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7507725 |
Compounds with sulphonamide group and pharmaceutical compositions containing these compounds
The invention relates to compounds which, acting as a prodrug and/or support, enable an active agent to be taken up by the erythrocytes and/or an active agent to bind to the erythrocytes. The...
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7378404 |
8β-hydrocarbyl-substituted estratrienes for use as selective estrogens
This invention describes the new 8β-substituted estratrienes of general formula I in which R 2 , R 3 , R 6 , R 6′ , R 7 , R 7′ , R 9 , R 11 , R 11′ , R 12 , R 14 , R 15 , R 15′ , R 16 , R...
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6894038 |
Use of biogenic estriol diester prodrugs for the treatment of autoimmune diseases
The invention relates to the use of esters of estriol, for example, an estriol 3,17-dipropionate or an estriol 3,17-dihexanoate, for the treatment of autoimmune diseases, such as multiple sclerosis...
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6670347 |
19-nor-17α-pregna-1,3,5(10)-trien-17β-ols with a 21,16α-lactone ring
This invention relates to new 19-nor-17α-pregna-1,3,5(10)-trien-17β-ols with a 21,16α-lactone ring of formula II, process for their production and pharmaceutical preparations that contain...
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6271220 |
Anti-angiogenic agents
The application discloses methods of treating mammalian diseases characterized by undesirable angiogenesis by administering compounds including those having the general formulae ##STR1## wherein A...
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5798348 |
Fatty-acid monoesters of estrogens for the treatment of obesity and/or overweight
The pharmaceutical and/or cosmetic compositions for treatment of obesity and/or overweight contain an effective amount of a fatty-acid monoester of an estrogen and a fatty acid wherein the estrogen...
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5705495 |
Sulfamate derivatives of 1,3,5(10)-estratriene derivatives, methods for their production and pharmaceuticals containing these compounds
The invention relates to new sulfamate derivatives of 1,3,5(10)-estratriene derivatives of the general formula I ##STR1## wherein the 3-sulfamate moiety is acylated, sulfonated or amidosulfonated....
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5529993 |
14α, 17α-ethano-16α-hydroxy-estratrienes
A 14α,17α-bridged estratriene of formula I ##STR1## wherein (a) OR 3 is in α-position R 1 , R 2 and R 3 , each independently are (i) hydrogen, (ii) ##STR2## in which R 4 is an organic...
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5438049 |
16-epiestriol to prevent, inhibit, or reduce inflammation without glycogenic effects
A method for the treatment of inflammation, its signs and symptoms, in a mammal which comprises the administration of an anti-inflammatory effective amount of 16-epiestriol without glycogenic...
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5252729 |
Extraction of compounds from plant materials using supercritical fluids
The present invention is directed toward a process for extracting compounds from plant material, comprising a) contacting hydrolyzed plant material with a supercritical fluid and optionally with...
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4855125 |
Iodinated estradiols, intermediate products and methods of production
A method of preparation of estradiol derivatives labeled by iodine, especially 123 I, substitution at C-16 are synthesized according to the present invention. A triflate intermediate is prepared...
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4780460 |
Glycoesters of estradiol and estriol
Glycoesters of estradiol (E 2 ) and of estriol (E 3 ) of Formula I (E 2 ,3)--O--CO--CH 2 --Z (I) wherein Z is hydroxy or the group --O--CO--R wherein R is methyl...
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4738957 |
Estriol esters
Estriol esters of Formula I ##STR1## wherein R is, in each case, the residue of an aliphatic monocarboxylic acid of 3-10 carbon atoms, surpass estriol in strength and duration of estrogen activity.
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4681875 |
3,17 β-estriol diesters, methods of their use, and pharmaceutical preparations containing them
Estriol esters of Formula I ##STR1## wherein R, in each case, means the residue of a monocarboxylic acid of 2-10 carbon atoms. The novel estriol esters surpass estriol in strength and duration of...
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4659517 |
Halogen labeled compounds including estradiol derivatives, their synthetic intermediates and the syntheses thereof
A method of preparation of halogen labeled organic compounds is described. In particular, estradiol derivatives labeled by halogen substitution at C-16 are synthesized according to the present...
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4592869 |
Selective acylation process
This invention relates to a selective acylation process for the preparation of phenolic N-disubstituted carbamate esters of steroids, comprising reacting in an inert solvent an acylating agent...
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4588717 |
Compounds and vitamin supplements and methods for making same
The present invention relates to novel compounds, vitamin supplements, diet pills, and methods for making the same. The vitamin supplements include one or more phytosterol esters, such as esters of...
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4537722 |
Steroid esters preparation
This invention relates to an improved steroid ester synthesis in which carbodiimides and catalytic amounts of 4-(tertiary amino)-pyridines, in combination with acid catalysts, are used as...
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4360663 |
Steroid hormone-antitumor derivatives
A process for producing a steroid hormone-antitumor derivative which selectively affects to tumor or cancer cells comprises reacting X group of a steroid hormone derivative having the formula...
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4330539 |
Novel 17-amino-16-hydroxy steroids of the androstane and oestrane series and derivatives thereof
New and pharmacologically useful 17-amino-16-hydroxy-steroids of the androstane and oestrane series are disclosed having the formula I: ##STR1## and pharmaceutically acceptable non-toxic acid...
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4321208 |
Preparation of directly iodinated steroid hormones and related compounds
A process for the direct iodination of steroids and steroid hormones in the presence of hydrogen peroxide or chloramine-T is disclosed. The antigenicity and the specific receptor binding of...
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4318908 |
Methylated prostaglandin derivatives
Methylated prostaglandine derivatives are steroids derivatives having at 17 position, methylated prostaglandine group such as (Me) 2 --PGE 2 --E (Me) 2 --PGE 2 --E--2AC (Me) 2 --PGE 2...
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4198405 |
Prostaglandine derivatives
Prostaglandine derivatives are composed of a prostaglandine and a steriod hormone with or without a binding group. The prostaglandine derivatives have extraordinarily reduced side-effect and...
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4181669 |
Steroid esters preparation
This invention relates to an improved steroid ester synthesis in which a carbodiimide, in combination with an acid catalyst, is used as condensing agent.
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4180504 |
Method for the preparation of esters
This invention relates to an improved ester synthesis in which a carbodiimide, in combination with an acid catalyst, is used as condensing agent.
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4082779 |
Acylation process for the preparation of steroid phenolic n-disubstituted carbamate esters, and ion pair solution for use in the process
This invention relates to a novel carbamoylation method for the preparation of steroid phenolic N-disubstituted carbamate esters, and novel compounds in said method. Phenolic carbamate esters are...
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4081461 |
Acylation process for the preparation of phenolic N-disubstituted carbamate esters, and ion pair solution for use in the process
This invention relates to a novel carbamoylation method for the preparation of phenolic N-disubstituted carbamate esters, and novel compounds in said method. Phenolic carbamate esters are useful...
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4052352 |
Tetrahydropyranyl ethers of estrogens
Tetrahydropyranyl ethers of estrogens have interesting properties in the cure of climateric and menopausal disturbances, with an excellent dissociation index between their selective effect on the...
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4051186 |
Amino-propranolol
Biologically active substances having labile aryl groups can be converted to the corresponding aryl amine derivatives. The biologically active substances are reacted with a diazonium compound which...
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RE29199 |
Certain steroid N-bis-(haloethyl)-carbamates
Antitumor active mono and poly N-Bis-(B-haloethyl)-carbamic acid esters of certain estrogenic steroid hormones, especially estradiol; such compounds wherein all hydroxyl groups of the steroid...
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3997664 |
Substituted carbinol derivatives
The compounds are steroidal 17-propadienyl carbinols and derivatives thereof. The compounds have estrogenic/progestational activity.
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3972906 |
Novel - 11-substituted steroids of the estrane series
The present invention relates to novel 11-substituted steroids of the estrane series having the general formula ##SPC1## In which R 1 = a free, esterified or etherified hydroxyl group or...
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3963707 |
Novel N-nitroso compounds, compositions containing such compounds, processes for their preparation and methods of treatment therewith, and novel intermediates
This invention relates to novel N-halogenoalkyl-N-nitroso carbamates and N 4 halogenalkyl-N 4 -nitroso allophanates of steroid compounds, having an anti-tumor activity, and to the preparation...
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3944576 |
Novel steroids of the oestrane series substituted in 7-position
The invention relates to novel 7-substituted-steroids of the oestrane series of the general formula: ##SPC1## In which Ring A including carbon atom 6 is ##SPC2## R 1 = an alkyl group with 1-4...
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3939186 |
Process for producing ethers of steroids
A process for producing a steroid ether which comprises admixing an alkali, a reactant steroid having a hydroxyl group attached directly to an aromatic ring in the steroid nucleus, and a dialkyl...
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3935245 |
Radioactively labeled steroid derivatives
Steroids bearing the substituent --X-NR 1 R 2 wherein --NR 1 R 2 is a tritium of carbon-14 labeled amino or amino-acid group and --X-- is --R 3 --, --OCOR 3 --, =N--O--R 3 -- or --NHCOR 3 ...
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3922292 |
Novel haptene steroids
Novel steroids of the formula ##SPC1## Wherein X is selected from the group consisting of =O and, ##EQU1## Y is selected from the group consisting of hydrogen and --OH and when R 1 is --(CH 2 ) a ...
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3920634 |
2,3-Dihydroestra-1,3,5(10)-trieno (16α,17α-β) furan-17βols
2',3'-Dihydroestra-1,3,5(10)-trieno[16α,17α-bβfuran-17.be
t a.-ols are new compounds useful in the treatment of menopausal syndrome and other conditions of estrogen deficiency.
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3875188 |
17-Beta-alpha-lower alkyl allene-substituted steroids
The compounds are 17-alpha(lower alkyl) allenyl steroids, e.g., 17α-(2',3'-butadien-2'-yl)estra-4-en-17β-ol-3-one. The compounds have estrogenic/progestational activity.
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3856829 |
16β-HYDROCARBON SUBSTITUTED ESTRANE COMPOUNDS
Novel 16β-hydrocarbon substituted estrane compounds are provided represented by the formula: Wherein A is hydrogen or an acyl radical and R is a hydrocarbon radical having at least 2 carbon atoms....
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3852312 |
PREPARATION OF MANNICH BASES
Steroidal Mannich bases are prepared by reaction of a steroid bearing an ethynyl and a hydroxy function at any of positions 3 and 17 (or 17a) with an N,N-dialkyl substituted-amino-methanol in the...
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3697558 |
PREPARATION OF 17ALPHA-ETHYNYLESTRIOL
An improved process for preparing 17α-ethynylestriol utilizing a novel isomer separation process
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3689512 |
NOVEL 3-ETHERIFIED-1,3,5(10)-TRIENE-STEROIDS AND PROCESS THEREOF
Disclosed are new and novel 3-cyclobutyloxy, 3-cyclopropylmethoxy and 3-cyclobutylmethoxy-1,3,5(10)-trien-steroids and a method for the production thereof by reacting the corresponding 3-hydroxy...
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3679716 |
NEW 3, 16α, 17α-TRIHYDROXY-Δ -OESTRATRIENE
The compound of the formula ##SPC1## Use: Oestrogenic agent for inhibiting the gonadotropic function and ovulation.
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3665022 |
DEGRADATION OF SIDE CHAIN IN SAPOGENINS
Compounds of the formula ##SPC1## Wherein X is oxo, lower alkylenedioxy, di(lower alkoxy), or in which R' is hydrogen or acyl; one of Z and Z' is oxo or in which R is hydrogen or acyl, and the...
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3551459 |
13-METHYL-8-ISOGONANES
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3549674 |
STEROID ESTROGEN SULFATES AND METHODS OF PREPARING THE SAME
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3541118 |
3 - ALKOXYALKOXY - 13 - ALKYLGONA - 1,3,5(10)-TRIENES UNSATURATED AT THE DELTA-6-,DELTA-7-,DELTA-8(9)-,DELTA-9(11)- AND DELTA-6,8(9)-POSITIONS AND 8-ISOGONA ANALOGS THEREOF
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3520881 |
LOWER ALKOXYTETRAHYDROPYRANYL ETHERS OF ESTROGENIC STEROIDS
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3519714 |
SYNTHESIS OF GONA-1,3,5(10)-TRIENES
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