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7601708 |
Bile-acid derived compounds for providing sustained systemic concentrations of drugs after oral administration
This invention is directed to methods for providing sustained systemic concentrations of therapeutic or prophylactic agents such as GABA analogs following oral administration to animals. This...
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7598235 |
Bile-acid conjugates for providing sustained systemic concentrations of drugs
This invention is directed to compounds that provide for sustained systemic concentrations of therapeutic or prophylactic agents following administration to animals. This invention is also directed...
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7501403 |
Bile acid or bile salt fatty acid conjugates
The present invention relates to the use of a bile acid or bile salt fatty acid conjugate of general formula II
W-X-G
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6803030 |
Bile acids conjugates with metal ion chelates and the use thereof
Compounds able to chelate paramagnetic metal ions and the use thereof as contrast agents in the technique known as “Magnetic Resonance Imaging” (M.R.I.).
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6793943 |
Health food products
An object of the present invention is to provide a very effective health food exhibiting the effect near that which has been already achieved by the traditional Chinese medical science. The present...
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6624156 |
Methods of making and method of using hybrid cholinergic agents and compositions
The present invention provides hybrid molecules and methods of synthesizing such hybrid molecules from a cholinergic agent and a bile acid. The hybrid molecules function as cholinergic agents and...
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6589946 |
Bile salt conjugates
The present invention relates to bile acid or bile salt fatty acid conjugates (hereinafter called “BAFAC), to their use in dissolving cholesterol gallstones in bile, preventing their occurrence...
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6468975 |
Liver specific bile acid derivatives of the glucocorticoid antagonist RU486
Novel glucocorticoid receptor ligands and methods of treating diseases such as diabetes, wherein the ligands have general formula (I) wherein the variables are as defined by the present...
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6448420 |
Acid-decomposable ester compound suitable for use in resist material
A novel ester compound having an exo-form 2-alkylbicyclo[2.2.1]heptan-2-yl ester as the acid-decomposable site is used as a dissolution regulator to formulate a resist composition having a high...
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6342489 |
Bile acid salts of metals with physiological action and the use thereof in therapy
Bile acid metal salts of therapeutic interest and pharmaceutical and veterinary composition containing same for the treatment of anemias and other conditions are described.
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6255502 |
Pharmaceutical composition containing acid addition salt of basic drug
A pharmaceutical composition contains an acid addition salt of a basic drug and a fatty acid or bile acid. The acid addition salts thus formed exhibit enhanced transmucosal and transdermal...
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5610151 |
Monomeric bile acid derivatives, processes for their preparation and the use of these compounds as medicaments
Monomeric bile acid derivatives, processes for their preparation and the use of these compounds as medicaments Monomeric bile acid derivatives of the formula I Z--X--GS ...
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5559258 |
Ethylenically unsaturated bile acid derivatives, processes for their preparation and precursors
Ethylenically unsaturated bile acid derivatives of the formula I G--X--A I in which G, X and A have the meanings indicated, are described. They...
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5541348 |
Bile acids for biological and chemical applications and processes for the production thereof
Novel bile acids according to the general formula ##STR1## wherein R 1 represents a hydroxyl group, R 2 and R 3 both represent a hydrogen or a hydroxyl group, or R 2 represents a hydroxyl group...
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5252729 |
Extraction of compounds from plant materials using supercritical fluids
The present invention is directed toward a process for extracting compounds from plant material, comprising a) contacting hydrolyzed plant material with a supercritical fluid and optionally with...
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4981983 |
Derivatives of biliary acids, process for the production thereof and corresponding pharmaceutical compositions
New derivatives of chenodeoxycholic, ursodeoxy cholic, cholic and ursocholic acids, bearing a methyl group in the side chain in an alfa position to the carboxylic group, the corresponding nor- and...
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4921848 |
Biliary acid derivatives, processes for the preparation thereof and pharmaceutical compositions containing them
Compounds of formula I ##STR1## wherein: R 1 is hydrogen or hydroxy, and the methyl and hydroxy groups at 6- and 7-positions respectively can be either in α or β configuration, are useful in...
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4921999 |
Method for making tertiary butyl esters
A method is provided for making tertiary butyl esters by effecting reaction between an organic carboxylic acid and isobutylene in the presence of an effective amount of trifluoromethane sulfonic...
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4917828 |
Process for preparing ketocholanates
A process for preparing ketocholanate(s) comprises oxidizing cholanic acid compound(s), such as alkyl 3α-alkoxycarbonyloxy-7α,12α- dihydroxycholanates or alkyl...
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4834919 |
Stereoselective reduction of the keto group at 7-position of a bile keto acid
The keto group at the 7-position of a bile keto acid is stereoselectively reduced to a beta-hydroxy group with hydrogen in the presence of nickel, a base (the quantity of which is at least 0.3 mole...
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4592868 |
11-hydroxypregn-4-en-3-one-20-carbaldehyde and a method for its production
There is provided the novel compound 11-hydroxypregn-4-en-3-one-20-carbaldehyde, as well as a microbial method for production of the same. This novel compound is of value as a starting material for...
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4499020 |
Mixed anhydrides and processes thereof
Mixed anhydrides products are described. These mixed anhydrides are produced by reaction of a carboxylic acid-containing steroid with a material having the formula: ##STR1## wherein: X is a halogen...
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4425273 |
Process for production of chenodeoxycholic acid
A process for producing chenodeoxycholic acid of the following formula ##STR1## which comprises reducing a 12-oxocholanic acid tosylhydrazone compound of the following formula ##STR2## wherein R 1 ...
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4379093 |
Process for preparing high purity ursodeoxycholic acid
A process for preparing very pure ursodeoxycholic acid starting from cholic acid (I) by: (a) selectively oxidizing it to 3 alpha, 12 alpha-dihydroxy-7-ketocholanic acid (II) (b) reducing acid...
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4279898 |
In vivo inhibitors of cholesterol biosynthesis
Dialkyl esters of 5-carbo[etiocholane-3'α-7'α, 12'α-trihydroxy-17'β(1" methyl-4' butyl]oxy-4-hydroxy-4-methylpentyl-1-phosphonate and 5-carbohexadecyloxy-4-hydroxy-4-methylpentyl-1-phosphonate...
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4202876 |
Investigating body function
Body function of a mammal is investigated using a γ-emitting 75 Se or 123m Te labelled derivative of a bile acid or bile salt. Thus bowel function may be investigated by oral administration of...
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4180504 |
Method for the preparation of esters
This invention relates to an improved ester synthesis in which a carbodiimide, in combination with an acid catalyst, is used as condensing agent.
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4172085 |
Labelled bile acids
The present invention provides compounds having the general formula ##STR1## wherein R is ##STR2## and A is 0 or 1, B is 0 to 4, C is 0 to 4, Z is Se or Te, R 6 is --OH or an amino...
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4107188 |
Pregnanes
The compound 5(3,12-dihydroxy-pregnan-20-yl)-pentanoic acid and 7-(3,12-dihydroxy-pregnan-20-yl)-heptanoic acid as well as ester and unsaturated derivatives thereof useful for decreasing the level...
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4104285 |
Taurine and glycine derivatives
Taurine and glycine derivatives of nor or bisnorcholanic acid or etiocholanic acid which are useful in increasing bile flow or decreasing lipid levels and their method of production from...
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4009178 |
Brominating and oxidizing agent and method of using same
There is provided a brominating and oxidizing agent of the formula: ##STR1## wherein R 1 , R 2 , R 3 and R 4 which may be the same or different, represents a member selected from the group...
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3998859 |
Introducing Δ.sup.11 unsaturation into steroid compounds
A process for the introduction of Δ 11 unsaturation into steroid compounds having a C-12 sulfonate ester group is described. Dehydrosulfonation is carried out by reacting the sulfonate with a...
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3944578 |
Organic superconductors with high transition temperatures and high critical magnetic fields
Organic compounds exhibit superconducting-like behavior, as to magnetic and lectrical properties, at elevated temperatures above 21°K, where 21°K is the transition temperature of most known...
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3931256 |
Chemical process for production of bile acids
This invention relates to new and novel methods for the production of substantially pure bile acids, and particularly, 3α,7α-dihydroxy 5β-cholanic acid, from natural sources thereof.
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3919266 |
Production of bile acids
This invention relates to new and novel methods for the production of substantially pure bile acids, and particularly, 3α,7α-dihydroxy 5β-cholanic acid, from natural sources thereof.
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3919268 |
Process for the preparation of 3-axial hydroxy steroids
It has been found that steroids having hydroxy groups in the equatorial orientation may be converted into corresponding steroids having said hydroxy group in the corresponding axial position. In...
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3901896 |
Process of oxidation of primary and secondary alcohols to the corresponding carbonyl derivatives
The process of oxidizing primary and secondary alcohols by reaction with lower dialkyl sulfoxides and halides or sulfonic acid anhydrides to produce the corresponding carbonyl compounds is...
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3684801 |
REMOTE OXIDATION OF UNACTIVATED STEROID METHYLENE GROUPS
There is provided a method of activating inactive methylene groups of the 5α-steroid nucleus. This method comprises forming a 3α-m- or p-benzoylphenyl 5α-steroid alkanoate and irradiating said...
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3531475 |
PROCESS FOR THE OXIDATION OF ALCOHOLS AND OXIDIZING AGENT UTILIZED THEREIN
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3463795 |
UNSATURATED CYCLOHEPTANO PERHYDRO PHENANTRENES AND THEIR PREPARATION
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3364219 |
Process of oxidation of primary and secondary alcohols to corresponding carbonyl derivatives
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3351638 |
Novel substituted 21-nor-delta20(22), 23-steroidal dienes
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3275665 |
Process for the preparation of delta9(11)-steroid compounds
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3225071 |
Arene group vib metal tricarbonyls and process for preparing same
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3221008 |
Ion exchange process for the recovery of ionic organic substances
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3197368 |
Process for the preparation of natural choline phosphoric acid diglyceride ester compounds
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3164611 |
Oxidation of primary and secondary alcohols to the corresponding carbonyl compounds using a tertiary amine chromium trioxide complex
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3087862 |
Test for cancer employing esters of bile acid degradation products
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3076000 |
Esters of bile acid degradation products and a process for preparing same
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3027385 |
Acyloxylated derivatives of steroids and method of preparing same
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