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7375243 |
Method for preparation of amino acid chelate
The present invention provides methods for preparation of metallic amino acid chelates that are electrically neutral and free of interfering ions, by reacting a metal carbonate and an acidic amino...
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7312348 |
Process for preparing sulfurized molybdenum dialkyldithiocarbamates
A process is provided for the manufacture of highly sulfurized metal dithiocarbamates, such as molybdenum dithiocarbamate. A metal source source, water and a reagent amine are heated under pressure...
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7268095 |
Transition metal catalysts for (co) polymerizing of olefinic monomers
A compound of the formula Ia or Ib;
where, in the formula Ia, E 1 is O, S, Se, Te, NR, CR 2 , or PR; E 2 , E 3 are each CR, N, or P; E 4 is N, or P; E 5 is OH, SH, NHR, OR′, SR′,...
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7141689 |
Metal complexes of alpha amino dicarboxylic acids
Neutral alpha amino diacid complexes of trace minerals and their use for animal nutrition.
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7087775 |
Method for preparation of organic chelate
A method for the preparation of organic chelates utilized as ingredients of animal feedstuffs. The organic chelates are passed to the intestines of livestock without decomposition in the stomach,...
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6992203 |
Metal complexes produced by Maillard Reaction products
A method is disclosed for the formation of metal chelates which are able to remain stable in high alkaline environments when compared to metal chelates produced from a reaction with amino acids....
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6911550 |
Derivatives of seleno-amino acids with improved bioavailability and method for their preparation
Metal L-seleno-alpha-amino acids salts and their use as a bioavailable feed and water ration supplement for domesticated animals such as cattle, pigs and poultry.
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6710079 |
Composition and method for preparing amino acid chelates and complexes free of interfering complex ions
A composition and method of preparing amino acid chelates and complexes free of interfering ions by blending an amino acid ligand, a calcium oxide and/or hydroxide, and a hydrated metal sulfate...
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6670494 |
Method for preparation of metal organic acid chelates
A method is disclosed where organic acid chelates can be made by reacting an organic acid ligand with a metal compound in a non aqueous environment. The chelate is thereafter recovered by means of...
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6579904 |
Process for making betaine transition metal complexes for use in animal feed supplements and compositions thereof
Betaine transition metal complexes are formed by: a) reacting a solution including an alkali metal salt of chloroacetic acid with a solution including the transition metal salt to give a solution...
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6426424 |
Composition and method for preparing granular amino acid chelates and complexes
Compositions and methods of preparing amino acid chelates and complexes are disclosed and described. Specifically, by (a) blending hydrated metal sulfate salts, amino acid ligands, and reaction...
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6407138 |
Composition and method for preparing electrically neutral amino acid chelates free of interfering ions
The present invention relates to compositions and methods of preparing amino acid chelates that are electrically neutral and free of interfering ions. The composition is prepared by reacting in an...
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6380278 |
Polyurethane salts
A urethane (meth)acrylate metal salt obtained by reacting (A) one or more polyisocyanates, (B) one or more hydroxy functional (meth)acrylates, and (C) one or more metal salt polyols which are the...
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6340560 |
Aminopolycarboxylic acid chelating agent, heavy metal chelate compound thereof, photographic additive and processing method
An aminopolycarboxylic acid compound represented by the following formula or analogous thereof: The aminopolycarboxylic acid compound of the present invention can be used as a chelating agent...
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6337064 |
Manganese chelates with high relaxivity in serum
Compounds of formula (I) both in the racemic and optically active forms, are used in MRI diagnostic imaging.
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6333292 |
Catalysts for olefin polymerization
Novel compounds are disclosed comprising the skeletal unit depicted in Formula (I) ##STR1## wherein O is oxygen; N is nitrogen; R 1 is hydrogen, hydrocarbyl, substituted hydrocarbyl,...
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6323354 |
Amino acid chelates from lipoproteins
A method of preparing amino acid transition metal chelates a palatable highly bioavailable source of transition metals for animal nutrition from lipoproteins and transition metal salts. The method...
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6303761 |
Triaminepentaacetic acid compound and paramagnetic metal complex prepared from using the compound as ligand
The present invention provides a triaminepentaacetic acid compound which can be used as a ligand to coordinate to a metal ion to form a paramagnetic metal complex. The paramagnetic metal complex of...
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6114379 |
Bioavailable chelates of creatine and essential metals
A chelate comprised of creatine bonded to an essential mineral selected from the group consisting of Mg, Ca, Cu, Zn, Fe, Cr, Co, Mo, Se and Mn to form a heterocyclic ring. Preferably, the metal is...
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6099824 |
Benzyloxy derivatives of DTPA for MRI
Compounds which can chelate paramagnetic bi- and trivalent metal ions, their chelates with said metal ions and their use as contrast agents in magnetic resonance imaging (MRI), the compounds having...
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6060040 |
Cross-linked polymeric compositions for increasing the MRI contrast in visualising the digestive tract of patients
The invention provides, as contrast signal generators in MR imaging of the digestive tract, paramagnetic metal chelates of novel acrylic compounds of formula C(R 1 R 2 )CR 3 --CO--Z--A (1)...
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6045776 |
Process for the production of metal-complex carboxylic acid amides
The invention relates to a process for the production of metal-complex carboxylic acid amides, characterized in that a metal-complex carboxylic acid mixture that consists of the metal-complex...
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5958372 |
Low viscosity chelating polymers for diagnostic imaging
Disclosed are linear and cross-linked polymers suitable for use as a contrast agent for magnetic resonance imaging containing units comprising the residue of a poly(amine) moiety linked to a...
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5932190 |
Multinuclear complexes for X-ray imaging
An x-ray contrast medium containing a multinuclear complex of the formula (M 6 (μ 3 B) 8 A v ) x L w , wherein M is Mo, W, Re Tc, V, Nb, Ta, Ru, or Fe; μ 3 B represent a tridentate bridging...
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5922920 |
Catalytic production of aryl alkyl hydroperoxides by polynuclear transition metal aggregates
A method is provided for preparing organic hydroperoxides by oxidizing aryl alkyl hydrocarbons having a benzylic hydrogen with an oxygen containing gas using as a catalyst an oxo (hydroxo) bridged...
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5914097 |
Amino-acyl-type and catecholamine-type contrast agents for MRI
The present invention relates to the preparation of amino-acyl-type and catecholamine-type compounds having multiple carboxylic acid functional groups. Paramagnetic metal (II) or (III) ion chelate...
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5914095 |
Polychelants containg amide bonds
There are provided polychelants and their metal chelates which are useful in diagnostic imaging and in radiotherapy and which comprise a plurality of macrocyclic chelant moieties, e.g. DOTA...
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5885548 |
Multiply substituted DTPA derivatives and their metal complexes, and their metal complexes, pharmaceutical agents that contain these complexes, their use in diagnosis and therapy, as well as process for the production of pharmaceutical agents
The invention relates to new, multiply substituted diethylenetriaminepentaacetic acid derivatives, their complexes and complex salts, that contain an element of atomic numbers 20-32, 39-51 or...
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5817292 |
MR imaging compositions and methods
This invention provides compositions useful in MR imaging comprising a polymer comprising units comprising the residue of a chelating agent linked to a poly(alkylene oxide) moiety, the polymer...
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5808013 |
Process for the preparation of N-alkyl substituted metal carbamate solutions and their use
Process for the preparation of N-alkyl substituted metal carbamate solutions characterized in that a water solution of the salt of the metal of which the corresponding carbamate is to be obtained,...
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5804164 |
Water-soluble lipophilic contrast agents
The present invention relates to water-soluble, lipophilic contrast-enhancing agents, pharmaceutical compositions thereof and methods for diagnostic analysis, particularly NMR or MRI analysis using...
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5804163 |
Contrast agents for magnetic resonance imaging aminosaccharide
A contrast enhancing agent for magnetic resonance images having a chelating agent, which can be bound to metals having at least one unpaired electron. Examples of such chelating agents include...
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5801228 |
Polymeric contrast agents for medical imaging
The invention provides polymeric polychelants containing polymer repeat units of formula L--Ch--L--B! (where Ch is a polydentate chelant moiety; L is an amide or ester linkage; B is a hydrophobic...
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5756540 |
Methods for in vivo reduction of nitric oxide levels and compositions useful therefor
In accordance with the present invention, there are provided methods for the in vivo reduction of nitric oxide levels in a mammalian subject. In contrast to the inhibitory approach described in the...
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5756069 |
Amphipathic polychelating compounds and method of use
An amphipathic polychelating compound including a hydrophilic polymeric moiety having a main backbone and a plurality of reactive side groups, a lipid-soluble anchor linked to the N terminal of the...
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5746995 |
DTPA derivatives substituted in a novel way, their metal complexes, and their use in diagnosis and therapy
The invention relates to new diethylenetriaminepentaacetic acid derivatives, their complexes and complex salts, that contain an element of atomic numbers 20-32, 39-51 or 57-83, pharmaceutical...
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5739294 |
Bicyclopol yazamacrocyclophosphonic acid complexes for use as contrast agents
Bicyclopolyazamacrocyclophosphonic acid compounds are disclosed which may form inert complexes with Gd, Mn or Fe ions. The overall charge of the complex can be varied to alter the in vivo...
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5730956 |
DTPA di-alkyl monoamides for x-ray and MRI
The invention relates to diethylenetriaminepentaacetic acid monoamide derivatives, their complexes and complex salts, containing gadolinium, dysprosium, iron or manganese, pharmaceutical agents...
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5698724 |
Amino acid metal complexes using hydrolyzed protein as the amino acid source and methods re same
The method and composition involves preparing a high yield of a metal amino acid complex visible as a source of highly bioavailable transition metal ions, highly bioavailable essential amino acid...
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5695737 |
Dimeric DTPA derivatives, their metal complexes and pharmaceutical agents containing these complexes
The invention relates to new dimeric DTPA derivatives, their metal complexes, containing at least one ion of an element of atomic numbers 21-32, 37-39, 42-51 and 57-83, agents containing these...
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5693309 |
Substituted complexing agents, complexes, and complex salts, processes for their production, and pharmaceuticals containing same
1. Compounds of general Formula I ##STR1## wherein n and m in each case mean the numbers 0, 1, 2, 3 and 4, X stands for a hydrogen atom and/or a metal ion equivalent of an element of atomic...
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5681544 |
Polymer-bonded complexing agents, their complexes and conjugates, processes for their production and pharmaceutical agents containing them
Polymers comprising a ligand containing a carboxylic acid group, optionally at least one ion of an element of the atomic numbers 21-29, 42, 44 or 57-83 as well as optionally cations of inorganic...
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5681543 |
Polymer-bonded complexing agents and pharmaceutical agents containing them for MRI
Polymers comprising a ligand containing a carboxylic acid group, optionally at least one ion of an element of the atomic numbers 21-29, 42, 44 or 57-83 as well as optionally cations of inorganic...
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5676923 |
Substituted DTPA monoamides of the central carboxylic acid group and their metal complexes
Diethylenetriaminepentaacetic acid monoamide derivatives, their complexes and complex salts, containing an element of atomic numbers 21-29, 31, 32, 39, 42-44, 49 or 57-83, pharmaceutical agents...
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5672335 |
Use of metal complexes as liver and gallbladder X-ray diagnostic agents
Metal complexes containing a metal of atomic numbers 39-42, 44-51 or 56-83 and a complexing agent can be used for the production of contrast media for use in the contrast-enhanced computer...
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5637759 |
Metal-ligating amino acid derivatives for MRI and for peptide synthesis
Novel organic compounds and metal ion-containing amino acid chelates are described which are useful in solid phase synthesis of polypeptides and as magnetic resonance imaging (MRI) enhancing...
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5614168 |
Multinuclear complexes for X-ray imaging
The invention relates to the use as contrast enhancing agents in medical imaging, especially X-ray imaging, of multinuclear complexes, i.e. complexes, such as those of W202 (U20) 2, in which the...
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5596016 |
1,2-disubstituted aromatic chelates
Mineral absorption is promoted in warm-blooded animals by means of a class of 1,2-disubstituted aromatic mineral chelates wherein the 1 and 2 substituents each donates a pair of electrons to a...
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5582814 |
1-(p-n-butylbenzyl) DTPA for magnetic resonance imaging
Paramagnetic metal complexes of 1-(p-n-butylbenzyl)diethylenetriamine pentaacetic acid and pharmaceutically acceptable salts thereof are effective as tissue-specific MRI contrast agents, and in...
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5571498 |
Emulsions of paramagnetic contrast agents for magnetic resonance imaging (MRI).
Emulsions of paramagnetic contrast agents, and processes of making and using them are disclosed. The emulsions contain water, a dispersed oil phase and a complex of a paramagnetic metal ion and an...
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