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7067681 |
Methods of preparing substituted tetracyclines with transition metal-based chemistries
The present invention relates to novel chemistries which allow for heretofore unobtainable substituted tetracycline compounds which exhibit significant antibacterial activity. The methods disclosed...
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5218130 |
4-substituted anthracyclinones and their preparation
4-substituted anthracyclinones of formula (I) ##STR1## wherein R represents a hydrogen atom or a straight or branched alkyl, alkenyl or alkynyl group having from 1 to 10 carbon atoms, are...
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5103029 |
Process for preparing 4-demethoxydaunomycinone
4-Demethoxy-daunomycinone I: ##STR1## the known aglycone of 4-demethoxy-daunorubicin, is prepared by protecting the 13-keto group of 4-demethyldaunomycinone, sulfonylating the 4-hydroxy group,...
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5049683 |
Process for the production of alpha-6-deoxytetracyclines
A process for the preparation of alpha-6-deoxytetracyclines from the corresponding 6-methylenetetracyclines is described using a silica-supported heterogeneous rhodium catalyst: ##STR1## The...
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4990636 |
Process for the production of alpha-6-deoxytetracyclines and hydrogenation catalyst useful therein
A coordination compound useful as a hydrogenation catalyst, having the formula: ##STR1## wherein Ph is phenyl; R is hydrogen or C 1 -C 4 alkyl; and X is chloro, bromo or iodo. This compound is...
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4911865 |
Process of preparation of novel rhodium hydrogenation catalysts
The present invention refers to complexes prepared by reacting rhodium trinitrate with a suitable hydrazine and a suitable tertiary phosphine, more specifically to the compounds di(μ-hydrazine-N 1...
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4863639 |
Application of catalysts containing rhodium
The present invention refers to the compounds (μ-hydrazine-N 1 :N 2 )-bis[bis(triphenylphosphine)-chlororhodium (I)] and di(μ-hydrazine-N 1 :N 2 )-bis[bis(triphenylphosphine)rhodium (I)]...
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4597904 |
Process for the preparation of α-6-deoxy-tetracyclines
A process for the preparation of α-6-deoxy-tetracyclines by the stereoselective heterogeneous hydrogenation of a 6-demethyl-6-deoxy-6-methylene-tetracycline or an acid addition salt thereof, in...
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4584135 |
Process for the preparation of an oxytetracycline-calcium silicate complex salt from fermentation broth
The invention relates to a process for the preparation of an oxytetracycline-calcium silicate complex salt from fermentation broth. By the process according to the invention the valuable antibiotic...
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4550096 |
Homogeneous catalytic system comprising rhodium, hydrazine and phosphine and a process for the preparation of same
Stable homogeneous hydrogenation catalysts are prepared by reacting a rhodium salt or complex with a hydrazine in the presence or absence of a tertiary phosphine.
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4207258 |
Process for the preparatin of α-6-deoxytetracyclines
A process is provided for preparing alpha-6-deoxytetracyclines depicted by the formula: ##STR1## wherein Y is H, F, Cl, Br or I; and R is H, OH or --O--CO--(C 1 -6 alkyl); which comprises:...
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4001321 |
Preparation of α-6-deoxytetracyclines
Hydrogenation of a mixture prepared from a 6-deoxy-6-demethyl-6-methylenetetracycline compound, and a catalytic amount of a dicarboxylato(triphenylphosphine)rhodium(II) or dicarboxylato(substituted...
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3962331 |
Process for the preparation of α-6-deoxytetracyclines
This invention relates to a process for the preparation of α-6-deoxytetracyclines, by the simultaneous reductive dehalogenation and reduction by hydrogen, in a polar solvent of the corresponding...
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3962131 |
Rhodium containing catalyst and use thereof in preparation of 6-deoxy-5-oxytetracycline
Catalyst produced by the process of reacting 1 mol of rhodium trichloride and 2 mols of sodium acetate in methanol at a temperature from about 50°C. to the reflux temperature of said reaction...
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3954862 |
Process for producing α-6-deoxytetracyclines
The catalytic hydrogenation of 6-methylenetetracyclines, or salts of these compounds, in a reaction-inert solvent medium containing a catalytic amount of rhodium metal to which a phosphine and a...
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3947517 |
Stereoselective introduction of tetracyclines hydroxyl group at 12(a) position in synthesis of tetracyclines
In the synthesis of tetracyclines, a critical step is the stereospecific or stereoselective introduction of a hydroxyl group at the C-12(a) position, a novel method for the introduction of this...
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3907890 |
Preparation of alpha-6-deoxy-5-hydroxytetracycline
A process for the synthesis of α-6-deoxy-5-hydroxytetracycline, a broad spectrum antibiotic, by reduction of 6-methylene-5-hydroxytetracycline using cobalt carbonyl, triphenyl phosphine and...
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3879456 |
Process for preparing chlortetracycline neutral base
Chlortetracycline neutral base is prepared by slurrying chlortetracycline hydrochloride in water or an aqueous alkanol solution, then adding a water soluble salt of a carboxylic acid having from 2...
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3637463 |
PRODUCTION OF OXYTETRACYCLINE USING STREPTOMYCES ALBOFLAVUS (ATCC 15388)
A fermentative process for the production of oxytetracycline which comprises fermenting a nutrient broth under aerobic conditions at a temperature between 22° and 30° C. by a mutant of...
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3609188 |
4-DEDIMETHYLAMINO-4-SUBSTITUTED-AMINO-6-DEMETHYLTETRACYCLINES
This disclosure describes compounds of the class of 4-dedimethylamino-4-substituted-amino-6-demethyltetracycline
s useful as antibacterial agents.
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3526662 |
EXTRACTION AND PURIFICATION OF TETRACYCLINE FROM FERMENTATION BROTHS
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3446841 |
ISOLATION OF 5-HYDROXY-7-CHLORTETRACYCLINE
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3428679 |
TETRACYCLINE HYDROXY CARBOXYLIC ACIDS
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3397231 |
Refining of alpha-6-deoxy-5-oxytetracycline
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3390055 |
Fermentative production of nu-ethyloxytetracycline
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3385765 |
Novel process of producing 1, 3, 4, 10, 11, 12-hexahydroxy-6-methylnaphthacene-2-carboxamide
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3364260 |
4n-demethyl-4n-ethyl tetracyclines
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3360557 |
9-hydroxytetracyclines and a process of preparing same
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3360558 |
Substituted 5alpha, 6-anhydrotetracycline methyl betaines
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3330841 |
Substituted 3-(4-carbamoyl-2, 3, 5-trihydroxy-benzyl)-1, 2, 3, 4-tetrahydro-4, 8-dihydroxy-1-oxo-2-naphthoic acid, gamma-lactones
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3280188 |
Tetracycline complexes and the use thereof in preparing and isolating tetracyclines
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3272862 |
Recovery of tetracycline antibiotics from fermentation broths
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3265732 |
Novel 5alpha, 6-anhydrotetracyclines
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3239499 |
Tetracycline derivative
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3230254 |
Process of precipitating tetracycline base in crystalline form
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3226441 |
2-decarboxamido-2-acetyl-tetracycline derivatives and process
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3201462 |
2-carboxymethyl 4-oxo-tetrahydro-naphthalenes
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3200149 |
alpha-6-deoxytetracycline derivatives and process
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3188348 |
12alpha-deoxytetracycline oxidation process
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3166474 |
Stable aqueous propylene glycol solutions of aluminum gluconate complexes of certain tetracycline antibiotics
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3159542 |
Stable aqueous glycol solution of tetracycline aluminum calcium gluconate complex having a ph of about 7. 5 to 9
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3146265 |
6-deoxy-6-hydroperoxy dehydrotetracyclines and process utilizing the same
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3145228 |
5-alkoxy-and 5-benzyloxy-tetracycline, derivatives and analogues thereof
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3122578 |
Complexes of tetracycline antibiotics and preparation of same
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3081346 |
Novel 12alpha-(o-formyl)tetracyclines
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3068264 |
Tetracycline antibiotic-aluminumphosphoric acid complexes
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3047617 |
Alkanoic acid esters of 5-hydroxytetracycline and process for preparation
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3043877 |
Process for the 12a-hydroxylation of 12a-deoxytetracyclines
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3028409 |
2-carboxamido-nu-(alkyl) substituted anhydrotetracycline compounds
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3026248 |
Thioglycerol and formaldehyde sulfoxylate stabilized tetracycline antibiotics in polyhydric alcohol solvents
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