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8178517 6-methylvitamin D3 analogs and their uses  
This invention discloses 6-methylvitamin D3 analogs, and specifically 1α,25-dihydroxy-6-methylvitamin D3, and pharmaceutical uses therefor. This compound exhibits vitamin D receptor binding ...
8173824 Process for producing vitamin D derivative using convergent method  
There are provided a novel process for producing [{(5Z,7E)-(1S,3R,20S)-1,3-dihydroxy-9,10-secopregna-5,7,10(1 9),16-tetraen-20-yl}oxy]-N-(2,2,3,3,3-pentafluoropropyl)acet amide, which process is...
8143238 Methods of increasing epidermal skin thickness by topical administration of a 19-nor containing vitamin D compound  
Methods of increasing the thickness of the epidermal layer in the skin of a human comprising topically administering a therapeutically effective dose of an active pharmaceutical ingredient...
8114859 2-methylene-(20S,25S)-19,27-dinor-(22E)-vitamin D analogs  
This invention discloses 2-methylene-(20S,25S)-19,27-dinor-(22E)-vitamin D analogs, and specifically 2-methylene-(20S,25S)-19,27-dinor-(22E)-1α,25-dihydroxyvita min D3, and pharmaceutical uses ...
8106035 25-SO2-substituted analogs of 1μ,25-dihydroxyvitamin D3  
The present invention provides novel D-ring and side-chain analogs of 1α,25-dihydroxyvitamin D3, compositions comprising these compounds and methods of using these compounds as selective ...
8093232 2α-methyl-19-nor-(20S)-1α-hydroxy-bishomopregnacalciferol and its uses  
This invention discloses 2α-methyl-19-nor-(20S)-vitamin D analogs, and specifically 2α-methyl-19-nor-(20S)-1α-hydroxy-bishomopregnacalciferol and pharmaceutical uses therefor. This compound ex...
8058265 1a-hydroxy-2-(3'-hydroxypropylidene)-19-nor-vitamin D compounds and methods of making and treatment thereof  
Disclosed are 1α-hydroxy-2-(3′-hydroxypropylidene)-19-nor-vitamin D compounds, pharmaceutical compositions, and methods of making and treatment thereof. The compounds are generally directed to bi...
8030295 19,26,27-trinor-1α,25-dihydroxyvitamin D3 compounds  
Compounds of formula 1 are provided where X1, X2, and X3 are independently selected from H or hydroxy protecting groups, and R1 and R2 have the definitions provided herein. Such compounds may be...
8026379 Paricalcitol intermediates  
The present invention relates to a compound and a novel process for the preparation of Paricalcitol intermediates.
8013176 Paricalcitol purification  
Paricalcitol, a synthetic vitamin D analog, is purified to a purity greater than 99.7% by crystallization from solution in isopropyl acetate solvent, followed by filtration and vacuum drying....
7985744 Vitamin D derivatives  
The object of the present invention is to provide vitamin D derivatives that have excellent physiological activities as medicines, particularly as therapeutic agents for skin diseases such as...
7947666 2-methylene-(20S,25S)-19,26-dinor-vitamin D analogs  
This invention discloses 2-methylene-(20S,25S)-19,26-dinor-vitamin D analogs, and specifically 2-methylene-(20S,25S)-19,26-dinor-1α,25-dihydroxyvitamin D3, and pharmaceutical uses therefor. This ...
7943601 2-methylene-20-methyl-19,24,25,26,27-pentanor-vitamin D analogs  
This invention discloses 2-methylene-20-methyl-19,24,25,26,27-pentanor-vitamin D analogs, and specifically 2-methylene-20-methyl-1α-hydroxy-19,24,25,26,27-pentanor-vi tamin D3, and pharmaceutical ...
7915241 Preparation of 24 alkyl analogs of cholecalciferol and non-racemic compounds  
Disclosed is a process for the preparation of 24-alkyl analogs of cholecalcyferol of Formula 1 having a (5E) or (5Z) configuration, wherein X represents a hydrogen atom, a hydroxy group or an OR1...
7915242 Vitamin D receptor antagonists and their use in treating asthma  
Various compounds such as those having the formula I and XIV where the variables have the values described herein antagonize the vitamin D receptor and are useful in treating conditions such as...
7906495 Monohalogenovinyl vitamin D derivative compounds  
New vitamin D derivative compounds containing a monohalovinyl moiety at position C-20 are described. A process for obtaining the new compounds, consisting of reacting an aldehyde precursor with a...
7893043 2-methylene-(17Z)-17(20)-dehydro-19,21-dinor-vitamin D analogs  
This invention discloses 2-methylene-(17Z)-17(20)-dehydro-19,21-dinor-vitamin D analogs, and specifically 2-methylene-(17Z)-17(20)-dehydro-19,21-dinor-1α, 25-dihydroxyvitamin D3, and ...
7888338 7-(2-cyclohexylidene-ethylidene)-spiro[4.5]decanes  
The present invention relates to 7-(2-cyclohexylidene-ethylidene)-spiro[4.5]-decanes, compositions which comprise said 7-(2-cyclohexylidene-ethylidene)-spiro[4.5]-decanes, and methods for treating...
7888339 2-methylene-20(21)-dehydro-19-nor-vitamin D analogs  
This invention discloses 2-methylene-20(21)-dehydro-19-nor-vitamin D analogs, and specifically 2-methylene-20(21)-dehydro-19-nor-1α,25-dihydroxyvitamin D3, and pharmaceutical uses therefor. This ...
7888000 Method for identifying salt-sensitive persons  
Salt sensitivity is measured as a function of the urinary 25-OHD binding activity, which may be evaluated by measuring 25-hydroxyvitamin D binding activity using radiolabeled 25-hydroxyvitamin D3....
7879829 19-nor-vitamin D analogs with 1,2-dihydrofuran ring  
19-nor-vitamin D analogs having an additional dihydrofuran ring connecting the 1α-oxygen and carbon-2 of the A-ring of the analog, and pharmaceutical uses therefore, are described. These compounds ...
7803789 Vitamin D analog—RAK, methods and uses thereof  
Compounds of formula IA or IB are provided where X1, X2 and X3 are independently selected from H or hydroxy protecting groups and R1 is selected from straight or branched chain alkyl groups having...
7795459 Paricalcitol purification  
Paricalcitol, a synthetic vitamin D analog, is purified to a purity greater than 99.7% by crystallization from solution in isopropyl acetate solvent, followed by filtration and vacuum drying....
RE41491 (20S)-1α-hydroxy-2-methylene-19-nor-bishomopregnacalciferol and its uses  
This invention discloses (20S)-1α-hydroxy-2-methylene-19-nor-bishomopregnacalciferol and pharmaceutical uses therefor. This compound exhibits pronounced activity in arresting the proliferation of ...
RE41474 (20S)-1α-Hydroxy-2-Methylene-19-Nor-Bishomopregnacalciferol and its uses  
This invention discloses (20S)-1α-hydroxy-2-methylene-19-nor-bishomopregnacalciferol and pharmaceutical uses therefor. This compound exhibits pronounced activity in arresting the proliferation of ...
7763598 1α-hydroxy-2-(3′-hydroxypropylidene)-19-nor-vitamin D compounds with a 1,1-dimethylpropyl side chain  
This invention discloses 1α-hydroxy-2-(3′-hydroxypropylidene)-19-nor-vitamin D compounds with a 1,1-dimethylpropyl side chain, and pharmaceutical uses therefor. These compounds exhibit pr...
7763599 Modified retinoid compounds and their uses  
A method of minimizing or reducing the toxicity of a retinoid having a free carboxyl group and the resulting modified retinoids are described. The method comprises the step of esterifying the...
7741313 17,20(E)-dehydro vitamin D analogs and their uses  
This invention discloses 17,20(E)-dehydro vitamin D analogs, and specifically 17(E)-1α,25-dihydroxy-17(20)-dehydro-2-methylene-19-nor-vit amin D3 and pharmaceutical uses therefor. This compound ...
7741314 2-Methylene-(20R,25S)-19,27-Dinor-(22E)-Vitamin D Analogs  
This invention discloses 2-methylene-(20R,25S)-19,27-dinor-(22E)-vitamin D analogs, and specifically 2-methylene-(20R,25S)-19,27-dinor-(22E)-1α,25-dihydroxyvita min D3, and pharmaceutical uses ...
7718636 Use of 2-methylene-19-nor-20(S)-1alpha,25dihydroxy vitamin d3 to inhibit mammary tumor  
This invention provides pharmaceutical uses for 2-methylene-19-nor-20(S)-1α,25-dihydroxyvitamin D3. Administration of this compound increases the life expectancy of human beings, especially ...
7718638 (20R)-23,23-difluoro-2-methylene-19-nor-bishomopregnacalciferol-vitamin D analogs  
This invention discloses (20R)-23,23-difluoro-2-methylene-19-nor-bishomopregnacalcife rol-vitamin D analogs, and specifically...
7718637 (20S)-23,23-difluoro-methylene-19-nor-bishomopregnacalciferol-vitamin D analogs  
This invention discloses (20S)-23,23-difluoro-2-methylene-19-nor-bishomopregnacalcife rol-vitamin D analogs, and specifically...
7713951 2-alkylidene-18,19-dinor-vitamin D compounds  
2-alkylidene-18,19-dinor-vitamin D compounds are disclosed as well as pharmaceutical uses for these compounds and methods of synthesizing these compounds. These compounds are characterized by low...
7713953 2-methylene-(22E)-25-(1-methylene-hexyl)-26,27-cyclo-22-dehydro-19-nor-vitamin D analogs  
This invention discloses 2-methylene-(22E)-25-(1-methylene-hexyl)-26,27-cyclo-22-dehy dro-19-nor-vitamin D analogs, and specifically...
7713952 2-methylene-19,26,27-trinor-(20S)-1α-hydroxyvitamin D3 and its uses  
This invention discloses 2-methylene-19,26,27-trinor-(20S)-vitamin D analogs, and specifically 2-methylene-19,26,27-trinor-(20S)-1α-hydroxyvitamin D3 and pharmaceutical uses therefor. This ...
7704981 2-methylene-1alpha,25-dihydroxy-18,19,21-trinorvitamin D3 and uses thereof  
Compounds of formula I are provided where X1, X2 and X3 are independently selected from H or hydroxy protecting groups. Such compounds are used in preparing pharmaceutical compositions and are...
7704982 2-methylene-19-nor-1α-hydroxy-17-ene-homopregnacalciferol and its uses  
This invention discloses 2-methylene-19-nor-17-ene vitamin D analogs, and specifically 2-methylene-19-nor-1α-hydroxy-17-ene-homopregnacalciferol and pharmaceutical uses therefor. This compound ...
7648973 2-methylene-1α,25-dihydroxy-19,21-dinorvitamin D3 analogs and uses thereof  
Compounds of formula I are provided where X1, X2 and X3 are independently selected from H or hydroxy protecting groups. Such compounds are used in preparing pharmaceutical compositions and are...
7648974 19-nor-vitamin D analogs with 3,2-dihydrofuran ring  
19-nor-vitamin D analogs having an additional dihydrofuran ring connecting the 3β-oxygen and carbon-2 of the A-ring of the analog, and pharmaceutical uses therefore, are described. These compounds ...
7648972 2-methylene-1α-hydroxy-19,21-dinorvitamin D3 analogs and uses thereof  
Compounds of formula I are provided where X1 and X2 are independently selected from H or hydroxy protecting groups. Such compounds are used in preparing pharmaceutical compositions and are useful...
7563783 2-methylene-19-nor-(20S-24S)-1α,25-dihydroxyvitamin-D2  
Compounds of formula I are provided where X1, X2, and X3 are independently selected from H or hydroxy protecting groups. Such compounds may be used in preparing pharmaceutical compositions and are...
7541348 2-methylene-19-nor-(20S)-1α-hydroxy-trishomopregnacalciferol  
Compounds of formula I are provided where X1 and X2 are independently selected from H or hydroxy protecting groups. Such compounds may be used in preparing pharmaceutical compositions and are...
7541349 2-methylene-19-nor-(23S)-25-dehydro-1α-hydroxyvitamin D3-26,23-lactone and 2-methylene-19-nor-(23R)-25-dehydro-1α-hydroxyvitamin D3-26,23-lactone  
Compounds of formula 1A and 1B are provided where X1 and X2 are independently selected from H or hydroxy protecting groups. Such compounds may be used in preparing pharmaceutical compositions and...
7538098 19-nor-vitamin D analogs with 1,2 or 3,2 heterocyclic ring  
19-nor-vitamin D analogs having an additional heterocyclic ring connecting the 3β-oxygen and carbon-2 or the 1α-oxygen and carbon-2 of the A-ring of the analog, and pharmaceutical uses therefore, a...
7534777 Des-C,D analogs of 1α,25-dihydroxy-19-norvitamin D3  
Des-C,D 2-methylene-19-norvitamin D3 analogs are provided including compounds of formula 1, in which R1 is a straight or branched chain alkyl or alkylene group having from 8 to 27 carbons and...
7531527 2-Propylidene-19-nor-vitamin D compounds  
2-propylidene-19-nor-vitamin D compounds are disclosed as well as pharmaceutical uses for these compounds and methods of synthesizing these compounds. These compounds are characterized by high bone...
7528122 Vitamin D analog—NEL, methods and uses thereof  
Compounds of formula IA or IB are provided where X1, X2 and X3 are independently selected from H or hydroxy protecting groups and R1 is selected from straight or branched chain alkyl groups having...
7524980 Vitamin D3 lactam derivative  
Compounds expressed by the following formula (1) or pharmaceutically permissible solvate thereof which is effective for treating Paget's disease of bone, hypercalcemia or osteoporosis. In the...
7511030 2-methylene-19-nor-(20S-24epi)-1α,25-dihydroxyvitamin D2  
Compounds of formula I are provided where X1, X2, and X3 are independently selected from H or hydroxy protecting groups. Such compounds may be used in preparing pharmaceutical compositions and are...
7491712 Process for preparation of paricalcitol and intermediates thereof  
The invention relates to a novel process for the preparation of Paricalcitol and intermediates thereof.
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