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7304171 |
Compounds and methods for cytoprotection
Compounds, compositions and methods for treating degenerative diseases and disorders are disclosed, the compounds having the following structure (I):
including stereoisomers, prodrugs and...
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7135581 |
Antiangiogenic agents
Compositions and methods for treating mammalian disease characterized by undesirable angiogenesis by administering derivatives of 2-methoxyestradiol of the general formula:
wherein the...
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6852710 |
2-alkoxyestradiol analogs with antiproliferative and antimitotic activity
The application discloses novel 2-alkoxyestradiol analogs which exhibit anti-proliferative properties, and methods of making and using such compounds to inhibit undesired cell proliferation and...
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6670353 |
Oxime-group containing oestrone sulphatase inhibitors
A sulphamate compound suitable for use as an inhibitor of oestrone sulphatase (E.C.3.1.6.2) is described. The compound is a polycyclic compound comprising at least two ring components, wherein the...
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6596885 |
19-Nor steroids having a thiocarbonated chain in position 11beta, their preparation process and the intermediates of this process, their use as medicaments and compositions
Novel compounds having a formula selected from the group consisting of wherein the substituents are defined as in the specification which are intermediates for the production of vinyl compounds...
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6579864 |
3-methylene steroid derivatives
The invention concerns a 3-methylene steroid derivative having general formula (1) wherein R 1 is H or together with R 3 forms a β-epoxide or R 1 is absent if there is a 5-10 or 4-5 double...
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6518262 |
22R-hydroxycholesta-8, 14-diene derivatives for the inhibition of meiosis
The invention relates to 22R-hydroxycholesta-8,14-diene derivatives having general formula (I) wherein R 1 is OR, OS0 3 H or ═NOR; with R being H, (C 1-6 )alkyl or (C 1-6 )acyl; each of R 2 and...
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6262282 |
17β-allyloxy(thio)alkyl-androstane derivatives for the modulation of meiosis
The invention relates to 17β-allyloxy(thio)alkyl-androstane derivatives having general formula (I) wherein R 1 is (H, OR), (H, OSO 3 H) or NOR; with R being H, (C 1 -6)alkyl or (C 1 -6)acyl;...
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6180803 |
19-nor-pregnene derivatives and pharmaceuticals containing such derivatives
The invention relates to compounds of the formula: ##STR1## in which R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , n and X are as defined in the specification, and to pharmaceutical compositions containing...
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6177420 |
20-aralkyl-5α-pregnane derivatives
The invention relates to 20-aralkyl-5α-pregnane derivative having general formula (I), or a pharmaceutically acceptable salt thereof, wherein R 1 is (H,OR), (H,OSO 3 H) or NOR; R is H, (C 1...
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6136992 |
2-alkoxy estradiols and derivatives thereof
Compounds represented by the following structural formula: ##STR1## wherein R 1 , R 2 and R 3 are as defined in the specification. The compounds are disclosed as useful in the treatment of...
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5194602 |
9α-hydroxy-17-methylene steroids, process for their preparation and their use in the preparation of corticosteroids
New 9α-hydroxy-17-methylene steroids are prepared by the introduction of a substituted 17-methylene group in 9α-hydroxyandrost-4-ene-3, 17-dione. The resulting compounds are useful starting...
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5182381 |
Intermediates for 3-keto-19-nor-Δ.sup.4,9 -steroids
Novel 3-keto-19-nor-Δ 4 ,9 -steroids of the formula ##STR1## and their non-toxic, pharmaceutically acceptable acid addition salts possessing a remarkable antiglucocorticoidal activity.
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5162312 |
11β-substituted 16α, 17α-methylene-estra-4,9-dien-3-ones
11β-substituted-16α, 17α-methylene-estra-4,9-dien-3-ones of formula I ##STR1## wherein R 1 is a methyl or ethyl group; R 2 is H; a C 1 -6 -alkyl, -alkoxymethyl, -alkanoyl or -alkoxcarbonyl...
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5132299 |
11β-phenyl-4,9,15-estratrienes, their manufacture and pharmaceutical preparations containing same
New 11β phenyl-4,9,15-estratrienes of formula I ##STR1## are described, where X implies an oxygen atom or a hydroxyimino grouping N.about.OH, R 1 stands for a hydrogen atom or a methyl group, ...
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5086047 |
Novel steroids
A compound selected from the group consisting of a compound of the formula ##STR1## wherein R is selected from the group consisting of hydrogen, alkyl, alkylthio and haloalkyl of 1 to 6 carbon...
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4753932 |
Novel 10-substituted steroids
A novel steroid of the formula ##STR1## wherein X is methylene and R is an optionally substituted carbocyclic aryl or heterocyclic aryl or optionally substituted vinyl or ethynyl or X is a simple...
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4634695 |
Steroid derivatives
Novel 19-nor steroids and 19-nor-D-homo-steroids of the formula ##STR1## wherein R 1 is an organic radical of 1 to 18 carbon atoms containing at least one atom selected from the group consisting...
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4591461 |
Preparation of tri-cyclo nitriles
A novel process for the preparation of a 16-imino-17-aza-steroid of the formula ##STR1## wherein A is selected from the group consisting of hydrogen and tritium comprising reacting a compound of...
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4519946 |
Steroids
Novel 19-nor steroids and 19-nor-D-homo-steroids of the formula ##STR1## wherein R 1 is an organic radical of 1 to 18 carbons atoms containing at least one atom selected from the group consisting...
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4515786 |
11α-Amino-androstanes
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4447424 |
Steroid derivatives
Novel 19-nor steroids and 19-nor-D-homo-steroids of the formula ##STR1## wherein R 1 is an organic radical of 1 to 18 carbon atoms containing at least one atom selected from the group consisting...
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4352798 |
11 α-Amino-androstanes
Compounds of formula ##STR1## (wherein): R 1 is a hydrogen atom, a C 1 -8 alkyl group or a C 3 -7 cycloalkyl group; and R 2 is a hydrogen atom, a C 1 -6 alkyl group or a C 3 -6 cycloalkyl...
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4297350 |
Male contraceptive steroids and methods of use
The steroids of the present invention have been found to be useful as male contraceptives when administered orally. Upon cessation of administration of the male contraceptive steroids of the...
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4220775 |
Preparation of 4-aza-17-substituted-5α-androstan-3-ones useful as 5α-reductase inhibitors
A method of preparing a compound of the formula: ##STR1## where Formula (I) may also have the structure of partial Formula (III); wherein, ##STR2## R' is hydrogen or methyl; R" is hydrogen or...
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4197296 |
Androstanes
Steroids of the androstane series are described which possess a 3α-hydroxy group, a 5α- or 5β- hydrogen atom, a 10- methyl group, an 11α- substituted amino group. The 17-position may be...
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3988356 |
Novel haptenes and antigens
Novel haptenes of the formula ##SPC1## Wherein when X is hydrogen, Y is =N-O-(CH 2 ) a --COOH and a is a whole number of 1 to 12 and when ##EQU1## X is hemiterephthaloyloxy in the α- or...
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3935245 |
Radioactively labeled steroid derivatives
Steroids bearing the substituent --X-NR 1 R 2 wherein --NR 1 R 2 is a tritium of carbon-14 labeled amino or amino-acid group and --X-- is --R 3 --, --OCOR 3 --, =N--O--R 3 -- or --NHCOR 3 ...
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3922292 |
Novel haptene steroids
Novel steroids of the formula ##SPC1## Wherein X is selected from the group consisting of =O and, ##EQU1## Y is selected from the group consisting of hydrogen and --OH and when R 1 is --(CH 2 ) a ...
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3689512 |
NOVEL 3-ETHERIFIED-1,3,5(10)-TRIENE-STEROIDS AND PROCESS THEREOF
Disclosed are new and novel 3-cyclobutyloxy, 3-cyclopropylmethoxy and 3-cyclobutylmethoxy-1,3,5(10)-trien-steroids and a method for the production thereof by reacting the corresponding 3-hydroxy...
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3519714 |
SYNTHESIS OF GONA-1,3,5(10)-TRIENES
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3506648 |
DIALKYLAMINOALKYL ESTRONE OXIME DERIVATIVES
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3503959 |
3-AMINO STEROIDS
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3492317 |
17 - TERTIARY AMINOALKOXYIMINOANDROSTANES AND THE PRODUCTION AND USE THEREOF
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3476794 |
13,17-SECO-17-NITRILE-DELTA**13(18) STEROIDS OF THE ANDROSTANE AND ESTRANE SERIES AND THE PROCESS FOR THE PREPARATION THEREOF
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3462464 |
2-OXIMINO-3-KETO STEROIDS OF THE ANDROSTANE SERIES
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3454641 |
METHOD FOR PREPARING OXIMES FROM CYCLIC OLEFINS
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3437658 |
STEROIDAL (16,17-C)-(1',2',5')OXADIAZOLES AND METHODS FOR THEIR MANUFACTURE
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3431286 |
2-ISONITROSO-3-OXO STEROIDS
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3415816 |
Preparation of 2-oxo steroids and novel derivatives thereof
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3415818 |
Dioximidoandrostanes and cyclized n-oxides derived therefrom
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3409609 |
Adrostano-pyridines and their preparation
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3391169 |
13-alkylgona-1, 3, 5 (10), 8-tetraenes
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3391170 |
13-alkylogona-1, 3, 5 (10), 9 (11)-tetraenes
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3318928 |
7alpha-alkyl-17alpha-alkinyl-estradiols
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3300484 |
Process and intermediates for manufacture of 13-alkyl-3, 17-bisoxygenated gona-1, 3, (10)-trienes
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3300487 |
Oxazepine derivative of 12beta-amino-5alpha-pregnane-3beta-20beta-diol
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3280112 |
Steroido [2, 3-d] triazoles
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3271426 |
Novel androstane oximino ethers and methods for their manufacture
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3271428 |
Novel estratriene oximino ethers and methods for their manufacture
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