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7365087 |
Oxazole derivatives of tetracyclines
This invention provides compounds of the formula:
wherein A″, X and Y are defined in the specification. These compounds are useful as antibacterial agents.
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7067681 |
Methods of preparing substituted tetracyclines with transition metal-based chemistries
The present invention relates to novel chemistries which allow for heretofore unobtainable substituted tetracycline compounds which exhibit significant antibacterial activity. The methods disclosed...
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6562615 |
Apparatus for the preparation of chlortetracycline-containing animal feed compositions
The present invention provides improved chlortetracycline-containing animal feed compositions and processes and apparatuses for their preparation. In certain embodiments, raw fermentation broth...
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5594158 |
Processes for producing doxorubicin, daunomycinone, and derivatives of doxorubicin
Daunomycinone is a known precursor of the well known antibiotic and antineoplastic, doxorubicin. Daunomycinone may be synthesized by preparing mono ketal of a 1,4-naphthoquinone as the precursor of...
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5495032 |
Process for producing 7-(substituted)-8-(substituted-9-[(substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines
The invention provides a process for the production of compounds of the formula: ##STR1## wherein, R, R 3 , R 4 , X and W are defined in the specification in which a compound of the following...
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5495031 |
Process for the production of 7-(substituted)-9-[(substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines
The invention provides a process for the production of compounds of the formula: ##STR1## wherein R, R 3 , R 4 and W are defined in the specification in which a compound of the following formula:...
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5488119 |
Polymerisable photochromic naphthacenediones, polymers of these monomers, process for their preparation and the use thereof
Compounds of formulae I and II ##STR1## wherein D is H or --OR wherein R is phenyl and R 1 to R 4 are H or a substituent such as phenylthio, and one of the substituents R 1 , R 2 , R 3 and R 4 ...
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5401863 |
9-amino-7-(substituted)-6-demethyl-6-deoxytetracyclines
Novel 9-amino-7-(substituted amino)-6-demethyl-6-deoxytetracyclines having activity against a wide spectrum of organisms including organisms which are resistant to tetracyclines are disclosed. Also...
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5387703 |
Process and intermediate for the purification of oxytetracycline
The invention relates to a new process for obtaining a completely pure oxytetracycline which does not contain any acetyldecarboxamidooxytetracycline as ingredient. In glacial acetic acid there is...
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5218130 |
4-substituted anthracyclinones and their preparation
4-substituted anthracyclinones of formula (I) ##STR1## wherein R represents a hydrogen atom or a straight or branched alkyl, alkenyl or alkynyl group having from 1 to 10 carbon atoms, are...
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5202449 |
Process for purifying 7-dimethylamino-6-demethyl-6-deoxytetracycline
A process for purifying 7-dimenthylamino-6-demethyl-6-deoxytetracycline represented by the following formula, ##STR1## which comprises dissolving 7-dimethylamino-6-demethyl-6-deoxytetracycline or...
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5180758 |
Process for preparing anthracyclinones
4-substituted anthracyclinones of general formula (I): ##STR1## wherein R represents a hydrogen atom or a COOR 1 group in which R 1 may be a hydrogen atom or an optionally substituted C 1 -C 10 ...
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5049683 |
Process for the production of alpha-6-deoxytetracyclines
A process for the preparation of alpha-6-deoxytetracyclines from the corresponding 6-methylenetetracyclines is described using a silica-supported heterogeneous rhodium catalyst: ##STR1## The...
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5015745 |
Process for the preparation of 4-demethoxydaunomycinone, the aglycone of 4-demethoxy-daunorubicin
4-Demethoxy-daunomycinone I: ##STR1## the known aglycone of 4-demethoxy-daunorubicin, is prepared by protecting the 13-keto group of 4-demethyl-daunomycinone, sulfonylating the 4-hydroxy group,...
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4997959 |
Process for the production of alpha-6-deoxytetracyclines
A process for the hydrogenation of a 6-methylenetetracycline in the production of alpha-6-deoxytetracycline, particularly the antibiotic doxycycline, in the presence of a transition metal complex...
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4960913 |
Process for the preparation of pharmaceutical compositions
The invention relates to a process for the preparation of tetracycline derivatives of the formula ##STR1## and acid addition salts thereof --wherein R stands for --CH 3 or CH 2 --by...
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4939282 |
The process for preparing 6-deoxynthracyclines
A new process for the preparation of 6-deoxyanthracyclinones of general formula I: ##STR1## wherein R represents a hydrogen atom, a hydroxy group or a lower alkoxy group is described. The process...
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4918208 |
Process for producing 7-dimethylamino-6-demethyl-6-deoxytetracycline
A process for producing 7-dimethylamino-6-demethyl-6-deoxytetracycline (minocycline) which comprises treating the reaction liquid containing minocycline and formaldehyde with hydroxylamine or urea,...
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4680338 |
Bifunctional linker
A selective bifunctional sequential linker has the formula YCN--Q--A--C(O)--Z wherein Q is a homoaromatic or heteroaromatic ring system; A is a single bond or an unsubstituted or...
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4584135 |
Process for the preparation of an oxytetracycline-calcium silicate complex salt from fermentation broth
The invention relates to a process for the preparation of an oxytetracycline-calcium silicate complex salt from fermentation broth. By the process according to the invention the valuable antibiotic...
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4579686 |
Process for the preparation of easy-flowing (flowable) oxytetracyclin hydrochloride
The invention relates to a new process for the preparation of easy-flowing (flowable) oxytetracyclin hydrochloride. According to the process of the invention, the crude, dry or filter-wet...
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4418060 |
Therapeutically active complexes of tetracyclines
Tri-tetracyclines are complexes of tetracyclines with an amino compound containing per molecule at least a tris (hydroxyalkyl) group and at least a primary or secondary amino group in a molar...
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4066694 |
4-Hydroxy-4-dedimethylamino-tetracyclines
4-Dedimethylaminotetracyclines and the corresponding 5a,6-anhydro derivatives having an oxo, hydroxy, substituted imino, amino or substituted amino group other than dimethylamino at the...
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4061676 |
Recovery of doxycycline and products thereof
The present invention provides a process for the recovery of doxycycline and products thereof.
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3993694 |
Tetracycline derivatives and process for preparing them
Antibacterially-active tetracyclines, substituted at the amide group, and physiologically-tolerable salts thereof, said tetracyclines having the formula ##SPC1## Methods of making the same;...
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3986927 |
Process for the purification and sterilization of acidophilic biologicals by extreme acidification at cold temperatures
Methods of sterilizing biologicals in which the biologicals are acidified to a pH of not higher than about 1.0, preferably 0.75 to about 0.5, and the acidified biologicals are stored at cold...
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3947517 |
Stereoselective introduction of tetracyclines hydroxyl group at 12(a) position in synthesis of tetracyclines
In the synthesis of tetracyclines, a critical step is the stereospecific or stereoselective introduction of a hydroxyl group at the C-12(a) position, a novel method for the introduction of this...
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3927094 |
Alkali metal polymetaphosphate complexes of doxycycline and preparation thereof
Alkali metal polymetaphosphate complexes of α-6-deoxy-5-hydroxytetracycline are superior to prior art tetra-cyclines and complexes thereof.
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3906043 |
Water-soluble tetracyclines
Water-soluble tetracycline derivatives are prepared by reacting a tetracycline with a methyleneaminosalicylate in the presence of a solvent selected from the group consisting of...
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3882124 |
3-(5-OXYPHENETHYL)-GLUTARIMIDES
Glutaric acid imides of the general formula ##SPC1## Wherein R 1 , R 2 , and R 3 are H or alkyl or alkoxy of up to 6 carbon atoms, respectively, R 4 , R 5 , and R 6 are H, halogen, OH or...
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3879456 |
Process for preparing chlortetracycline neutral base
Chlortetracycline neutral base is prepared by slurrying chlortetracycline hydrochloride in water or an aqueous alkanol solution, then adding a water soluble salt of a carboxylic acid having from 2...
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3876699 |
Purification of tetracycline antibiotic
A tetracycline antibiotic is obtained free of colored impurities by treating a solution of the antibiotic, obtained from a harvest broth, with an organic base at a low pH.
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3697552 |
ANTHRACYCLIDINE-ACETIC ACID DERIVATIVES
The total synthesis of tetracycline-type antibiotics by a multistep process beginning with 3,4,10-trioxo-1,2,3,4,4a,9,9a,10-octahydroanthracenes comprising: (1) an aldol condensation with a...
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3637463 |
PRODUCTION OF OXYTETRACYCLINE USING STREPTOMYCES ALBOFLAVUS (ATCC 15388)
A fermentative process for the production of oxytetracycline which comprises fermenting a nutrient broth under aerobic conditions at a temperature between 22° and 30° C. by a mutant of...
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3526629 |
BETA-HYDROXYETHYLPIPERAZINOCARBOXYMETHYL - 7 - DIMETHYLAMINO - 6 - DEOXY-6-DEMETHYLTETRACYCLINE
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3515717 |
PROCESS FOR ISOLATING ANTIBIOTICS
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3502660 |
2-((5'-(3' AND/OR 4'-SUBSTITUTED)ISOXAZOYL) METHYLIDENE)-3,4,10-TRIOXO-1,2,3,4,4A,9,9A,10-OCTAHYDROANTHRACENES
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3484483 |
PROCESS FOR PRODUCING ALPHA-6-DEOXYTETRACYCLINES
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3463791 |
7-CHLORO-4-DEDIMETHYLAMINO-12,12ALPHA-SECOTETRACYCLINE-12-OIC ACID-6,12-LACTONES
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3458572 |
TETRACYCLINE RECOVERY PROCESS
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3454639 |
TETRACYCLINE RECOVERY
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3446841 |
ISOLATION OF 5-HYDROXY-7-CHLORTETRACYCLINE
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3442943 |
PROCESS FOR PREPARING 6-DEOXYTETRACYCLINES
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3428679 |
TETRACYCLINE HYDROXY CARBOXYLIC ACIDS
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3409616 |
4-oxo-10-hydroxy-1, 2, 3, 4-tetrahydroanthracene-2-(alpha-amino)acetates
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3408258 |
Process for producing oxytetra-cycline antibiotic
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3397231 |
Refining of alpha-6-deoxy-5-oxytetracycline
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3385765 |
Novel process of producing 1, 3, 4, 10, 11, 12-hexahydroxy-6-methylnaphthacene-2-carboxamide
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3376339 |
Purification of amphoteric and basic antibiotics
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3375165 |
Fusidic acid salts of tetracycline bases and therapy
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