Patents in Class 549/65

Matches 1 - 50 out of 336

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Match	Document	Document Title
1	7598422	Production of chirally pure amino alcohol intermediates, derivatives thereof, and uses thereof A method of selectively preparing a chiral 2S-amino alcohol useful in preparation of an amide sulfonated or acylated with alkyl, substituted aryl or substituted heteroaryl is described. The method...
2	7560573	Process for the preparation of (S)-(-)-N,N-dimethyl-3-(2-thienyl)-3-hydroxypropananine, a duloxetine intermediate A chiral resolution process for the preparation of (S)-AT-OL, and a process for the racemization of AT-OL are provided.
3	7547725	Fluoro- and trifluoroalkyl-containing heterocyclic sulfonamide inhibitors of beta amyloid production and derivatives thereof Compounds of Formula (I), are provided where T is CHO, COR 8 , or C(OH)R 1 R 2 ; R 1 and R 2 are hydrogen, optionally substituted lower alkyl, CF 3 , optionally substituted alkenyl, or...
4	7524859	(2-carboxamido)(3-amino)thiophene compounds A method of treatment of hyperproliferative disorders comprises a step of administering an effective amount of a compound represented by
5	7482376	Conjugated complement cascade inhibitors The present invention is directed to conjugated complement cascade inhibitors, and a method of treating a patient using a conjugated complement cascade inhibitor.
6	7446213	Detection of negatively charged polymers using water-soluble, cationic, polythiophene derivatives Novel methods allowing for the simple optical detection and electrochemical detection of doubled-straded oligonucleotides are disclosed. The methods are rapid, selective and versatile....
7	7365196	Sulphonamido-substituted bridged bicycloalkyl derivatives A class of compounds is disclosed, comprising sulphonamido-substituted bridged bicycloalkyl structures. The compounds are inhibitors of gamma-secretase, and hence are useful in the treatment of...
8	7358375	Low molecular weight conjugated nitrogen compounds and devices fabricated using the same Low molecular weight conjugated nitrogen compounds having linear conjugated chains, and devices fabricated using the conjugated nitrogen compounds as organic semiconductor materials, hole...
9	7351825	Cyclopropane compounds and pharmaceutical use thereof The present invention provides a compound having aggrecanase inhibitory activity and MMP-13 inhibitory activity, and useful as a therapeutic agent for osteoarthritis, rheumatoid arthritis and the...
10	RE39530	3-amino-3-arylpropan-1-ol-compounds, their preparation and use 3-amino-3-arylpropan-1-ol compounds corresponding to the formula I in which R 1 to R 5 , A and X have the meanings according to claim 1, and their preparation and use as medicaments.
11	7161006	Sulphones for inhibition of gamma secretase The invention provides compounds of formula I: which are inhibitors of γ-secretase and hence useful in the treatment or prevention of Alzheimer's disease.
12	7138530	Thiophene amidines, compositions thereof, and methods of treating complement-mediated diseases and conditions Disclosed is a method for treating the symptoms of an acute or chronic disorder mediated by the classical pathway of the complement cascade, comprising administering to a mammal in need of such...
13	7105545	N-p-propargyloxyphenethyl-thioacetic acid amides The invention relates to N-propargyloxy-phenethyl thioacetic acid amide derivatives of the general formula (I) including the optical isomers thereof and mixtures of such isomers, wherein R 1 is...
14	7094911	Biphenyl and biphenyl-analogous compounds as integrin antagonists The present invention relates to biphenyl and biphenyl-analogous compounds, their preparation and use as pharmaceutical compositions, as integrin antagonists and in particular for the production of...
15	7091219	Bis-sulfonamide hydroxyethyl-amino retroviral protease inhibitors Bis-sulfonamido hydroxyethylamino compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to retroviral protease...
16	7083928	Detection of negatively charged polymers using water-soluble, cationic, polythiophene derivatives Novel methods allowing for the simple optical and electrochemical detection of double-stranded oligonucleotides are disclosed. The methods are rapid, selective and versatile. Advantageously, they...
17	7084170	Thiophene-amd thiazolesulfonamides as antineoplastic agents The present invention provides antineoplastic compounds of the formula: and antineoplastic methods.
18	7026339	Inhibitors of HCV NS5B polymerase The present invention relates to compounds, process for their synthesis, compositions and methods for the treatment and prevention of hepatitis C virus (HCV) infection. In particular, the present...
19	7019024	Pharmaceutical for treatment of neurological and neuropsychiatric disorders The invention provides a pharmaceutical for treatment of neurological and neuropsychiatric disorders comprising a compound of the formula: or a pharmaceutically acceptable salt thereof.
20	6960688	Use of compounds for the elevation of pyruvate dehydrogenase activity The use of compounds of formula (I), and salts thereof; and pharmaceutically acceptable in vivo cleavable prodrugs of said compound of formula (I); and pharmaceutically acceptable salts of said...
21	6949563	(2-carboxamido)(3-amino)thiophene compounds Compounds represented by Formula (I): or a pharmaceutically acceptable salt or N-oxide thereof, wherein R1 is R2 is and R3 is C 0-4 alkyl, are useful in the treatment of cancer.
22	6949536	Sulfonylbenzene compounds as anti-inflammatory/analgesic agents This invention provides a compound of the formula: or its pharmaceutically acceptable salt thereof, wherein A is partially unsaturated or unsaturated five membered heterocyclic, or partially...
23	6919369	Serine protease inhibitors Compounds having the structure shown below are useful to inhibit serine protease enzymes, such as TF/factor VIIa, factor Xa, thrombin and kallikrein. These compounds may be used in methods of...
24	6916837	Amidino derivatives and anticoagulants and thrombosis therapeutic agents containing them Amidino derivatives represented by the following general formula (I): {where X is a group represented by R 1 SO 2 NR 2 — (wherein R 1 represents optionally substituted C 6-14 aryl, etc....
25	6890942	Acyl sulfonamides as inhibitors of HIV integrase The present invention relates a series of compounds of Formula I wherein R 1 , R 2 , R 3 , and B are as defined in the specification. The compounds are useful for the inhibition of HIV...
26	6878742	Heterocyclic sulfonamide inhibitors of beta amyloid production Compounds of Formula (I), wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , T, W, X, Y and Z are as defined herein are provided, together with pharmaceutically acceptable salt, hydrates and/or...
27	6878723	LTA4 hydrolase inhibitors The invention concerns compounds inhibiting LTA 4 hydrolase of formula (I). The invention also concerns their therapeutic, in particular anti-inflammatory, applications.
28	6800764	Process for the synthesis of chirally pure beta-amino-alcohols A process is provided for preparing chirally pure S-enantiomers of α-amino acids comprising the steps of: a) preparing an organometallic reagent from an alkyl halide of the formula (R) 2 CH(CH 2 )...
29	6768024	Triamine derivative melanocortin receptor ligands and methods of using same The invention provides triamine derivative melanocortin receptor ligands of the formula: wherein R 1 to R 8 and n have the meanings provided herein. The invention further provides methods of...
30	6743929	Sulfonylalkanoylamino hydroxyethylamino sulfonamides useful as retroviral protease inhibitors Sulfonamide-containing hydroxyethylamine compounds are effecive as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.
31	6706755	Cyclopentane heptan(ene) acyl sulfonamide, 2-alkyl or 2-arylalkyl, or 2-heteroarylalkenyl derivatives as therapeutic agents The present invention provides a method of treating ocular hypertension or glaucoma which comprises administering to an animal having ocular hypertension or glaucoma therapeutically effective...
32	6686478	Thienylsulphonylamino(thio)carbonyl compounds The invention relates to novel thienylsulphonylamino(thio)carbonyl compounds of the formula (I), in which Q represents oxygen or sulphur, R 1 represents cyano, halogen or in each case...
33	6677360	Biphenyl and biphenyl-analogous compounds as integrin antagonists The present invention relates to biphenyl and biphenyl-analogous compounds, their preparation and use as pharmaceutical compositions, as integrin antagonists and in particular for the production of...
34	6657070	Production of chirally pure α-amino acids and N-sulfonyl α-amino acids Methods for production of chirally pure α-amino acids and N-sulfonyl α-amino acids are described. An aldehyde and a cyanide salt are reacted with an α-methylbenzylamine to afford product. The...
35	6566375	Elevation of HDL cholesterol by 4-&lsqb (aminothioxomethyl)-hydrazono&rsqb -N-(substituted)-4-arylbutanamides Compounds of this invention increase plasma levels of high density lipoprotein or HDL, the “good” cholesterol and as such may be useful for treating diseases such as atherosclerosis. These...
36	6562842	Protease inhibitors The present invention provides compounds which inhibit proteases, including cathepsin K, pharmaceutical compositions of such compounds, and methods for treating diseases of excessive bone loss or...
37	6545154	Method for the production of N-(5-amino-2-cyano-4-fluoro-phenyl)-sulphonamides and new intermediate products The invention relates to a process for preparing N-(5-amino-2-cyano-4-fluoro-phenyl)-sulphonamides in which, in a first step, 2-amino-4,5-difluoro-benzonitrile is reacted with sulphonyl halides in...
38	6509499	Nitromethylthiobenzene derivatives as inhibitors of aldose reductase The invention concerns novel compound of general formula (1) in which: P, T 1 , T 2 , X and n are as defined in claim 1, their tautomeric forms, and their additive salts with pharmaceutically...
39	6506780	Benzophenones and sulfones as inhibitors of glycine uptake This invention relates to a series of substituted benzophenone and sulfone compounds of the formula I wherein ring A, Z, Y, R and X are defined as in the specification, that exhibit activity as...
40	6465060	Tetrahydrothiophene derivatives, and their use in liquid-crystalline mixtures Tetrahydrothiophene derivatives of the formula (I) R 1 —X—(A 1 —M 1 ) a —(A 2 —M 2 ) b —A 3 —Y—T—Z—R 2 (I) where the symbols and indices have the following meanings, for...
41	6451791	Amidoaromatic ring sulfonamide hydroxamic acid compounds An amidoaromatic ring sulfonamide hydroxamic acid compound that inter alia inhibits matrix metalloprotease activity is disclosed, as are a treatment process that comprises administering a...
42	6441177	Tertiary amines Tertiary amines of the formula wherein A 1 , A 2 , A 3 , A 4 , M, p, T and Q are as defined herein, and acid addition salts thereof, have antimycotic and cholesterol-lowering activity.
43	6433009	Sulfonyl urea derivatives and their use in the control of interleukin-1 activity A compound of the formula wherein R 1 and R 2 are as defined above, useful in the treatment and condition selected from the group consisting of meningitis and salpingitis, septic shock,...
44	6391918	N-sulphonyl and N-sulphinyl phenylglycinamide Novel α-amino acid amides of formula (I) as well as possible isomers and mixtures of isomers thereof, wherein the substituents are defined as follows: n is the number zero or one; R 1 is...
45	6369273	Chemical compounds and their use to elevate pyruvate dehydrogenase activity The use of a compound of the formula (I): wherein: ring C is phenyl or carbon-linked heteroaryl selected from pyridyl, pyrazinyl, pyrimidinyl and pyridazinyl; and wherein said phenyl or...
46	6355673	Substituted diaminocarboxylic acids Compounds of formula (I) are suitable for the production of pharmaceuticals for the prophylaxis and therapy of disorders in the course of which an increased activity of matrix-degrading...
47	6350909	Methoxymino-phenylacetamide derivatives and their utilization as pesticides The invention relates to new imides, to a plurality of processes for their preparation and to their use as fungicides.
48	6350761	Benzenamine derivatives as anti-coagulants This invention is directed to benzenamine derivatives of formula (I): wherein A, W, m, n, R 1 , R 2 , R 3 , R 4 , R 5 and R 6 are defined herein. These compounds are useful as anti-coagulants.
49	6342610	N-aryl thienyl-, furyl-, and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin Thienyl-, furyl- and pyrrolyl-sulfonamides and methods for modulating or altering the activity of the endothelin family of peptides are provided. In particular, N-(isoxazolyl)thienylsulfonamides,...
50	6323315	Dolastatin peptides The present invention provides compounds of the formula ##STR1## where R 1 -R 5 are each, independently, a hydrogen atom or a normal or branched C 1 -C 6 -alkyl group; A is a methionyl,...

Matches 1 - 50 out of 336

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