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8173704 Difluorophenol derivatives and their use  
The present application relates to novel difluorophenol derivatives, processes for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for producing...
8173685 Pleuromutilin derivatives and their use as antimicrobials  
A compound of formula (I) or of formula (II) wherein X is oxygen or sulfur, and Y is a residue of pipecolic acid or a residue of an amino acid, preferably a naturally occurring amino acid.
8110703 Retinoid derivative and pharmaceutical composition and use thereof  
The invention relates to a retinoid derivative and pharmaceutical composition and use thereof. The compound of the invention is capable of preventing or treating hematological tumors, such as acute...
8022243 Low odour oligomeric photoinitiator and method of making the same  
Disclosed herein are a class of low odor oligomeric photoinitiators produced from the poly-condensation of dimethyl dicarboxylates and diols of a photo-active moiety. The disclosed oligomeric...
8013180 Method for immobilizing compound onto column carrier  
It is intended to provide a method for immobilizing, onto a column carrier, a compound having a sulfo group or a compound to which a sulfo group can be added. The method comprises immobilizing the...
7977491 Dendron and dendrimer, method of producing the same, and method of producing a thioacetal compound  
A dendron or dendrimer, which has, as a recurring unit of each branch, a structure of formula (I): wherein TC designates a linkage to a former generation in the direction to a focal point of the...
7932416 Ortho-substituted pentafluorosulfanylbenzenes, process for their preparation and their use as valuable synthetic intermediates  
Pentafluorosulfanyl-benzenes according to Formula (I): a process for their preparation and their use as valuable synthetic intermediates for preparing, for example, medicaments, diagnostic aids,...
7902381 Synthesising method and benzoxathiepine intermediates  
The invention relates to preparing derivatives of formula (1), wherein, in particular R1 and R2, identical or different, represent a hydrogen, flourine or chlorine atom, a hydroxy group, an alkyl...
7528276 Process for preparing the intermediate compounds for PPAR α ligands  
The present invention provides a process for preparing the compounds of formula (II) according to a single reaction, which is an important intermediate compound for synthesizing GW7647 (III) and...
7442718 Inhibitors of aspartyl protease  
The present invention relates to a novel class of sulfonamides which are aspartyl protease inhibitors. In one embodiment, this invention relates to a novel class of HIV aspartyl protease inhibitors...
7271283 High refractive index, UV-curable monomers and coating compositions prepared therefrom  
Disclosed herein are high refractive index monomers that are curable by ultraviolet light. These monomers may be a component of curable compositions useful in the preparation of optical articles....
7262318 Substituted heteroaryl- and phenylsulfamoyl compounds  
The present invention is directed at substituted heteroaryl- and phenylsulfamoyl compounds, pharmaceutical compositions containing such compounds and the use of such compounds as peroxisome...
7232930 Compounds and methods for preparing methanesulfonamides  
A process for preparing (S)-(−)-N-[4-[4-[ethyl(6-fluoro-6-methylheptyl)amino]-1-hy droxy]phenyl]methanesulfonamide hemifumarate salt, which comprises reacting N...
7217831 Insecticide and method of controlling insects  
An insecticide of formula 1 and the agriculturally acceptable salts thereof, wherein: R1 is selected from the group consisting of:the group OR5 wherein R5 is selected from the group consisting of...
7129268 Peroxisome proliferator activated receptor-active arylene acetic acid derivatives  
Novel compounds of the general formula (I), wherein Ar, R1, R2, X1, X2, Y1, Y, and Z are as defined in the specification, the use of these compounds as pharmaceutical compositions, pharmaceutical...
7087644 Derivatives of dicarboxylic acid having pharmaceutical properties  
The invention relates to compounds of formula (I) as well as the salts and stereoisomers thereof wherein the several variable groups are as defined in the specification and claims. Processes for...
7045649 C2-substituted idan-1-ols and their derivatives, processes for their preparation and their use as pharmaceuticals  
Embodiments of the invention relate to C2-substituted indan-1-ols and to their physiologically acceptable salts and physiologically functional derivatives. Compounds of embodiments of the invention...
7015208 C2-substituted indan-1-ols and their derivatives, processes for their preparation and their use as pharmaceuticals  
Embodiments of the invention relate to C2-substituted indan-1-ols and to their physiologically acceptable salts and physiologically functional derivatives. Compounds of embodiments of the invention...
RE38947 Method of enantioselectively catalyzing a reaction  
A chiral catalyst is disclosed together with methods of using it for enantioselective syntheses. The chiral catalyst includes a nucleus with two metal atoms that has four bridging ligands oriented...
6849648 Phenylene alkyne matrix metalloproteinase inhibitors  
A compound of Formula I or a pharmaceutically acceptable salt thereof, or a tautomer thereof, wherein G1, G2, and B are as defined in the application, are selective inhibitors of MMP-13. The...
6777442 Diphenyl derivatives  
The present invention relates to compounds of the general formula (I) in which X represents O, S, SO, SO2, CH2, CHF, CF2 or NR8, and Z represents a group of the formula in which A represents O or...
6720445 Acetyloxymethyl esters and methods for using the same  
Novel acetyloxymethyl esters are disclosed. Methods of treating an illness, including cancer, hemological disorders and inherited metabolic disorders, and treating or ameliorating other conditions...
6667413 Uracil compounds and use thereof  
The present invention relates to an uracil compound of the formula [I]: wherein W represents oxygen, sulfur, imino or C1 to C3 alkylimino; Y represents oxygen, sulfur, imino or C1 to C3 alkylimino;...
6649639 Antipicornaviral compounds, compositions containing them, and methods for their use  
Picornaviral 3C protease inhibitors, obtainable by chemical synthesis, inhibit or block the biological activity of the picornaviral 3C protease. These compounds, as well as pharmaceutical...
6610747 Phenoxybenzylamine derivatives as SSRIs  
A compound of general formula (I) wherein R1 and R2 are H, C1-C6alkyl or (CH2)d(C3-C6cycloalkyl) wherein d=0, 1, 2 or 3; or R1 and R2 together with the nitrogen to which they are attached form an...
6608196 Process for solid supported synthesis of pyruvate-derived compounds  
Provided are processes for synthesizing structurally diverse pyruvate-derived compounds using a parallel approach on a solid phase support. Examples of such a solid phase support include resins...
6590119 Methods for the synthesis of dioxoalkanoic acid compounds  
The invention relates to improved methods of producing aryl dioxoalkanoic acid compounds and derivatives useful as intermediates for diarylpyrrole therapeutic agents by the alcoholysis of...
6492550 Alpha-substituted thio, -oxo trifluoromethylketones as phospholipase inhibitors  
Inhibitors of the cytosolic phospholypase A2 enzymes are provided which are of use in controlling a wide variety of inflammatory diseases. The inhibitors of the present invention have the general...
6407281 Process for producing optically active cysteine derivatives  
A process for producing optically active cysteine derivatives with high optical purity and good quality which is economically advantageous and is high in productivity even on a commercial scale is...
6337417 N-phenyltetrahydrophthalamic acid derivatives, methods of producing same, and herbicides containing same as effective components  
The invention provides N-phenyltetrahydrophthalamic acid derivatives represented by the general formula [I], methods of producing the same, herbicides containing the same as the effective...
6306873 Substituted β-thiocarboxylic acids  
This invention relates to compounds of general formula (I): ##STR1##in which Ar is a group selected from: ##STR2##A1, A2, B, C, D, E, Q1-Q3, R1-R9, Z1 and Z2 are as defined in the disclosure, and Y...
6300514 Aryl (sulfide, sulfoxide and sulfone) derivatives and drugs containing the same as the active ingredient  
Pharmaceutical composition containing aryl (sulfide, sulfoxide, sulfone) derivatives of the formula (1) and the salts thereof as active ingredient (wherein R1 is H, alkyl; R2 is COOR7, CONHOR8 ; E...
6288071 1-ethylene-2-alkylene-1,4-cyclohexadiene pesticides  
Pesticidally active cyclohexadienyl derivative compounds of the formula I that are esters, oximes or amides are claimed. These compounds may be used as fungicides, acaricides and insecticides in...
6255522 Process for reducing α-amino ketones  
The present invention has its objects to provide a method for reducing α-aminoketone derivatives under mild conditions with high stereoselectivity. This invention is a method for reducing ...
6180785 Process for preparing diltiazem  
A process for preparing a 2R-hydroxy-3-[(2-amino-phenylthio)]-3-[(p-alkoxyaryl)] propanoic acid alkyl ester of formula (V) ##STR1##wherein R is an alkyl, or benzoyl residue, R1 is hydrogen, an...
6153650 Substituted gamma aminobutyric acids as pharmaceutical agents  
6143917 Process for producing aryl carbamates  
A process for producing an aryl carbamate of a high purity at a high yield by reacting a diaryl carbonate with an amine compound having one or more hydrogen atoms bonded to the N position in the...
6114523 Process for the recycle of a waste product of diltiazem synthesis  
A process which allows the re-use of compounds of formula ##STR1## in diltiazem synthesis through a process of conversion to a mixture of enantiomers III-(2R,3R) and III-(2S,3S) is described.
6096773 Compounds that inhibit the binding of integrins to their receptors  
A method for the inhibition of the binding of α4 β1 integrin to its receptors, for example VCAM-1 (vascular cell adhesion molecule-1) and fibronectin; compounds that inhibit this binding; p...
6013606 Substituted cinnamic oxime and hydroxamide derivatives  
Substituted cinnamic oxime derivatives I and cinnamic hydroxamide derivatives II ##STR1## (R1= halogen, NO2, CN, CF3 ; R2 =H, halogen; R3= H, halogen, C1 -C6 -alkyl, C1 -C6 -haloalkyl, C3 -C6...
5945548 Process for the synthesis of α-substituted acrylic acids and their application  
Process for the synthesis of α-substituted acrylic acids of general formula (I) and their application to the synthesis of N-(mercaptoacyl)aminoacid derivatives of formula (II). ##STR1##
5945450 Naphthalene derivative  
Naphthalene derivatives represented by formula I!: ##STR1## (wherein A is a hydrogen atom, a hydroxy group, a C7 -C11 aralkyloxy group, or an alkoxy group composed of an oxy group and a C1 -C12...
5925764 Process and intermediated for the manufacture of pyridine-2, 3-dicarboxylate compounds  
The present invention provides a process to prepare a pyridine-2,3-dicarboxylate derivative via the reaction of a dailkyl alkoxy(or alkylthio)oxalacetate with an appropriately substituted acrolein...
5919824 Aminophenol derivatives  
Aminophenol derivatives represented by the following formula (1): ##STR1## wherein X is O or S; A is alkylene, R1 is phenyl, etc., R2 and R3 are H or alkyl; R4 is substituted carbamoylalkyl, etc.;...
5883285 Process for production of thioaryl compound  
The present invention provides: a process for producing an alkali metal salt of an arylmercaptan compound, represented by general formula (3): ##STR1## which process comprises reacting a disulfide...
5849943 Stilbene derivatives useful as cyclooxygenase-2 inhibitors  
The invention encompasses novel compounds of Formula Iuseful in the treatment of cyclooxygenase-2 mediated diseases. ##STR1## The invention also encompasses certain pharmaceuticalcompositions and...
5756809 Process for the preparation of (2RS,3RS)-3-(2'-aminophenylthio)-2-hydroxy-3-(4"-methoxyphenyl)-propioni c acid methyl ester  
(2RS,3RS)-3-(2'-aminophenylthio)-2-hydroxy-3-(4"-methoxyphen yl)-propionic acid methyl ester, an important precursor for the preparation of the pharmaceutical active substance diltiazem, is...
5750711 Dicarboxylic acid derivatives  
The dicarboxylic acid derivatives according to the invention have the following structure ##STR1## wherein X denotes O, S, (CF2)m, C(CF3)2 or CF2 --CF(CF3) (m=1 to 10), and R stems from the...
5734077 Substituted 2,2-dimethyl-omega-phenoxyalkanoic acids and esters  
New substituted 2,2-dimethyl-ω-phenoxyalkanoic acids and esters of formula: ##STR1## wherein: X, A, B, R, R1, R2, R3, R4, R5, R6, R7 and Z are as defined in the specification,The corresponding ...
5731452 7-thiaprostaglandins and method of production thereof  
7-thiaprostaglandins having the formula (I) which inhibit cell migration induced by monocyte chemoattractant protein MCP-1/MCAF and other chemokines and can serve as drugs for the treatment of...
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