Matches 101 - 150 out of 345 < 1 2 3 4 5 6 7 >
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6150086 Encapsulation of oleophilic substances and compositions produced thereby  
Multiple micro-encapsulations of a high concentration oleophilic substance using heat to set the primary particle renders the composition suitable for the production of free-flowing powders or...
6143910 Methods for preparation and use of 1α, 24(S) -dihydroxy vitamin D2  
1α,24(S)-Dihydroxy vitamin D 2 which is useful as an active compound of pharmaceutical compositions for the treatment of disorders of calcium metabolism and for various skin disorders. The...
6127559 2-alkyl-19-nor-vitamin D compounds  
This invention provides a novel class of vitamin D related compounds, namely, the 2-alkyl-19-nor-vitamin D derivatives, as well as a general method for their chemical synthesis. The compounds have...
6124276 Vitamin D derivative with substituent at the 2β-position  
1α-hydroxy-vitamin D derivatives represented by formula ##STR1## wherein R 1 represents a hydrogen atom or a hydroxyl group; and R 2 represents a straight-chain or branched C 2 -C 7 alkyl, C 2...
6121469 Therapeutically effective 1α,25-dihydroxyvitamin D.sub.3 analogs  
Novel analogs of 1α,25-dihydroxyvitamin D 3 which are selective agonists for the genomic responses or agonists or antagonists for the rapid cellular responses in a wide array of diseases in which...
6080879 Hexafluoro-vitamin synthesis and crystallization method, solvent and product  
This invention provides a novel synthesis and crystallization method and solvent for producing hexafluoro-vitamin D compounds, including 26, 26, 26, 27, 27, 27-hexafluoro-1α, 25-dihydroxyvitamin D...
6072062 Synthesis of C.sub.18 -modified vitamin D compounds and compounds resulting therefrom  
The invention relates to a new vitamin D compound, substituted in the 18-position with an alkyl group, a hydroxy group, an alkoxy group, an alkenyl group, an alkynyl group, a fluorinated alkyl...
6043386 Non-calcemic, antiproliferative, transcriptionally active 24-fluorinated hybrid analogs of 1α,-25-dihydroxy vitamin D.sub.3  
Fluorinated analogs of 1α,25-dihydroxyvitamin D 3 . These analogs are synthesized in a convergent manner by joining A-ring and C,D-ring fragments. Each hybrid analog, having a calcemia-lowering...
6042855 Use of vitamin D, its metabolites and analogs to improve tenderness of meat and meat products  
A method of improving the tenderness of meat and meat products is described. The method includes administering excessive doses of vitamin D to meat producing animals prior to slaughter. The vitamin...
6043385 Vitamin D derivatives  
The present invention relates to vitamin D derivatives of the formula I ##STR1## wherein X is CCH 2 or CH 2 ; Y is hydrogen, fluorine or hydroxy Z is hydroxy n is 1 or 2 R 1 is...
6030963 16-ene-26,27-bishomo cholecalciferols  
The invention relates to a compound of the formula ##STR1## wherein A is ##STR2## Et is ethyl, and R is hydroxy and R 1 is hydrogen or CH 2 or R is hydrogen or fluoro and R 1 is CH 2 ....
6028208 Vitamin D.sub.3 derivative and treating agent for inflammatory respiratory disease using same  
Provided are vitamin D 3 derivatives expressed by the following general formula [1] ##STR1## [wherein, R 1 and R 2 are each a hydrogen atom, a trialkylsilyl group, an acetyl group, a...
6025346 1α-hydroxy vitamin D.sub.4 and novel intermediates and analogues  
Disclosed is 1α,24-dihydroxy vitamin D 4 having the following structure: ##STR1## and pharmaceutical compositions containing said compound. The compound and composition are useful in the...
6017908 3-EPI vitamin D.sub.2 compounds and uses thereof  
Novel 3-epi vitamin D2 compounds having the orientation of the substituent attached to the carbon at position 3 of the A-ring of vitamin D2 inverted from a beta (β) to an alpha (α) configuration...
5994569 Dihomo-seco-cholestanes  
Polyunsaturated 24a,24b-dihomo-9,10-secocholestane derivatives of formula ##STR1## wherein A is a single or double bond, B 1 and B 2 are each independently CHCH or C.tbd.C, T is CH 2 or...
5981780 19-nor-vitamin D.sub.3 compounds with calcemic activity  
The 26 and/or 27 homologated analogs of 19-nor-1α,25-dihydroxyvitamin D 3 are disclosed as having relatively high calcemic activity. The 26 and/or 27 homologated analogs showed strong in vivo...
5972917 1 α-hydroxy-25-ene-vitamin D, analogs and uses thereof  
The invention provides 1α-hydroxyvitamin D compounds in which the C-25 or equivalent position of the C-17 side chain has a double bond and method for their use in the treatment and prophylaxis of...
5939408 Vitamin D.sub.3 analogs  
Compounds of the formula ##STR1## wherein R is hydrogen, fluorine, or hydroxyl, each R 2 is lower alkyl or C(R 3 ) 3 and R 3 is halogen, X is CH 2 or when R is hydroxy, X is hydrogen or...
5936105 14-EPI-19-nor-vitamin D compounds and methods  
19-nor-vitamin D analog compounds and a method of synthesizing such compounds are disclosed. More particularly, examples of such compounds include 14-epi-19-nor-1α,25-dihydroxyvitamin D 3 ,...
5932565 Vitamin D analogues  
The invention relates to compounds of formula (I): ##STR1## wherein Q and R are as defined in the specification. The compounds are useful in the treatment of a number of disorders including...
5929056 Vitamin D compounds and method of preparing these compounds  
The present invention relates to vitamin D compounds of the general formula ##STR1## wherein: R 1 is a hydrogen atom or a hydroxy group; R 2 is a (C 1 -C 3 )alkyl group, a hydroxy(C 1 -C 3...
5905074 Vitamin D derivative  
A compound of the formula ##STR1## useful for treating vitamin D dependent disorders.
5902806 Crystalline vitamin D derivative  
A crystalline (5Z,7E,23S)-26,26,26,27,27,27-hexafluoro-9,10-secocholesta-5 ,7,10(19)-trie n-1α,3β,23,25-tetraol monohydrate has an excellent preservation stability, and is therefore useful as a...
5891865 Treatment of arthritic disease induced by infectious agents  
A method of treating arthritis symptoms induced by an infectious agent of an arthritis patient comprising administering to an arthritis patient an amount of vitamin D compound effective to reduce...
5888994 Fluorinated Vitamin D.sub.3 analogs  
A compound of formula I ##STR1## wherein R is hydrogen, fluorine or hydroxy, and X is CH 2 or when R is hydroxy, X is hydrogen or CH 2 which are useful in the treatment of...
5883271 2-Substituted vitamin D derivatives  
A compound represented by general formula (I): ##STR1## wherein R 1 and R 2 , each presents an ethyl group and R 3 represents an alkoxy group having (1) to (7) carbon atoms which may be...
5880113 19-nor-vitamin D compounds  
This invention provides a novel class of vitamin D-related compounds, namely the 1c-hydroxy-19-nor-vitamin D analogs, as well as a general method for their chemical synthesis. The compounds exhibit...
5880114 Treatment of immune deficiency with vitamin D compounds  
A method for treating immune deficiency in a mammal by administering an amount of a vitamin D compound, such as Vitamin D 3 , its active form 1α,25-dihydroxyvitamin D 3 or other compounds...
5872113 Fluorinated vitamin D3 analogs  
Fluorinated Vitamin D 3 analogs, intermediates for their preparation, compositions comprising the analogs and methods of treatment of osteoporosis and related conditions with these and related...
5869472 Synthesis of 1α-hydroxy vitamin D  
A method for 1α-hydroxylation of vitamin D compounds using the appropriate vitamin D as the starting material. The method requires no separatory procedures prior to the actual hydroxylation step.
5856536 Preparation of 19-Nor-vitamin D compounds  
Disclosed are 20-epi-19-nor-vitamin D compounds having the structure: ##STR1## where each of X 1 and X 2 independently represents hydrogen or a hydroxy-protecting group, and Z represents various...
5843927 18,19-dinor-vitamin D compounds  
18,19-dinor-vitamin D 3 analogs in which the angular methyl group attached to carbon 13 of the CD-ring and the exocyclic methylene group attached to carbon 10 of the A-ring have been removed and...
5840938 20(S)-25-hydroxy vitamin D compounds  
Vitamin D 3 analogs in which the methyl group normally attached to the side chain at carbon 20 has been exchanged with the hydrogen atom to form the 20-epi configuration. The compounds are...
5840718 22-epimeric-1,25-dihydroxy-16,22,23-triene-cholecalciferol  
The invention relates to a compound of the formula ##STR1## wherein R is hydroxy and R 1 is H 2 or CH 2 or R is hydrogen or fluoro and R 1 is CH 2 and (b) an inert carrier. Compounds of...
5824811 22-Thiavitamin D.sub.3 derivatives  
Compounds of the general formula: ##STR1## wherein R 1 represents a C1-10 alkyl group which may be substituted by one or more hydroxyl groups, R 2 represents a hydrogen atom or a hydroxyl group,...
5817648 Vitamin D.sub.3 analogues having an unsaturated side chain  
Vitamin D 3 analogues of the formula (I): ##STR1## wherein R 1 is hydrogen or hydroxy, R 2 is hydrogen, (C 1 -C 3 ) alkyl, phenyl, or trifluoromethyl, R 3 is branched or unbranched (C 1 -C 4...
5811562 Vitamin-D amide derivatives  
The present invention relates to compounds of general formula (I) ##STR1## where R 1 and R 2 , which may be the same or different, each represent a hydrogen atom or an aliphatic, cycloaliphatic,...
5786347 Vitamin D amine and amide derivatives  
The invention relates to vitamin D amine and amide derivatives of general formula ##STR1## where R represents a hydrogen atom, an aliphatic, cycloaliphatic or araliphatic group, or an acyl group...
5767111 18-nor-vitamin D compounds  
18-nor-vitamin D 3 analogs in which the angular methyl group attached to carbon 13 of the CD-ring has been removed and replaced by a hydrogen atom. The 18-nor vitamin D compounds are characterized...
5763428 Methods of treating skin disorders with novel 1a-hydroxy vitamin D.sub.4 compounds and derivatives thereof  
The disclosure is of methods of treating various skin disorders, including skin cancer, with compounds of novel 1α-hydroxy vitamin D 4 and novel analogues, thereof, including 1,25 dihydroxy...
5756783 1α-Hydroxy-24-EPI-vitamin D.sub.4  
1α-Hydroxy-24-epi-vitamin D 4 and novel intermediates formed in a novel method of preparing this compound. The method includes campesterol as a starting material which is converted to...
5753638 Method of treating hyperproliferative skin disease with Vitamin D3 fluorinated analogs  
Compounds of the formula ##STR1## wherein R is hydrogen, hydroxy, or fluorine are useful as agents for the treatment of hyperproliferative disorders of the skin such as psoriasis, as agents for the...
5750517 Method of treating sebaceous gland diseases with vitamin D.sub.3 fluorinated analogs  
Compounds of the formula ##STR1## wherein R is hydrogen, hydroxy, or fluorine are useful as agents for the treatment of hyperproliferative disorders of the skin such as psoriasis, as agents for the...
5750746 Homologated vitamin D2 compounds and the corresponding 1α-hydroxylated derivatives  
The invention provides new 24, 26, and/or 27 homologated vitamin D 2 compounds, such as 26,27-dihomo-1α-hydroxyvitamin D 2 , 26,27-dihomo-1α-hydroxy-24-epivitamin D 2 ,...
5726330 Highly crystalline 22-oxavitamin D derivatives  
Highly crystalline vitamin D derivatives are represented by the formula: ##STR1## (where R 1 is a straight or branched C 4 -C 9 alkyl group optionally having a hydroxyl group; R 2 and R 3 ...
5719297 Vitamin D.sub.3 derivatives and production process thereof  
A vitamin D 3 derivative represented by the following formula: ##STR1## wherein, R is, independently, a hydrogen atom, tri(C 1 to C 7 hydrocarbon)silyl group, C 2 to C 8 acyl group, or group...
5700791 Vitamin D derivatives modified in the 20-position and pharmaceutical compositions thereof  
The invention relates to vitamin D derivatives, modified in 20-position, of general formula I ##STR1## in which X, Y, Z, R 1 , R 2 as well as R 3 have the meaning indicated in the description,...
5698714 Process for the preparation of 9, 10-secocholesta-5,7,10 (19)-trienes  
The invention recites a process for preparing 9,10-secocholesta-5,7,10(19)-trienes of formula (I) ##STR1## where R 1 is hydrogen or a hydroxy-protecting group and R 2 and R 3 are independently...
5691328 Phosphoethanolamine conjugates of vitamin D compounds  
Certain phosphoethanolamine conjugates of vitamin D compounds are disclosed wherein the phosphoethanolamine moiety is bonded at the 3-position of the vitamin D moiety. The conjugates exhibit...
5665716 24-homo vitamin D derivatives, process for their production and pharmaceutical preparations obtained therefrom  
New 24-homo vitamin D derivatives of formula I ##STR1## are described, in which R 1 means a hydrogen atom, a hydroxy, an alkanoyloxy group with 1 to 8 carbon atoms or an aralkanoyloxy group with...
Matches 101 - 150 out of 345 < 1 2 3 4 5 6 7 >