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7514574 |
Biodegradable penetration enhancers with multiple hydrophilic moieties
Design of new, safe and effective biodegradable agents, which can cover a wide range of drug molecules in the transdermal permeation and other membranes absorption of physiologically active agents...
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7253296 |
Acylated aminopropanediols and analogues and therapeutic uses thereof
The invention relates to novel acylated aminopropanediols and the nitrogen and sulfur analogues thereof, pharmaceutical compositions comprising same, therapeutic uses thereof, in particular for the...
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7235586 |
Cyclopentane heptan(ene)oic acid, 2-thiocarbamoyloxy and 2-carbamoyloxy compounds as therapeutic agents
The invention relates to the use of cyclopentane heptan(ene)oic acid, 2-thiocarbamoyloxy and carbamoyloxy as therapeutic agents e.g. as ocular hypotensives. The compounds used in accordance with...
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6914146 |
Methods of using esterquats having acyl groups derived from short-chain monocarboxylic acids and short-chain dicarboxylic acids to improve cosmetic compositions
Methods of improving the stability of a composition containing a long-chain esterquat and methods of improving the microbicidal properties of a cosmetic composition are described wherein a...
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6700006 |
Internally plasticizing and crosslinkable monomers and applications thereof
Novel compounds derived from traditional semi- drying and non-drying oils featuring internally plasticizing and crosslinkable properties are disclosed and claimed. Preferred embodiments include...
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6649780 |
Cationic lipids
Cationic lipids are provided which are useful in the preparation of liposomes and other lipid vesicle carriers. The lipids of the invention are particularly useful as carriers of nucleic acids and...
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6600059 |
Cytoprotective compounds
The present invention provides compositions and methods for protecting cells from injury due to intrinsic membrane lysis, oxidation and/or invasion by destructive agents. Even more particularly,...
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6562780 |
Esters derived from alkanolamines, dicarboxylic acids and fatty alcohols and the cationic surfactants obtainable therefrom
Esters derived from alkanolamines, dicarboxylic acids and fatty alcohols and the cationic surfactants obtainable therefrom. Novel alkanolamine esters based on the esterification reaction of...
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6555120 |
ISOLATION, STRUCTURAL DETERMINATION, SYNTHESIS, BIOLOGICAL ACTIVITY AND APPLICATION AS CONTROL AGENT OF THE HOST MARKING PHEROMONE (AND DERIVATIVES THEREOF) OF THE FRUIT FLIES OF THE TYPE ANASTREPHA (DIPTERA: TEPHRITIDAE)
The 2-(2,14-Dimethyl-pentadecanoylamin)-pentanedioic acid (I) and compounds of the formula (II), wherein the substituents have the meaning disclosed in the specification, are used as oviposition...
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6503945 |
Cationic amphiphiles containing N-hydroxyalkyl group for intracellular delivery of biologically active molecules
The present invention provides novel cationic amphiphiles containing novel N-hydroxyalkyl group and therapeutic formulations containing the said amphiphiles that are capable of facilitating...
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6379294 |
Process for preparing esterquats
A process for preparing an esterquat composition comprising (a) reacting a tertiary amine according to formula I: wherein R 1 represents a C 3 -C 6 hydrocarbon group, R 2 represents a C 3 -C...
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6353124 |
Therapeutic compound-fatty acid conjugates
The present invention provides therapeutic conjugates which comprise a therapeutic compound bound to one to three acyl groups derived from fatty acids. The therapeutic compounds are preferably...
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6271185 |
Water soluble vegetable oil esters for industrial applications
Industrial oils containing partial esters of triacylglycerol and triethanolamine or ethoxylated triethanolamine are described, as well as methods for making such oils.
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6245811 |
Fatty acid esters as bioactive compounds
Compounds of structure (I), and when for use in therapy: where R 1 is an acyl group derived from a C 16 -30 fatty acid with two or more cis or trans double bonds and particularly an n-6 or n-3...
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6235914 |
Amine and quaternary ammonium compounds made from ketones and aldehydes, and compositions containing them
A process for making a tertiary amine ester of the following formula (I): ##STR1## the process comprising: (a) reacting a ketone or an aldehyde having the formula ##STR2## with a glycol to...
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6207173 |
Lysine derivatives containing an Nε-alkoxy or Nε-alkenoxycarbonyl group, their preparation and their use in cosmetic, pharmaceutical, hygiene or food compositions
Lysine derivatives, salts of the derivatives, their optical isomers of D or L configuration, or their mixtures, the derivatives containing an N e -alkoxy or N e -alkenoxycarbonyl group and having...
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6180667 |
Esters of acyl L-carnitines and pharmaceutical compositions containing same for treating endotoxic shock
Esters of alkanoyl L-carnitines wherein the alkanoyl is a saturated or unsaturated, staight or branched alkanoyl having 2-26 carbon atoms, optionally ω-substituted with trialkylammonium,...
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6166232 |
Process for producing ester quats
A process is described for producing ester quats of the formula (I) ##STR1## where X - is an anion of an inorganic or organic acid, R a is a C 1 to C 4 alkyl group, R b and R c are each,...
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6072063 |
Low-melting ester quats
Ester quats of the formula (1) below are described: ##STR1## where RCO is an aliphatic acyl radical having 6 to 22 carbon atoms, R 1 is a methyl radical, R 2 is a C 1 -C 6 -alkyl radical, R 3 ...
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6020489 |
Cytoprotective fatty moiety compounds
Water or lipid soluble, pharmacologically active, antioxidant, anti-phospholipase compounds that are chemically defined. The compounds protect mammalian cells by inhibiting PLA 2 and preventing...
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5990165 |
Pharmaceutical compounds
A pharmaceutical compound of the formula: ##STR1## in which n is 1 or 2, R 1 is --CO 2 H, R 2 is hydrogen or C 1 -4 alkyl and R 3 is hydrogen, C 1 -10 alkyl, C 2 -10 alkenyl, optionally...
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5961966 |
Quaternary fatty diesters of hydroxypropyl diethanol amine
A quaternary fatty diester of 2-hydroxypropyl diethanol amine and aqueous dispersions thereof useful as fabric softening products, laundering products, household cleaning products and personal hair...
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5886201 |
Quaternized fatty acid triethanolamine ester salts with improved solubility in water
A process for producing quaternized fatty acid triethanolamine ester salts having improved solubility in water, by esterifiying a fatty acid mixture containing a) 40% to 60% by weight of linear...
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5869715 |
Polyfunctional cationic cytofectins
For use in transporting biologically active species into and through membrane barriers, a cationic amine compound is utilized that has the general structure: ##STR1## wherein R 4 and R 5 are a...
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5851982 |
Liquid softener compositions and quaternary ammonium salt
To provide a liquid softener composition which is satisfactory in respects of softening effect, storage stability and water absorption properties, is excellent in biodegradability and is gentle...
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5824812 |
Polyfunctional cationic cytofectins, formulations and methods for generating active cytofectin: polynucleotide transfection complexes
Amine containing compounds and their use in the generation of cytofectin:polynucleotide complexes for transfection of cells, formulations, counterions, and reaction conditions for maximizing the...
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5792786 |
Non-steroidal anti-inflammatory fatty acid conjugates and their therapeutic use thereof
The present invention provides therapeutic conjugates which comprise a therapeutic compound bound to one to three acyl groups derived from fatty acids. The therapeutic compounds are preferably...
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5783534 |
Process for the production of solid esterquats
A process for the production of a solid esterquat free from solvents comprising the steps of A) forming a mixture comprising (i) at least one fatty acid triethanolamine ester corresponding to...
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5773465 |
Tartronic acids, their acetalic ethers and o-esters
Tartronic acid acetalic ethers and esters of the general formula: ##STR1## are provided and are useful in treatment of bone dysmetabolism. As examples, Ra and Rb may be hydrogen, B is a C 2 -C 12 ...
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5750492 |
Surfactants based on quaternary ammonium compounds preparation processes softening bases and compositions derived
Cationic surfactant compound comprising, in the form of a quaternary ammonium salt, a product of condensation between, on the one hand a fraction of saturated or unsaturated fatty acids, or of...
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5734069 |
Biodegradable amidoaminoesters
Compounds of the formula R-- C(O)O(CH 2 ) 1 -5 ! 0 -1 --C(O)NH(CH 2 ) 2 -5 --N(R 2 )--(CH 2 ) 2 -5 --OC(O)R 1 wherein R and R 1 are each C 8 -C 22 alkyl or alkenyl and R 2 is C 1 -C 3 alkyl...
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5705663 |
Quaternized triethanolamine difatty acid esters
The invention relates to quaternized triethanolamine difatty acid esters prepared from triethanolamine, fatty acid, fatty acid ester and a quaternizing agent and to a process for their preparation...
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5670677 |
Process for the production of color- and odor-stable quaternized fatty acid triethanolamine ester salts
A process for the production of color- and odor-stable quaternized fatty acid triethanolamine ester salts comprising the steps of A) partially or fully esterifying triethanolamine with at least...
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5663138 |
Fabric conditioning molecules derived from glycerol and betaine
Novel fabric conditioning compounds derived from glycerol and betaine are described. Fabric conditioning compositions containing the compounds, which provide effective fabric softening and...
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5659049 |
Antioxidant, antiphospholipase derivatives of ricinoleic acid
Water or lipid soluble, pharmacologically active, antioxidant, anti-phospholipase compounds that are chemically defined. The compounds protect mammalian cells by inhibiting PLA 2 and preventing...
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5658942 |
Octahydronaphthalene oxime compounds for cholesterol synthesis inhibition
Compounds of formula (I): ##STR1## in which: R represents hydrogen, methyl or hydroxy; X represents an alkyl, alkenyl, cycloalkyl, aryl, aralkyl, or heterocyclic group; A represents a single bond,...
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5654445 |
δ-amino-γ-hydroxy-ω-aryl-alkanoic acids
δ-Amino-γ-hydroxy-ω-aryl-alkanoic acid amides of formula I ##STR1## and the salts thereof, have renin-inhibiting properties and can be used as antihypertensive medicinal active ingredients.
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5637743 |
Quaternary ammonium surfactants derived from tertiary amines and fabric softeners containing quaternary ammonium surfactants
Cationic surfactant compound comprising, in the form of a quaternary ammonium salt, a product of condensation between, on the one hand a fraction of saturated or unsaturated fatty acids, or of...
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5625085 |
Esters of acyl L-carnitines and pharmaceutical compositons containing same for treating endotoxic shock
Esters of alkanoyl L-carnitines wherein the alkanoyl is a saturated or unsaturated, straight or branched alkanoyl having 2-26 carbon atoms, optionally ω-substituted with trialkylammonium,...
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5574179 |
Concentrated biodegradable quaternary ammonium fabric softener compositions and compouds containing intermediate iodine value unsaturated fatty acid chains
The present invention relates to softening compounds; stable, homogeneous, preferably concentrated, aqueous liquid and solid textile treatment compositions; and intermediate compositions and/or...
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5525709 |
Process for the preparation of ceramides
The invention relates to the preparation of ceramides by a two step process involving conversion of a 2-hydroximino-3-oxo-alkanoate into a 2-alkanoylamido-3-oxo-alkanoate intermediate by acylation...
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5523433 |
Process for the preparation of diethyl ester dimethyl ammonium chloride
Disclosed is a process for making di(acyloxyalkyl) di(alkyl) ammonium compounds useful as fabric softeners. The corresponding di(hydroxyalkyl) tertiary amine is diesterified under conditions...
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5516438 |
Fabric softening
A method of preparing a fabric softening material which comprises a quaternary ammonium material and at least one C 8 -28 alkyl or alkenyl group connected to the molecule via an ester linkage. The...
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5500139 |
Biodegradable fabric conditioning molecules based on glyceric acid
Novel fabric conditioning agents which contain either an ester or a NH link between a glyceric carboxyl group and a quaternary ammonium group are described. The compounds based on glyceric acid are...
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5482636 |
Process for the quaternization of triethanolamine fatty acid esters and imidazolinamides and the use of the reaction mixtures in laundry softener compositions
A process for the quaternization of triethanolamine fatty acid esters and imidazolinamides with customary quaternizing agents in a reaction medium containing alkoxylated naturally occurring fats or...
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5463094 |
Solvent free quaternization of tertiary amines with dimethylsulfate
A process for a high temperature, solvent free quaternization of certain tertiary amines using dimethylsulfate to produce quaternary ammonium methyl sulfates which may be used in fabric softening...
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5436343 |
Alkenecarboxylic acid compounds
Compounds of formula (I): ##STR1## in which: R 1 and R 2 , which may be identical or different, represent a linear or branched (C 1 C 6 ) alkyl radical, a substituted or unsubstituted phenyl...
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5296622 |
Quaternized esters
Quaternized esters having fabric-softening and hydrophilicizing properties are obtained by reaction of unsaturated fatty acids containing at least 40 mol-% transconfigured double bonds or esters...
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5292915 |
Compounds containing carbonate groups and carbonyl groups and the preparation and use thereof
The invention relates to compounds containing carbonate groups and carbonyl groups and having the general formula ##STR1## in which R stands for a C 1 -C 4 -alkyl radical, an aryl radical, or a...
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5219884 |
Immunosuppressant
The present invention relates to an immunosuppressive agent which comprises at least one compound selected from the compounds of formula ##STR1## wherein R represents a hydrogen atom or an acyl, Y...
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