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7553828 |
9-aminomethyl substituted minocycline compounds
The present invention pertains, at least in part, to novel 9-substituted minocycline compounds. These minocycline compounds can be used to treat numerous tetracycline compound-responsive states,...
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RE40183 |
7-Substituted-9-substituted amino-6-demethyl-6-deoxytetracyclines
The invention is drawn to 7-substituted-9-(substituted amino)-6-demethyl-6-deoxytetracycline compounds of the formula
wherein R, X, R 5 and R 6 are defined in the specification. The...
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7208482 |
9-aminoacyl tetracycline compounds and methods of use thereof
A compound of formula (I):
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7067504 |
Di-steroidal prodrugs of ethinyl estradiol
The present invention is a di-steroidal prodrug of ethinyl estradiol according to formula I:
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7067505 |
Di-steroidal prodrugs of estradiol
The present invention is a di-steroidal prodrug of estradiol having the following formula:
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7001918 |
7-pyrrolyl tetracycline compounds and methods of use thereof
A compound of Formula (I): wherein variables R, R 1 , R 2 , R 3 and A are as defined in the
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6846939 |
9-substituted minocycline compounds
The present invention pertains, at least in part, to novel 9-substituted minocycline compounds. These minocycline compounds can be used to treat numerous tetracycline compound-responsive states,...
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6165999 |
Tetracycline derivatives
The present invention relates to novel tetracycline derivatives, to intermediates used in their preparation, to pharmaceutical compositions containing them and to their medicinal use.
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6028207 |
Bone resorption inhibition/osteogenesis promotion compound
A compound represented by the following formula (I): X--Y--Z (I) where Y is represented by the following formulae: ##STR1## X is a monovalent...
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5886175 |
7-(substituted)-8-(substituted)-9-(substitued amino)-6-demethyl-6-deoxytetracyclines
The invention provides compounds of the formulas ##STR1## which are useful as intermediates for the preparation of 6-demethyl-6-deotetracycline antibiotic agents.
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5834450 |
9- (substituted amino) -alpha-6-deoxy-5-oxy tetracycline derivatives, their preparation and their use as antibiotics
This invention relates to compounds of the formula ##STR1## wherein R 1 , R 2 and R 3 are defined as in the specification and the pharmaceutically acceptable salts of such compounds. Compounds of...
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5686588 |
Amine acid salt compounds and process for the production thereof
A stoichiometric acid moiety transfer reaction for the preparation of an acid salt of an amine compound is disclosed. The acid moiety transfer reaction provides amine acid salts of high purity and...
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5675030 |
Method for selective extracting a 7-(hydrogen or substituted amino)-9- (substituted glycyl) amido!-6-demethyl-6-deoxytetracycline compound
The invention provides a method for selectively extracting a compound of formula I: ##STR1## wherein: R is hydrogen or --NR 3 R 4 ; and when R=--NR 3 R 4 , R 3 and R 4 may be the same or...
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5639742 |
9-[(substituted glycyl)amido]-6-(substituted)-5-hydroxy-6-deoxytetracyclines
The invention provides compounds of the formula: ##STR1## wherein R, R 1 , R 2 and W are defined in the specification. These compounds are useful as antibiotic agents.
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5495032 |
Process for producing 7-(substituted)-8-(substituted-9-[(substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines
The invention provides a process for the production of compounds of the formula: ##STR1## wherein, R, R 3 , R 4 , X and W are defined in the specification in which a compound of the following...
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5495018 |
7-(substituted-9-(substituted amino)-6-demethyl-6-deoxytetracyclines
The invention provides compounds of the formulas ##STR1## which are useful as intermediates for the preparation of 6-demethyl-6-deotetracycline antibiotic agents.
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5495031 |
Process for the production of 7-(substituted)-9-[(substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines
The invention provides a process for the production of compounds of the formula: ##STR1## wherein R, R 3 , R 4 and W are defined in the specification in which a compound of the following formula:...
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5488119 |
Polymerisable photochromic naphthacenediones, polymers of these monomers, process for their preparation and the use thereof
Compounds of formulae I and II ##STR1## wherein D is H or --OR wherein R is phenyl and R 1 to R 4 are H or a substituent such as phenylthio, and one of the substituents R 1 , R 2 , R 3 and R 4 ...
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5430162 |
7-(substituted)-8-(substituted)-9-substituted amino)-6-demethyl-6-deoxytetracyclines
The invention provides compounds of formula ##STR1## wherein X, R and R 1 are defined in the specification. These compounds are useful as antibiotic agents.
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5284963 |
Method of producing 7-(substituted)-9-[(substituted glycyl)-amidol]-6-demethyl-6-deoxytetra-cyclines
The invention provides a novel method for producing compounds of the formula I: ##STR1## wherein X and R are defined in the specifications. The invention also provides a method for making...
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5248797 |
Method for the production of 9-amino-6-demethyl-6-deoxytetracycline
The invention relates to a novel method for producing [4S-(4alpha, 12aalpha)]-9-amino-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-oc
tahydro-3,...
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4924015 |
Substituted anthraquinones and use thereof in epoxy resins
Anthraquinones having α,α-(dialkyl)alkyl groups which are functionally substituted, for example by --COOH or --CONH--NH 2 , are described. Compositions which contain such anthraquinones, an...
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4918208 |
Process for producing 7-dimethylamino-6-demethyl-6-deoxytetracycline
A process for producing 7-dimethylamino-6-demethyl-6-deoxytetracycline (minocycline) which comprises treating the reaction liquid containing minocycline and formaldehyde with hydroxylamine or urea,...
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4849136 |
Process for producing 7-amino-6-demethyl-6-deoxytetracycline
This invention provides a new process for producing 7-amino-6-demethyl-6-deoxytetracycline (Compound 3) which is an intermediate for the synthesis of minocycline. Compound 3 can be obtained by...
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4038315 |
Isolation and recovery of calcium chloride complex of 7-dimethylamino-6-dimethyl l-6-deoxytetracycline hydrochloride
This disclosure describes a process for the recovery of 7-dimethylamino-6-demethyl-6-deoxytetracycline from an aqueous solution thereof by means of a calcium chloride complex of...
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4031137 |
Catalysts based on carbon supports and use in catalytic deoxidation process
Carbon particulates comprising carbon black spheres and a carbon binder having large pores as well as desirable pore size distribution are disclosed which serve as catalyst supports. The support...
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3993694 |
Tetracycline derivatives and process for preparing them
Antibacterially-active tetracyclines, substituted at the amide group, and physiologically-tolerable salts thereof, said tetracyclines having the formula ##SPC1## Methods of making the same;...
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3991111 |
N-alkenyltetracycline derivatives
N-alkenyltetracycline derivatives, for example, N-(1-methyl-2-α-naphthylethenyl)tetracycline represented by the formula ##SPC1## The compounds have excellent antibacterial action as compared with...
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3983173 |
2-Carboxamido-substituted tetracyclines and process for their manufacture
2-Carboxamido-substituted tetracyclines of the general formula ##SPC1## A process for their preparation and compositions containing these compounds.
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3925432 |
Boronated tetracycline compounds
Boronated tetracycline compounds in which a polymeric boron-amino group is substituted on the 7-position of tetracycline or anhydrotetracycline and metal complexes of these compounds. Process for...
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3901942 |
Tetracycline derivatives substituted in the 7 position and process for preparing the same
Process for the preparation of tetracycline derivatives substituted in the 7 position comprising first obtaining tetracycline derivatives substituted in the 7 and 9 positions, transforming the...
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3882124 |
3-(5-OXYPHENETHYL)-GLUTARIMIDES
Glutaric acid imides of the general formula ##SPC1## Wherein R 1 , R 2 , and R 3 are H or alkyl or alkoxy of up to 6 carbon atoms, respectively, R 4 , R 5 , and R 6 are H, halogen, OH or...
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3862225 |
D-RING SUBSTITUTED TETRACYCLINES
The total synthesis of tetracycline-type antibiotics by a multistep process beginning with 3,4,10-trioxo-1,2,3,4,4a,9,9a,10-octahydroanthracenes comprising: (1) an aldol condensation with a...
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3697552 |
ANTHRACYCLIDINE-ACETIC ACID DERIVATIVES
The total synthesis of tetracycline-type antibiotics by a multistep process beginning with 3,4,10-trioxo-1,2,3,4,4a,9,9a,10-octahydroanthracenes comprising: (1) an aldol condensation with a...
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3549681 |
6-SULFURIC ACID ESTERS OF 6-DEMETHYLTETRACYCLINES
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3526629 |
BETA-HYDROXYETHYLPIPERAZINOCARBOXYMETHYL - 7 - DIMETHYLAMINO - 6 - DEOXY-6-DEMETHYLTETRACYCLINE
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3518306 |
7- AND/OR 9-(N-NITROSOALKYLAMINO)-6-DEMETHYL-6-DEOXYTETRACYCLINES
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3483251 |
REDUCTIVE ALKYLATION PROCESS
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3433834 |
NITRATION OF 11A-CHLORO TETRACYCLINES
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3423457 |
SUBSTITUTION PRODUCTS OF 7-CHLORO-6-DEMETHYLTETRACYCLINE
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3403179 |
Novel 7-(1, 2-bis-substituted-hydrazino)-tetracyclines and methods of preparing same
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3397230 |
Nitration of tetracyclines
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3388162 |
7-and/or 9-nitro or amino tetracyclines
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3373198 |
Substituted 5a, 11a-dehydro-6-epitetracyclines
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3373197 |
Substituted 6-epitetracyclines and 5a-epi-6-epitetracyclines
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3373196 |
7-and/or 9-(lower alkyl) amino-5a, 6-anhydrotetracyclines
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3360561 |
Nitration of tetracyclines
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3360557 |
9-hydroxytetracyclines and a process of preparing same
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3345410 |
Substituted 7- and/or 9-amino tetracyclines
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3341585 |
Substituted 7-and/or 9-amino-6-deoxytetracyclines
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