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9000037 Precursors of glutamate derivatives  
This invention relates to novel precursors suitable for 18F radiolabeling of glutamate derivatives, methods for preparing such compounds and its intermediates, compositions comprising such...
8637713 Process for preparation of optically active compounds using transfer hydrogenation  
A catalytic process for the preparation of optically active compounds and their conversion thereafter to desired drug substances. In particular, the process relates to the preparation of...
8609864 Hydroxamic acid derivatives  
The disclosure includes hydroxamic compounds of Formula I: (I) wherein P, Z, and m are defined herein. Also disclosed is a method for treating a neoplastic disease or an immune disease with these...
8546607 Cross-coupling of phenolic derivatives  
Embodiments of the invention provide methods and materials for chemical cross-coupling reactions that utilize unconventional phenol derivatives as cross-coupling partners. Embodiments of the...
8501382 Acid amplifiers  
There are disclosed sulfonic acid precursor compositions, as are methods of using these compositions in, for example, photolithography. Other embodiments are also disclosed.
8435717 Compound for photoacid generator, resist composition using the same, and pattern-forming method  
A sulfonic acid onium salt represented by the following formula (1) can be used as a superior radiosensitive acid generator for resist compositions. It is possible to form a good pattern by using...
8420846 Process for producing (S)-3-[(1-dimethylamino)ethyl] phenyl-N-ethyl-N-methyl-carbamate via novel intermediates  
Disclosed herein are novel intermediates and process for large scale production of (S)-3-[(1-dimethylamino)ethyl]phenyl-N-ethyl-N-methyl-carbam ate (rivastigmine) or its pharmaceutically...
8415508 Process for the preparation of optically active compounds using transfer hydrogenation  
A catalytic process for the preparation of optically active compounds and their conversion thereafter to desired drug substances. In particular, the process relates to the preparation of...
8329934 Isotopically labeled chemically stable reagents and process for the synthesis thereof  
A radioisotope labeled reagent includes a compound having the general formula (I), L-(aCbH2)naC5bH3 (I) where a in each occurrence independently is a carbon mass number between 11 and 14...
8173350 Oxime compound and resist composition containing the same  
An oxime compound represented by the formula (I): wherein Y represents an unsubstituted or substituted n-valent C6-C14 aromatic hydrocarbon group, n represents an integer of 1 to 6, R1 represents...
8168617 Complex pantoic acid ester neopentyl sulfonyl ester cyclization release prodrugs of acamprosate, compositions thereof, and methods of use  
Pantoic acid ester neopentyl sulfonyl ester prodrugs of acamprosate, pharmaceutical compositions comprising such prodrugs, and methods of using such prodrugs and compositions thereof for treating...
7994357 Cinamic compounds and derivatives therefrom for the inhibition of histone deacetylase  
The invention relates to a compound represented by the following formula (I): and pharmaceutically acceptable salts, stereoisomers, enantiomers, prodrugs and solvates thereof. The compounds are...
RE42132 Antitumoral D-homoestra-1,3,5(10)-trien-3-yl 2-substituted sulfamates  
This invention relates to 2-substituted D-homo-estra-1,3,5(10)-trien-3-yl sulfamates of general formula I (I), in which R3 means a C1-C5-alkyl or C1-C5-alkyloxy group as well as their use for the...
7396923 Method for the sulfonation of compounds comprising free hydroxyl (OH) groups or primary or secondary amines  
A method for sulfonating compounds having one or more free hydroxyl functional groups and/or one or more optionally substituted primary or secondary functional groups, including treating the...
7355021 Single pot process for the preparation of diazonaphthoquinonesulfonyl ester  
The present invention provides a single pot process for the preparation of diazonaphthoquinonesulfonyl ester, a useful organic material for micro electronic and dye industry. This study pertains...
7244762 Antitumoral d-homoestra-1,3,5 (10)-trien-3-yl 2-substituted sulfamates  
This invention relates to 2-substituted D-homo-estra-1,3,5(10)-trien-3-yl sulfamates of general formula I (I), in which R3 means a C1-C5-alkyl or C1-C5-alkyloxy group as well as their use for the...
7196209 Continuous process for the preparation of fructopyranose sulfamate derivatives  
The present invention is directed to a continuous process for the preparation of fructopyranose sulfamate derivatives of the general formula (I) wherein R1, R3, R4, R5, R6 and X are as herein...
7157589 One step process for the preparation of anticonvulsant derivatives  
The present invention is directed to a one-step process for the preparation of fructopyranose sulfamate derivatives of the general formula (I) wherein X, R1, R3, R4, R5 and R6 are as described in...
7119206 Derivative of dihydro-dibenzo (a) anthracenes and their use as selective estrogen receptor modulators  
The present invention provides a compound of the formula (I) wherein R1 is —H, —OH, —O(C1–C4 alkyl), —OCOC6H5, —OCO(C1–C6 alkyl), or —OSO2(C2–C6 alkyl); R0, R2 and R3 are each independently —H,...
7034015 Aminobenzoephenones  
The invention relates to a novel class of aminobenzophenones derivatives, to pharmaceutical preparations comprising said compounds, to dosage units of such preparations, to methods of treating...
6992205 Process for the production of sulfonic esters  
Sulfonic acid ester derivatives represented by the general formula (4) or (5) are produced by reacting an amino alcohol derivative represented by the general formula (1) or (2) with an organic...
6852755 Nitrogen mustard compounds and prodrugs therefor  
This invention pertains to nitrogen mustard compounds (Formula (II)) and prodrugs therefor (Formula (I)), methods for their preparation, pharmaceutical compositions comprising such compounds, and...
6756409 Phenoxyphenyl alkanesulphonates  
The invention relates to novel phenoxyphenyl alkanesulphonates, processes for their preparation, their use for producing medicaments for the treatment and/or prophylaxis of diseases, in particular...
6730783 Process for preparing aminoguanidines and alkoxyguanidines as protease inhibitors  
Aminoguanidine and alkoxyguanidine compounds, including compounds of the formula: wherein X is O or NR9 and R1-R4, R6-R9, R11, R12, Ra, Rb, Rc, Y, Z, n and m are set forth in the specification, as...
6706765 Aminoguanidines and alkoxyguanidines as protease inhibitors  
Aminoguanidine and alkoxyguanidine compounds, including compounds of the formula: wherein X is O or NR9 and R1-R4, R6-R9, R11, R12, Ra, Rb, Rc, Y, Z, n and m are set forth in the specification, as...
6268520 Tricyclic compounds  
Novel tricyclic compounds of formula I as defined in the specification, a process for their preparation and their use for the preparation of optically active or racemic colchicine and...
6187944 Acrylonitrile compounds, process for their production and pesticides containing them  
Acrylonitrile compounds having pesticidal activity of formula (I) and salts thereof. ##STR1##wherein Q is ##STR2##Y is C(R4)-- or N--, R1 is alkyl, haloalkyl, etc., each of R2 and R3 is halogen,...
6169116 Amino-tetralines, pharmaceutical compositions containing them and their pharmaceutical uses  
Compounds of formula I ##STR1##wherein R1, R2, R3, R4 and R5 are as defined in the description, are useful as pharmaceuticals.
6111102 Processes for preparing sulfonylureas  
Compounds of the formula I or salts thereof, in which X is oxygen, --O--NR2 -- or --SO2 --NR2 --, and Y is N or CH, R1 is (C1 -C6)alkyl, (C2 -C6)alkenyl or (C2 -C6)alkynyl, which are in each case...
6084131 Process for the preparation of protected dihydroxypropyl trialkylammonium salts and derivatives thereof  
A process for the preparation of protected dihydroxypropyl trialkylammonium salts, particularly in chiral form is described. In particular, a process for the preparation of...
6075146 Process for preparing benzoic acid derivative intermediates and benzothiophene pharmaceuticals  
The invention relates to intermediates and processes for producing benzothiophenes employing hydroxylamines.
5892088 Sulfamate compound containing N-substituted carbamoyl group and method for preparing the same  
There are disclosed novel sulfamate compounds containing N-substituted carbomoyl group including their racemates and (R)- and (S)-optical isomers represented by Formulas I, II and III,...
5869725 Derivatives of aminosulfonic acids, utilization of the same in the synthesis of pseudopeptides and process for their preparation  
Derivatives of gamma-amino-alpha,beta-unsaturated sulfonic acids, a process for the preparation of the same and their utilization in the synthesis of pseudopeptides characterized by the presence...
5811454 4-amino-fluorobenzamides and their use as cytotoxic prodrugs  
The invention provides a compound which is a 3-fluorobenzamide of the formula (A) ##STR1## wherein R-NH is the residue of an α-amino acid R-NH2 or oligopeptide R-NH2, and M is a nitrogen mustard...
5804532 Herbicidal 2-cyano-1,3-diones  
Herbicides derived from 2-cyano-1,3-diones have the formula: ##STR1## wherein R, R1, R2 R3, R4 and R5 are as defined in the description. The compounds are intended for use pre- and post-emergence...
5760006 Anticonvulsant derivatives useful in treating psoriasis  
The use of compounds of the following formula I: ##STR1## for treating psoriasis is disclosed.
5654461 Sulfamate compound containing carbamoyl group  
3-O-Carbamoyl-2-phenyl-1,3-propanediol sulfamate racemate, represented by the following structural formula I: ##STR1## and its (R)- and (S)-optical isomers, which are very effective for...
5550273 Process for preparing fluorocarbon fluoroalkanesulfonates  
A process for preparing fluorocarbon fluoroalkanesulfonates comprises (a) forming a mixture comprising at least one fluoroalkanesulfonyl halide, e.g., perfluoromethanesulfonyl fluoride, at least...
5491260 Process for manufacturing L-(-)-carnitine from derivatives having a configuration opposite to that of L-(-)-carnitine  
A Process for Preparing L-(-)-carnitine is disclosed which comprises acylating D-(+)-carnitinenitrile or D-(+)-carnitineamide to their respective acyl derivatives which, via acid hydrolysis, yield...
5488118 Process for producing optically active erythro-3-amino-1,2-epoxy compound  
The present invention relates to a process for producing an optically active erythro-3-amino-1,2-epoxy compound represented by the following general formula (3): ##STR1## wherein R1 represents a...
5405871 Benzophenonehydrazones  
Compounds of the formula ##STR1## wherein each of o and p, independently of the other, is 0, 1, 2, 3, 4 or 5, the radicals R1 being the same or different when o is greater than 1 and the radicals...
5387700 Process for the preparation of chlorosulfate and sulfamate derivatives of 2,3:4,5-bis-O-(1-methylethylidene)-β-D-fructopyranose and (1-methylcyclohexyl)methanol  
A process for producing chlorosulfate and sulfamate esters of 2,3:4,5-bis-O-(1-methylethylidene)-β-D-fructopyranose and (1-methylcyclohexyl)methanol is disclosed. The process involves a two step...
5387707 Route of synthesis for tertiary alkyl esters  
4-[(2-chloroethyl)-(2-hydroxyethyl)-amino]benzoyl amino acids of formula (IV), wherein X represents a group (a), where Pro represents hydrogen or a straight or branched chain C1-6 alkyl group, and...
5292911 Monocyclic terpene derivatives  
Novel monocyclic terpene derivative of the formula: ##STR1## wherein R is hydrogen atom, trimethylsilyl group or 1-ethoxyethyl group, and novel intermediates therefor. The terpene derivative (I)...
5273993 Compounds having one or more aminosulfonyloxy radicals useful as pharmaceuticals  
Methods of treating chronic arthritis and osteoporosis which utilize both known and novel compounds which would fall under the general formula: (HO)p--A--[--OS(O)2 NR1 R2 ]zwherein A encompasses a...
5248828 Method for preparing sulfones  
A method for preparing a sulfone represented by the following formula: ##STR1## wherein R' represents a lower alkyl group, an aryl group or an aryl group whose nucleus has at least one substituent...
5194446 Compounds having one or more aminosulfaonyloxy radicals useful as pharmaceuticals  
Methods of treating chronic arthritis and osteoporosis which utilize both known and novel compounds which would fall under the general formula: (HO)p--A--[--OS(O)2 NR1 R2 ]zwherein A encompasses a...
5192785 Sulfamates as antiglaucoma agents  
Sulfamate esters of the formula (HO)p --A--[OSO2 NR1 R2 ]zwhere A is aryloxyalkyl, p is the number of unreacted hydroxy groups present on the alkyl moiety and may be zero, z is the number of...
5179212 Process for the preparation of 3-pyrrolidinols and intermediates therefor  
3-Pyrrolidinol or its salt is economically produced by cyclizing an aminobutanol derivative of the formula: ##STR1## wherein R is an alkyl or a substituted or unsubstituted phenyl group, or its salt.
5140044 UCN-1028D derivatives  
A UCN-1028D derivative represented by the formula: ##STR1## has protein kinase C inhibitory activity and is expected to be used as an active ingredient in anti-tumor agents, etc.

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