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9040728 Crystallization of (20R) 19-nor-24-difluoro-1α,25-dihydroxyvitamin D3  
Disclosed are methods of purifying the compound (20R)-19-nor-24-difluoro-1α,25-dihydroxyvitamin D3 to obtain the compound in crystalline form. The methods typically include the steps of dissolving...
9018194 Vitamin D receptor modulators with partial agonist activity  
The present invention provides a compound which functions as a selective vitamin D receptor modulator and has action-selectivity or tissue-selectivity such that it does not induce hypercalcemia...
9006220 23-yne-vitamin D3 derivative  
To provide a novel vitamin D3 derivative useful as a therapeutic agent for osteoporosis. Provided is a vitamin D3 derivative represented by the following formula (1) or a medicinally acceptable...
8993547 3-desoxy-2-methylene-19-nor-vitamin D analogs and their uses  
This invention discloses 3-desoxy-2-methylene-19-nor-vitamin D analogs, and specifically (20S)-3-desoxy-2-methylene-1α,25-dihydroxy-19-nor-vitamin D3 and...
8987235 N-cyclopropyl-(20R)-2-methylene-19,26,27-trinor-25-aza-vitamin D analogs and their uses  
This invention discloses N-cyclopropyl-(20R)-2-methylene-19,26,27-trinor-25-aza-vitam in D analogs, and specifically N-cyclopropyl-(20R)-2-methylene-19,26,27-trinor-25-aza-1α-hy droxyvitamin D3...
8940916 Crystallization of (20R)-2-methylene-19-nor-24-difluoro-1α,25-dihydroxyvitamin D3  
Disclosed are methods of purifying the compound (20R)-2-methylene-19-nor-24-difluoro-1α,25-dihydroxyvitamin D3 to obtain the compound in crystalline form. The methods typically include the steps...
8906888 Low-calcemic 16,23-diene 25-oxime analogs of 1α,25-dihydroxy vitamin D3  
The present invention provides novel 16,23-diene 25-oxime ether analogs of 1,25-dihydroxy vitamin D3, compositions comprising these compounds and methods of using these compounds as inhibitors of...
8906410 Oral dosage form of 25-hydroxyvitamin D  
Methods and compositions for treating 25-hydroxyvitamin D insufficiency and deficiency in a patient are described herein. The method includes orally administering to the patient a delayed,...
8884039 Crystallization of (20R) and (20S) analogs of 2-methylene-19-nor-24-dimethyl-1α,25-dihydroxyvitamin D3  
Disclosed are methods of purifying (20R) and (20S) analogs of 2-methylene-19-nor-22-dimethyl-1α,25-dihydroxyvitamin D3 to obtain the (20R) and (20S) analogs in crystalline form. The method...
8853188 Compositions and methods for cancer treatment  
Bromoacetoxycalcidiol (B3CD), which is structurally related to calcidiol, exhibits cytotoxic and apoptotic activity toward cancer cells, including highly aggressive neuroblastoma cells. A series...
8796246 9, 10-secopregnane derivative and pharmaceutical  
A main object of the invention is to provide a novel useful vitamin D3 derivative, which has an excellent vitamin D3 activity and, as compared with conventional vitamin D3 derivatives, has a...
8785422 A-ring modified 19-nor-vitamin D analogs and their uses  
Disclosed are 19-nor-vitamin D compounds, and specifically seco-A-2,19-dinor-1,25-dihydroxyvitamin D3 as well as pharmaceutical uses therefor. These compounds exhibit relatively high activity in...
8759555 Stereoselective synthesis of vitamin D analogues  
The present invention relates to intermediates useful for the synthesis of calcipotriol or calcipotriol monohydrate, to methods of producing said intermediates, and to methods of stereoselectively...
8754067 22-haloacetoxy-homopregnacalciferol analogs and their uses  
This invention discloses 22-haloacetoxy-homopregnacalciferol analogs and specifically 22-bromoacetoxy-homopregnacalciferol and pharmaceutical uses therefor. This compound exhibits relatively...
8729054 3-desoxy-2-methylene-vitamin D analogs and their uses  
This invention discloses 3-desoxy-2-methylene-vitamin D analogs, and specifically (20S)-3-desoxy-1α,25-dihydroxy-2-methylene-vitamin D3 and (20R)-3-desoxy-1α,25-dihydroxy-2-methylene-vitamin D3 as...
8664206 Diastereomers of 2-methylene-19-nor-22-methyl-1α,25-dihydroxyvitamin D3  
Compounds of formula I are provided where X1, X2, and X3 are independently selected from H or hydroxy protecting groups. Such compounds may be used in preparing pharmaceutical compositions and are...
8642579 1-desoxy-2-methylene-19-nor-vitamin D analogs and their uses  
This invention discloses 1-desoxy-2-methylene-19-nor-vitamin D analogs, and specifically (20S)-25-hydroxy-1-desoxy-2-methylene-19-nor-vitamin D3 and pharmaceutical uses therefor. This compound...
8614202 2α-methyl and 2β-methyl analogs of 19,26,27-trinor-(20S)-1α-hydroxyvitamin D3 and their uses  
This invention discloses 2α-methyl and 2β-methyl analogs of 19,26,27-trinor-(20S)-1α-hydroxyvitamin D3 and pharmaceutical uses therefor. These compounds exhibit pronounced activity in arresting...
8609643 2-methylene-(20S,25R)-19,26-dinor-vitamin D analogs  
This invention discloses 2-methylene-(20S,25R)-19,26-dinor-vitamin D analogs, and specifically 2-methylene-(20S,25R)-19,26-dinor-1α,25-dihydroxyvitamin D3, and pharmaceutical uses therefor. This...
8604008 2-methylene-19,21-dinor-1α-hydroxy-bishomopregnacalciferol  
Compounds of formula I are provided where X1 and X2 are independently selected from H or hydroxy protecting groups. Such compounds may be used in preparing pharmaceutical compositions and are...
8604009 (20S)-2-methylene-19-nor-22-dimethyl-1α,25-dihydroxyvitamin D3 and (20R)-2-methylene-19-nor-22-dimethyl-1α,25-hydroxyvitamin D3  
Compounds of formula I are provided where X1, X2 and X3 are independently selected from H or hydroxy protecting groups. Such compounds may be used in preparing pharmaceutical compositions and are...
8575136 2-methylene-1α-hydroxy-18,19,21-trinorvitamin D3 analogs and uses thereof  
Compounds of formula I are provided where X1 and X2 are independently selected from H or hydroxy protecting groups. Such compounds are used in preparing pharmaceutical compositions and are useful...
8519169 Crystallization a 1alpha-hydroxy-20-methyl-2-methylene-19,24,25,26,27-pentanorvitamin D3  
A method of purifying 1α-hydroxy-20-methyl-2-methylene-19,24,25,26,27-pentanorvita min D3 to obtain 1α-hydroxy-20-methyl-2-methylene-19,24,25,26,27-pentanorvita min D3 in crystalline form. The...
8518917 2-methylene-19-nor-vitamin D analogs and their uses  
This invention discloses 2-methylene-19-nor-vitamin D analogs, and specifically (20S)-25-hydroxy-2-methylene-19-nor-vitamin D3 and (20R)-25-hydroxy-2-methylene-19-nor-vitamin D3, as well as...
8455466 Vitamin d analogues, compositions comprising said analogues and their use  
Compounds according to formula I in which formula R1 and R2, which may be the same or different, represent halogen, (C1-C6)hydrocarbyl, optionally substituted with one or two hydroxyl group or one...
8455467 2-methylene-vitamin D analogs and their uses  
This invention discloses 2-methylene-vitamin D analogs, and specifically (20S)-25-hydroxy-2-methylene-vitamin D3 and (20R)-25-hydroxy-2-methylene-vitamin D3, as well as pharmaceutical uses...
8445468 (20S,22E)-2-methylene-19-nor-22-ene-1α,25-dihydroxyvitamin D3  
This invention discloses (20S,22E)-2-methylene-19-nor-22-ene-1α,25-dihydroxyvitamin D3 analogs, and specifically(20S,22E)-2-methylene-19-nor-22-ene-1α,25-dihydr oxyvitamin D3, and pharmaceutical...
8440647 2α-methyl and 2β-methyl analogs of 19,26,27-trinor-(20S)-1α-hydroxyvitamin D3 and their uses  
This invention discloses 2α-methyl and 2β-methyl analogs of 19,26,27-trinor-(20S)-1α-hydroxyvitamin D3 and pharmaceutical uses therefor. These compounds exhibit pronounced activity in arresting...
8431112 Photostabilization of cholecalciferol with alkoxycrylene compounds  
A method of reducing photodegradation of cholecalciferol when exposed to UV radiation in a composition containing cholecalciferol comprising combining with cholecalciferol a compound of formula...
8420839 Crystallization of 1α-hydroxy-2-methylene-18,19-dinor-homopregnacalciferol  
A method of purifying 1α-hydroxy-2-methylene-18,19-dinor-homopregnacalciferol to obtain 1α-hydroxy-2-methylene-18,19-dinor-homopregnacalciferol in crystalline form using precipitation with hexane...
8410080 2-methylene-vitamin D analogs and their uses  
This invention discloses 2-methylene-vitamin D analogs, and specifically (20S)-1α,25 -dihydroxy-2-methylene-vitamin D3 as well as (5E)-(20S)-1α,25-dihydroxy-2 -methylene-vitamin D3 and...
8404874 (20R,25S)-2-Methylene-19,26-Dinor-1α,25-Dihydroxyvitamin D3 in crystalline form  
A method of purifying (20R,25S)-2-methylene-19,26-dinor-1α,25-dihydroxyvitamin D3 to obtain (20R,25S)-2-methylene-19,26-dinor-1α,25-dihydroxyvitamin D3 in crystalline form. The method includes the...
8404667 Compounds, compositions, kits and methods of use to orally and topically treat acne and other skin conditions by 19-Nor vitamin D analog  
Oral and topical pharmaceutical compositions, kits and methods of treatment thereof for treating various skin disorder including acne, psoriasis, ichthyosis, photoaging, photodamaged skin, and,...
8404666 2-substituted-1α,25-dihydroxy-19,26,27-trinor vitamin D analogs and uses thereof  
Compounds of formula I, II or III are provided where X1, X2 and X3 are independently selected from H and hydroxy protecting groups and R1 and R2 are independently selected from H or straight or...
8399438 2α-methyl-19-nor-1α-hydroxy-homopregnacalciferol and its uses  
This invention discloses 2α-methyl-19-nor-vitamin D analogs, and specifically 2α-methyl-19-nor-1α-hydroxy-homopregnacalciferol and pharmaceutical uses therefor. This compound exhibits pronounced...
8399439 2-methylene-19,26-dinor-(20S,22E,25R)-vitamin D analogs  
This invention discloses 2-methylene-19,26-dinor-(20S,22E,25R)-vitamin D analogs, and specifically 2-methylene-19,26-dinor-(20S,22E,25R)-1α,25-dihydroxyvitamin D3, and pharmaceutical uses...
8377913 Vitamin D receptor activators and methods of making  
The invention relates to compounds that are vitamin D receptor activators, compositions comprising such compounds, methods of using such compounds and compositions, processes for preparing such...
8362287 Stereoselective synthesis of vitamin D analogues  
The present invention relates to intermediates useful for the synthesis of calcipotriol or calcipotriol monohydrate, to methods of producing said intermediates, and to methods of stereoselectively...
8232263 17,20(Z)-dehydro vitamin D analogs and their uses  
This invention discloses 17,20(Z)-dehydro vitamin D analogs, and specifically 17(Z)-1α,25-dihydroxy-17(20)-dehydro-2-methylene-19-nor-vita min D3 and pharmaceutical uses therefor. This compound...
8222235 2-methylene-19-nor-(20R)-1α-hydroxy-bishomopregnacalciferol  
Compounds of formula I are provided where X1 and X2 are independently selected from H or hydroxy protecting groups. Such compounds may be used in preparing pharmaceutical compositions and are...
8222236 2-methylene-(20E)-20(22)-dehydro-19-nor-vitamin D analogs  
This invention discloses 2-methylene-(20E)-20(22)-dehydro-19-nor-vitamin D analogs, and specifically 2-methylene-(20E)-20(22)-dehydro-19-nor-1α,25-dihydroxyvitam in D3, and pharmaceutical uses...
8217023 19-nor-vitamin D analogs with 1,2- or 3,2-cyclopentene ring  
19-nor-vitamin D analogs having an additional cyclopentene ring connecting carbon 1 and carbon 2, or connecting carbon 3 and carbon-2 of the A-ring of the analog, and pharmaceutical uses...
8212059 Process for producing vitamin D derivative using photoreaction  
There are provided a novel process for producing [{(5Z,7E)-(1S,3R,20S)-1,3-dihydroxy-9,10-secopregna-5,7,10(1 9),16-tetraen-20-yl}oxy]-N-(2,2,3,3,3-pentafluoropropyl)acet amide, which process is...
8198263 Vitamin D derivatives active on the vitamin D nuclear receptor, preparation and uses thereof  
The invention relates to vitamin D derivatives and their uses, particularly in the pharmaceutical industry. The invention discloses compounds having different interesting biological properties,...
8193171 13,13-dimethyl-des-C,D analogs of 1α,25-dihydroxy-19-nor-vitamin D3 compounds and topical composition dosage forms and methods of treating skin conditions thereof  
13,13-Dimethyl-des-C,D analogs of 1α,25-dihydroxy-19-nor-vitamin D3 compounds and topical composition dosage forms thereof, and methods of treating skin conditions thereof. Exemplary active...
8193169 (20R)-2α-methyl-19,26,2-trinor-vitamin D analogs  
This invention discloses (20R)-2α-methyl-19,26,27-trinor-vitamin D analogs, and specifically (20R)-2α-methyl-19,26,27-trinor-1α,25-dihydroxyvitamin D3, and pharmaceutical uses therefor. This...
8193170 2-methylene-19,26-dinor-(20R,22E,25R)-vitamin D analogs  
This invention discloses 2-methylene-19,26-dinor-(20R,22E,25R)-vitamin D analogs, and specifically 2-methylene-19,26-dinor-(20R,22E,25R)-1α,25-dihydroxyvitamin D3, and pharmaceutical uses...
8188064 Vitamin D analogs for obesity prevention and treatment  
Methods for treating and preventing obesity, inhibiting adipocyte differentiation, inhibiting increased SCD-1 gene transcription, and/or reducing body fat in a subject include administering at...
8178517 6-methylvitamin D3 analogs and their uses  
This invention discloses 6-methylvitamin D3 analogs, and specifically 1α,25-dihydroxy-6-methylvitamin D3, and pharmaceutical uses therefor. This compound exhibits vitamin D receptor binding...
8173824 Process for producing vitamin D derivative using convergent method  
There are provided a novel process for producing [{(5Z,7E)-(1S,3R,20S)-1,3-dihydroxy-9,10-secopregna-5,7,10(1 9),16-tetraen-20-yl}oxy]-N-(2,2,3,3,3-pentafluoropropyl)acet amide, which process is...

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