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8178704 |
Inositol-phosphate derivatives and method of detecting inositol-1-phosphate
The present invention relates to inositol phosphate derivatives, in which the inositol phosphate is substituted with one or two reactive groups G or one or two conjugated substances or molecules M,...
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7977497 |
Inositolphospholipids and analogues phosphatidylinositol products and processes
Embodiments of the invention relate to natural and synthetic inositolphospholipid (IPL) materials, their preparation and applications. They provide compositions of the parent IPL comprising...
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7968737 |
Producing method of phospholipids including long-chain polyunsaturated fatty acids as constituents, and use of such phospholipids
The present invention provides a method of efficiently and stably producing LCPUFA-PL. Specifically, the invention provides a method for producing phospholipids that contain LCPUFA as a constituent...
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7939683 |
Phospholipid-analogous compounds
Phospholipid-analogous compounds of the general formula (I) in which A is where R1 and R2 are, independently of one another, hydrogen, a saturated or unsaturated acyl or alkyl radical which can...
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7923052 |
Method and apparatus for processing vegetable oil miscella, method for conditioning a polymeric microfiltration membrane, membrane, and lecithin product
A method for processing vegetable oil miscella is provided. The method includes steps of feeding vegetable oil miscella to a conditioned polymeric microfiltration membrane, and recovering a...
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7868196 |
Preparation of glycerol derivatives and intermediates therefor
Disclosed is a process for the regioselective preparation of glycerol derivative in a high efficiency and yield. The process for the regioselective preparation of 1-R1-2-R2-3-acetyl-glycerol...
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7847113 |
Phospholipids including long-chain polyunsaturated fatty acids as constituents, and use of such phospholipids
The present invention provides a method of efficiently and stably producing LCPUFA-PL. Specifically, the invention provides a method for producing phospholipids that contain LCPUFA as a constituent...
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7625883 |
Glycerophosphoinositol derivatives as modulators of cytosolic A2 phospholipase
Optionally O-substituted glycero-phosphoinositol derivatives, their analogues and their salts wherein the substitutents: R′1, R′2, R2, R3, R4, R5, R6 have the described meaning, their synthesis and...
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7495116 |
Phospholipid derivative
A phospholipid derivative represented by the formula (1) (Z represents a residue of a compound having 3 to 10 hydroxyl groups; AO represents an oxyalkylene group having 2 to 4 carbon atoms; R1CO...
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7371877 |
Glycerol ester derivative
A compound represented by the following general formula (IA) or a salt thereof: wherein Ar1 represents hydrogen atom or an aryl group having at least one iodine atom as a substituent; Ar2...
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7259273 |
Compositions containing lysophosphotidic acids which inhabit apoptosis and uses thereof
The invention provides anti-apoptotic compositions containing lysophosphatidic acids and methods for making and using the compositions. Such compositions may also contain LPA potentiating agents,...
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7214384 |
Lipid-conjugated polyamide compounds
In accordance with the present invention, there are provided lipid-conjugated polyamide compounds and related compositions and methods thereof. Lipid-conjugated polyamide compounds of the present...
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7034168 |
Process for the production of phospholipids
A new enzymatic process for preparing 1,2-diacylated phospholipids using an enzyme preparation possessing phospholipase activity towards acylation at the sn-1 and sn-2 sites in a microaqueous...
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6982092 |
Method of complexing a nucleic acid with a lipid-conjugated polyamide
In accordance with the present invention, there are provided lipid-conjugated polyamide compounds and related compositions and methods thereof. Lipid-conjugated polyamide compounds of the present...
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6979460 |
Vinyl ether lipids with cleavable hydrophlic headgroups
A novel amphiphilic lipid compound having a cleavable, vinyl ether linked hydrophilic headgroup is described. Also described are liposomes containing the vinyl ether lipid compound, which may be...
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6949528 |
Compositions containing lysophosphatidic acids which inhibit apoptosis and uses thereof
The invention provides anti-apoptotic compositions lysophosphatidic acids and methods for making and using the compositions. Such compositions can also contain LPA potentiating agents, including...
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6852870 |
Omega-3 fatty acids in the treatment of depression
The present invention is directed to a method of treating patients with major depression by administering omega-3 fatty acids. These may be administered in a substantially purified form, as part of...
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6797835 |
Phospholipid composition and use of same
A phospholipidic composition with an L-α-glycerophosphatidyl-choline concentration of at least 10% by weight is described, where said composition is granular and also contains, in addition to ...
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6794524 |
Ester based phosphobetaine compounds
The invention relates to a series of novel ester containing phosphobetaine compounds, which are exceptional surface active agents that provide outstanding foam and are very mild to the hair and...
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6737536 |
Inositolphospholipids and analogues
This invention relates to inositolphospholipids, particularly to synthetic phosphatidyl-myo-inositols (PtdIns), ceramide-phosphoinositols (CerPhosIns) and their structural and stereochemical...
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6706280 |
Carboxylated phosphatidic acid esters
Novel compounds of formula in which R1 and R2 are phospholipid fatty acid residues and A is an aliphatic and/or cycloaliphatic hydrocarbon chain optionally substituted by hydroxy and/or further...
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6602861 |
Acylated phospholipid drugs
This invention relates to a method for improving the efficiency of a drug containing a free carboxy group, the improvement comprising esterifying said carboxy group to the hydroxy group of the...
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6572881 |
Lipid-conjugated polyamide compounds and related compositions and methods thereof
In accordance with the present invention, there are provided lipid-conjugated polyamide compounds and related compositions and methods thereof. Lipid-conjugated polyamide compounds of the present...
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6569451 |
Targeted polymerized liposome diagnostic and treatment agents
Polymerized liposome particles which are linked to a targeting agent and may also be linked to a contrast enhancement agent and/or linked to or encapsulating a treatment agent. The targeting...
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6528667 |
Phosphated castor oil and derivatives
The present invention relates to phosphated derivatives of castor oil and hydrogenated castor oil as well as phosphated esters of ricinoleic acid. The inclusion of the phosphate group results in...
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6517884 |
Water and oil containing emulsion
The invention relates to a food product comprising 0.1 to 1.5 wt % of one or more anti-spattering agents comprising no native soy lecithin or native soy lecithin in an amount of from 0 to 0.05 wt %...
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6448422 |
Chromogenic compound
This application relates to a novel compound of formula I, as defined herein, processes and intermediates for its preparation and the use of the compound of formula I as a substrate for a...
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6331293 |
Dimer amidopropyl dimethyl phospholipids as barrier compounds
The present invention relates to compounds and, more particularly, to a class of compounds having specific quaternized amine based upon a dimer acid amido amine linked to specific phosphate esters....
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6319952 |
Compositions and methods for reversibly increasing permeability of biomembranes
The present invention provides a family of branched fatty acids and their derivatives, which improve and enable the penetration and absorption of active ingredients through biomembranes, such as...
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6313106 |
Phospholipid derivatives of valproic acid and mixtures thereof
The present invention relates to compounds, which are phospholipid derivatives of valproic acid, to compositions comprising said compounds and their use for treating epilepsy, migraine, bipolar...
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6303803 |
Removal of sterols from fats and oils
Disclosed is a method for reducing the sterol, for example cholesterol, content of sterol-containing substances such as fats and oils. The method provides an efficient and cost effective process...
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6278004 |
Stabilized phospholipidic composition
A method for the stabilization of a phospholipidic composition as well as a method for the production of a stabilized phospholipidic composition comprising at least one phospholipide as well as a...
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6251946 |
Branched chain fatty acids, their derivatives and use in the treatment of central nervous system disorders
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6224903 |
Polymer-lipid conjugate for fusion of target membranes
A fusogenic liposome composition for delivering a liposome-entrapped compound into the cytoplasm of a target cell is described. The liposomes have an outer surface coating of chemically releasable...
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6183979 |
Preparation of dried synthetic prothrombin time reagents
A method for preparation of an air-dried prothrombin time (PT) reagent which uses a recombinant protein and synthetic phospholipids is described. The source for the recombinant protein is rabbit...
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6171614 |
Synthesis of glycophospholipid and peptide-phospholipid conjugates and uses thereof
The present invention provides glycophospholipid and peptide-phospholipid conjugates comprising a phospholipid moiety and a saccharide or peptide moiety joined by an ether linkage comprising a...
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6165997 |
Phospholipids having antimicrobial activity with or without the presence of antimicrobials
A pharmaceutical formulation for stimulating growth of Gram-positive Bacilli and increasing the acidity in vagina comprises sucrose and/or maltose, optionally with other sugars, viscous base, and...
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6133463 |
Active phospholipids as a vector for active molecules
An active phospholipid of the formula ##STR1## wherein R1 is aliphatic of 14 to 24 carbon atoms saturated or containing 1 or 2 unsaturations, R3 is a residue selected from the group consisting of...
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6100413 |
Method for the stabilization of a phospholipidic composition, method for the production of such a stabilized composition and its use
A method for the stabilization of a phospholipidic composition as well as a method for the production of a stabilized phospholipidic composition comprising at least one phospholipide as well as a...
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6015716 |
Detection of endotoxin levels in liposomes, lipid bilayers and lipid complexes
Endotoxin incorporated into liposomes, lipid bilayers or lipid complexes can be detected by combining an aqueous suspension of the liposomes, lipid complexes or lipid bilayers with a suitable...
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5989587 |
Formation of stable liposomes from lipid extracts of archaeobacteria (archaeu)
Novel ether lipids were obtained from methanogenic (Methanospirillum hungatei, Methanococcus jannaschii, Methanococcus voltae, Methanosarcina mazei, and Methanobrevibacter smithii), and extremely...
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5972380 |
Aminophospholipid compositions and uses thereof
Described are reversibly N-acylated phosphotidylserine and phosphatidylethanolamine derivatives which are useful as caged aminophospholipids. Also described are pharmaceutical preparations...
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5955452 |
Covalent lipid-phosphono-carboxylic acid conjugates and application thereof as antiviral medicaments
The present invention concerns new lipid derivatives of phosphonocarboxylic acids of the general formula I, ##STR1## in which the meaning of the symbols is elucidated in the description, tautomers...
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5902802 |
Cationic amphiphiles
Cationic amphiphiles are provided that are alkyl or alkoxyalkyl O-phosphate esters of diacylphosphatidyl zwitterionic compounds such as phosphatidylcholine or phosphatidyl ethanolamine. The...
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5876747 |
Liposome preferentially traveling to cardiac and skeletal muscles
Carnitine, aminocarnitine and cysteic acid serve as carriers to bring pharmaceutically active compounds to desired sites in the body, e.g. skeletal muscle or the heart. The pharmaceutically active...
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5801260 |
Carbonothioate phospholipid analogs as substrate of phospholipases and lipases
Novel substrates of phospholipases, lysophospholipases and lipases are disclosed.
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5616745 |
Lipopolyamines, their preparation and their use
New lipopolyamines of general formula (I), their salts, their preparation and their use. ##STR1## n=1 to 5 and m=2 to 6 R represents a radical ##STR2## (R1 and R2 : aliphatic radical containing 12...
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5567597 |
Hydrolytic enzyme inhibitors/inactivators and methods for using same
The present invention provides compounds that function as hydrolytic enzyme inhibitors (inactivators) and substrates. These compounds are useful in assays to detect and measure levels of hydrolytic...
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5552070 |
Phosphorylation of epoxides
A process for the phosphorylation of epoxides, in particular of epoxidised fatty acid esters, and the use of the phosphorylation products for the production of lubricants.
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5466841 |
Formulations containing unsaturated fatty acids
A phospholipid comprising two different unsaturated fatty acids, the fatty acids being selected from the twelve n-6 and n-3 essential fatty acids, oleic acid, parinaric acid and combinic acid.
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