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7595309 |
7-substituted tetracycline compounds
The present invention pertains, at least in part, to novel 7-substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states,...
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7521437 |
7-phenyl-substituted tetracycline compounds
7-phenyl-substituted tetracycline compounds, methods of treating tetracycline responsive states, and pharmaceutical compositions containing the 7-phenyl-substituted tetracycline compounds are...
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RE40183 |
7-Substituted-9-substituted amino-6-demethyl-6-deoxytetracyclines
The invention is drawn to 7-substituted-9-(substituted amino)-6-demethyl-6-deoxytetracycline compounds of the formula
wherein R, X, R 5 and R 6 are defined in the specification. The...
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7208482 |
9-aminoacyl tetracycline compounds and methods of use thereof
A compound of formula (I):
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7067505 |
Di-steroidal prodrugs of estradiol
The present invention is a di-steroidal prodrug of estradiol having the following formula:
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7067504 |
Di-steroidal prodrugs of ethinyl estradiol
The present invention is a di-steroidal prodrug of ethinyl estradiol according to formula I:
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7056902 |
4-dedimethylamino tetracycline compounds
The present invention pertains, at least in part, to novel substituted 4-dedimethylamino tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline...
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7001918 |
7-pyrrolyl tetracycline compounds and methods of use thereof
A compound of Formula (I): wherein variables R, R 1 , R 2 , R 3 and A are as defined in the
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6946453 |
4-dedimethylaminotracycline derivatives
The present invention provides new chemically modified 4-dedimethylaminotetracycline compounds that can be substituted with aryl, alkenyl, or alkynyl groups. The 7, 8, and/or 9 positions and...
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6818635 |
7-substituted tetracycline compounds
The present invention pertains, at least in part, to novel 7-substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states,...
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6683068 |
7, 9-substituted tetracycline compounds
The present invention pertains to novel 7,9-substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial...
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6165999 |
Tetracycline derivatives
The present invention relates to novel tetracycline derivatives, to intermediates used in their preparation, to pharmaceutical compositions containing them and to their medicinal use.
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6028207 |
Bone resorption inhibition/osteogenesis promotion compound
A compound represented by the following formula (I): X--Y--Z (I) where Y is represented by the following formulae: ##STR1## X is a monovalent...
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5932437 |
Control of lyme disease spirochete
A method is described for controlling the spread of Lyme Disease spirochete from rodents which have been infected. The method involves orally administering to the rodents a composition which...
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5641762 |
Bone targeted inhibitors of carbonic anhydrase
The present invention relates to novel compounds useful for the treatment and prophylaxis of degenerative bone disorders and to the preparation thereof. These compounds are particularly...
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5538954 |
Salts of tetracyclines
A salt of sucrose-octa-O-sulfonic acid and a tetracycline useful in inhibiting protein synthesis of bacteria.
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5495032 |
Process for producing 7-(substituted)-8-(substituted-9-[(substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines
The invention provides a process for the production of compounds of the formula: ##STR1## wherein, R, R 3 , R 4 , X and W are defined in the specification in which a compound of the following...
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5495031 |
Process for the production of 7-(substituted)-9-[(substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines
The invention provides a process for the production of compounds of the formula: ##STR1## wherein R, R 3 , R 4 and W are defined in the specification in which a compound of the following formula:...
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5488119 |
Polymerisable photochromic naphthacenediones, polymers of these monomers, process for their preparation and the use thereof
Compounds of formulae I and II ##STR1## wherein D is H or --OR wherein R is phenyl and R 1 to R 4 are H or a substituent such as phenylthio, and one of the substituents R 1 , R 2 , R 3 and R 4 ...
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5387703 |
Process and intermediate for the purification of oxytetracycline
The invention relates to a new process for obtaining a completely pure oxytetracycline which does not contain any acetyldecarboxamidooxytetracycline as ingredient. In glacial acetic acid there is...
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5202449 |
Process for purifying 7-dimethylamino-6-demethyl-6-deoxytetracycline
A process for purifying 7-dimenthylamino-6-demethyl-6-deoxytetracycline represented by the following formula, ##STR1## which comprises dissolving 7-dimethylamino-6-demethyl-6-deoxytetracycline or...
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5003097 |
Method for the sulfurization of phosphorous groups in compounds
A method is disclosed for the sulfurization of a phosphorus containing compound, which comprises: solubilizing the phosphorous containing compound and then contacting the phosphorous containing...
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5001243 |
Substituted naphthacene-5, 12-diones
Naphthacene-5,12-diones which are substituted by at least one organic thio radical are not only photoinitiators for the photopolymerization but also sensitizers for the photodimerization of...
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4990636 |
Process for the production of alpha-6-deoxytetracyclines and hydrogenation catalyst useful therein
A coordination compound useful as a hydrogenation catalyst, having the formula: ##STR1## wherein Ph is phenyl; R is hydrogen or C 1 -C 4 alkyl; and X is chloro, bromo or iodo. This compound is...
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4743699 |
Homogeneous catalytic system and a process for the preparation of same
A homogeneous stereospecific rhodium complex hydrogenation catalyst is prepared using a degassed organic solvent and eventually water.
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RE32535 |
Process for the preparation of α-6-deoxytetracyclines
An improved process for the preparation of α-6-deoxytetracyclines and more particularly to the stereo specific hydrogenation of the 6-methylene group of...
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4581166 |
Method for isolating and purifying antibiotics
A process is proposed for the isolation and purification of antibiotics wherein an antibiotic containing solution is extracted with an extraction agent at a temperature of from 0° to 40° C. and...
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4550096 |
Homogeneous catalytic system comprising rhodium, hydrazine and phosphine and a process for the preparation of same
Stable homogeneous hydrogenation catalysts are prepared by reacting a rhodium salt or complex with a hydrazine in the presence or absence of a tertiary phosphine.
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4418060 |
Therapeutically active complexes of tetracyclines
Tri-tetracyclines are complexes of tetracyclines with an amino compound containing per molecule at least a tris (hydroxyalkyl) group and at least a primary or secondary amino group in a molar...
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4160783 |
4-Dedimethylamino-4-arylsulfonamido-5a,6-anhydrotetracyclines
Novel 4-dedimethylamino-4-arylsulfonamido-5a,6-anhydrotetracycline
s of the general formula I ##STR1## wherein R stands for C 1 -C 3 -alkyl, halogen or --NHCOR 1 , R 1 being C 1 -C 3 -alkyl.
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4060605 |
Water-soluble derivative of 6-deoxy-tetracyclines
This invention relates to a novel water soluble derivatives of 6-deoxy-tetracyclines, particularly of doxycycline, in which a methionine group is linked to the tetracycline group through a...
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3993694 |
Tetracycline derivatives and process for preparing them
Antibacterially-active tetracyclines, substituted at the amide group, and physiologically-tolerable salts thereof, said tetracyclines having the formula ##SPC1## Methods of making the same;...
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3991111 |
N-alkenyltetracycline derivatives
N-alkenyltetracycline derivatives, for example, N-(1-methyl-2-α-naphthylethenyl)tetracycline represented by the formula ##SPC1## The compounds have excellent antibacterial action as compared with...
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3983173 |
2-Carboxamido-substituted tetracyclines and process for their manufacture
2-Carboxamido-substituted tetracyclines of the general formula ##SPC1## A process for their preparation and compositions containing these compounds.
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3962131 |
Rhodium containing catalyst and use thereof in preparation of 6-deoxy-5-oxytetracycline
Catalyst produced by the process of reacting 1 mol of rhodium trichloride and 2 mols of sodium acetate in methanol at a temperature from about 50°C. to the reflux temperature of said reaction...
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3932490 |
Doxycycline aceturate
Doxycycline aceturate is prepared by reacting doxycycline with aceturic acid in a solvent. The compound is useful for the same pharmacological purposes as doxycycline and is more soluble in water...
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3927094 |
Alkali metal polymetaphosphate complexes of doxycycline and preparation thereof
Alkali metal polymetaphosphate complexes of α-6-deoxy-5-hydroxytetracycline are superior to prior art tetra-cyclines and complexes thereof.
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3914299 |
Tetracyclines
A group of tetracycline compounds have been discovered having unexpected biological activity. These compounds are the 5a-epitetracyclines having the structure: ##SPC1## Wherein R 1 is H or OH, R 2...
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3862225 |
D-RING SUBSTITUTED TETRACYCLINES
The total synthesis of tetracycline-type antibiotics by a multistep process beginning with 3,4,10-trioxo-1,2,3,4,4a,9,9a,10-octahydroanthracenes comprising: (1) an aldol condensation with a...
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3835190 |
CHEMICAL COMPOUND, N, N'-DIBENZYLETHYLENEDIAMINODIMETHYLTETRACYCLINE
A compound, N, N'-dibenzylethylenediaminodimethylditetracycline is prepared by reacting tetracycline base with formaldehyde and N, N'-dibenzylethylenediamine with heating in an organic solvent. The...
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3739924 |
APPARATUS FOR BUNDLING, TRANSPORTING, AND FEEDING SHEETS
Apparatus for bundling, transporting, and feeding sheets of paper which are preferably in a folded or signature form to be assembled and form a magazine, book, or the like. The sheets are handled...
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3697552 |
ANTHRACYCLIDINE-ACETIC ACID DERIVATIVES
The total synthesis of tetracycline-type antibiotics by a multistep process beginning with 3,4,10-trioxo-1,2,3,4,4a,9,9a,10-octahydroanthracenes comprising: (1) an aldol condensation with a...
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3622627 |
4-DEDIMETHYLAMINATETRACYCLINE AND 5A, 6-ANHYDRO DERIVATIVES THEREOF
4-Dedimethylaminotetracyclines and the corresponding 5a,6-anhydroderivatives having an oxo, hydroxy, substituted imino, amino or substituted amino group other than dimethylamino at the C . ...
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3609188 |
4-DEDIMETHYLAMINO-4-SUBSTITUTED-AMINO-6-DEMETHYLTETRACYCLINES
This disclosure describes compounds of the class of 4-dedimethylamino-4-substituted-amino-6-demethyltetracycline
s useful as antibacterial agents.
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3549681 |
6-SULFURIC ACID ESTERS OF 6-DEMETHYLTETRACYCLINES
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3546339 |
STABLE DIMETHYL SULFOXIDE SOLUTIONS OF TETRACYCLINE ANTIBIOTICS FOR PARENTERAL USE
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3536759 |
TETRACYCLINE SULFAMATE AND DERIVATIVES THEREOF
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3530179 |
CONDENSATION PRODUCTS OF TETRACYCLINES CONTAINING SULFUR
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3510544 |
DIGUAIACYL PHOSPHATE SALT OF TETRACYCLINE
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3502660 |
2-((5'-(3' AND/OR 4'-SUBSTITUTED)ISOXAZOYL) METHYLIDENE)-3,4,10-TRIOXO-1,2,3,4,4A,9,9A,10-OCTAHYDROANTHRACENES
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