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7595343 |
Inhibitors of histone deacetylase
The invention relates to the inhibition of histone deacetylase. The invention provides compounds and methods for inhibiting histone deacetylase enzymatic activity. The invention also provides...
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7569600 |
Compounds and methods for the treatment of prevention of Flavivirus infections
Compounds represented by formula I:
or pharmaceutically acceptable salts and solvates thereof, wherein R 1 , X, Y, Y 1 , and Z are as defined herein, are useful for treating flaviviridae...
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7524973 |
Nitrate esters of phenylaminothiophenacetic acid derivatives
The compounds of formula I
in which R1, R2, R3, R4 and R5 have the meanings as given in the description are novel effective antiinflammatory compounds.
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7521473 |
Inhibitors of protein tyrosine phosphatase 1B
Protein tyrosine phosphatases (PTPases) such as PTP1B can play a role in regulating a wide variety of cellular responses such as insulin signaling. Substituted thiophene compounds such as, for...
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7498126 |
Photoacid generators, chemically amplified resist compositions, and patterning process
A photoacid generator has formula (1). A chemically amplified resist composition comprising the photoacid generator has advantages including a high resolution, focus latitude, long-term PED...
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7482490 |
Amine compound having fluorene group as framework, process for producing the amine compound, and use of the amine compound
Novel amine compounds that can be utilized as hole transport materials, hole injection materials or the like of organic electroluminescence devices, electrophotographic receptors or the like, and...
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7479357 |
Electrophotographic organophotoreceptors with novel charge transport materials
An organophotoreceptor that includes:
(a) a charge transport material having the formula
wherein A is selected from heterocyclic groups, naphthyl group, alkylsulfonylphenyl,...
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7423170 |
Anticancer agents based on regulation of protein prenylation
Oncoproteins such as Ras and RhoB are known to induce cell division in an unrestrained manner when such proteins are localized at the inner surface of a cancer cell membrane. The localization is...
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7423061 |
Substitute thiophenes and uses thereof
This invention relates to novel compounds having the structural formula (I) and to their pharmaceutical salts, compositions and methods of use. These novel compounds provide a treatment or...
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7388012 |
(Hydrazido)(amino)thiophene compounds
Compounds represented by Formula (I):
or a pharmaceutically acceptable salt or N-oxide thereof, wherein A and J are defined herein, are useful in the treatment of tumors and cancers such as...
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7351841 |
Heterocyclic compounds and thrombopoietin receptor activators
A compound represented by the formula (1):
wherein A is a nitrogen atom or CR 4 , B is an oxygen atom, a sulfur atom or NR 9 (provided that when A is a nitrogen atom, B is not NH), R 1 is a C...
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7300956 |
Acyloxyalkyl carbamate prodrugs, methods of synthesis and use
The disclosures herein relate generally to acyloxyalkyl carbamate prodrugs of (±)-4-amino-3-(4-chlorophenyl)butanoic acid and analogs thereof, pharmaceutical compositions thereof, methods of...
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7173030 |
Inhibitors of 11-β-hydroxy steroid dehydrogenase type 1
The present invention relates to compounds with the formula (I)
and also to pharmaceutical compositions comprising the compounds, as well as to the use of the compounds in medicine and for...
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7166639 |
NF-κB inhibitors
The present invention provides novel compounds and methods for using them to treat diseases with aminothiophene inhibitors of IKK-β phosphorylation of IκB. In so doing these aminothiophene...
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7153980 |
Thiophene-containing compound and thiophene-containing compound polymer
The present invention relates to a thiophene-containing compound and a thiophene-containing compound polymer which are useful for organo-electronic devices such as electrophotographic...
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7084178 |
Antiamyloid phenylsulfonamides: N-cycloalkylcarboxamides derivatives
A series of N-cycloalkylcarboxamide derivatives of N-benzyl benzenesulfonamides of Formula I are described.
The compounds inhibit β-amyloid peptide (β-AP) production and are useful in the...
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7064122 |
Pancreatic lipase inhibitor compounds, their synthesis and use
The subject invention features compounds having the structure:
wherein X is O, S, CH 2 or NR 5 ; Y is O or S; R 1 is H, substituted or unsubstituted C 1 -C 15 alkyl, C 1 -C 8 alkylaryl,...
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7026094 |
Substituted oxime derivatives and the use thereof as latent acids
New oxime sulfonate compounds of the formula (I) and (II), wherein R 1 is C 1 -C 12 alkyl, C 1 C 4 haloalkyl, hydrogon, OR 9 , NR 10 R 11 , SR 12 or is phenyl which is unsubstituted or...
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7019024 |
Pharmaceutical for treatment of neurological and neuropsychiatric disorders
The invention provides a pharmaceutical for treatment of neurological and neuropsychiatric disorders comprising a compound of the formula:
or a pharmaceutically acceptable salt thereof.
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6984737 |
Di(het)arylaminothiophene derivatives
The invention relates to novel 2-(N,N-di(het)arylamino)-thiophene derivatives of formula (I), wherein R 1 , R 2 , R 3 , R 4 and R 5 are, independently each of other, each a monofunctional...
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6962929 |
Pentafluorobenzenesulfonamides and analogs
The invention provides methods and compositions relating to novel pentafluorophenylsulfonamide derivatives and analogs and their use as pharmacologically active agents. The compositions find...
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6849738 |
Processes for the production of thienopyrimidine derivatives
The present invention provides a process for producing an intermediate for thienopyrimidine derivatives having the GnRH antagonistic activity at an industrial large scale. The process for...
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6841669 |
Functionalized thiophene oligomers and their use as fluorescent markers
Thiophene oligomers which are excitable in the visible and ultraviolet region and each having at least one functional group able to form a covalent bond with organic and/or biological molecules, so...
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6840965 |
P-aminophenols and colorants containing said compounds
The object of the invention are p-aminophenol derivatives of general formula (I) or physiologically tolerated, water-soluble salts thereof
and oxidative coloring preparations based on a...
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6835745 |
Phenyl substituted thiophenes as estrogenic agents
This invention provides estrogen receptor modulators of formula I, having the structure wherein, R 1 , R 2 , R 3 , X, and Y are as defined in the specification, or a pharmaceutically acceptable...
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6822118 |
Process for the hydrogenation of imines
A process for the hydrogenation of imines with hydrogen under elevated pressure in the presence of iridium catalysts and with or without an inert solvent, wherein the reaction mixture contains an...
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6818775 |
Alkyl or aryl substituted dihydronaphthalene derivatives having retinoid and/or retinoid antagonist-like biological activity
Compounds of the formula where the symbols have the meaning described in the application, have retinoid-like or retinoid antagonist-like biological activity.
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6794521 |
Process for the preparation of 2-nitrothiophene selectively from thiophene using metal exchanged clay catalysts
The present invention provides an ecofriendly process for the preparation 2-nitrothiophenes selectively from thiophene, using metal exchanged clay catalysts and nitric acid, dispensing with the use...
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6680337 |
Cyclopentane heptan(ene)oic acid, 2-heteroarylalkenyl derivatives as therapeutic agents
The present invention provides cyclopentane heptanoic acid, 2 heteroaryl alkyl or alkenyl derivatives which may be substituted in the 1-position with hydroxyl, alkyloxy, amino and amido groups,...
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6677341 |
(R)-Chiral halogenated substituted heteroaryl benzyl aminoalcohol compounds useful for inhibiting cholesteryl ester transfer protein activity
The invention relates to substituted aryl and heteroaryl (R)-Chiral Halogenated 1-Substitutedamino-(n+1)-Alkanol compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma...
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6660769 |
N substituted 3-amino-2,2-di-c-alkyl-1,4-butyrolactones and 1,4-thiobutyrolactones for use as promoter of &ggr -aminobutyric acid activity and for treating nervous disorders and preparation method
The invention concerns compounds represented by general formula (I) wherein: Z represents a sulfur or oxygen atom; the groups R1 and R2, identical or different, represent each a alkyl group or an...
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6620767 |
Pesticidal n-heteroaryl alpha-alkoximino-carboxamides
The invention relates to compounds of the general formula wherein R 1 is hydrogen, halogen, C 1 -C 6 -alkyl, C 1 -C 6 -alkoxy, C 1 -C 6 -haloalkyl or unsubstituted or mono- to penta-substituted...
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6599932 |
Alpha, beta-unsaturated sulfones for treating proliferative disorders
Sulfones of formula I are useful as antiproliferative agents, including, for example, anticancer agents: wherein: Q 1 is selected from the group consisting of (a) a phenyl radical according to...
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6586433 |
Substituted N-heteroaryl-N-phenyl aminoalcohol compounds useful for inhibiting cholesteryl ester transfer protein activity
The invention relates to substituted polycyclic aryl and heteroaryl tertiary-heteroalkylamine compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer...
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6566375 |
Elevation of HDL cholesterol by 4-&lsqb (aminothioxomethyl)-hydrazono&rsqb -N-(substituted)-4-arylbutanamides
Compounds of this invention increase plasma levels of high density lipoprotein or HDL, the “good” cholesterol and as such may be useful for treating diseases such as atherosclerosis. These...
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6495683 |
4-oxo-4,7-dihydro-thieno&lsqb 2,3-b&rsqb pyridine-5-carboxamides as antiviral agents
The invention provides a compound of formula I: wherein R 1 , R 2 , R 3 , and R 4 have any of the values defined in the specification, or a pharmaceutically acceptable salt thereof, as well as...
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6476023 |
Aromatic heterocyclic compounds as anti-inflammatory agents
Disclosed are novel aromatic heterocyclic compounds of the formula(I) wherein Ar 1 ,Ar 2 ,L,Q and X are described herein. The compounds are useful in pharmaceutic compositions for treating diseases...
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6414013 |
Thiophene compounds, process for preparing the same, and pharmaceutical compositions containing the same background of the invention
Compounds which are 3-aminocarbonyl-2-carboxamido-thiophene derivatives of formula (I): wherein R 1 and R 2 are, independently from each other, hydrogen, halogen or an optionally substituted...
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6407247 |
Photo-stable cosmetic and pharmaceutical formulations containing UV-filters
A method of using compounds of formula I in which the C═C double bond is present in E and/or Z configuration and the variables have the following meanings: R 1 denotes COOR 5 , COR 5 , CONR 5...
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6350761 |
Benzenamine derivatives as anti-coagulants
This invention is directed to benzenamine derivatives of formula (I): wherein A, W, m, n, R 1 , R 2 , R 3 , R 4 , R 5 and R 6 are defined herein. These compounds are useful as anti-coagulants.
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6342511 |
Phencyclidine derivatives, preparation method and pharmaceutical compositions containing same
The invention concerns novel phenylcyclidine derivatives with selective affinity for low affinity receptors, methods for preparing them, pharmaceutical compositions containing them and their use as...
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6337306 |
Phenoxyacetic acid derivatives and their use as herbicides
Phenoxyacetic acid derivatives of the formula: wherein R 1 , R 2 , X n and A are as defined herein, and a process for preparing the derivatives. The derivatives are used as herbicides.
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6329373 |
Metalloproteinase inhibitors
A compound of formula (I) ##STR1## wherein X is a --CONHOH group and the R groups are defined in the claims. The compounds are inhibitors of matrix metalloproteinases involved in tissue degradation...
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6313302 |
Pyrrolidinyl and pyrrolinyl ethylamine compounds as kappa agonists
A compound of the following formula: ##STR1## and the salts thereof, wherein A is hydrogen, halo, or hydroxy; the broken line represents an optional double bond with proviso that if the broken line...
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6310067 |
Urocanic acid derivatives
Urocanic acid derivatives useful as antiallergic agents represented by the following formula (I) or a pharmacologically acceptable salt thereof: ##STR1## wherein R 2 denotes hydrogen or lower...
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6291514 |
Heteroaryl amidines, methylamidines and guanidines, preparation thereof, and use thereof as protease inhibitors
The present invention is directed to compounds of Formula I: ##STR1## wherein X is O, S or NR 7 and R 1 -R 7 , Y and Z are set forth in the specification, as well as hydrates, solvates or...
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6166074 |
Pharmaceutical compositions
Pharmaceutical compositions which are useful for the treatment of cancer or illnesses which arise due to an abnormally elevated cell proliferation comprise acyl derivatives of aromatic aldehydes,...
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6162823 |
LTA.sub.4 hydrolase inhibitors
The present invention provides compounds having the of the formula I: ##STR1## and pharmaceutically acceptable salts and stereoisomers thereof that are useful in the treatment of inflammatory...
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6156788 |
Polycyclic aromatic compounds and pharmaceutical/cosmetic compositions comprised thereof
Novel pharmaceutically/cosmetically-active polycyclic aromatic compounds have the structural formula (I): ##STR1## wherein Ar is a radical having one of the formulae (a)-(e): ##STR2## and are...
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6156741 |
Therapeutic substituted guanidines
The present invention provides therapeutically useful substituted guanidines of the following Formula: ##STR1## and methods of treatment and pharmaceutical compositions that utilize or comprise one...
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