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7592478 Ligand antagonists of RAR receptors and pharmaceutical/cosmetic applications thereof  
Novel ligand antagonists of the RAR receptors have the following structural formula (I): in which A is a CH 2 , CHOH, C═O or C═N—OH radical or a sulfur or selenium atom; B is a radical...
7476754 Biphenyl derived thiamides as calpain inhibitors  
The present invention relates to compounds derived from biphenyl with activity as calpain inhibitors. One compound of the present invention is a 2,2′-disubstituted biphenyl, where the...
7442418 Polymerizable liquid crystal compound, liquid crystal composition, optical anisotropic material and optical element  
The present compound represented by formula(I) CH 2 ═CR 1 —COO—(L) k -E 1 -E 2 -E 3 -(E 4 ) m -(E 5 ) n -R 2 ...
7358386 Indane acetic acid derivatives and their use as pharmaceutical agents, intermediates, and method of preparation  
This invention relates to novel indane acetic acid derivatives which are useful in the treatment of diseases such as diabetes, obesity, hyperlipidemia, and atherosclerotic diseases. The invention...
7348449 Ligand antagonists of RAR receptors and pharmaceutical/cosmetic applications thereof  
Novel ligand antagonists of the RAR receptors have the following structural formula (I): in which A is a CH 2 , CHOH, C═O or C═N—OH radical or a sulfur or selenium atom; B is a radical...
7323587 Selective estrogen receptor modulators  
The present invention provides, inter alia, triphenylethylene derivatives, such as, 3-{4-[6-(3-Methoxy-phenyl)-8,9-dihydro-7H-benzocyclohepten-5 -yl]-phenyl}-acrylic acid, as selective estrogen...
7122695 Process for the preparation of cyclopropyl carboxylic acid esters and derivatives  
The invention relates to a novel process for the preparation of certain cyclopropyl carboxylic acid esters and other cyclopropyl carboxylic acid derivatives; a novel process for the preparation of...
7087796 Cyclopropanecarboxaldehydes and their use in perfume compositions  
The present invention is directed to novel cyclopropanecarboxaldehyde compounds of the general formula wherein R is a straight, branched, or cyclic hydrocarbon moiety consisting of 1 to 30...
7074826 R-NSAID esters and their use  
The present invention concerns esters of R-enantiomers of a non-steroidal anti-inflammatory drug, which is substantially free from the S-enantiomer. The compounds of the invention may be used in...
6992095 Stilbene compounds comprising an adamantyl group, compositions and methods thereof  
The invention relates to novel stilbene compounds having the general formula (I): as well as to pharmaceutical compositions for use in human or veterinary medicine, including dermatological,...
6972340 Selective protein tyrosine phosphatatase inhibitors  
Compounds of formula (I) or therapeutically acceptable salts thereof, are selective protein tyrosine kinase-B (PTP1B) inhibitors. Preparation of the compounds, compositions containing the...
6924388 Bicyclic aromatic compounds and pharmaceutical/cosmetic compositions comprised thereof  
Novel pharmaceutically/cosmetically-active bicyclic aromatic compounds having the structural formula (I): in which Ar 1 is a radical having one of the structural formulae (a)-(c): and Ar...
6924082 Double-bond shifts of substituted (4n)-annulenes for information storage and data processing  
The present application describes a method for information storage and data processing comprising the steps of thermo inducing or photo inducing double-bond shifts (DBS) in substituted (4 n...
6849757 Antiangiogenic drug to treat cancer, arthritis and retinopathy  
Compounds having Formula I or pharmaceutically acceptable salts or prodrugs thereof, are useful for treating pathological states which arise from or are exacerbated by angiogenesis. The...
6838574 Dicarba-closo-dodecarborane derivatives  
A medicament comprising as an active ingredient a compound or a physiologically acceptable salt thereof represented by general formula (I): wherein R 1 represents a...
6730804 Process for preparing cyclopropanecarboxylates of lower alcohols  
Cyclopropanecarboxylates of lower alcohols are prepared by esterification of the corresponding cyclopropanecarboxylic acids with the corresponding lower alcohols in the presence of an acid...
6627656 Method of treatment using phenyl and biaryl derivatives as prostaglandin E inhibitors and compounds useful therefore  
This invention encompasses a method for the treatment or prevention of prostaglandin mediated diseases comprising administering to a mammalian patient a compound of formula I: in an amount that...
6617469 Process for preparing malonic diesters in a reactor with internal heat exchangers  
A process for preparing malonic diesters by carbonylation of haloacetic esters and reaction with monohydric alcohols and a base in the presence of a transition metal catalyst, preferably a...
6583307 Convenient and efficient Suzuki-Miyaura cross-coupling catalyzed by a palladium/diazabutadiene system  
A Pd(OAc) 2 /diazabutadiene system has been developed for the catalytic cross-coupling of aryl halides with arylboronic acids. A combination of the diazabutadiene DAB-Cy (1,...
6518306 1,4-substitued 4,4-diaryl cyclohexanes  
This invention relates to compounds of Formula (I) where Z is an amine, alcohol or derivative thereof, and the ketone analog thereof.
6515163 Hydrogenated phenanthrenes and their use in liquid-crystal mixture  
The invention concerns hydrogenated phenanthrenes of formula I wherein the parameters have the meanings given in the text and their use in liquid crystal compositions.
6492542 Method for producing carboxylic acid tertiary alkyl ester  
A carboxylic acid tertiary alkyl ester (Chemical formula 1) of high purity is obtained at a high yield ratio, by continually adding an esterification agent possessing a monovalent acid group, which...
6469198 Chiral copper complex catalyst composition and asymmetric production process using the same  
There is disclosed chiral copper complex catalyst composition, which is obtained by contacting an optically active N-salicylideneaminoalcohol compound of formula (1): with a mono-valent or...
6455727 Process for preparing carbetapentane tannate  
The invention pertains to a process for preparing carbetapentane tannate. The process involves the steps of heating carbetapentane to a temperature of about 80 to about 120° C. and slowly adding...
6452037 Multioligonanilinated fullerenes  
A compound, of the following formula: Also disclosed is a pharmaceutical composition containing a pharmaceutically effective amount of the compound.
6433214 Process for the preparation of 2-(4-methylphenyl)-benzoic acid derivatives  
A process for the preparation of 2-(4-methylphenyl)benzoic acid C 1-6 alkyl esters by reaction of a sulfonic derivative of formula wherein R is C 1-6 alkyl and R 1 is optionally perfluorinated...
6403638 2,4-pentadienoic acid derivatives having selective activity for retinoid X (RXR) receptors  
Compounds having the formulas below, where R is H, lower alkyl, or a pharmaceutically acceptable salt, and where R 1 represents i-propyl, t-butyl or n-butyl groups, have selective RXR retionoid...
6379590 Method for making unsymmetrically substituted fluorenyl compounds for nonlinear optical applications  
A new method for producing unsymmetrically substituted fluorenyl compounds, one step of which is the preparation of 2,7-disubstituted fluoren-9-one derivatives via the nucleophilic substitution of...
6369266 Process for producing tert-butyl 4′-methyl-2-biphenylcarboxlate  
A process for preparing tert-butyl 4′-methyl-2-biphenylcarboxylate characterized in that 4′-methyl-2-biphenylcarboxylic acid is reacted with isobutene in the presence of an acid catalyst....
6344583 Oxidation of ketones to esters using a tin substituted zeolite beta  
Applicants have developed a process for the oxidation of ketones to esters. The process involves contacting the ketone with hydrogen peroxide and a catalyst at oxidation conditions. The catalyst is...
6319948 Retinoid antagonists and uses thereof  
Retinoid antagonist compounds have been found to be useful in the prevention and/or minimization of surgical adhesion formation. Also provided by the invention are certain novel substituted...
6271411 Process for preparing 2-aryl-substituted indenes  
A process is disclosed for preparing 2-aryl-substituted indenes by reacting an indene with an arene compound substituted with an halogen atom, preferably a iodine atom, or with an organosulphonate...
6248919 Process for the preparation of farnesyltransferase inhibitors  
A process for the preparation of preparation of farnesyltransferase inhibitors of formula (I) ##STR1## or pharmaceutically acceptable salts or prodrugs thereof, is disclosed.
6214999 Method for preparing bromomenthyl-biphenyl derivatives  
The present invention relates to a process for the preparation of 4'-bromomethyl-biphenyl derivatives of the formula: ##STR1## by reacting a 4'-methyl-biphenyl derivative of the formula: ##STR2##...
6194599 Process for preparing biaryl compounds  
The present invention provides a process for preparing biaryl compounds comprising reacting an arylzinc reagent with an arylchloride in the presence of a nickel catalyst or a palladium catalyst....
6150413 Triaromatic compounds and pharmaceutical/cosmetic compositions comprised thereof  
Novel pharmaceutically/cosmetically-active triaromatic compounds have the structural formula (I): ##STR1## and are useful for the treatment of a wide variety of disease states, whether human or...
6147111 Phenyl derivatives useful as endothelin receptor antagonists  
Novel phenyl derivatives which are useful as endothelin receptor antagonists.
6124474 Synthesis of chiral 2-azetidinemethanol compounds  
A process for preparing chiral isomers of N-protected 2-azetidinemethanol compounds, particularly N-(phenylmethyl)-2-azetidinemethanol and N-BOC-2-azetidinemethanol, and especially the (R)-isomers...
6124354 Arylcycloalkane carboxylic esters, their use, pharmaceutical compositions and preparation  
This invention relates to the use of 2-(diisopropylamino)-ethyl-1-phenyl-cyclopentane-carboxylate or 2-(diisopropylamino)-ethyl-1-phenyl-cyclohexane-carboxylate, or a pharmaceutically accceptable...
6117359 Tetralin compound, liquid crystal material and liquid crystal composition  
The invention to provide novel tetralin compounds, liquid crystal materials and liquid crystal compositions, which can constitute a liquid crystal element affording a wide operating temperature...
6111130 Process for the preparation of trifluoromethyl containing derivatives  
The present invention relates to a process for the preparation of trifluoromethylated derivatives of the formula CF 3 CClCHCH 2 OC(O)R, wherein R is unsubstituted or substituted C 1 to C 6...
6110955 Metabolically stabilized oxyalkylene esters and uses thereof  
This invention relates to compositions for and methods of treating, preventing or ameliorating cancer and other proliferative diseases as well as methods of inducing wound healing, treating...
6080784 Protein kinase C modulators N  
Compositions with protein kinase C-modulatory, anti-inflammatory and other activities are disclosed.
6030546 Trans-olefin compounds, method for production thereof, liquid crystal composition containing the same as active ingredient, and liquid crystal element using said composition  
The present invention relates to trans-olefin compounds represented by the general formula (1) useful as an ingredient of liquid crystal composition, trans-olefin compounds useful as intermediate...
6020519 Diphenyl-cyclopropenes as selective K-agonists  
The diphenyl-cyclopropene derivatives of the instant invention are kappa opioids useful in the treatment of pain, inflammation, Parkinsonism, dystonia, cerebral ischemia, diuresis, asthma,...
5994379 Bisaryl COX-2 inhibiting compounds, compositions and methods of use  
The present invention relates to inhibitors of COX-2, compositions which contain such compounds and methods of use. The compounds are represented by formula I: ##STR1## and include pharmaceutically...
5976409 Swallow-tail-shaped liquid crystal compound  
A swallow-tail-shaped liquid crystal compound of the following general formula (1), ##STR1## wherein A is --O--, --COO-- or a single bond (--), m is an integer of 4 to 12, and n is an integer of 2...
5976408 Acrylonitrile derivative, liquid crystal composition, and liquid crystal display device  
An acrylonitrile derivative expressed by the following general formula I, a composition comprising the derivative and having an improved viscosity and optical anisotropy, and a liquid crystal...
5968908 Restricted 9-cis retinoids  
The invention is novel analogs of 9-cis-retinoic acid which are useful for the treatment and prevention of coronary artery disease and to protect against premature atherosclerosis by increasing HDL...
5945561 Retinoid-like compounds  
Certain novel substituted (5,6)-dihydroanthracenyl compounds of the general formula ##STR1## wherein A, n, p, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 and R 8 are as defined in the specification...
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