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8927586 Thromboxane A2 (TP) receptor antagonists  
The present invention relates to novel TP receptor antagonists, which optionally cross the blood-brain barrier of a mammal. The invention also provides methods for treating a disorder related to...
8664425 Bluegreen fluorescent compounds  
Fluorescent compositions having emission under long UV excitation can be utilized as security taggants in printing inks. The fluorescent compositions can be esters of 2-naphthalenesulfonamide, and...
8163806 Controlled release of biologically active compounds from multi-armed oligomers  
The present invention relates to the discovery of biodegradable multi-armed oligomers wherein the end groups of these oligomers have been functionalized with biologically active molecules. The...
8066906 Polymerizable compound and polymerizable composition  
A polymerizable compound represented by general formula (1): wherein A represents a ring assembly composed of at least two 6-membered rings each optionally having a substituent; X1 and X2 each...
8008297 Lysine based compounds  
The present invention provides lysine based compounds of the formula; and when the compound of formula I comprises an amino group, pharmaceutically acceptable ammonium salts thereof, wherein R1...
7538165 Conductive polyaniline composition, film thereof and processes for producing these  
The invention provides an electrically conductive polyaniline composition comprising polyaniline which contains at least one of novolac resins selected from the group consisting of phenolsulfonic...
7446222 Phenyl compounds  
Compounds of formula (I) or derivatives thereof: wherein A, B, Z, R1, R2a, R2b, Rx, R8, and R9 are as defined in the specification, a process for the preparation of such compounds, pharmaceutical...
7388008 Lysine based compounds  
The present invention provides lysine based compounds of the formula; and when the compound of formula I comprises an amino group, pharmaceutically acceptable ammonium salts thereof, wherein R1...
7365196 Sulphonamido-substituted bridged bicycloalkyl derivatives  
A class of compounds is disclosed, comprising sulphonamido-substituted bridged bicycloalkyl structures. The compounds are inhibitors of gamma-secretase, and hence are useful in the treatment of...
7217831 Insecticide and method of controlling insects  
An insecticide of formula 1 and the agriculturally acceptable salts thereof, wherein: R1 is selected from the group consisting of:the group OR5 wherein R5 is selected from the group consisting of...
7199265 Thyroid receptor ligands, pharmaceutical compositions comprising them and their use in the treatment of disorders influenced by thyroid hormones  
This invention relates to compounds of the formula (I) which are thyroid receptor ligands, and are preferably selective for the thyroid hormone receptor β, to methods of preparing such compounds...
6936636 5-[phenyl-tetrahydronaphthalene-2-yl dihydronaphthalen-2-yl and heteroaryl-cyclopropyl]-pentadienoic acid derivatives having serum glucose reducing activity  
Compounds of the formula: where the variables have the meaning defined in the specification are capable of reducing serum glucose levels in diabetic mammals without the undesirable side effects of...
6906046 Pharmaceutical uses and synthesis of benzobicyclooctanes  
Benzobicyclooctane compounds, their use in inhibiting cellular events involving TNF-α and IL-8, and in the treatment of inflammation events in general; a combinatorial library of diverse...
6875895 Bis (diphenylvinyl) arene compound  
Provided is a bis(diphenylvinyl)arene compound having a reactive functional group on phenyl group, represented by below formula (1), wherein, Ar is an arylene group and has one or more...
6846890 Norbornene derivative and norbornene polymer obtained therefrom through ring opening polymerization  
A novel norbornene derivative represented by a general formula (1m) shown below is provided. By conducting a ring opening polymerization of this norbornene derivative, or by performing a...
6747148 Sulfonamide derivatives as inhibitors of bone resorption and as inhibitors of cell adhesion  
Sulfonamide derivatives, their physiologically tolerable salts and their prodrugs according to the present invention are vitronectin receptor antagonists and inhibitors of cell adhesion, as well...
6632816 Aromatic derivatives as HIV aspartyl protease inhibitors  
The present invention provides HIV aspartyl protease inhibitors of the formula; and when the compound of formula I comprises an amino group, pharmaceutically acceptable ammonium salts thereof,...
6603012 RAR selective retinoid agonists  
New compounds containing bicyclic fused rings, one of which being a phenyl moiety connected by an aliphatic chain to a cycloalkyl or aryl moiety, and pharmaceutically active salts thereof are...
6326510 Bi-aromatic compounds, compositions containing them and uses  
The invention relates to novel biaromatic compounds having general formula I ##STR1##and their use in pharmaceutical compositions for use in human and veterinary medicine, in particular for...
6291702 Azulenyl nitrone spin trapping agents, methods of making and using same  
The present invention relates to chromotropic nitrone spin trapping agents, methods of making these agents, compositions comprising same, and methods of their use. In particular, azulenyl nitrones...
6277845 Hydrazono-benzazulene derivatives, pharmaceutical compositions and intermediates  
Compounds of the formula ##STR1##wherein the substituents are as defined in the application and their pharmaceutically acceptable acid and base salts thereof which are useful for preventing loss...
6265603 Inhibitors of isoprenyl transferase  
Peptidomimetic isoprenyl transferase inhibitors R6SCHR1'CHR1WCHR2YC(:X)NR3CHR5COR4 wherein R1=OH, H, alkyl, amino group or R1 and R6 together form a heterocyclic ring; R1'=H, alkyl, aryl; R2=H,...
6258977 Alkyl3-oxoalkanoates  
An alkyl 3-oxoalkanoate, a process for preparation and use for the synthesis of fatty hydroxylated amino acids, fatty amino alcohols and ceramides.
6201019 Bi-aromatic compounds bound by a heteroethynylene radical and pharmaceutical and cosmetic compositions containing same  
Bi-aromatic compounds linked via a heteroethynylene radical are provided along with pharmaceutical and cosmetic compositions containing these compounds and methods for their use.
H001950 Processes for preparing indeno[1,2-E][1,3,4]oxadiazine-dicarboxylates  
Oxadiazines of formula I, wherein R1 is F, Cl or fluoroalkoxy and R2 is alkyl, are prepared by reacting hydrazine derivatives of formula II with a dialkoxymethane in the presence of a protic acid...
6166072 Amino acid derivatives  
Described herein are compounds having the general formula: ##STR1## wherein: Ar1 and Ar2 are independently selected aryl groups, optionally substituted with substituents selected from the group...
6110955 Metabolically stabilized oxyalkylene esters and uses thereof  
This invention relates to compositions for and methods of treating, preventing or ameliorating cancer and other proliferative diseases as well as methods of inducing wound healing, treating...
6018068 Naphthyloxyacetic acid derivatives and drugs comprising the same as active ingredients  
The naphthyloxyacetic acid derivatives of the formula (I) ##STR1## wherein A is H, --(alkylene)COOR1, --(alkylene)CONR2 R, --(alkylene)OH, --(alkylene)tetrazole, --(alkylene)CN; E is single bond...
5945561 Retinoid-like compounds  
Certain novel substituted (5,6)-dihydroanthracenyl compounds of the general formula ##STR1## wherein A, n, p, R1, R2, R3, R4, R5, R6, R7 and R8 are as defined in the specification exhibit...
5889053 Farnesyl transferase inhibitors, preparation thereof and pharmaceuticals compositions containing said inhibitors  
Novel farnesyl transferase inhibitors of general formula (I), ##STR1## the preparation thereof and pharmaceutical compositions containing said inhibitors, are disclosed. In general formula (I), R1...
5866604 Thiol derivatives with metallopeptidase inhibitory activity  
Compounds of formula (I) wherein R, R1, R2, R3, R4, m and n have the meanings reported in the description, processes for their preparation and pharmaceutical compositions which contain them as...
5849793 HIV matrix protein tyrosine position 29 pocket binders  
There is disclosed a structural genus of compounds, defined according to coordinates in three-dimensional space, that binds amino moieties on neighboring lysine residues in a tyrosine residue 29...
5843910 Colchicine derivatives and the therapeutical use thereof  
The present invention relates to novel colchicine derivatives of formula (1), where Y is a --CH2 --CH--NH--R3 group or a --CH--CH2 OR3 group and the other variables are as defined in claim 1,...
5843999 2-phenylazulene derivatives and a manufacturing method of these compounds  
A series of new azulene derivatives are disclosed, which are represented by the following formula; ##STR1## wherein: R1 is hydrogen atom, lower alkoxycarbonyl group, carboxy group, halogen atom,...
5837807 Tetrahydronaphthalene compounds  
This invention is directed to tetrahydronaphthalene compounds of the formula ##STR1## wherein R1 is hydrogen, bromine, cyano, formyl, hydroxy, lower alkyl, lower alkenyl, lower alkynyl, lower...
5808124 O- or S-substituted dihydronaphthalene derivatives having retinoid and/or retinoid antagonist-like biological activity  
Compounds of the formula ##STR1## where the symbols have the meaning described in the application, have retinoid-like or retinoid antagonist-like biological activity.
5760048 Alpha-mercaptoacrylic acid derivatives having calpain inhibitory activity  
The invention covers a novel series of α-mercaptoacrylic acid derivatives that inhibit both calpain I and calpain II with a high affinity and selectivity. The compounds are useful in the treatment...
5741819 Arylsulfonylaminobenzene derivatives and the use thereof as factor Xa inhibitors  
The present invention is directed to non-peptidic factor Xa inhibitors which are useful for the treatment of arterial and venous thrombotic occlusive disorders, inflammation, cancer, and...
5739374 Processes of preparing diphenylheteroalkyl derivatives  
Diphenylheteroalkyl derivatives of the formula I ##STR1## where A and R1 -R6 have the meanings specified in the description, and the preparation thereof are described.The substances are suitable...
5728864 Liquid crystal compound having ferrielectric phase and liquid crystal composition  
A liquid crystal compound of the formula (1) ##STR1## wherein R is a linear alkyl group having 6 to 12 carbon atoms, both X and Y are hydrogen atoms or one of X and Y is a fluorine atom and the...
5723493 Naphthyloxyacetic acid  
(1) Naphthyloxyaetic acid represented by the compound of the formula (I): ##STR1## and non-toxic salts thereof, (2) process for the preparation of the compounds represented by the compound of the...
5705533 10-thio-substituted 1,8-dihydroxy-9 (10H) -anthracenone pharmaceuticals  
10-thio-substituted 1,8-dihydroxy-9(10H) anthracenones, therapeutic compositions containing at least one of the 10-thio-substituted 1,8-dihydroxy-9(10H) anthracenones of the invention and methods...
5693846 Process for preparation of 4-mercapto-1-naphthol compounds  
A process for preparation of 4-mercapto-1-naphthol compounds which comprises the steps of: (i) obtaining a 4-heterocyclylthio-1-naphthol compound by reacting a 1-naphthol compound with a...
5676923 Substituted DTPA monoamides of the central carboxylic acid group and their metal complexes  
Diethylenetriaminepentaacetic acid monoamide derivatives, their complexes and complex salts, containing an element of atomic numbers 21-29, 31, 32, 39, 42-44, 49 or 57-83, pharmaceutical agents...
5618931 Acetylenes disubstituted with a 5 substituted dihydronaphthyl group and with an aryl or heteroaryl group having retinoid-like biological activity  
Compounds of the formula ##STR1## wherein the symbols have the meaning described in the specification have retinoid-like biological activity.
5574017 Antibacterial agents  
The present invention provides methods and pharmaceutical preparations for inhibiting the growth of bacterial microorganisms.
5536870 Process for preparing olefins  
A process for preparing olefin compounds of the formula ##STR1## where A is aryl, substituted aryl, heteroaryl, substituted heteroaryl, benzyl, substituted benzyl, vinyl or substituted vinyl and...
5536874 Process for preparing arylacetic acid and arylpropionic acid derivatives  
There is provided a process for preparing an arylacetic acid or arylpropionic acid divative from an arylcarbinol which comprises the step of subjecting said arylcarbinol to suitable carbonylation...
5536867 Process for the manufacture of dicarboxamides  
The present invention is directed to a process, and novel intermediates used in the manufacture of, dicarboxamides of the formula I ##STR1## wherein A, G, L, Q, X and Y have the meaning given in...
5530014 Cyclohexadiene derivatives  
The cyclohexadiene derivatives are prepared by reaction of cyclohexanones with amines and subsequent dehydration. The compounds are suitable as active compounds in medicaments on account of their...

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