Matches 1 - 50 out of 143 1 2 3 >
Match Document Document Title
7238340 Monoamine, diamide, thiol-containing metal chelating agents  
Therapeutically active thiazole derivatives of formula (I) wherein R 1 -R 2 , X and X′ as are defined in the specification, processes for the preparation thereof, the use thereof in therapy,...
7045547 Acyl-CoA dehydrogenase allenic inhibitors  
Compounds of formula I wherein A is R 3 , OR 3 , SR 3 , and NR 3 R 4 ; and R 1 , R 2 , R 3 and R 4 are as defined. The compounds of the invention are reversible inhibitors of acyl-CoA...
6740684 Process for producing a strong-acid cation exchange resin  
A strong-acid cation exchange resin in acid form is contacted with an alkylcarhamoyl alkylthioester in the presence of water for producing a strong-acid cation exchange resin comprising a plurality...
6683200 N-substituted-N′-substituted urea derivatives and pharmaceutical compositions containing the derivatives  
N-Substituted-N′-substituted urea derivatives represented by the following formula, analogs thereof or pharmaceutically acceptable salts thereof are herein provided. These compounds show a TNF-α...
6667341 Delta dicarbonyl compounds and methods for using the same  
Amidomethyl esters, carbonylmercaptomethyl esters, keto-containing esters, amidomethyl thioesters, amidomethyl amides, and methylene dithioesters are disclosed. The novel compounds have two...
6307001 Curable hybrid electron donor compounds containing vinyl ether  
Hybrid electron donor compounds, suitable for use as adhesives or as components in adhesives, contain a carbon to carbon double bond attached to an aromatic ring and conjugated with the...
6303799 Polynucleotide crosslinking agents  
Novel aryl derivatives comprising an aryl olefin moiety linked to a non-nucleosidic backbone moiety are disclosed. The resulting molecules are typically used as photoactivated crosslinking groups...
6300456 Compounds with electron donor and electron acceptor functionality  
Compounds containing both electron donor and electron acceptor functionality are suitable for use in adhesives. The electron donor group is a carbon to carbon double bond attached to an aromatic...
6277957 Method for production of acylthio derivatives  
A method is provided which facilitates and enables the production of a wide range of complex conjugates composed of similar or dissimilar units linked together by amide bonds. Said method for the...
6235922 Processes and intermediates for preparing benzo-fused azepinone and piperidinone compounds useful in the inhibition of ACE and NEP  
Compounds having the following formula I, and pharmaceutically acceptable salts thereof, including dual inhibitors of ACE and NEP and selective ACE inhibitors: ##STR1## wherein: Y 1 and Y 2 ...
6114372 Peptidyl compounds having MMP and TNF inhibitory activity  
Compounds of formula (I) having MMP and TNF inhibitory activity. ##STR1##
6004531 Metal chelating compounds having an SNNN donor set  
Ligands for radiopharmaceutical use are capable of chelating radiometal species and of being bound to biological targeting molecules. The ligands have formula (a) and (b), where A, A'=--SZ or Y,...
5994539 Mercapto acyl aminoacid derivatives endowed with dual ACE-NEP inhibitory activity, useful in the treatment of cardiovascular diseases  
Compounds of formula ##STR1## wherein R, R 1 , R 2 , R 3 , R 4 , m and n have the meanings reported in the description, processes for their preparation and pharmaceutical compositions which contain...
5976812 Activated amphetamines  
The invention concerns activated amphetamine derivatives, a process for their production as well as their use for producing immunogens or detection conjugates carrying amphetamine groups. A further...
5783735 Process for preparing polymeric amides useful as additives in fuels and lubricating oils  
A process for preparing polymeric amides is disclosed. The process comprises sequentially reacting a hydrocarbon polymer functionalized (e.g., via the Koch reaction) to contain acid, ester,...
5710256 Methadone derivatives and protein and polypeptide methadone derivative conjugates and labels  
The present invention is directed to novel methadone derivatives which are synthesized for the covalent attachment to antigens (proteins or polypeptides) for the preparation of antibodies or...
5646313 Amino acid derivatives, processes for their preparation and their therapeutic application  
New amino acid derivatives, processes for their preparation, and their therapeutic application are described. These amino acid derivatives correspond to the general formulae ##STR1## These...
5629343 N-(mercaptoacyl) peptidyl derivatives as antidegenerative agents  
Novel N-(mercaptoacyl)peptidyl compounds are useful as inhibitors of matrix metalloendoproteinases which degrade major components of articular cartilage and basement membranes causing degenerative...
5624955 Compounds that enhance the concentration of glutathione in tissues  
A pharmaceutical unit dosage form comprising an amount of a compound of the formula: ##STR1## is provided wherein R 1 is a (C 1 -C 20 )alkyl group, a (C 6 -C 12 )aryl group, or a C 3 -C 18...
5525629 Inhibition of cytokine production  
Hydroxamic acid derivatives of formula (I): ##STR1## wherein R 1 represents hydrogen or an (C 1 -C 6 )alkyl, (C 1 -C 6 )alkoxycarbonyl(C 1 -C 6 )alkyl, phenyl, substituted phenyl, phenyl(C 1 ...
5508266 Gem-disubstituted amino acid derivatives  
Disclosed are the compounds of formula I ##STR1## wherein R represents hydrogen, lower alkyl, carbocyclic or heterocyclic aryl-lower alkyl or cycloalkyl-lower alkyl; R 1 represents hydrogen, lower...
5475130 Anilide derivative  
An anilide derivative useful as an atherosclerosis treating drug, represented by the following formula (I): ##STR1## wherein X is an alkyl group having 1 to 4 carbon atoms or an alkoxy group having...
5470997 Amphetamine derivatives and protein and polypeptide amphetamine derivative conjugates and labels  
The present invention is directed to novel amphetamine derivatives which are synthesized for the covalent attachment to antigens (proteins or polypeptides) for the preparation of antibodies or...
5414017 Trifluoromethyl mercaptan and mercaptoacyl derivatives and method of using same  
Compounds of the formula ##STR1## wherein m is zero or 1; n is zero, 1 or 2; p is zero or 1 to 6 provided that m and p are not both zero; R 3 is hydrogen, acyl, or benzyl; and R 1 is hydrogen,...
5356925 N-(mercaptoalkyl)ureas and carbamates  
Novel N-(mercaptoalkyl)urea or carbamates of the formulae I and II ##STR1## wherein A is a monocyclic or bicyclic arylene or heteroarylene; Q is hydrogen or R 9 CO--; Y is --O--,--S-- or...
5354495 Alkenoylcarbamate compounds as elasticity, adhesion, and dispersibility enhancer  
A physical property-improving reagent which comprises an alkenoylcarbamate compound of the formula: ##STR1## wherein R is a hydrogen atom or a lower alkyl group, X is an oxygen atom (--O--), a...
5300672 S-substituted carbonyl substituted beta-thioacrylamide biocides and fungicides  
A compound of the formula ##STR1## wherein R 1 is an organic radical having at least 2 carbon atoms; R 2 is an organic radical; and A=CO, CH 2 , or CHR 3 where R 3 is unsubstituted or...
5241078 Coupling agents and sterically hindered disulfide linked conjugates prepared therefrom  
This invention discloses heterobifunctional coupling agents for making a wide array of molecular conjugates. The agents contain a sterically hindered thiol, linked through a spacer arm to a second...
5231113 Tetralin esters of phenols or benzoic acids having retinoid like activity  
Retinoid-like activity is exhibited by compounds of the formula ##STR1## where the R groups are independently hydrogen, or lower alkyl; A is --C(O)O--, --OC(O)--, --C(O)S--, or --SC(O)--; n is 0-5;...
5223516 3,3,3-trifluoro-2-mercaptomethyl-N-tetrazolyl substituted propanamides and method of using same  
Compounds of the formula ##STR1## wherein Y can be tetrazolyl are disclosed. These compounds are useful as cardiovascular agents.
5219886 Mercapto-acylamino acids  
Novel mercapto-acylamino acids of the formula ##STR1## wherein Q is hydrogen or R 7 CO--; R 1 is lower alkyl, cyclolower alkyl, aryl or heteroaryl; R 2 is hydrogen; lower alkyl; cyclolower...
5218128 Bifunctional coupling agents and radionuclide labeled compositions prepared therefrom  
A bifunctional coupling agent for joining a sulfhydryl-containing protein or peptide and a metallic radionuclide comprising a sulfhydryl selective electrophile, a chelator containing at least one...
5214181 Amino acid derivatives  
This invention relates to novel compounds of the formula [I], which are useful for treatment of various diseases such as immunodeficiency and autoimmune diseases caused by immune disorders,...
5210266 N-substituted mercaptopropanamide derivatives  
Novel N-substituted mercaptopropanamide derivatives of the formula: ##STR1## wherein R 1 is mercapto or a group convertible into mercapto when cleaved within the biobody, W is hydrogen atom, an...
5205947 Dispersant additives comprising amine adducts of dicarboxylic acid monoepoxy thiol reaction products  
The present invention is directed to an oil-soluble lubricating oil additive comprising at least one adduct of (A) a polyolefin of 700 to 5,000 number average molecular weight substituted with...
5200101 Arylamine/hindered phenol, acid anhydride and thioester-derived multifunctional antioxidant, antiwear and rust inhibiting additives  
Arylamine/hindered phenol, acid anhydride and thioester-derived reaction products, have been found to be effective multifunctional antioxidant, antiwear and rust inhibiting additives for lubricants...
5179121 Thiobutyric acid derivatives  
Novel 4-chloro-4,4-difluorothiobutyric acid derivatives of the formula I ##STR1## in which R 1 and R 2 are, independently of one another, hydrogen, C 1 -C 4 alkyl or C 1 -C 4 halogenoalkyl...
5177109 2-amino-4,5-methyleneadipic acid compounds for treatment of CNS disorders  
Compounds, compositions and methods are described for treating a CNS disorder such as a cognitive disorder, epilepsy, depression, Parkinson's disease, Alzheimer's disease, a neurodegenerative...
5175257 Radiolabeled proteins for diagnostic or therapeutic use  
Chelating compounds of specified N 2 S 2 N 3 S derived structure are useful for radiolabeling targeting molecules such as antibodies. Cleavable ester orthioester linkers connect the radionuclide...
5147868 Thienamycin renal peptidase inhibitors  
Novel chemical compounds are provided which selectively inhibit the metabolism of dipeptidase (E.C.3.4.13.11) and therefore are useful in combination with antibacterial products. These chemical...
5136076 Process for the preparation of amino acid-derived enatiomeric compounds  
The (R) or (S) isomer of acetorphan or N-12-acetylthiomethyl-1-oxo-3-phenyl propyl/(S) alanine methyl ester is prepared by splitting of racemic 3-acetylthio-2-benzyl propanoic acid by reaction with...
5124322 Dipeptide collagenase inhibitors  
Novel compounds of formula (I), salts, solvates and hydrates thereof: ##STR1## in which: R 1 and R 2 are independently hydrogen; alkyl; alkoxy; halogen; or CF 3 ; R 3 is hydrogen; acyl, such...
5112953 Radiolabeled proteins for diagnostic or therapeutic use  
Chelating compounds of specified structure are useful for radiolabeling targeting molecules such as antibodies. Cleavable linkers connect the radionuclide metal chelates to the antibodies. The...
5110348 Glycine compounds and herbicidal compositions thereof  
Novel herbicidal compounds of the general formula ##STR1## in which X represents a phenyl group substituted in the 2-position and optionally substituted in one or more of the 3-, 4-, 5- and...
5105002 Ammonium salt of methyl 4,4,4-trifluoro-3-oxo-butanethioate  
Ammonium salt of methyl 4,4,4-trifluoro-3-oxobutanethioate (TMTFAA).
5098934 Method of relieving pain with mercaptoalkanamides  
Novel ω-mercaptopropanamides and their homologs of the formula ##STR1## wherein R 1 is selected from the group consisting of hydrogen and ##STR2## R 1 ' is selected from the group consisting of...
5093361 D-2-(6-methoxy-2-naphthyl)-propionic acid and pharmaceutical compositions containing it  
The S-[d-2-(6-methoxy-2-naphthyl)-propionyl]d-2-mercaptopropiona midoacetic acid having formula: ##STR1## has improved therapeutic properties not only in comparison with the starting active...
5019285 Thioalkanoic acid substituted N,N-dialkylhydroxylamines and stabilized lubricant compositions  
Lubricants are stablized against oxidative degradation by the incorporation therein of hydroxylamines substituted with thioalkanoic acid residues of the formula ##STR1## wherein R and R 1 are...
5001251 Optical resolution of DL-3-acylthio-2-methylpropanoic acid  
An optically active amine compound and a method for preparing same are provided which compound has the structure ##STR1## in the form of its R-(+) enantiomer or S-(-) enantiomer, wherein R and R 1 ...
4977272 Olefinic N,N'-disubstituted ureas  
This invention relates to new compounds of the formula: ##STR1## where each of R 1 , R 2 , R 3 , R 4 , R 5 , R 6 and R 7 has zero to 10 C atoms, and no acetylenic unsaturation; each of R 1 , R 2...
Matches 1 - 50 out of 143 1 2 3 >