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7432388 |
Disubstituted chalcone oximes having RARγ retinoid receptor antagonist activity
Compounds of the formula
where the variables have the values described in the specification are antagonists of RAR γ retinoid receptors.
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7414040 |
Thrombopoietin mimetics
Invented are non-peptide TPO mimetics. Also invented are novel processes and intermediates used in the preparation of the presently invented compounds. Also invented is a method of treating...
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7351849 |
Process for producing optically active β-amino acid derivatives
The present invention is to provide a method for producing the desired optically active β-amino acid derivatives of high optical purities in high yields, without requiring a step of deprotection....
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7314888 |
Compounds and medicinal use thereof
A compound or a salt thereof having the atom corresponding to N 3 and the two or more atoms selected from N 1 , N 2 , N 4 and N 5 , said atoms constitute the pharmacophore represented by the...
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7282605 |
Optically active 2-allylcarboxylic acid derivative and process for producing the same
The present invention provides a process for producing an optically active 2-allylcarboxylic acid derivative, which is useful as a pharmaceutical intermediate, from readily available and...
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7244864 |
Process for the preparation of N,N-substituted 5-amino-1,3-benzenedicarboxamides
The invention relates to a process for the preparation of a compound of formula (I), wherein R represents a 2,3-dihydroxy-1-propyl or a 1,3-dihydroxy-2-propyl radical, via direct amidation of a...
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7138538 |
Process for the separation of enantiomers and enantiopure reagent
Process for the separation of enantiomers comprising at least one free functional group, in which process a reagent based on an enantiopure amino acid is reacted in basic medium with a mixture...
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7094919 |
Preparation of substituted aromatic carboxylic acid esters
Methods for preparing substituted aromatic carboxylic acid esters are described. In particular, the invention relates a method for preparing a nitro-substituted aromatic carboxylic acid ester:
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7012151 |
Method for nitrating aniline derivatives
The present invention relates to a process for the highly regioselective aromatic nitration of alkyl 4-alkanoylamino-3-alkyl-benzoates in the 5-position in a mixture containing nitric acid and the...
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6949585 |
Cyclooctanone derivatives and cyclodecanone derivative, and use thereof
The present invention provides a compound which has cytokine production inhibitory activity and is useful for the treatment of diseases which is associated with cytokine. The compound is...
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6855842 |
Intermediates for making a bezofuran or benzothiophene derivative nitrated in position 5 and uses thereof
The invention concerns novel nitroaromatic compounds of general formula (I′) wherein: R, R′1, R2, Z and n are as defined in claim 1 . The invention also concerns a method for preparing...
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6753347 |
Intermediates for the synthesis of benzimidazole derivatives and a process for the preparation thereof
This invention provides a process for the preparation of a benzimidazole derivative (I) or a pharmaceutically acceptable salt thereof, wherein R 1 is C 1 -C 6 alkyl, C 1 -C 6 alkoxyl, etc., R...
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6727098 |
Biaryl-type compounds, CD color fixing agent and method for determination of absolute configuration
A novel achiral biaryl-type compound and a circular dichroism (CD) color fixing agent are provided. Furthermore, a method for determining an absolute configuration of a chiral compound is carried...
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6699463 |
Photostable cationic organic sunscreen compounds with antioxidant properties and compositions obtained therefrom
Compounds of Formula I Each R is independently linear or branched C 1 to C 8 alkyl, or linear or branched C 1 to C 8 alkoxy or one R is H and the other R is linear or branched C 1 to C 8 ...
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6686496 |
Treatment of myeloma
The compounds of the invention which encompasses a class of compounds having the property of anti-carcinogenic activity against human myeloma r comprising 4-oxo-2-butenoic acid compounds and...
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6656737 |
Isocynate derivatizing agent and methods of production and use
An organic compound useful for detecting the total quantity of isocyanate in an environmental sample is provided. The compound is 9-anthrcenylmethyl-1-piperazinecarboxylate (PAC), an isocyanate...
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6630598 |
Process for producing N-acylnitroaniline derivative
A process of reacting a nitroaniline compound of formula (2): with an acid anhydride or acid halide is carried out in the presence of an alkali metal compound or an alkaline earth metal compound...
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6555703 |
Process for the preparation of carboxylic acid benzyl esters
The invention relates to a process for forming a carboxylic benzyl ester comprising reacting a dibenzyl ether with a carboxylic acid in the presence of a heteropolyacid and forming a carboxylic...
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6531624 |
Aminoacrylic acid derivatives and process for producing the same
A process for producing a benzoylacrylic acid derivative (formula 1) in high yield through a small number of steps and a simple purification step. The process comprises reacting...
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6403638 |
2,4-pentadienoic acid derivatives having selective activity for retinoid X (RXR) receptors
Compounds having the formulas below, where R is H, lower alkyl, or a pharmaceutically acceptable salt, and where R 1 represents i-propyl, t-butyl or n-butyl groups, have selective RXR retionoid...
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6369194 |
Vicinyl tricarbonyl compounds and combinatorial libraries containing same
The invention relates to compounds of formula where R is a structural diversity element selected from the group consisting of alkyl, cycloalkyl, aryl, heteroaryl, peptidyl,...
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6348619 |
Process for producing a carboxylic acid ester by reacting an aldehyde and an alcohol using a palladium type catalyst
A carboxylic acid ester is prepared by a process comprising: reacting an aldehyde and an alcohol in a liquid phase in the presence of molecular oxygen as indicated by the following reaction:...
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6337418 |
Preparation of C1-C5 alkyl esters of nitro or thioether substituted aromatic carboxylic acids
Methods for preparing substituted aromatic carboxylic acid esters are described. In particular, the invention relates a method for preparing a nitro-substituted aromatic carboxylic acid ester: ...
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6329377 |
Ketomethylene group-containing cysteine and serine protease inhibitors
The present invention is directed to novel ketomethylene group-containing inhibitors of cysteine or serine proteases. Methods for the use of the protease inhibitors are also described.
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6310245 |
3-aminocarbonyl/3-aminothiocarbonyl-substituted 2-benzoyl-cyclohexan-1,3-diones with herbicidal effect
The invention relates to 2-benzoylcyclohexane-1,3-diones of the formula I ##STR1## where R 1 , R 2 are hydrogen, nitro, halogen, cyano, thiocyanato, alkyl, haloalkyl, alkoxyalkyl, alkenyl,...
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6284910 |
Farnesyl pyrophosphate analogs
The post-translational addition of a farnesyl moiety to the Ras oncoprotein is essential for its membrane localization and is required for both its biological activity and ability to induce...
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6284894 |
Preparation of allylic aromatic compounds
A process for the preparation of an allylic aromatic compound in which an aromatic amine is reacted first with a nitrite and then with an allylic olefin having an eliminatable terminal substituent....
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6258982 |
Process for the preparation of substituted aromatic amino compounds
The present invention relates to a hydrogenation process for the preparation of aromatic amino compounds containing directly on the aryl ring or in a side chain one or more entities that may also...
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6255517 |
Thymol derivatives having anti-tumor activity, and anti-cancer agent comprising the same
The present invention relates to a thymol derivative represented by following Chemical Formula 1, pharmaceutically acceptable salts or esters thereof, and anti-cancer agents comprising the same as...
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6251944 |
Para-substituted phenylene derivatives
The present invention relates to a class of compounds represented by Formula I ##STR1## or a pharmaceutically acceptable salt thereof, pharmaceutical composition comprising compounds of the Formula...
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6162943 |
Method for producing α-alkoxy-α-trifluoromethyl-aryl acetic esters and -aryl acetic acids
Process for the preparation of α-alkoxy-α-trifluoromethyl-arylacetic esters of the formula (I) ##STR1## wherein R is a component selected from the group consisting of C 1 -C 6 -alkyl, C 2 -C 6...
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6057269 |
Benzylhydroxylamines and intermediates used to prepare them
Benzylhydroxylamines I ##STR1## (X=--N(R 7 )--O--; Y=O, S; R 1 =halogen, CN, NO 2 , CF 3 ; R 2 =H, halogen; R 3 =H, NH 2 , CH 3 ; R 4 =H, halogen, C 1 -C 6 -alkyl, C 1 -C 6 -haloalkyl,...
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6043360 |
Intermediates and a process for preparing benzo[B]thiophenes
The instant invention provides intermediates and processes for the preparation of compounds of formula IV ##STR1## wherein: n is 0, 1, or 2; R is hydrogen or C 1 -C 4 alkyl; X 1 is...
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6030803 |
Dibenzodihydropyridinecarboxylic esters and their use in chemiluminescent assay methods
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6002041 |
Process for preparing di-C.sub.1 - C.sub.4 -alkyl 5-nitro-isophthalates
Particularly pure di-C 1 -C 4 -alkyl 5-nitro-isophthalates are obtained in good yield and in a simple process by dissolving 5-nitro-isophthalic acid in a mixture of a C 1 -C 4 -alkyl alcohol...
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5985919 |
(Het)aryloxy-, -thio- , aminocrotonates, methods of preparing them and their use as insecticides and fungicides
(Het)aryloxy-, -thio- and -aminocrotonates of the formula I ##STR1## where the substituents have the following meanings: U is oxygen, sulfur or amino; V is oxygen, sulfur, amino or alkylamino; ...
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5905164 |
Polyalkylene polyol esters of dialkylaminobenzoic acid and their use in photoinitiated curing processes
Amine compounds of general formula (I), ##STR1## wherein: each R 1 independently represents an alkyl group; each R 2 independently represents an alkyl group; each group X independently represents...
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5885990 |
Substituted amidinonaphthyl ester derivative
Substituted amidinonaphthyl ester compounds effective for treatment of thrombosis are represented by the following formula (I) and pharmaceutically acceptable acid addition salts thereof: ##STR1##...
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5773656 |
Process for the preparation of optically active 1-aryl-alkylamines
Known (R)-1-aryl-alkylamines of the formula ##STR1## in which R 1 and Ar have the meanings indicated in the description, are prepared by a new process, which comprises a) reacting a racemate...
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5763719 |
Thermally stable fullerene derivatives and process for producing the same
A fullerene derivative of the formula I ##STR1## where the symbols and indices have the following meanings: F is a fullerene radical of the formula (C 20 +2m), where m is a number from 1 to 50 R...
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5756810 |
Process of preparing 3-nitro benzoate compounds in lower alkanol
A process for preparing t-butyl 4-(hydroxymethyl)-3-nitrobenzoate from t-butyl 4-(acetoxymethyl)-3-nitrobenzoate which comprises reacting t-butyl 4-(acetoxymethyl)-3-nitrobenzoate with hydrazine or...
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5728864 |
Liquid crystal compound having ferrielectric phase and liquid crystal composition
A liquid crystal compound of the formula (1) ##STR1## wherein R is a linear alkyl group having 6 to 12 carbon atoms, both X and Y are hydrogen atoms or one of X and Y is a fluorine atom and the...
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5721234 |
Glutamate receptor antagonists: fused cycloalkylouinoxalinediones
Novel glutamate receptor antagonists represented by the formula ##STR1## or a pharmaceutically acceptable salt thereof, wherein Z is an alicyclic fused ring having 5 to 7 carbon atoms; R 1 ...
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5719307 |
Diamine chain extenders and method of use
Polyurethane-urea elastomers are made using as a chain extender 2-methyl-1,3-propanediol-bis-p-aminobenzoate which is the reduction product from hydrogenating...
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5719306 |
LTA.sub.4 hydrolase inhibitors
The present invention provides compounds of the formula Ar 1 --Q--Ar 2 --Y--R--Z and pharmaceutically acceptable salts thereof wherein Ar 1 and Ar 2 are optionally substituted aryl moieties, Z...
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5717109 |
Excitatory amino acid receptor antagonists
The present invention provides compounds of formula ##STR1## in which R represents an organic group, or a pharmaceutically acceptable metabolically labile ester or amide thereof, or a...
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5709719 |
Poly(oxyalkylene) esters of substituted polyphenylethers and fuel compositions containing the same
A poly(oxyalkylene) ester of a substituted polyphenylether having the formula: ##STR1## wherein A is amino, aminomethyl, cyano, nitro, N-alkylamino or N-alkylaminomethyl wherein the alkyl group...
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5703269 |
Process for preparing aromatic olefins
The preparation of aromatic olefins from haloaromatics and olefins (Heck reaction) is carried out in the presence of palladium complexes as catalysts, which complexes contain heterocyclic carbenes...
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5693617 |
Inhibitors of the 26s proteolytic complex and the 20s proteasome contained therein
Disclosed herein is a method for reducing the rate of degradation of proteins in an animal comprising contacting cells of the animal with certain proteasome inhibitors. The structure of the...
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5663461 |
Process for producing geranylgeraniol
A process for producing geranylgeraniol is provided, which comprising the steps of subjecting a mixture of at least one ester derivative wherein one or more carbon-carbon double bonds in the...
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