Matches 1 - 50 out of 172 1 2 3 4 >
Match Document Document Title
7629334 Mesoprogrestins (progesterone receptor modulations) as a component of compositions for hormone replacement therapy (HRT)  
The use of mesoprogestins as pharmaceutical components for the manufacture of a medicament for hormone replacement therapy (HRT) and as components for the combined use together with an estrogen for...
7579335 Androstane 17α-carbonate derivatives for use in the treatment of allergic and inflammatory conditions  
The present invention is directed to compounds of formula (I): wherein R 1 represents C 4 -C 7 branched alkyl group, a bicycloalkyl group, or a C 5 -C 6 cycloalkyl which optionally may be...
7498321 17β-carbothioate 17α-arylcarbonyloxyloxy androstane derivative as anti-inflammatory agents  
There are provided according to the invention compounds of formula (I) wherein R 1 represents C 1-6 alkyl or C 1-6 haloalkyl; R 2 represents —C(═O)-aryl or —C(═O)-heteroaryl; R 3 ...
7427610 2-substituted estra-1,3,5(10)-triene-3-yl sulfamate with an anti-tumour action  
Disclosed are compounds of formula I and use thereof in a method of treating a tumor disease that can be influenced positively by the inhibition of tubulin polymerization.
7371741 Estradiol derivatives and pharmaceutical compositions using same  
Compositions and methods for treating mammalian disease characterized by undesirable angiogenesis by administering compounds of the general formula: wherein the variables are defined in the...
7291609 Specific glucocorticosteroid compound having anti-inflammatory activity  
A compound of formula (I): or a physiologically acceptable solvate thereof.
7291608 Anti-inflammatory 17.β.-carbothioate ester derivatives of androstane with a cyclic ester group in position 17.α  
There are provided compounds of formula (I) wherein the variables are as defined by the present specification; and solvates thereof, processes for preparing them and their use in therapy.
7208613 Synthesis of s-fluoromethyl 6α,9α-difluoro-11β-hydroxy-16α-methyl-17α-propionyloxy-3-oxoandrosta-1,4-diene-17β-carbothioate  
The present invention provides a convenient process for the preparation of S-fluoromethyl 6α,9α-difluoro-11β-hydroxy-16α-methyl-17α-propionyloxy- 3-oxoandrosta-1,4-diene-17β-carbothioate, a...
7009063 Process for the production of oxandrolone  
The present invention relates to a process for the synthesis of oxandrolone from mestanolone. The process comprises the steps of: (a) oxidizing mestanolone to form...
6921757 Organic compounds  
Compounds of formula (I), where R is a monovalent cyclic organic group having from 3 to 15 atoms in the ring system, useful as pharmaceuticals
6706701 6, 7-oxygenated steroids and uses related thereto  
Steroid compounds having various oxygen substitution on the steroid nucleus are disclosed. A specific functionality present on many of the steroid compounds is oxygen substitution at both of...
6689768 Pharmaceutical preparations for treating side effects during and/or after GnRHa therapy  
The pharmaceutical preparations for treating side effects, such as hot flashes, prostate enlargement and gynecomastia, during and/or after treatment with analogs or antagonists of...
6610866 Stereoselective synthesis of 24-hydroxylated compounds useful for the preparation of aminosterols, vitamin D analogs, and other compounds  
A method is described for stereoselectively reducing an unsaturated alkyl ketone substituent attached to a fused ring base. In this method, the unsaturated alkyl ketone reacts with a chiral...
6610675 Inactive metabolite approach to soft drug design  
The invention provides novel soft steroidal anti-inflammatory agents, pharmaceutical compositions containing said agents, and methods of administering same to mammals in the treatment of...
6596885 19-Nor steroids having a thiocarbonated chain in position 11beta, their preparation process and the intermediates of this process, their use as medicaments and compositions  
Novel compounds having a formula selected from the group consisting of wherein the substituents are defined as in the specification which are intermediates for the production of vinyl compounds...
6492536 Steroids, their use as medicaments, their preparation process, the intermediates of this process and the compositions containing them  
The subject of the invention is the products of formula (I): in which either R 1 represents halogen, hydroxyl, (C 1 -C 8 ) alkyloxy or (C 1 -C 12 ) acyloxy, and R 2 represents halogen or...
6468981 Compositions and methods for targeting pharmaceutically active materials to cells containing androgen receptors  
A water soluble delivery system for nucleic acids to cells having androgen receptors, preferably prostate cells, is provided comprising a steroid moiety capable of binding to said receptors, said...
6436917 Non-estrogenic estradiol derivative compounds with anti-oxidative activity  
New non-estrogenic derivative compounds of estradiol, which have no estrogenic activity and comparatively high anti-oxidative activity, are disclosed. These new non-estrogenic derivative compounds...
6388109 14,15-cyclopropano steroids of the 19-norandrostane series, method for the production thereof and pharmaceutical preparations containing said compounds  
Described are new 14,15-cyclopropano steroids of the 19-norandrostane series of general formula (I) and their pharmaceutically acceptable salts, a process for their production and pharmaceutical...
6365582 S-substitute 11β-benzaldoxime-estra-4, 9-diene-carbonic acid thiolesters, method for the production thereof and pharmaceutical preparations containing these compounds  
Thiol esters of S-substituted 11β-benzaldoxime-estra-4,9-dien-carboxylic acids of the formula I their pharmaceutically acceptable salts, a method for their synthesis and pharmaceutical...
6080735 Estra-1,3,5(10)-trien derivatives, processes for their preparation and pharmaceutical compositions containing these compounds  
5977096 Steroids with radical-attracting aromatic substituents, process for the production thereof and pharmaceutical compounds containing the said substances  
Novel substituted steroid compounds are disclosed which are more effective than known radical-trapping agents in methods of prophylaxis and therapy of radical-mediated cell damage and of treatment...
5972922 Steroids which inhibit angiogenesis  
Novel angiostatic Δ 4 ,9(11) -steroids (I), ##STR1## C 21 -oxygenated steroids (II) and other known steroidal compounds have been found to be useful in treating angiogenesis in mammals who have a...
5859266 "N-T-butyl-androst-3-5-diene-17 β-carboxamide-3-carboxylic" acid polymorph A  
Polymorph "A" a novel polymorphic form of N-t-butyl-androst-3,5-diene-17β-carboxamide-3-carboxylic acid. Novel processes for preparing polymorph "A" are also disclosed.
5760025 Steroid derivatives for the treatment of prostatic hypertrophy, their preparation and uses  
Compounds of formula (I): ##STR1## wherein: R 1 is hydrogen, alkyl, aryl-substituted alkyl or aromatic heterocyclic-substituted alkyl; R 2 is: aryl-substituted alkyl, aromatic...
5717088 Method of making steroid derivatives for the treatment of prostatic hypertrophy  
Compounds of formula (I): ##STR1## wherein: R 1 is hydrogen, alkyl, aryl-substituted alkyl or aromatic heterocyclic-substituted alkyl; R 2 is: aryl-substituted alkyl, aromatic...
5698720 Steroid derivatives  
The invented compound ##STR1## is useful for the production of steroidal-17-amides that have 5α-reductase inhibitory activity.
5693629 Progesterone compound and use thereof  
A progesterone compound represented by the following formula (1): ##STR1## wherein R 1 represents a C1-C23 hydrocarbon group!, and a neovascularization inhibitor containing the same as the active...
5683995 17 substituted acyl-3-carboxy 3,5-diene steroidals as α-reductase inhibitors  
Invented are 17α and 17β-substituted acyl-3-carboxy-3,5-diene analogues of steroidal synthetic compounds, pharmaceutical compositions containing these compounds, and methods for using these...
5641877 17-α and 17-β substituted acyl-3-carboxy-3, 5-dienes and use in inhibiting 5-α-reductase  
Invented are 17α and 17β-substituted acyl-3-carboxy-3,5-diene analogues of steroidal synthetic compounds, pharmaceutical compositions containing these compounds, and methods for using these...
5641765 17-αand 17-βsubstituted acyl-3-carboxy-3,5-dienes and use in inhibiting 5-α-reductase  
Invented are 17α and 17β-substituted acyl-3-carboxy-3,5-diene analogues of steroidal synthetic compounds, pharmaceutical compositions containing these compounds, and methods for using these...
5618806 17α and 17β-substituted estra-1,3,5(10)-triene-3-carbboxlic acid  
Invented are 17α and 17β-substituted acyl-3-carboxy aromatic A ring analogues of steroidal synthetic compounds. Representative of such compounds include the following ##STR1## wherein Z is α or...
5599806 Hydrazino and hydroxyamino-14-β-hydroxyandrostane derivatives active on the cardiovascular system processes for their preparation and pharmaceutical compositions containing same  
The invention describes hydrazino and hydroxyamino-14β-hydroxyandrostane derivatives having general formula (I): ##STR1## wherein the symbol means α or β configuration and A, B, R 1 , R 2 , R 3...
5596110 Process for the preparation of 3 β, 14 β-dihydroxyethianaldehyde  
An improvement in a process for producing 3β,14β-dihydroxyethianaldehyde is disclosed wherein the oxidation of the lactone ring of digitoxigenin-3-acetate is conducted with an alkaline periodate...
5596109 N-t-butyl-androst-3,5-diene-17β-carboxamide-3-carboxylic acid polymorph A  
The invention describes a process for the preparation of the polymorph A form of a compound having the structure ##STR1## which involves triturating, crystallizing, or precipitating crude...
5576310 11-benzaldoxime-17β-methoxy-17α-methoxymethyl-estrasdiene derivatives, methods for their production and pharmaceuticals containing such compounds  
This invention relates to new 11-benzaldoxime-estra-diene derivatives of the general formula I ##STR1## wherein Z is --CO--CH 3 , --CO--O--C 2 H 5 , --CO--NH-phenyl, --CO--NH--C 2 H 5 , --CO--C 2...
5565588 9-alpha-hydroxy steroids, process for their preparation, process for the preparation of the corresponding 9(11)-dehydro derivatives and pharmaceutical preparations containing said steroids  
New 9-alpha-hydroxy steroids are prepared by the introduction of substituents on the D-ring of 9-alpha-hydroxy-androst-4-ene-3,17-dione. The resulting compounds are useful intermediates in the...
5561124 17-α-acyl steroids which inhibit 5-α-reductase  
The invention relates to substituted 17α-acyl steroidal 5α-reductase inhibiting compounds. The invention also relates to pharmaceutical compositions containing these compounds and their use for...
5478957 Preparation of 6α, 9α-difluoro steroids  
A process for the preparation of 6α,9α-difluoro steroids of the formula ##STR1## wherein R is hydrogen or an ester remainder.
5444055 17-hydroxyiminomethyl-5-β, 14 β-androstane derivatives active on the cardiovascular system, processes for their preparation and pharmaceutical compositions containing same  
17-hydroxyiminomethyl-14β-hydroxy-5β androstane derivatives, active on the cardiovascular system, a process for their preparation and pharmaceutical compositions thereof having the general...
5438134 Process for the production of unsaturated 17 α-cyanomethyl-17 β- h  
The unsaturated 17α-cyanomethyl-17β-hydroxy steroids of the formula I, ##STR1## in which R 1 =Me, Eth; R 2 =H, Me; R 3 =H, OH, an acetoxy or alkoxy group; R 4 =H, R 5 =OH, an acetoxy, alkoxy...
5436401 22-oxacholecalciferol derivative and process for preparing the same  
A 22-oxacholecalciferol derivative represented by formula (I): ##STR1## wherein R 1 represents a hydrogen atom or a hydroxyl group; and R 2 and R 3 , which may be the same or different, each...
5426102 14β-H-, 14-and 15-En-11β-aryl-4-oestrenes  
Novel compounds of the general formula I ##STR1## and the pharmacologically tolerable addition salts thereof with acids are described, in which either Ia) R 11 represents a hydrogen atom in the...
5407928 11β-aryl-gona-4,9-dien-3-ones  
This invention relates to 11β-aryl-gona-4,9-dienes of the general formula I ##STR1## wherein the variables are defined in the specification. The compounds are progesterone antagonists and are...
5399727 Preparation of Δ.sup.9(11) steroid  
A process for the preparation of a compound of the formula ##STR1## comprising reacting a compound of the formula ##STR2## with chlorosulfonic in an organic solvent wherein the reaction is effected...
5212166 Unsaturated 17β-subsituted 3-carboxy steroids  
The present invention concerns steroidic 5α-reductase inhibitors having the following formula (I) ##STR1## wherein Y is oxygen or sulphur; R is a group; a) --OR 4 , wherein R 4 is hydrogen...
5196411 17β-acyl-3-carboxy-androsta-3,5-dienes as testosterone 5α-reductase inhibitors  
17β-acyl-3-carboxy-androsta-3,5-dienes as testosterone 5α-reductase inhibitors of the formula: ##STR1## wherein R is C 3 -C 8 cycloalkyl, which can be substituted with C 1 -C 4 alkoxy or C 6 ...
5149696 19➝nor➝steroids  
Novel 19-nor-steroids of the formula ##STR1## wherein the A and B rings have a structure selected from the group consisting of ##STR2## having hormonal properties and their preparation and...
5140106 Process for the production of 3-deoxy-4-ene steroids  
A process for the production of 3-deoxy-4-ene steroids of the general formula I ##STR1## is described, in which R 1 , R 2 and R 3 mean a hydrogen atom or a methyl group, R 4 represents a...
5116830 Stereoisomerically pure 17α-ethynyl-estra-2-en-17β-ol and the 17β esters thereof, methods of preparation and uses  
This invention relates to a stereoisomerically pure Δ 2 compound of the formula (I): ##STR1## wherein: R 1 is hydrogen or --(CO)--R 2 , wherein: R 2 is an organic substituent selected...
Matches 1 - 50 out of 172 1 2 3 4 >