisocyanate containing at least 85% by...
|