Match Document Document Title
9012665 Amorphous cabazitaxel  
The present invention is directed to an amorphous form of cabazitaxel, which can be prepared by dissolving a solid form of cabazitaxel in an organic solvent, and removing the organic solvent to...
9000193 Process for the preparation of cabazitaxel  
The present invention discloses a process for the preparation of 4-acetoxy-2α-benzoyloxy-5β,20-epoxy-1-hydroxy-7β,10β-dimetho xy-9-oxotax-11-en-13α-yl(2R,3S)-3-tert-butoxycarbonylamino-2 -hydroxy-3...
8993790 Oxetane-ring-containing (meth)acrylic acid ester compound  
Provide is an oxetane-ring containing (meth) acrylic ester compound which can give, through polymerization, a cured article being highly flexible or thermally stable. The oxetane-ring-containing...
8981040 Cationically polymerizable resin, cationically polymerizable resin composition, and cured products thereof  
Provided is a cationically polymerizable resin which is rapidly cured upon irradiation with light and forms a cured product excellent in flexibility and thermal stability. The cationically...
8962871 Method for producing 4-benzyl-1-methyl-6-oxabicyclo[3,2,0]heptane derivative  
A 4-benzyl-1-methyl-6-oxabicyclo[3,2,0]heptane derivative is manufactured by reducing, in the presence of both a halogenating agent and a hydride-type reducing agent, a methylene moiety bound to a...
8962870 9, 10-α, α-OH-taxane analogs and methods for production thereof  
Provided herein are compounds, compositions containing the compounds, and methods for the treatment of cancer in a cancer patient. In particular, the compounds are made by a process comprising...
8921411 Solid state forms of cabazitaxel and processes for preparation thereof  
The invention relates to solid state forms of Cabazitaxel, and processes for preparation, via novel synthetic intermediates, thereof, and formulations comprising one or more of the solid state...
8912212 Therapeutic polymeric nanoparticle compositions with high glass transition temperature or high molecular weight copolymers  
The present disclosure relates in part to pharmaceutical compositions comprising polymeric nanoparticles having certain glass transition temperatures. Other aspects of the invention include...
8912229 Taxane and abeo-taxane analogs  
The present application discloses new taxane analogs, intermediates and methods for producing them. The present application is also directed to pharmaceutical formulations comprising abeo-taxanes...
8905997 Therapeutic particles suitable for parenteral administration and methods of making and using same  
Disclosed herein are therapeutic compositions for treating and preventing diseases such as neointimal hyperplasia (NIH), where the compositions comprise a therapeutic particle that has a localized...
8901327 Process for the preparation cabazitaxel  
The present invention discloses a process for the preparation of 4-acetoxy-2α-benzoyloxy-5β,20-epoxy-1-hydroxy-7β,10β-dimetho xy-9-oxotax-11-en-13α-yl(2R,3S)-3-tert-butoxycarbonylamino-2 -hydroxy-3...
8895589 Pyridinyl amides as P2X3 and P2X2/3 inhibitors  
Compounds of the formula I: or a pharmaceutically acceptable salt thereof, wherein, R1 is optionally substituted phenyl or optionally substituted pyridinyl, and R2, R3, R4, R5, R6, R7, R8 and R9...
8877759 Aminopyrazines as ATR kinase inhibitors  
The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this...
8846644 Phosphate-containing nanoparticle delivery vehicle  
A phosphate-containing nanoparticle delivery vehicle includes nanoparticle, an active ingredient, and a phosphodiester moiety connecting the nanoparticle and the active ingredient and forms a...
8829210 Process for preparing docetaxel and its hydrate  
The present invention provide process of preparation of (2R,3S)—N-carboxy-3-phenylisoserine, N-tert-butyl ester, 13-ester with 5(β)-20-epoxy-1,2(α),4,7(β),10(β),13(α)-hexa hydroxy tax-11-en-9-one...
8828975 Phosphate-containing nanoparticle delivery vehicle  
A phosphate-containing nanoparticle delivery vehicle includes a nanoparticle, an active ingredient, and a phosphodiester moiety connecting the nanoparticle and the active ingredient and forms a...
8809557 Method for producing optically active fluorinated oxetane  
Disclosed is a method of producing an optically active fluorinated oxetane, which can be an important pharmaceutical or agricultural intermediate, by reaction of a fluorinated α-keto ester with an...
8791279 Process for preparing taxoids from baccatin derivatives using lewis acid catalyst  
The present invention relates to a process of preparing a taxoid (X) by reacting a protected baccatin derivative (B) with a β-lactam (C) in the presence of one or more Lewis acids and a base...
8791119 3,4-dihydropyrrolo[1,2-A]pyrazine-2,8(1H)-dicarboxamide derivatives, preparation thereof and therapeutic use thereof for diseases involving casein kinase 1 epsilon and/or casein kinase 1 delta  
Compounds corresponding to the general formula (I) wherein R2 represents a group C1-10-alkyl, C3-10-cycloalkyl, C3-7-cycloalkyl-C1-6-alkyl, C1-6-alkyl-C3-7-cycloalkyl,...
8790691 Modified drugs for use in liposomal nanoparticles  
Drag derivatives are provided herein which are suitable for loading into liposomal nanoparticle carriers. In some preferred aspects, the derivatives comprise a poorly water-soluble drag...
8785669 Taxane compounds, compositions and methods  
The present invention provides a method for the preparation of orally available pentacyclic taxane compounds, as well as intermediates useful in their preparation.
8735611 Crystalline forms of cabazitaxel  
The present invention provides crystalline forms, including an anhydrate form, of cabazitaxel and processes for the preparation of these forms, designated as Forms C1, C2, C3, C4, C5, C6, C7, C8,...
8703982 Purification of taxanes  
Disclosed is a method of crystallizing a taxane comprising combining the taxane and methylene chloride to obtain a solution and adding an anti-solvent to the solution to obtain a crystalline...
8697894 Preparation of taxanes from 9-dihydro-13-acetylbaccation III  
A new process for preparing a compound of Formula V, wherein P is a hydroxy protecting group and R is acetyl, said process including the steps of: i) selectively deacetylating the 10-hydroxy group...
8697892 Taxane compounds, compositions and methods  
The present invention provides a method for the preparation of orally available pentacyclic taxane compounds, as well as intermediates useful in their preparation.
8686165 Process for preparation of taxane derivatives  
The present disclosure relates to processes for the preparation of taxane derivatives with improved purity and enhanced stability. The taxane derivatives prepared according to the processes...
8658794 8-methyl-1-phenyl-imidazol[1,5-a]pyrazine compounds as Lck inhibitors and uses thereof  
The present invention provides 8-methyl-1-phenyl-imidazo[1,5-a]pyrazine derivatives according to formula I or pharmaceutically acceptable salts thereof. The compounds of the current invention show...
8658811 Process for the preparation of docetaxel, its intermediates, and methods for preparation thereof  
Described is a process for preparing docetaxel 1, including the following steps: a) hydroxyl acylation reaction of compound 2 and 3 to obtain compound 4; b) deprotection group R1 of the hydroxyl...
8633326 Method for preparing taxane derivatives  
Provided is a method for preparing a taxane derivative, comprising: carrying out condensation of a phenylisoserine derivatives having a protective group introduced thereto or a mixture of isomers...
8633240 Paclitaxel trihydrates and methods of making thereof  
Novel paclitaxel trihydrates. The paclitaxel trihydrates described herein are obtained by recrystallizing paclitaxel from a water/alcohol solution. Such recrystallization is known in the art to...
8617608 Drug loaded polymeric nanoparticles and methods of making and using same  
The present disclosure generally relates to nanoparticles having about 0.2 to about 35 weight percent of a therapeutic agent; and about 10 to about 99 weight percent of biocompatible polymer such...
8613954 Drug loaded polymeric nanoparticles and methods of making and using same  
The present disclosure generally relates to nanoparticles having about 0.2 to about 35 weight percent of a therapeutic agent; and about 10 to about 99 weight percent of biocompatible polymer such...
8603947 (4-haloalkyl-3-thiobenzoyl)cyclohexanediones and use thereof as herbicides  
A description is given of (4-haloalkyl-3-thiobenzoyl)cyclohexanediones of the formula (I) and of their use as herbicides. In this formula (I), X, Y, R1, R2, R3, and R4 are radicals such as...
8575373 Crystalline forms of cabazitaxel  
The present invention provides crystalline forms, including an anhydrate form, of cabazitaxel and processes for the preparation of these forms, designated as Forms C1, C2, C3, C4, C5, C6, C7, C8,...
8575203 Chemical compounds  
The present invention encompasses compounds of general formula (1) wherein the groups R1 to R4, Qa, Qb, QH, L and n are defined as in claim 1, which are suitable for the treatment of diseases...
8569331 Substituted benzo[f]lmidazo[1,2-d]pyrido[2,3-b][1,4]diazepine compounds  
The present invention relates to substituted benzo[f]imidazo[1,2-d]pyrido[2,3-b][1,4]diazepine compounds and methods of synthesizing these compounds. The present invention also relates to...
8563041 Therapeutic particles suitable for parenteral administration and methods of making and using same  
Disclosed herein are therapeutic compositions for treating and preventing diseases such as neointimal hyperplasia (NIH), where the compositions comprise a therapeutic particle that has a localized...
8552054 Fatty amine drug conjugates  
The invention provides conjugates of fatty amines and pharmaceutical agents useful in treating cancer, viruses, psychiatric disorders. Compositions, pharmaceutical preparations, and methods of...
8552056 Biologically active taxane analogs and methods of treatment by oral administration  
The present invention relates to a novel chemical compound of formula S-(1): for use in the treatment of cancer, to compositions containing said compound, methods of manufacture and combinations...
8541608 Method for preparing a polymer conjugate  
Provided herein is a straightforward and efficient method for covalently attaching a polyethylene glycol polymer to a taxane. The method involves, among other things, a step of reacting a taxame...
8481589 Taxoid-based compositions  
The disclosure relates to novel taxoid-based compositions comprising injectable formulations of these derivatives in the form of an emulsion.
8460577 Polymerizable oxetane derivative  
The invention provides a compound represented by formula (1). In the formula (1), R1 is hydrogen, methyl or ethyl; X1 is a single bond, —O— or —OCO—; X2 is a single bond, —O—, —COO— or —OCO—; A1...
8455061 Optically active compound having polymerizable group and its polymer  
An optically active compound having a polymerizable group which is represented by formula (1) or (2). P1-Q1-(A1-Z1)m—X1—(Z1-A1)m-Q1-P2 (1) P1-Q1-(A1-Z1)m—X2 (2) For example, A1 is independently...
8425988 Polymerizable liquid crystal compound, polymerizable liquid crystal composition and anisotropic polymer  
The main aim of the invention is to provide a polymerizable compound that is excellent in the stability of a liquid crystal phase, a polymerizable liquid crystal composition, and an anisotropic...
8415388 Pharmaceutical compositions containing paclitaxel orotate  
This invention is related to orotic acid compounds of taxane cytotoxic agents and in particular to the conversion of the taxanes to their orotate esters. More particularly the pharmaceutical...
8410294 Method for preparing highly pure anhydrous crystalline docetaxel  
A method for preparing highly pure anhydrous crystalline docetaxel is provided. The method for preparing highly pure anhydrous crystalline docetaxel enables preparation of anhydrous crystalline...
8399507 Antidiabetic tricyclic compounds  
Tricyclic compounds containing a cyclopropanecarboxylic acid fused to a bicyclic ring, including pharmaceutically acceptable salts, are agonists of G-protein coupled receptor 40 (GPR40) and are...
8394418 Combination preparation of a biological response modifier and an anticancer agent and uses thereof  
The present invention provides anticancer biological response modifier combinations. In accordance with an aspect of the present invention, there is provided a combination comprising: (i) a...
8378128 Crystalline forms of dimethoxy docetaxel and methods for preparing the same  
The invention relates to anhydrides, solvates and ethanol hetero-solvates and hydrates of dimethoxy docetaxel or (2R,3S)-3-tert-butoxycarbonylamino-2-hydroxy-3-phenyl-propio nate of...
8357811 Crystalline forms of docetaxel and process for preparation thereof  
New anhydrous crystalline form of docetaxel and process of making anhydrous docetaxel and docetaxel trihydrate are provided.