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7615653 |
Anti-tuberculosis taxane compounds
The present invention relates to compounds having the formula (I):
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7605278 |
Methods and compositions for converting taxane amides to paclitaxel or other taxanes
The invention relates to methods and compositions for converting taxane amides to paclitaxel or other taxanes. In one alternative embodiment, the present invention comprises; (i) selectively...
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7589111 |
C10 cyclopentyl ester substituted taxanes
A taxane having a cyclopentyl ester substituent at C10, a keto substituent at C9, a hydroxy substituent at C2, a 2-thienyl substituent at C3′ and an isopropoxycarbamate substituent at C3′.
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7585986 |
Semi-synthesis of taxane intermediates and aziridine analogues and their conversion to paclitaxel and docetaxel
A process is provided for the semi-synthesis of taxane intermediates and aziridine analogues of cephalomannine and baccatin III intermediates, and the conversion of such intermediates and analogues...
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7550609 |
Cytotoxic agents comprising taxanes and their therapeutic use
A cytotoxic agent comprising one or more taxanes linked to a cell binding agent. A therapeutic composition for killing selected cell populations comprising: (A) a cytotoxic amount of one or more...
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7550608 |
Processes for the preparation of docetaxel
The present invention provides processes for the production of docetaxel. Docetaxel is produced by protecting the C(7) and the C(10) hydroxy groups of 10-DAB with a bridging silicon-based...
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7524869 |
Taxanes having a C10 ester substituent
Taxanes having an ester substituent at C(10), a hydroxy substituent at C(7), and a range of C(2), C(9), C(14), and side chain substituents.
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7524610 |
Oxetane-containing compound, photoresist composition having the same, method of preparing pattern using the photoresist composition, and inkjet print head including polymerization products of the oxetane-containing compound
An oxetane-containing compound, a photoresist composition including the same, a method of preparing patterns using the photoresist composition, and an inkjet print head including polymerization...
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7498452 |
Taxane derivatives functionalized at the 14-position and a process for the preparation thereof
A general process for the functionalization at the 14-position of 13-ketobaccatin derivatives of formula I to give derivatives of formula II wherein the substituents are as defined in the...
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7495114 |
Cytotoxic agents containing novel potent taxanes and their therapeutic use
Included within the scope of the present invention are potent taxanes and taxanes containing a linking group. Also included is a cytotoxic agent comprising one or more taxanes linked to a cell...
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7393569 |
Polymerizable liquid crystal composition and polymer thereof
A polymerizable liquid crystal composition containing compounds represented by the formula (1-1) and the formula (1-2), compounds represented by the formula (2-1) and the formula (2-2), and a...
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7368473 |
Paclitaxel enhancer compounds
One embodiment of the present invention is a compound represented by the Structural Formula (I):
Y is a covalent bond of a substituted or unsubstituted straight chained hydrocarbyl group. In...
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7354985 |
Fluorinated thermoset polyurethane elastomers prepared from polyether prepolymers formed from mono-substituted fluorinated oxetane monomers
This application is directed to novel fluorinated polymers and prepolymers derived from mono-substituted oxetane monomers having fluorinated alkoxymethylene side-chains and the method of making...
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7326796 |
Fluorinated monomers, fluorinated polymers having polycyclic groups with fused 4-membered heterocyclic rings, useful as photoresists, and processes for microlithography
The present invention provides novel fluorine-containing copolymers which comprise at least one fluorinated olefin, at least one polycyclic ethylenically unsaturated monomer with a fused 4-membered...
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7317113 |
Process for the preparation of the 14β-hydroxy-baccatin III-1,14-carbonate
A process for the preparation of 14β-hydroxy-baccatin III-1,14-carbonate useful for the preparation of novel taxane derivatives with antitumor activity.
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7309755 |
Method of producing polycarbonate articles by rotation molding and rotation molded articles made by the method
A method for making a polycarbonate article is described wherein the article is made by rotation molding a melt polycarbonate having a weight average molecular weight from 25,000 to about 36,000....
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7307176 |
Inclusion complex of taxol with 2-hydroxypropyl-beta-cyclodextrin
The present invention relates to a method for producing a 2-hydroxypropyl-beta-cyclodextrin inclusion complex of taxol, said 2-hydroxypropyl-beta-cyclodextrin having a degree of substitution of 0.4...
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7288665 |
Process for selective derivatization of taxanes
Processes for the preparation of taxol and other taxanes through selective derivatization of the C(7) and C(10) hydroxyl groups of 10-DAB, particularly a novel process using a new strategy in which...
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7276228 |
Methods for treating hematological disorders through inhibition of DNA methylation and histone deacetylase
Methods are provided for treating hematological disorders by inhibition of DNA hypomethylation and histone deacetylase. Such disorders include, for example, acute promyelocytic leukemia, acute...
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7264951 |
Enhanced production of taxol and taxanes by cell cultures of Taxus species
This invention provides methods whereby taxol, baccatin III, and other taxol-like compounds, or taxanes, can be produced in very high yield from all known Taxus species, e.g., brevifolia,...
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7259268 |
Method for purification of paclitaxel from paclitaxel-containing materials
This invention relates to methods for purification of paclitaxel from a paclitaxel-containing material. The method comprises the following steps: (a) extracting a paclitaxel-containing material...
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7247738 |
Method of preparation of anticancer taxanes using 3-[(substituted-2-trialkylsilyl) ethoxycarbonyl]-5-oxazolidine carboxylic acids
This invention relates to a process for preparation of taxanes comprising
subjecting 7,10-diprotected intermediates 7-O-(2-haloacyl)baccatin III 6c or 7,10-O-di-(2-haloacyl)-10-deacetylbaccatin...
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RE39723 |
Semi-synthetic taxanes with antitumor and antiangiogenetic activities
Seco-baccatin III derivatives of formula:
wherein R, R 1 -R 4 , R 1 R′ , R 11 R″ , and R 111 R′″ are disclosed herein; pharmaceutical compositions comprising seco-baccatin...
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7235583 |
Fatty acid-anticancer conjugates and uses thereof
The invention provides conjugates of fatty acids and anticancer agents useful in treating cancer, and compositions and formulations thereof. Methods for using the conjugates also are provided.
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7232917 |
Cyclic fluorine compounds, polymerizable fluoromonomers, fluoropolymers, and resist materials containing the fluoropolymers and method for pattern formation
The present invention provides a fluorine-containing cyclic compound represented by general formula (1):
wherein R 1 represents a halogen atom, and R 2 and R 3 each represents hydrogen or a...
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7230013 |
C10 carbamoyloxy substituted taxane compositions
Compositions comprising a taxane having a carbamoyloxy substituent at C(10), a hydroxy substituent at C(7), and a range of C(2), C(9), C(14), and side chain substituents.
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7226944 |
Taxanes having a C7 carbonate substituent
Taxanes having a carbonate substituent at C(7), a hydroxy substituent at C(10), and a range of C(2), C(9), C(14), and side chain substituents.
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7220872 |
Conversion of taxane molecules
The invention provides methods and compositions for reductively deoxygenating an amide group at a C-3′ position of a taxane molecule followed by subsequent intra-molecular acyl migration of an...
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7202370 |
Semi-synthesis of taxane intermediates from 9-dihydro-13-acetylbaccatin III
A method is provided for the semi-synthesis of taxane intermediates useful in the preparation of paclitaxel and docetaxel from 9-dihydro-13-acetylbaccatin III. The preparation of a suitably...
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7186849 |
C7 ester substituted taxanes
Taxanes having an ester substituent at C(7), a hydroxy substituent at C(10), and a range of C(2), C(9), C(14), and side chain substituents.
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7176326 |
β-Lactams, methods for the preparation of taxanes, and sidechain-bearing taxanes
Novel β-lactams finding utility as intermediates in the preparation of sidechain-bearing taxanes such as taxol and taxol derivatives. The present invention also relates to novel methods of...
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7176325 |
Selective acylation of secondary hydroxyl groups
The invention provides methods and compositions for selectively acylating a specific hydroxyl group in a molecule of interest containing at least two unprotected secondary hydroxyl groups. Although...
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7169446 |
Oxetane compound, actinic ray curable composition, ink composition for ink jet recording, and image formation method
Disclosed is an oxetane compound represented by the following formula (I), (II), (III), (IV) or (V):
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7169307 |
Process for the extraction of paclitaxel and 9-dihydro-13-acetylbaccatin III from Taxus
This invention teaches a purification technology to extract an organic solution of paclitaxel by using a “Load and Lock Axial Compression Column” for industrial scale preparative high...
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7112687 |
Methods for obtaining paclitaxel from taxus plants
Methods for obtaining paclitaxel from plants containing paclitaxel are disclosed. Plant material is first obtained from plants containing paclitaxel. Paclitaxel is then extracted from the plant...
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7078538 |
Baccatin III derivatives
A process for the preparation of 14 beta-hydroxy-1,4-carbonate-deacetylbaccatin III and intermediates useful for the preparation of novel taxan derivatives with antitumor activity are disclosed.
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7078432 |
Process for the preparation of the 14β-hydroxy-baccatin III-1,14-carbonate
A process for the preparation of 14β-hydroxy-baccatin III-1,14-carbonate useful for the preparation of novel taxane derivatives with antitumor activity.
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7074945 |
Metal alkoxide taxane derivatives
A process for preparing N-acyl, N-sulfonyl and N-phosphoryl substituted isoserine esters in which a metal alkoxide is reached with a β-lactam.
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7074821 |
Taxoids, their preparation and pharmaceutical composition containing them
New taxoids of general formula (I), their preparation and pharmaceutical compositions containing them. In general formula (I),
Ar represents an aryl radical, R represents a hydrogen atom or an...
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7067552 |
Radiosensitizing taxanes and their pharmaceutical preparations
Taxanes containing electron-affinic radiosensitizing functional groups, their pharmaceutical preparations, and methods of making and using this new class of highly potent radiosensitizers of tumor...
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7063977 |
Enzymatic resolution of t-butyl taxane derivatives
A method for the resolution of a mixture of the cis or trans enantiomers of a compound of the formula
wherein R 1 is —O—C(O)alkyl, —O—C(O)aryl or —O—C(O)cycloalkyl by contacting...
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7060724 |
Water soluble paclitaxel derivatives
Disclosed are water soluble compositions of paclitaxel and docetaxel formed by conjugating the paclitaxel or docetaxel to a water soluble polymer such as poly-glutamic acid, poly-aspartic acid or...
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7056946 |
C10 carbonate taxane compositions
Taxanes having a carbonate substituent at C(10), a hydroxy substituent at C(7), and a range of C(2), C(9), C(14), and side chain substituents.
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7053222 |
Semi-synthetic process for the preparation of N-debenzoylpaclitaxel
A process for the preparation of N-debenzoylpaclitaxel (I) through esterification of 7-protected baccatin III with a carboxylic acid reactive derivative of general formula (II), and elimination of...
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6992104 |
C7 carbonate taxane compositions
Taxanes having a carbonate substituent at C(7), a hydroxy substituent at C(10), and a range of C(2), C(9), C(14), and side chain substituents.
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6972317 |
Monohydric polyfluorooxetane polymer and radiation curable coatings containing a monofunctional polyfluorooxetane polymer
Monofunctional polyfluorooxetane oligomers and polymers are prepared by the cationic polymerization of fluorooxetane monomers with a monoalcohol. The fluorooxetane oligomers or polymers can be...
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6962966 |
Monohydric polyfluorooxetane oligomers, polymers, and copolymers and coatings containing the same
Monofunctional polyfluorooxetane oligomers, polymers, and co-polymers are prepared by the cationic polymerization of fluorooxetane monomers with a monoalcohol. In addition to serving as an...
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6956124 |
Process for the preparation of 4,10β-diacetoxy-2α-benzoyloxy-5β,20-epoxy-1,13α-dihydroxy-9-oxo-19-norcyclopropa[g]tax-11-ene
There is disclosed a process for the preparation of 4-acetoxy-2α-benzoyloxy-5β,20-epoxy-1,13α-dihydroxy-9-oxo
-19-norcyclopropa[g] tax-11-ene from...
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6939978 |
Production of taxol and taxanes
A high yield, economical process for purifying taxanes from yew biomass is disclosed. The process does not require initial liquid:liquid portioning of the crude extract to separate highly polar...
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6916942 |
Process for the preparation of C-4 carbonate taxanes
A process for the preparation of novel C-4 carbonate taxanes useful as antitumor agents
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