|
Match
|
Document |
Document Title |
|
|
7563924 |
9-chloro-15-deoxyprostaglandin derivatives, process for their preparation and their use as medicaments
The present invention relates to 9-chloroprostaglandin derivatives of the general formula I which may be advantageous for the treatment of fertility problems.
|
|
|
7517873 |
Substituted pyrimidodiazepines
The present invention provides PLK1 inhibitor compounds of formula I:
Useful in the treatment or control of cell proliferative disorders, particularly oncological disorders. These compounds and...
|
|
|
7514474 |
Prostaglandin analog compositions and methods to treat epithelial-related conditions
The present invention relates to the formulation and delivery of prostaglandin analogs to treat epithelial-related condition. In some embodiments, the compositions of the invention are used to...
|
|
|
7501222 |
Photoresist monomer polymer thereof and photoresist composition including the same
A polymer including a monomer represented by the following Formula and a photoresist composition including the same are disclosed. The polymer and photoresist composition can improve the resolution...
|
|
|
7476755 |
Therapeutic compounds
Therapeutic substituted cyclopentane compounds, and compositions, medicaments, and therapeutic methods related thereto are disclosed herein.
|
|
|
7449595 |
Nitrosated and nitrosylated prostaglandins, compositions and methods of use
The invention describes novel nitrosated and/or nitrosylated prostaglandins, and novel compositions comprising at least one nitrosated and/or nitrosylated prostaglandin, and, optionally, at least...
|
|
|
7425651 |
Jasmonate derivative compounds, pharmaceuticals compounds and methods of use thereof
The present invention provides novel jasmonate derivative compounds, methods for their preparation, pharmaceutical compositions including such compounds, and methods of using these compounds and...
|
|
|
7388103 |
Cyclopentane carboxylate compounds, process and intermediates for preparing the same and use thereof
The present invention discloses cyclopentane carboxylate compounds. The 1-hydrocarbyl-2-acyloxy-cyclopentane carboxylates according to the invention have a general formula (I):
wherein groups R...
|
|
|
7285613 |
Free-radical curable polyesters and methods for use thereof
The invention is based on the discovery that certain polyester compounds bearing free-radical curable moieties are useful as b-stageable adhesives for the microelectonic packaging industry.
|
|
|
7271283 |
High refractive index, UV-curable monomers and coating compositions prepared therefrom
Disclosed herein are high refractive index monomers that are curable by ultraviolet light. These monomers may be a component of curable compositions useful in the preparation of optical articles....
|
|
|
7214813 |
Preparation of chiral cyclic amino acids and derivatives
Cyclic β-(acylamino)acrylate derivatives were hydrogenated using Ru-chiral phosphine ligand catalysts and thereafter converted to the corresponding cyclic β-aminoacids in high yield and...
|
|
|
7176238 |
Nitrostated and nitrosylated prostaglandins, compositions and methods of use
The present invention describes novel nitrosated and/or nitrosylated prostaglandins, and novel compositions comprising at least one nitrosated and/or nitrosylated prostaglandin, and, optionally, at...
|
|
|
7091231 |
12-Aryl prostaglandin analogs
Compounds comprising
are disclosed, wherein Y, A, X, R, D, and n are as described.
A compound comprising a prostaglandin EP 2 selective agonist wherein the ω-chain comprises a substituted...
|
|
|
7045653 |
Pharmaceuticals
The invention relates to NEP inhibitors for treating cardiovascular disorders. Preferred NEP inhibitors are compounds of formula (I) wherein R 1 is C 1 –C 6 alkyl, C 1 –C 6 alkoxyC 1 –C 3...
|
|
|
7005437 |
Substituted aryl and heteroaryl derivatives, the preparation thereof and the use therof as pharmaceutical compositions
The present invention relates to new substituted aryl and heteroaryl derivatives of general formula
wherein
A, Ar, n, X, Y 1 , Y 2 , Y 3 , Y 4 , R 1 and R 5 are defined as in claim 1...
|
|
|
6956056 |
Method for providing a cathartic effect
The present invention relates to a novel method for providing a cathartic effect to a patient in need of cathartic induction, which comprises administering to the patient a cathartic-inducing...
|
|
|
6909014 |
Intermediates for the synthesis of ether compounds
The present invention relates to novel ether compounds, compositions comprising ether compounds, and methods useful for treating and preventing cardiovascular diseases, dyslipidemias,...
|
|
|
6878723 |
LTA4 hydrolase inhibitors
The invention concerns compounds inhibiting LTA 4 hydrolase of formula (I). The invention also concerns their therapeutic, in particular anti-inflammatory, applications.
|
|
|
6753443 |
Preparing method of chiral ester
The present invention relates to a process for preparing a chiral ester according to the formula (100): by reacting (i) a racemic alcohol, (ii) a selected ruthenium complex to activate...
|
|
|
6750363 |
Olefination process to itaconate and succinate derivatives
An efficient and selective process, capable of scale-up, to make itaconate derivatives of formula (IV), and/or succinate derivatives of formula (V) and/or (VI) by asymmetric hydrogenation of the...
|
|
|
6710081 |
Erection insufficiency remedies
Therapeutic agents for erectile dysfunction containing as the active ingredient prostaglandin derivatives of formula (I) (wherein symbols have the same meanings as described in the description),...
|
|
|
6680339 |
15-fluoro prostaglandins as ocular hypotensives
15-fluoro substituted analogs of PGF 2α and methods of their use in treating glaucoma and ocular hypertension are disclosed.
|
|
|
6642274 |
Methods and compositions for preventing and treating prostate disorders
The present invention relates to methods, compositions, devices and kits for the prevention and treatment of prostate disorders in mammals, including, but not limited to, benign prostatic...
|
|
|
6632958 |
Process for producing a purified prostaglandin derivative
An alkene (1) is added to cyclopentenone (2) under the action of an alkyl lithium and an organic copper reagent to form an adduct, said adduct is reacted with e.g. a carboxylic anhydride (4) to...
|
|
|
6576786 |
Process for preparing substituted cyclopentane derivatives and novel crystalline structures thereof
The invention relates to a process for preparing substituted cyclopentane derivatives represented by the formula (I) wherein R 1 , R 2 , R 3 , R 4 , X and Y are as described in the...
|
|
|
6541655 |
Catalytic compositions and methods for asymmetric allylic alkylation
Complexes of a selected class of chiral ligands with molybdenum, tungsten or chromium, preferably molybdenum, are effective as catalysts in highly enantioselective and regioselective alkylation of...
|
|
|
6528688 |
Prostacyclin derivatives
An improved method is described for making 9-deoxy-PGF 1 -type compounds. In contrast to the prior art, the method is stereoselective and requires fewer steps than the known methods for making...
|
|
|
6512139 |
Oxidation inhibitors in prostane derivatives
The invention relates to the use of an oxidation inhibitor, i.e. active carbon, for ambient air in industrial manufacturing, especially in the processing of prostane derivatives, whereby the...
|
|
|
6495725 |
Process for the preparation of optically active enones and intermediates thereof
The present invention provides a simplified and convenient process for the preparation of an optically active enone such as 7,7-dimethyl-6,8-dioxabicyclo-[3,3,0]oct-3-en-2-one. The invention...
|
|
|
6455584 |
Prostaglandin E1 derivatives
To provide a prostaglandin derivative represented by the formula: wherein A is an ethylene group, a vinylene group, an ethynylene group, O(CH 2 ) q or S(O) r (CH 2 ) q , R 1 is a C 3-10 ...
|
|
|
6452039 |
Endothelin antagonist
An endothelin antagonist comprising as the active ingredient a prostanoic acid derivative wherein the α-chain has eight or more skeletal carbon atoms.
|
|
|
6444840 |
C11 oxymyl and hydroxylamino prostaglandins useful as FP agonists
The invention provides novel prostaglandin analogs. In particular, the present invention relates to compounds having a structure according to formula (I) wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 ,...
|
|
|
6410780 |
C11 oxymyl and hydroxylamino prostaglandins useful as medicaments
The invention provides novel prostaglandin analogs. In particular, the present invention relates to compounds having a structure according to formula (I) wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 ,...
|
|
|
6410591 |
3,7 or 3 and 7 thia or oxa prostanoic acid derivatives as agents for lowering intraocular pressure
The present invention provides a method of treating ocular hypertension or glaucoma which comprises administering to an animal having ocular hypertension or glaucoma a therapeutically effective...
|
|
|
6395786 |
Sleep inducing agent
A sleep-inducing preparation which comprises as an effective ingredient a prostaglandin derivative represented by the formula: wherein X is a halogen atom, Y is a group represented by (CH 2 ) m...
|
|
|
6376699 |
Process for preparing alkoxytriazolinones
Hydroazinecarboxylic acid ester of the formula In which R 1 is an optionally substituted alkyl group, an aryl group, an arylalkyl group or a cycloalkyl group, and R 3 is an optionally...
|
|
|
6369194 |
Vicinyl tricarbonyl compounds and combinatorial libraries containing same
The invention relates to compounds of formula where R is a structural diversity element selected from the group consisting of alkyl, cycloalkyl, aryl, heteroaryl, peptidyl,...
|
|
|
6326369 |
Bicyclic quinone compounds, their production and use
A compound of the formula: ##STR1## wherein R 1 and R 2 each represents a lower alkyl, or R 1 and R 2 may be bonded together to form a ring; X represents a spacer of which the number of atoms...
|
|
|
6313341 |
Process for the preparation of prostaglandins
A hydroxy-1-alkyne is reacted with a tin hydride compound, and the obtained (E,Z)-hydroxyvinylstannanes are separated to give the (E)-substance which is further converted to a vinylcopper complex...
|
|
|
6288113 |
Angiogenesis promoters
An angiogenesis promoter containing a compound of the following formula (I) ##STR1## wherein R 1 is acyl, R 2 is alkyl, R 3 and R 4 are the same or different and each is hydrogen atom or...
|
|
|
6271408 |
Process for making metabolites of lycopene
This invention relates to trimethylsilyloxy-cyclopentane derivatives: 3-(1-Acetoxy-1-methylethyl)- 2-formyl-1-methyl-1-trimethylsilyloxy-cyclopentane;...
|
|
|
6265440 |
Prostaglandins E and anti ulcers containing same
The novel 13,14-dihydro-15-keto prostaglandins E of the invention have remarkable preventive effects against ulcers. Further, the novel 13,14-dihydro-15-keto-prostaglandins E of the invention have...
|
|
|
6258975 |
Process for producing optically active 2-hydroxy-4-arylbutyric acid or its ester
Provided is an industrially useful process for producing an optically active 2-hydroxy-4-arylbutyric acid or its ester. An optically active acyloxysuccinic anhydride is reacted with an aromatic...
|
|
|
6235780 |
ω-cycloalkyl-prostaglandin E1 derivatives
|
|
|
6225347 |
9-halogen-(Z)-prostaglandin derivatives, process for their production and their use as pharmaceutical agents
The invention relates to 9-halogen-(Z) prostane derivatives of formula I ##STR1## in which ##STR2## Z represents the radicals Hal represents a chlorine or fluorine atom in the alpha or beta...
|
|
|
6160013 |
14-aza prostaglandins for the treatment of glaucoma and ocular hypertension
14-Aza analogs of PGF 2 α, PGD 2 , and PGE 2 and methods of their use in treating glaucoma and ocular hypertension are disclosed.
|
|
|
6156799 |
Method of increasing bone volume using non-naturally-occurring FP selective agonists
The present invention relates to novel methods of increasing bone volume comprising the administration of a non-naturally-occurring selective FP agonist to a subject in need of such treatment. This...
|
|
|
6153650 |
Substituted gamma aminobutyric acids as pharmaceutical agents
|
|
|
6147254 |
Process for resolving mixtures of carbocyclic stereoisomers
A process for the preparation of carbocyclic stereoisomers of formulae (I), (I'), (IIA'), (IIB'), (VA') and (VB'), including enantiomerically pure (IIA'), (I) and (I') utilizing fractional...
|
|
|
6118019 |
3-alkoxypropionic ester derivative
A 3-alkoxypropionic ester derivative, an olefin polymerization solid catalyst component using the same, an olefin polymerization catalyst using the same, and a process for the preparation of a...
|