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8183194 |
Carboxylic derivatives as violet and/or woody odorant
The present invention relates to certain ester and nitrile derivatives of formula (I): wherein one dotted line represents a carbon-carbon single or double bond and the other dotted lines each...
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RE43343 |
Inhibitors of histone deacetylase
The invention relates to the inhibition of histone deactylase. The invention provides compounds and methods for inhibiting histone deacetylase enzymatic activity. The invention also provides...
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8106141 |
Cure accelerators for anaerobic curable compositions
Reaction products prepared from reactants including: (a) at least one compound of structural Formula (I): wherein R1 is selected from aryl and heteroaryl; X is selected from a direct bond, —O—, —S—...
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8076500 |
Production of N-aryl carbamates and N-aryl isocyanates
A method for the production of N-aryl carbamates (urethanes) and N-aryl isocyanates is described in which aromatic nitro compounds are subjected to a reductive carbonylation in the presence of...
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8058468 |
Carbamate antibiotics
The invention relates to the field of antibiotic compositions, both inside and outside the medical field. Presented is a new class of antibiotic compounds around the lead compound...
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8053590 |
Method for producing enantiomeric form of 2,3-diaminopropionic acid derivatives
The invention relates to a method for producing enantiomers form of 2,3-diaminopropionic acid derivatives of formula (I) by asymmetric hydrogenation from compounds of formula (II).
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8017776 |
Methods for synthesis of acyloxyalkyl compounds
Disclosed herein are methods for synthesizing 1-(acyloxy)-alkyl prodrug derivatives of drugs through oxidation of 1-acyl-alkyl derivatives of drugs under anhydrous reaction conditions. The methods...
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7973196 |
Asymmetric synthesis of (S)-(+)-3-(aminomethyl)-5-methylhexanoic acid
The invention encompasses processes for the synthesis of (S)-(+)-3-(aminomethyl)-5-methylhexanoic acid, (S)-Pregabalin, and intermediates of (S)-Pregabalin.
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7960583 |
Asymmetric synthesis of (S)-(+)-3-(aminomethyl)-5-methylhexanoic acid
The invention encompasses processes for the synthesis of (S)-(+)-3-(aminomethyl) -5-methylhexanoic acid, (S)-Pregabalin, and intermediates of (S)-Pregabalin.
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7807677 |
HIV protease inhibitors
Compounds of the formula I: wherein R1, R2, X and N are as defined in the specification;E is N, CH;A′ and A″ are terminal groups as defined in the specification. The compounds have utility as HIV...
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7786242 |
Ring-containing modified resins and dispersants including it
The ring-containing modified resin is represented by the following chemical formula (1) R1[—(—O—CO—NH—R2—NH—CO—O—R3—)p—O—R4]
q (1) (in the chemical formula (1), R1 is a dehydroxyl residue of a...
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7777069 |
Prodrugs of carbamate inhibitors of IMPDH
The present invention relates to novel compounds, methods of preparing these compounds, and pharmaceutical compositions comprising these compounds. These compounds are carbamate prodrugs that...
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7763751 |
Hydroxylamine derivatives
This invention is related to hydroxylamino derivatives of the general formula (I) wherein n is 0, 1 or 2; R1 and R2, independently of each other, are H, OH or OCH3; R3 is H or CH3; R4 is H, C1-C3...
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7750162 |
Process for preparation of nonnatural amino acid and intermediate thereof
A process for the preparation of a nonnatural amino acid represented by the following formula (C): which is characterized by reacting a compound represented by the following formula (A1), a...
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7745657 |
D-homoandrosta-17-yl carbamate derivatives as selective glucocorticoid receptor ligands
The present invention is directed to D-homoandrosta-17-yl-carbamate derivatives as selective glucocorticoid receptor ligands useful for treating a variety of autoimmune and inflammatory diseases or...
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7662987 |
Methods for synthesis of acyloxyalkyl compounds
Disclosed herein are methods for synthesizing 1-(acyloxy)-alkyl prodrug derivatives of drugs through oxidation of 1-acyl-alkyl derivatives of drugs under anhydrous reaction conditions. The methods...
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7642369 |
Epoxyketone-based immunoproteasome inhibitors
An efficient new route for the preparation of dihydroeponemycin, an active eponemycin derivative, is provided, which includes the synthesis of the intermediate compound, a hydroxymethyl-substituted...
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7612226 |
Amino acid derivatives
The present invention relates to a method of treating pain using a compound of formula wherein R1, R2, R3 and R4 are as defined herein. The invention also relates to certain novel derivatives of...
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7520222 |
Phase change ink formulation containing a combination of a urethane resin, a mixed urethane/urearesin, a mono-amide and a polyethylene wax
Phase change ink carrier compositions comprising an admixture of (1) at least one urethane resin; and/or (2) at least one mixed urethane/urea resin; and/or (3) at least one mono-amide; and/or (4)...
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7468460 |
Method for producing amines from hydroxamic acids
A method for producing unprotected or carbamate-protected amines of formulae (II) and (III) or R1—NH2 (II) or R1—NHCO2R2 (III) by reacting hydroxamic acids of formula (I) (R1 CONHOH) with a) alk...
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7446220 |
Asymmetric synthesis of (S)-(+)-3-(aminomethyl)-5-methylhexanoic acid
The invention encompasses processes for the synthesis of (S)-(+)-3-(aminomethyl)-5-methylhexanoic acid, (S)-Pregabalin, and intermediates of (S)-Pregabalin.
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7439382 |
4-alkyl-2-haloaniline derivatives and process for producing the same
The present invention relates to a compound of formula (1), wherein R1, R2, R3, n, and X are as defined in the specification, and a process for producing the same. This compound is useful as an...
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7432389 |
Compounds for the treatment of Alzheimer's disease
The present invention is substituted amine s of formula (XV) useful in treating Alzheimer's ease and other similar disease.
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7429658 |
Synthesis of protected pyrrolobenzodiazepines
A method of synthesis of a N-10 protected PBD compound of formula (I): via an intermediate of formula (II) or formula (V):
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7405319 |
Process for the preparation of carbamates
The present invention provides an improved process for the preparation of carbamates with high selectivity of pharmaceutical interest by an eco-friendly, non-toxic, phosgene-/isocyanate-/CO-free...
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7396952 |
Process for preparing carbamic ester derivatives
An improved process for preparing carbamic ester derivatives of the general formula (1) by reaction with carbon monoxide and water in the presence of a palladium catalyst is provided.
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7323532 |
Low-viscosity radiation-curing and thermally curing polyisocyanates
The present invention concerns a process for producing low-viscosity polyisocyanates or secondary products thereof, which carry activated, radiation-curable double bonds and can optionally also...
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7300956 |
Acyloxyalkyl carbamate prodrugs, methods of synthesis and use
The disclosures herein relate generally to acyloxyalkyl carbamate prodrugs of (±)-4-amino-3-(4-chlorophenyl)butanoic acid and analogs thereof, pharmaceutical compositions thereof, methods of ...
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RE39850 |
Inhibitors of histone deacetylase
The invention relates to the inhibition of histone deactylase. The invention provides compounds and methods for inhibiting histone deacetylase enzymatic activity. The invention also provides...
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7262209 |
Carbonyloxy-cyanomethyl compounds as antiparasitic agents
The invention relates to compounds of the general formula wherein Ar1, Ar2, R4, R5, R6, R7, R8, W, X, a and b have the significances given in the specification, and optionally the enantiomers...
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7232923 |
Method of hydroaminating N-alkenoylcarbamates with primary aromatic amines
The invention provides methods for hydroaminating N-alkenoyl carbamates with aromatic amines.
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7220814 |
Hydrophilicized blocked polyisocyanates
The present invention relates to new hydrophilicized blocked polyisocyanates, a process for preparing them and their use.
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7220876 |
Arylcycloalkyl derivatives having branched side chains, processes for their preparation and their use as pharmaceuticals
Arylcycloalkyl derivatives having branched side chains, processes for their preparation and their use as pharmaceuticals The invention relates to arylcycloalkyl derivatives having branched side...
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7192980 |
Certain substituted polyketides, pharmaceutical compositions containing them and their use in treating tumors
The present invention relates to certain substituted polyketides of formula I, wherein A, B, C, D, E, F and m are as defined herein, pharmaceutical compositions containing said compounds, and the...
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7119229 |
Alkaloid derivative and a pharmaceutical composition containing the same
Colchicine derivatives represented by the formula (I) with a halogen or nitric ester group, or pharmaceutically acceptable salts thereof, are described. Pharmaceutical compositions containing the...
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7033522 |
Pulverulent, water-dispersible, blocked polyisocyanate adducts, a process for the preparation and their use
A blocked polyisocyanate adduct including 5 to 95% by weight of at least one isocyanate component having at least one NCO group, the isocyanate component selected from the group consisting of...
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7030263 |
Method of preparing a carbamate- or urea-functional compound
A method of preparing a carbamate or urea-functional compound is described comprising the step of reacting a lactone or hydroxy carboxylic acid with a compound (A) comprising a carbamate or urea...
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7026515 |
Optically active amine derivatives and preparation process therefor
A readily available and inexpensive natural α-amino acid is converted into a compound represented by formula (1), which is then reacted with an organometallic reagent represented by formula (2) to ...
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6998364 |
Process for the formation of urethane via transcarbamation
The invention concerns a novel catalyst for forming urethanes. Said catalyst is characterized by the general formula: MY3−q[Z]q, wherein: Z is the radical corresponding to the anion of a super a...
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6972340 |
Selective protein tyrosine phosphatatase inhibitors
Compounds of formula (I) or therapeutically acceptable salts thereof, are selective protein tyrosine kinase-B (PTP1B) inhibitors. Preparation of the compounds, compositions containing the...
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6897236 |
Aminobenzophenones as inhibitors of IL-1β and TNF-α
The present invention relates to compounds of formula (I) wherein R1, R2 and R3 independently represent one or more, same or different substituents selected from the group consisting of hydrogen,...
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6894139 |
Catalysts, in particular for the preparation of polyisocyanate polyadducts
Catalysts contain, as structural units, at least one tertiary amino group and at least one group which, after its decomposition, is capable of complexing or protonating the tertiary amino group.
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6878841 |
Diethyloctandioldicarbamates and diethyloctandioldiallophanates, method for the production and use thereof
Positionally isomeric diethyloctanediol dicarbamates and diethyloctanediol diallophanates, processes for preparing them, and their use as synthesis building blocks and constituents of adhesives,...
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6878795 |
Alternative moisture cure catalysts and cold curing polyisocyanate adhesives prepared therefrom
Cold curing polyisocyanate adhesive compositions suitable for use in the preparation of engineered lumber composites. Additionally provided are catalysts comprising tertiary amine alkoxylates that...
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6861547 |
Process for preparing aryl-iminomethyl-carbamino acid esters
The invention relates to a process suitable for large-scale industrial use for preparing compounds of general formula (I) wherein: R1 denotes a group selected from among methyl, ethyl, propyl,...
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6849626 |
Aza-amino acid derivatives (factor Xa inhibitors 15)
The invention relates to semicarbazides of the general formula I where R1, R2, R3, R4 and I have the meaning indicated in claim 1. The compounds of the formula I can be employed as pharmaceutical...
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6841701 |
Inhibitors for the blood-clotting factor Xa
The invention relates to derivatives of amidino-benzylamine, especially derivatives of 4-amidino-benzylamine, with two bonded amino acids. These derivatives represent a novel group of highly active...
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6812229 |
Carbamate derivative and agricultural/horticultural fungicide
It is to provide a novel fungicide having high controlling effects on plant diseases particularly on wheat powdery mildew and cucumber gray mold, without ill effects on crops. A carbamate...
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6710151 |
Terminal-blocked isocyanate prepolymer having oxadiazine ring, process for producing the same, and composition for surface-coating material
The end-blocked isocyanate prepolymer having an oxadiazine ring according to the present invention is characterized in that at least one of isocyanate groups of a NCO-terminated isocyanate...
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6710157 |
Polycarbamates and method for the production thereof
The invention relates to polycarbamates of the formula I in whichR and R′ are identical or different and are alkyl groups having 1-4 carbon atoms andn is a number from, on average, 2 to 5.
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