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7119081 |
Oestrogen-17-sulphamates as inhibitors of steroid sulphatase
There is provided a compound of Formula I
wherein X is a ring system; R 1 is any one of a sulphamate group, a phosphonate group, a thiophosphonate group, a sulphonate group or a sulphonamide...
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6251887 |
17β-aryl(arylmethyl)oxy(thio)alkyl-androstane derivatives
The invention relates to 17β-aryl(arylmethyl)oxy(thio)alkyl-androstane derivatives having general formula (I), wherein R 1 is (H,OR), (H,OSO 3 H) or NOR; with R being H, (C 1 -6)alkyl or (C 1...
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5010071 |
Androstane derivatives
Androstane derivatives of the general Formula I ##STR1## in which R 1 represents a hydrogen atom or a methyl group, X and Y each mean hydrogen atoms or together a carbon-carbon bond, and R 2...
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4898694 |
17-Hydroxy-steroids
Compounds of the formulae: ##STR1## are useful as anti-cancer, anti-obesity, anti-diabetic, anti-coronary agents, anti-aging agents, anti-hypolipidemic agents and anti-autoimmune agents.
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4865766 |
Process for the preparation of 4-amino-androstenedione derivatives
A process for the preparation of 4-aminoandrostenediones of formula (I) ##STR1## and pharmaceutically acceptable salts thereof, wherein one of R 1 and R 2 is hydrogen and the other is hydrogen, C...
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4808616 |
6-substituted androsta-1,4-diene-3,17-diones
The invention relates to 6-alkylidenandrosta-1,4-diene-3,17-dione derivatives, having the following general formula ##STR1## wherein each of R and R 2 , independently, is hydrogen or C 1 -C 6 ...
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4757061 |
4-amino androstendione derivatives and process for their preparation
The invention discloses 4-substituted androstendione derivatives of the following formula (I) ##STR1## wherein R is amino or substituted amino or azido, one of R 1 and R 2 is hydrogen and the...
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4587235 |
Novel androstane derivatives, process for their production, and pharmaceutical preparations containing them
Androstane derivatives of Formula I ##STR1## wherein is a single bond or a double bond, R 1 is methyl or ethyl, R 2 is hydrogen or alkyl of 1-8 carbon atoms, --X-- is --(CH 2 ) n --,...
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4459235 |
2-Cyanosteroids
The invention relates to novel 2-cyanosteroids of Formula I which are useful for the induction of menses and the termination of pregnancy.
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4346037 |
Base catalyzed acylation with enol esters
This invention relates to processes for base catalyzed acylations using enol esters, for example, isopropenyl acetate. Particularly, the processes are useful for acylating acid sensitive alcohols...
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4329296 |
Branched chain and cycloaliphatic esters of the androstane and oestrane series and pharmaceutical compositions containing same
There are disclosed branched chain and cycloaliphatic esters of steroids having the formula: ##STR1## or the 5αH analog thereof, where R is H or CH 3 ; R 1 is H or CH 3 ; R 2 is H or CH...
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4321208 |
Preparation of directly iodinated steroid hormones and related compounds
A process for the direct iodination of steroids and steroid hormones in the presence of hydrogen peroxide or chloramine-T is disclosed. The antigenicity and the specific receptor binding of...
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4317817 |
Novel steroid 5α-reductase inhibitors
Compounds of the following general formula are testosterone 5α-reductase inhibitors rendering the compounds useful in the treatment of acne and oily skin and benign prostatic hypertrophy: ##STR1##...
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4297350 |
Male contraceptive steroids and methods of use
The steroids of the present invention have been found to be useful as male contraceptives when administered orally. Upon cessation of administration of the male contraceptive steroids of the...
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4198336 |
Chemical process for preparing androsta-4-ene 17α-carboxylic acids
This invention is a process for preparing 3-keto-androst-4-ene 17α-carboxylic acids, androsta-1,4-diene 17α-carboxylic acids and their 17α-esters by reacting a corresponding...
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4160027 |
Steroid cyanoketones and intermediates
2α-Cyano-3-oxosteroids having a 4α,5α-epoxy group and alkylated in the 4- and/or 6-position, useful as interceptive agents, are prepared by alkaline cleavage of the corresponding...
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4150126 |
Novel enol esters of steroids, compositions containing such compounds, processes for their preparation and methods of treatment therewith
This invention relates to novel enol esters of steroids having an antitumor activity and to the preparation thereof. The invention is also concerned with pharmaceutical compositions containing the...
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4119625 |
Process for the manufacture of steroid carboxylic acids and the esters thereof
The present invention provides a novel process for the manufacture of 17- and 17a-carboxylic acids of the androstane and D-homo-androstane series respectively, of the following partial formula of...
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4052421 |
13-Ethinyl-steroids and processes for their manufacture
A new class of 13-ethinyl-steroids is prepared by a novel process comprising Wittig reaction of a 13-formyl steroid with a chloro- or bromomethylenephosphorane and dehydrohalogenation of the...
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3980638 |
Testosterone derivatives
Novel testosterone 17-ether 2,3-isoxazole and 2-cyano derivatives are disclosed as useful steroid enzyme inhibitors and for other pharmaceutical purposes.
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3966713 |
11β-FLUOROANDROSTENES
11β-Fluoroandrostenes of the formula ##SPC1## Wherein R 1 and R 2 are hydrogen atoms, methylene or another C--C bond; R 3 is H or Cl, R 4 is H, F or Cl; and X is carbonyl, β-hydroxymethylene,...
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3963707 |
Novel N-nitroso compounds, compositions containing such compounds, processes for their preparation and methods of treatment therewith, and novel intermediates
This invention relates to novel N-halogenoalkyl-N-nitroso carbamates and N 4 halogenalkyl-N 4 -nitroso allophanates of steroid compounds, having an anti-tumor activity, and to the preparation...
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3953429 |
Anaesthetic steroids of the androstance and pregnane series
Steroids of the androstane and pregnane series possessing a 2α-hydrogen or halogen or an alkyl group; a 3α-hydroxy or acyloxy group, a 3β-hydrogen or alkyl group; an 11β-hydrogen or hydroxy...
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3914420 |
Novel antiandrogenic compounds
Novel steroids of the formula ##SPC1## Wherein R is alkyl of 1 to 3 carbon atoms and R 1 is selected from the group consisting of hydrogen, alkyl of 1 to 4 carbon atoms and α-tetrahydropyranyl...
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3897460 |
3β-Tertiarybutoxy-decahydro-benz[E]indenes
Total synthesis of known progestationally active steroidal materials. The steroids can be synthesized depending on the particular starting reactants selected by employing as intermediates bicyclic...
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3890356 |
7-Alkyl-Δ3,5 -steroids
Novel steroids of the class of 7-alkyl-3,5-androstadienes, estradienes and gonadienes are prepared which are useful as antiprogestational and antifertility agents.
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3884945 |
Synthesis of steroids by cyclization in nitro solvents
Synthesis of steroids by cyclization of a dienyne cyclization substrate to a steroid or A-nor steroid employing a primary or secondary aliphatic nitro compound as solvent, thereby forming an oxime...
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3879383 |
2-Halogen-18-methyl-1-androstene
An androstene steroid of the formula ##SPC1## Wherein R is hydrogen or an acid residue or a lower alkyl or tetrahydropyranyl group and wherein X is chlorine or bromine. The compounds are useful for...
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3862193 |
O-(NITROARYL) OXIMES OF 3-KETO STEROIDS
O-(Nitroaryl)oximes of variously substituted 3-keto steroids in which the aryl ring is in turn substituted in the ortho and/or para position with nitro groups are antilittering, anabolic and...
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3846456 |
ORGANIC COMPOUNDS
The invention relates to novel steroid compounds, more particularly to certain 7α-methyl-4-androstenes, 2α,7α-dimethyl-4-androstenes and their 19-nor-counterparts.
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3835160 |
3'-KETO-2',3'-SECO-1'-(2')-YNE STEROIDAL DERIVATIVES, METHODS FOR THEIR MANUFACTURE, AND COMPOUNDS PRODUCED THEREBY
Described herein are novel 3'-keto-2',3'-seco-1'(2')-yne steroidal structures and processes for their preparation and, in particular, the preferred embodiment thereof, i.e., 5-keto-4,5-seco-3-ynes...
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3789087 |
4,6-DICHLOR- Δ -STEROIDS AND METHOD OF MAKING AND USING THE SAME
4,6-dichlor-Δ 4 ,6 -steroids of the pregnane and androstane series are produced by reacting a 4-chlor- or a 6-chlor-Δ 4 ,6 -steroid which includes a group of the formula: ##SPC1## Wherein X 1 ...
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3691212 |
17α-(1',3'-ALKADIYNYL)-17β-ACYLOXY(17β-AROYLOXY) STEROIDS
17α-(1',3'-Alkadiynyl)-17β-acyloxy(17β-aroyloxy) steroids of the androstane and oestrane series having utility in treatment of conditions or defects of the reproductive system are disclosed.
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3689521 |
ORGANIC COMPOUNDS AND PROCESSES
This invention relates to novel ring-D seco steroid transformation products, of the following formula and tautomeric forms thereof and to processes for their preparation: ##SPC1## Wherein R is...
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3687943 |
FLUORINATION OF UNSATURATED STEROIDS
Electrophilic addition of fluorine to carbon-carbon multiple bonds which comprises reacting various unsaturated organic compounds in the liquid phase at low temperature with hypofluorites in which...
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3676426 |
2-(1-HYDROXYALKYLIDENE)-3-OXO STEROIDS
Steroido[3.2-c]pyrazoles, having endocrinological, including anabolic, activities, are prepared by interacting 2-(1-hydroxyalkylidene)-3-oxo steroids with hydrazine or a substituted hydrazine. The...
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3547908 |
17BETA-HYDROXY-5ALPHA-ANDROSTANO(2,3-D) IMIDAZOLES
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3542770 |
RING A-FUSED PYRIDAZONE STEROIDS
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3531503 |
TETRACYCLIC COMPOUNDS AND PROCESSES
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3527778 |
3,17 - BISOXYGENATED 11BETAMETHYL - 19 - NORPREGN - 4 - EN - 20 - ONES AND DERIVATIVES THEREOF
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3523958 |
4 - ALKYL - 6 - DEHYDRO - TESTOSTERONE AND INTERMEDIATES IN THE PRODUCTION THEREOF
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3523942 |
17-TERTIARY AMINO-SUBSTITUTED STEROID DERIVATIVES
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3523126 |
TESTOSTERONE AND 19-NORTESTOSTERONE(4'-METHYLBICYCLO(2,2,2)OCTANE - 1' - METHYL)CARBONATE AND SELECTED DERIVATIVES
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3515720 |
ESTERS OF TESTOSTERONE AND SELECTED DERIVATIVES THEREOF WITH BICYCLO(2.2.2)OCTANE-1- AND -OCTENE-1-CARBOXYLIC ACIDS
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3514448 |
17-OXYGENATED 2-HALO-4-(METHYL/METHYLENE) - 5ALPHA - ANDROST - 1 - EN-3-ONES AND PRECURSORS
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3499014 |
17-HYDROXYALKYNYLATION PROCESS
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3497533 |
METHOD OF PREPARING 1-DEHYDRO-9BETA,10ALPHA-STEROIDS
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3496199 |
PROCESS FOR THE PREPARATION OF 9BETA,10ALPHA-STEROIDS
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3483235 |
NEW OESTRATRIENES AND PROCESS FOR THEIR MANUFACTURE
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3483234 |
STEROIDAL 17-ADAMANTOYL ESTERS
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