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7625948 |
Ester compound and medicinal use thereof
A novel therapeutic agent for hyperlipidemia, which is an ester compound represented by the formula (1″)
(wherein
R 1 and R 2 are each hydrogen atom or optionally substituted aryl,...
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7608731 |
Phenylacetic acid compounds
The present invention provides a process for the preparation 6-[3-(hetero)aryloxy-2-fluoro-benzyl]-2H-pyridazin-3-one compounds 1 where R2 is an optionally substituted aryl or an optionally...
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7576129 |
Carboxylic acid compounds
The present invention relates to a carboxylic acid compound of formula (I):
wherein R 1 is H, alkyl; m is 2, 3; n is 0-2; R 2 is phenyl, naphthyl, benzofuran, benzothiophene; Q is —CH 2...
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7538140 |
Ester compound and medicinal use thereof
A novel therapeutic agent for hyperlipidemia, which is an ester compound represented by the formula (1″)
(wherein
R 1 and R 2 are each hydrogen atom or optionally substituted aryl,...
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7491748 |
Carboxylic acid derivative compounds and drugs comprising these compounds as the active ingredient
A carboxylic acid derivative of formula (I):
wherein R 1 is —COOH, —COOR 6 , etc.; A is a single bond, alkylene, etc.; R 2 is alkyl, alkoxy, etc.; B is a carbocyclic ring or a...
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7485742 |
Non-glycosidic and non-peptidic inhibitors of selectin, and the use thereof
A new class of non-glycosidic and non-peptidic inhibitors of selectins with low molecular weight according to the general formula 1
is described, as well as methods for their production. These...
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7476754 |
Biphenyl derived thiamides as calpain inhibitors
The present invention relates to compounds derived from biphenyl with activity as calpain inhibitors. One compound of the present invention is a 2,2′-disubstituted biphenyl, where the...
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7432388 |
Disubstituted chalcone oximes having RARγ retinoid receptor antagonist activity
Compounds of the formula
where the variables have the values described in the specification are antagonists of RAR γ retinoid receptors.
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7411076 |
Coumarin derivative
A medicament for enhancing an effect of a cancer therapy based on a mode of action of DNA injury, which comprises as an active ingredient a compound represented by the following general formula...
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7314888 |
Compounds and medicinal use thereof
A compound or a salt thereof having the atom corresponding to N 3 and the two or more atoms selected from N 1 , N 2 , N 4 and N 5 , said atoms constitute the pharmacophore represented by the...
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7235585 |
Enzyme activated self-immolative n-substituted nitrogen mustard prodrugs
This invention pertains to certain enzyme (CPG2) activated self-immolative nitrogen mustard prodrugs, which are useful in enzyme prodrug therapy (EPT), such as ADEPT and GDEPT, for the treatment of...
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7138538 |
Process for the separation of enantiomers and enantiopure reagent
Process for the separation of enantiomers comprising at least one free functional group, in which process a reagent based on an enantiopure amino acid is reacted in basic medium with a mixture...
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7115766 |
Nucleophilic approach for preparing radiolabeled imaging agents and associated compounds
Radiolabeled fluorinated compounds useful for imaging in the diagnosis of Parkinson's Disease are disclosed. Methods and kits for their synthesis are also disclosed.
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7030261 |
Method for preparing 2-hydroxy-6-ureidocarbonyl naphthalene derivative
Disclosed is a method for preparing a 2-hydroxy-6-ureidocarbonyl naphthalene derivative. The method comprises the step of reacting 2-hydroxy-6-aminocarbonyl naphthalene and a isocyanate in an...
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6951943 |
Process for the preparation of phenylalanine enamide derivatives
A process for the preparation of a class of phenylalanine enamide derivatives is described:
wherein:
Ar 1 is an optionally substituted aromatic or heteroaromatic group; L 2 is a linker...
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6875884 |
Urea derivatives as inhibitors for CCR-3 receptor
Urea and thiourea derivatives inhibit cell function of the chemokine receptor CCR-3. These compounds offer an effective means for treating a range of diseases thought to be mediated by the CCR-3...
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6858747 |
Process to prepare, 1,4-dihydropyridine intermediates and derivatives thereof
An improved catalyst is disclosed for a process involving the preparation of benzylidene intermediates useful in the preparation of 1,4-dihydropyridine compounds and derivatives thereof useful as...
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6849742 |
Binaphthol derivative and process for producing the same
The present invention provides a binaphthol compound represented by formula [1]:
and a salt thereof. The binaphthol compound of the present invention is useful for manufacturing antiseptic...
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6811833 |
4-membered ring compound and optical phase optical retardation plate using the same
A 4-membered compound is represented by the following formula (I) is disclosed (in the formula, X 1 and X 2 each independently represent an oxygen atom, a sulfur atom or a substituted or...
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6803479 |
Reagents and method for spatio-temporal control of gene expression by illumination
A caged non-steroidal ecdysome memetic (NSE) compound and a method for producing free NSE by subjecting the charged NSE to UV irradiation.
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6784287 |
Organic dye molecules and nonlinear optical polymeric compounds containing chromophores
Organic dye molecular materials prepared by coupling existing organic chromophore molecules to benzene or carbazole derivatives and nonlinear optical polymeric compounds having polyimide repeating...
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6727098 |
Biaryl-type compounds, CD color fixing agent and method for determination of absolute configuration
A novel achiral biaryl-type compound and a circular dichroism (CD) color fixing agent are provided. Furthermore, a method for determining an absolute configuration of a chiral compound is carried...
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6699463 |
Photostable cationic organic sunscreen compounds with antioxidant properties and compositions obtained therefrom
Compounds of Formula I Each R is independently linear or branched C 1 to C 8 alkyl, or linear or branched C 1 to C 8 alkoxy or one R is H and the other R is linear or branched C 1 to C 8 ...
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6686496 |
Treatment of myeloma
The compounds of the invention which encompasses a class of compounds having the property of anti-carcinogenic activity against human myeloma r comprising 4-oxo-2-butenoic acid compounds and...
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6667413 |
Uracil compounds and use thereof
The present invention relates to an uracil compound of the formula [I]: wherein W represents oxygen, sulfur, imino or C 1 to C 3 alkylimino; Y represents oxygen, sulfur, imino or C 1 to C 3 ...
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6656737 |
Isocynate derivatizing agent and methods of production and use
An organic compound useful for detecting the total quantity of isocyanate in an environmental sample is provided. The compound is 9-anthrcenylmethyl-1-piperazinecarboxylate (PAC), an isocyanate...
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6630589 |
Identification of compounds for the treatment or prevention of proliferative diseases
The invention features screening assays for compounds that are potentially useful for treating or preventing a proliferative disease. The assays are based on contacting a candidate compound with a...
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6630598 |
Process for producing N-acylnitroaniline derivative
A process of reacting a nitroaniline compound of formula (2): with an acid anhydride or acid halide is carried out in the presence of an alkali metal compound or an alkaline earth metal compound...
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6627656 |
Method of treatment using phenyl and biaryl derivatives as prostaglandin E inhibitors and compounds useful therefore
This invention encompasses a method for the treatment or prevention of prostaglandin mediated diseases comprising administering to a mammalian patient a compound of formula I: in an amount that...
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6590118 |
Aromatic compounds
Disclosed are compounds of formula I wherein A, R 1 , R 2 , R 3 , R 4 and R 5 are described in the specification, pharmaceutical formulations comprising these compounds, the use of these...
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6589970 |
6-(aryl-amido or aryl-amidomethyl)-naphthalen-2-yloxy-acidic derivatives as inhibitors of plasminogen activator inhibitor type-1 (PAI-1)
This invention provides novel compounds, pharmaceutical compositions and methods of treating thrombotic disorders in mammals, the compounds having the formula: Wherein: Ar is phenyl, naphthyl,...
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6541422 |
Method for improving the selectivity of 1,3-cyclohexanedione herbicide
A method of selectively controlling undesirable vegetation in crops by using a postemergent application of an herbicidally effective amount of a metal chelate of a 2-(substituted...
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6521646 |
Dibenzoazulene derivatives for treating thrombosis, osteoporosis, arteriosclerosis
Compounds of the formula (I) and their physiologically acceptable salts and solvates are useful as integrin-inhibiting substances. They are especially useful in the prophylaxis and treatment of...
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6403638 |
2,4-pentadienoic acid derivatives having selective activity for retinoid X (RXR) receptors
Compounds having the formulas below, where R is H, lower alkyl, or a pharmaceutically acceptable salt, and where R 1 represents i-propyl, t-butyl or n-butyl groups, have selective RXR retionoid...
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6379590 |
Method for making unsymmetrically substituted fluorenyl compounds for nonlinear optical applications
A new method for producing unsymmetrically substituted fluorenyl compounds, one step of which is the preparation of 2,7-disubstituted fluoren-9-one derivatives via the nucleophilic substitution of...
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6376546 |
Biphenyl-5-alkanoic acid derivatives and use thereof
Compounds represented by general formula I or salts thereof, wherein n is an integer of 2 or 3; R represents a straight-chain or branched saturated alkyl group having 4 or 4 carbon atoms, a...
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6369194 |
Vicinyl tricarbonyl compounds and combinatorial libraries containing same
The invention relates to compounds of formula where R is a structural diversity element selected from the group consisting of alkyl, cycloalkyl, aryl, heteroaryl, peptidyl,...
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6348615 |
Process for producing (2R, 3S)-3-amino-1, 2-oxirane
A process for producing (2R, 3S)-3-amino-4-phenylbutane-1,2-epoxide compounds which comprises treating a (2S, 3S)-3-amino-1-halo-2-hydroxy-4-phenylbutane compound or a (2S,...
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6251944 |
Para-substituted phenylene derivatives
The present invention relates to a class of compounds represented by Formula I ##STR1## or a pharmaceutically acceptable salt thereof, pharmaceutical composition comprising compounds of the Formula...
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6239308 |
Method for producing α-hydroxy-β-aminocarboxylic acids
The present invention provides a simple and inexpensive method for producing α-hydroxy-β-aminocarboxylic acids and their esters. An ester of an N-protected α-amino acid ester is converted into a...
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6191165 |
Pharmaceutical for treatment of neurological and neuropsychiatric disorders
The invention provides a pharmaceutical for treatment of neurological and neuropsychiatric disorders comprising a compound of the formula: ##STR1## or a pharmaceutically acceptable salt thereof.
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6162810 |
Inadone and tetralone compounds for inhibiting cell proliferation
A new family of inadone and tetralone tubulin-binding compounds (TBs) is disclosed. Unlike classical TBs, which inhibit mitosis among affected dividing cells, the TBs of the invention possess two...
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6147111 |
Phenyl derivatives useful as endothelin receptor antagonists
Novel phenyl derivatives which are useful as endothelin receptor antagonists.
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6136999 |
C-2 hydroxyl protected-n-acyl (2R,3S)-3-phenylisoserine substituted phenyl activated esters and method for production thereof
A chemical compound having the formula: ##STR1## wherein P 1 is a hydroxyl protecting group, R 1 may be H or electron withdrawing group, R 2 may be H or electron withdrawing group, R 3 may be H...
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6130246 |
Pesticides
The compounds of formula I ##STR1## wherein: a) X is O, and Y is OC 1 -C 4 alkyl; or b) X is O or S, and Y is NHCH 3 have fungicidal properties and can be used in plant protection for...
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6103925 |
Dimethyl-substituted cyclohexane diene derivatives
The present invention relates to dimethyl-substituted cyclohexanediene derivatives, to a process for their preparation, to their use as pharmaceuticals and to corresponding pharmaceuticals.
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6028219 |
Process for the nitration of diphenylethers
A process for the preparation of a compound of general formula I: ##STR1## wherein: R 1 is hydrogen or C 1 -C 6 alkyl, C 2 -C 6 alkenyl or C 2 -C 6 alkynyl, any of which may optionally be...
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6017918 |
Phenyl glycine compounds and methods of treating atherosclerosis and restenosis
The present invention provides compounds having the Formula I ##STR1## The present invention also provides methods of treating atherosclerosis, coronary heart disease, and restenosis using the...
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6013827 |
Compounds
This invention relates to componds of formula I ##STR1## which are useful as PDE IV inhibitors and for treating diseases related thereto.
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6005002 |
Nitrogen mustard prodrugs with novel lipophilic protecting groups, and processes for their production
The invention provides compounds of formula (I) and (II) wherein X and Y are independently chlorine, bromine, iodine, a mesyl group CH 3 SO 3 or a tosyl group OSO 2 phenyl (wherein phenyl is...
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