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7183312 |
Taxanes having a C7 heterosubstituted acetate substituent
Texanes having a heterosubstituted acetate substituent at C(7), a hydroxy substitutent at C(10), and a range of C(2), C(9), C(14), and side chain substituents.
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7176326 |
β-Lactams, methods for the preparation of taxanes, and sidechain-bearing taxanes
Novel β-lactams finding utility as intermediates in the preparation of sidechain-bearing taxanes such as taxol and taxol derivatives. The present invention also relates to novel methods of...
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7175993 |
Taxol immunoassay
Novel conjugates of taxol and novel taxol immunogens derived from the 9 and 7 positions of taxol and monoclonal antibodies generated by these taxol linked immunogens are useful in immunoassays for...
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7176325 |
Selective acylation of secondary hydroxyl groups
The invention provides methods and compositions for selectively acylating a specific hydroxyl group in a molecule of interest containing at least two unprotected secondary hydroxyl groups. Although...
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7169446 |
Oxetane compound, actinic ray curable composition, ink composition for ink jet recording, and image formation method
Disclosed is an oxetane compound represented by the following formula (I), (II), (III), (IV) or (V):
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7169307 |
Process for the extraction of paclitaxel and 9-dihydro-13-acetylbaccatin III from Taxus
This invention teaches a purification technology to extract an organic solution of paclitaxel by using a “Load and Lock Axial Compression Column” for industrial scale preparative high...
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7163796 |
Process for detecting the presence or quantity of enzymatic activity in a sample
This invention provides for labeling reagents, labeled targets and processes for preparing labeling reagents. The labeling reagents can take the form of cyanine dyes, xanthene dyes, porphyrin dyes,...
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7160919 |
C7 lactyloxy-substituted taxanes
A taxane having the formula:
wherein X 3 is furyl, X 5 is t-butoxycarbonyl, Bz is benzoyl, and Ac is acetyl.
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7153884 |
C-2′ methylated derivatives of paclitaxel for use as antitumour agents
Taxane derivatives of formula (I) in which: R is trifluoromethyl, phenyl, 2-furyl, 2-thienyl; R 1 is t-butoxycarbonyl or benzoyl; R 2 is hydroxy; R 3 is hydrogen or, together with R 2 , it forms...
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7153946 |
Molecular conjugates for use in treatment of cancer
A molecular conjugate is provided having the formula:
wherein R 1 is a de-hydroxyl or de-amino moiety respectively of a hydroxyl-bearing or amino-bearing biologically active molecule or an...
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7144876 |
3,5-Disubstituted-[1,2,4]-oxadiazoles and analogs as activators of caspases and inducers of apoptosis and the use thereof
Disclosed are 3,5-disubstituted-[1,2,4]-oxadiazoles and analogs thereof, represented by the Formula I:
wherein Ar 1 , R 2 , A, B and D are defined herein. The present invention relates to the...
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7132554 |
Therapeutic synergy of anti-cancer compounds
This invention relates to a synergistic therapeutic combination of anti-cancer compounds which comprises a) a taxane, and b) a substance that binds to the epidermal growth factor receptor (EGFR)...
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7125590 |
Liquid crystal film and liquid crystal display device equipped with same
Liquid crystal films with excellent heat resistance and mechanical strength are provided. A liquid crystal film is obtained by fixing an aligned liquid crystal material containing at least a side...
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7115755 |
Reactive mesogenic azulenes
The invention relates to new reactive mesogenic azulene derivatives, their use as semiconductors or charge transport materials, in optical, electro-optical or electronic devices like for example...
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7115757 |
1,2-dioxetane derivatives and reagents employing them
A 1,2-dioxetane derivative of the formula (I):
wherein Ar is an aryl group which may have an alkyl group, an aryl group, a halogen atom, an alkoxyl group, a carboxyl group, a formyl group, an...
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7112687 |
Methods for obtaining paclitaxel from taxus plants
Methods for obtaining paclitaxel from plants containing paclitaxel are disclosed. Plant material is first obtained from plants containing paclitaxel. Paclitaxel is then extracted from the plant...
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7109343 |
Metal catalysts and methods for making and using same
Compounds having the formula:
are disclosed. M 1 and M 2 are the same or different and are transition metal atoms or ions; Z 2 and Z 3 , independently, are the atoms necessary to complete a...
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7105187 |
Method for obtaining taxanes
A method for obtaining a taxane by which a taxane is isolated from a growth medium, such as soil, in which a taxane-producing plant has grown.
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7101595 |
Photo-curable fluorene derivative and composition containing the same
The present invention provides a compound represented by formula (1) defined in the specification. The invention further provides a liquid crystal composition comprising at least two compounds,...
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7081352 |
Chemiluminescent influenza diagnostic kit
A chemiluminescent system for detecting the presence of influenza virus in a biological fluid sample is provided. An influenza diagnostic kit is provided which includes (1) a sampling device for...
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7078538 |
Baccatin III derivatives
A process for the preparation of 14 beta-hydroxy-1,4-carbonate-deacetylbaccatin III and intermediates useful for the preparation of novel taxan derivatives with antitumor activity are disclosed.
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7078432 |
Process for the preparation of the 14β-hydroxy-baccatin III-1,14-carbonate
A process for the preparation of 14β-hydroxy-baccatin III-1,14-carbonate useful for the preparation of novel taxane derivatives with antitumor activity.
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7074821 |
Taxoids, their preparation and pharmaceutical composition containing them
New taxoids of general formula (I), their preparation and pharmaceutical compositions containing them. In general formula (I),
Ar represents an aryl radical, R represents a hydrogen atom or an...
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7074945 |
Metal alkoxide taxane derivatives
A process for preparing N-acyl, N-sulfonyl and N-phosphoryl substituted isoserine esters in which a metal alkoxide is reached with a β-lactam.
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7067552 |
Radiosensitizing taxanes and their pharmaceutical preparations
Taxanes containing electron-affinic radiosensitizing functional groups, their pharmaceutical preparations, and methods of making and using this new class of highly potent radiosensitizers of tumor...
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7064179 |
Peg-based macromonomers, chemically inert polymers prepared therefrom and the use of these polymers for organic synthesis and enzyme reactions
The present invention relates to macromonomers containing ethylene glycol repeat units, to chemically inert polymers prepared therefrom and to the use of such polymers in solid phase biochemical...
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7063977 |
Enzymatic resolution of t-butyl taxane derivatives
A method for the resolution of a mixture of the cis or trans enantiomers of a compound of the formula
wherein R 1 is —O—C(O)alkyl, —O—C(O)aryl or —O—C(O)cycloalkyl by contacting...
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7060724 |
Water soluble paclitaxel derivatives
Disclosed are water soluble compositions of paclitaxel and docetaxel formed by conjugating the paclitaxel or docetaxel to a water soluble polymer such as poly-glutamic acid, poly-aspartic acid or...
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7056946 |
C10 carbonate taxane compositions
Taxanes having a carbonate substituent at C(10), a hydroxy substituent at C(7), and a range of C(2), C(9), C(14), and side chain substituents.
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7053222 |
Semi-synthetic process for the preparation of N-debenzoylpaclitaxel
A process for the preparation of N-debenzoylpaclitaxel (I) through esterification of 7-protected baccatin III with a carboxylic acid reactive derivative of general formula (II), and elimination of...
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7037940 |
Taxol enhancer compounds
Disclosed is a compound represented by the Structural Formula (I):
Y is a covalent bond, a phenylene group or a substituted or unsubstituted straight chained hydrocarbyl group. In...
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7030253 |
Process for preparing 4-alkyl- or 4-aryl-oxycarbonyl paclitaxel analogs and novel intermediates
A process is provided for preparing 4-alkyl- or 4-aryl-oxycarbonyl paclitaxel analogs which includes the steps of converting paclitaxel into a C-7 acylprotected paclitaxel employing an...
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6992104 |
C7 carbonate taxane compositions
Taxanes having a carbonate substituent at C(7), a hydroxy substituent at C(10), and a range of C(2), C(9), C(14), and side chain substituents.
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6982336 |
1,2-dioxetane derivatives, luminescent reagents, luminescence methods and measuring methods
A 1,2-dioxetane derivative of the formula (I):
wherein R 1 –R 3 and Ar are defined in the claims is provided.
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6962633 |
Amine azide propellant
A novel family of amine azides having a cyclic structure therein is disclosed. These compounds have attractive properties as rocket propellants.
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6956123 |
Purification of taxanes and taxane mixtures using polyethyleneimine-bonded resins
This invention is directed to a method for isolating and/or purifying one or more taxanes from materials comprising taxanes. In one embodiment, the method comprises the steps of: (a) treating a...
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6956124 |
Process for the preparation of 4,10β-diacetoxy-2α-benzoyloxy-5β,20-epoxy-1,13α-dihydroxy-9-oxo-19-norcyclopropa[g]tax-11-ene
There is disclosed a process for the preparation of 4-acetoxy-2α-benzoyloxy-5β,20-epoxy-1,13α-dihydroxy-9-oxo
-19-norcyclopropa[g] tax-11-ene from...
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6953862 |
Oxetane compounds containing styrenic functionality
These compounds contain an oxetane functionality and a styrenic functionality. The oxetane functionality is homopolymerizable in reactions that undergo cationic or anionic ring opening, and the...
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6939978 |
Production of taxol and taxanes
A high yield, economical process for purifying taxanes from yew biomass is disclosed. The process does not require initial liquid:liquid portioning of the crude extract to separate highly polar...
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6916942 |
Process for the preparation of C-4 carbonate taxanes
A process for the preparation of novel C-4 carbonate taxanes useful as antitumor agents
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6913897 |
Kit for conducting an assay to detect a substance using enzymatically-induced decomposition of dioxetanes
In an assay method in which a member of a specific binding pair is detected by means of an optically detectable reaction, the improvement wherein the optically detectable reaction includes the...
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6911549 |
Method of preparing a taxol derivative
This invention provides 7-deoxy-taxol analogs of Formula I:
The compounds of Formula I (including II and III) are useful for the same cancers for which taxol has been shown active, including...
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6906088 |
Taxanes having a C10 carbamoyloxy substituent
Taxanes having a carbamoyloxy substituent at C(10), a hydroxy substituent at C(7), and a range of C(2), C(9), C(14), and side chain substituents.
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6900342 |
Anticancer taxanes such as paclitaxel, docetaxel and their structural analogs, and a method for the preparation thereof
A process for the preparation of taxanes comprising
wherein R is a tert. butoxycarbonyl or benzoyl group; PMP is p-methoxyphenyl group; G 1 is acetyl group; G 2 is haloacetyl group...
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6894033 |
Combination therapies using vitamin B12 and therapeutic agents for treatment of viral, proliferative and inflammatory diseases
Pharmaceutical compositions for treating viral, proliferative and inflammatory diseases are disclosed comprising an amount of pharmaceutically acceptable vitamin B12 compounds in combination with...
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6891050 |
Process for the preparation of taxanes such as paclitaxel, docetaxel and structurally similar analogs
A process for the preparation of taxanes including paclitaxel, docetaxel, and structurally similar analogs, as well as intermediates produced by the process.
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6881852 |
Process of purification of paclitaxel and docetaxel
A process for the purification of paclitaxel or docetaxel comprising: (a) mixing crude paclitaxel with a mixture of solvents such as alkane and chlorinated alkane, filtering the solid followed by...
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6878834 |
14-hydrido-9β-hydroxytetracyclic taxanes
Process for the preparation of a derivative or analog of baccatin III or 10-desacetyl baccatin III having a C9 substituent other than keto in which the C9 keto substituent of taxol, a taxol analog,...
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6878832 |
Isolation of taxanes
An improved method for the isolation of taxanes of high purity from the crude extract of naturally occurring Taxus canadensis which comprises the steps of: a) filtering the crude extract by liquid...
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6878833 |
Tetraalkylammonium alkoxides
A process for preparing N-acyl, N-sulfonyl and N-phosphoryl substituted isoserine esters in which a metal or an ammonium alkoxide is reacted with a β-lactam.
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