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7638256 |
Fluorinated cyclic structure-bearing silicon compounds and silicone resins, resist compositions using the same, and patterning process
Silicon compounds having fluorinated hemiacetal structure are provided. Silicone resins having the same structure have an appropriate acidity to enable formation of a finer pattern by minimizing...
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7622598 |
Phenol derivatives and antitrypanosoma preventive/therapeutic agent comprising the same as active ingredient
A compound represented by formula (I):
[wherein, for example, X is a hydrogen atom or a halogen atom; R 1 is a hydrogen atom; R 2 is a hydrogen atom or a C 1-4 alkyl group; R 3 is...
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7592368 |
Sulphonamide derivatives as prodrugs of aspartyl protease inhibitors
The present invention relates to prodrugs of a class of sulfonamides which are aspartyl protease inhibitors. In one embodiment, this invention relates to a novel class of prodrugs of HIV aspartyl...
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7563888 |
Process for the preparation of diphenyl azetidinone derivatives
The present invention is a process for the preparation of diphenylazetidinone derivatives of the formula (I) or forms thereof comprising the substituents X, R 1 and/or R 2 as defined herein. More...
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7544810 |
Processes for preparing biaryl ureas and analogs thereof
The present invention relates to processes for preparing biaryl ureas derivatives and analogs thereof. The invention also provides compounds useful as intermediates in the processes of the present...
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7514439 |
Oxime derivative and preparations thereof
The problem of the present invention is to provide a useful compound as a glucokinase activating agent, which is the oxime derivative of the formula [I]:
wherein Ring A is aryl or heteroaryl;
...
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7507817 |
Prostaglandin prodrugs
Novel compounds, and therapeutic methods, compositions and medicament related thereto are disclosed herein.
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7402606 |
Derivatives of 1-(oxoaminoacetyl) pentylcarbamate as cathepsin K inhibitors for the treatment of bone loss
Heterocycle substituted ketoamide derivatives of Formula (I), wherein the substitutes A, D, A and R are defined as in claim in, which are useful as cathepsin K inhibitors are described herein. The...
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7361745 |
Process for the preparation of 1-chloro-3,5-di-o-acyl-2-deoxy-l-ribofuranoside derivatives
Herein described is a process for the preparation of 1-chloro-3,5-di-O-acyl-2-de-oxy-L-ribofuranoside derivatives of general formula (I) useful as intermediates in processes for preparing...
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7300948 |
Alkynyl compounds as non nucleoside reverse transcriptase inhibitors
Inhibitors of HIV reverse transcriptase which are useful for the treatment of HIV infection. Exemplars of the invention are compounds of the formula
wherein the substituents are as defined in...
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7232930 |
Compounds and methods for preparing methanesulfonamides
A process for preparing (S)-(−)-N-[4-[4-[ethyl(6-fluoro-6-methylheptyl)amino]-1-hy
droxy]phenyl]methanesulfonamide hemifumarate salt, which comprises reacting...
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7202274 |
Cyclic hemiacetal derivative and use thereof
A compound represented by the following formula (I)
wherein R 1 is a lower alkyl group, R 2 is a hydrogen, a halogen, a cyano group, a lower alkyl group or a lower alkoxy group, and n is 0 or...
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7196089 |
EP4 receptor antagonists
Compounds of formula (I):
wherein: R 2 is H or an optionally substituted C 1-4 alkyl group; Y is either —(CH 2 ) n —X—, where n is 1 or 2 and X is O, S, S(═O), S(═O) 2 , or NR N1 ,...
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7148363 |
Process for preparing acrylate compound
An acrylate compound of formula (4):
is produced by allowing an acrylic acid compound of formula (1):
to react with an unsaturated compound of formula (2) or (3):
In formulae (1)...
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7144897 |
Hydroxy alkyl amines
Disclosed are compounds of formula X,
which are useful in treating Alzheimer's disease and other similar diseases. Pharmaceutical compositions comprising compounds of formula X and methods of...
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7132449 |
Inhibitors of cruzipain and other cysteine proteases
Compounds of general formula (I):
wherein R 1 , R 2 , Y, (X) o , (W) n , (V) m , Z and U are as defined in the specification, are inhibitors of cruzipain and other cysteine protease inhibitors...
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7122661 |
Method for purifying a composition containing at least one internal dehydration product of a hydrogenated sugar
The invention concerns a method for purifying a composition containing at least a product for internal dehydration of a hydrogenated sugar. The invention is characterised in that it comprises: (a)...
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7102027 |
Adamantanetricarboxylic acid derivatives
An adamantanetricarboxylic acid derivative is represented by following Formula (1):
wherein X is a hydrogen atom or a hydrocarbon group; and R 1 , R 2 and R 3 may be the same as or different...
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7052742 |
Five membered-ring compounds and utilization thereof in liquid crystal mixtures
Fluorinated five-membered ring compounds of the formula (I)
R 1 —X—(A 1 —M 1 ) a —(A 2 —M 2 ) b —A 3 —Y—E ...
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7049338 |
Antiproliferative agents
This invention relates to certain dioxodihydropyridine derivatives and certain methacrylic acid and furan derivative precursors thereof, processes for their preparation, pharmaceutical compositions...
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7037937 |
Cytotoxic compounds
Compounds are described that bind to tubulin causing tubulin depolymerization and inhibiting tubulin polymerization. The compounds of the invention are therapeutically effective to inhibit cellular...
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7029606 |
Hyperpolarizable organic chromophores
A dihydrofuran-containing nonlinear optical chromophore having a π-electron donor group conjugated to the dihydrofuran group through a π-electron conjugated bridge group. The nonlinear optical...
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6969731 |
Protease inhibitors that overcome drug resistance
HIV protease inhibitors are among the most powerful drugs in suppressing HIV in human patients. However, HIV developed resistance to all protease inhibitor drugs so far marketed or used in clinical...
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6964981 |
Tetrahydrofuran derivatives and their use as NK-1 antagonists
The present invention relates compounds that are NK-1 antagonists and that are of use in the treatment or prevention of depression, anxiety, pain, inflammation, migaine, emesis or postherpetic...
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6906196 |
Processes for the preparation of 1,5-diaryl-3-substituted-pyrazoles
Provided are processes and chemical intermediates useful for preparing a compound of the formula I
wherein X is selected from the group consisting of C 1 -C 6 trihalomethyl; C 1 -C 6 ...
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6897324 |
Process for the preparation of 11-oxaprostaglandins and intermediates therein
For the preparation of an 11-oxaprostaglandin such as [2R,(1E,3R),3S,(4Z),4R)]-7-{tetrahydro-2-[4-(3-chlorophenoxy
)-3-hydroxy-1-butenyl]-4-hydroxy-3-furanyl}-4-heptenoic acid and its ester...
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6875784 |
Antimibicrobial [3.1.0.] bicyclic oxazolidinone derivatives
The present invention provides certain [3.1.0] bicyclic oxazolidinone derivatives of Formulea I and II, described herein, or pharmaceutically acceptable salts or prodrugs thereof that are...
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6864283 |
Oxy-and amino-substituted tetrahydrofuryl derivatives with antitumour activity
Compounds of formula (I) wherein R 1 is selected from H, C(═O)R′, P(═O)R′R″, S(═O)R′R″, substituted or unsubstituted C 1 -C 18 alkyl, substituted or unsubstituted C 2 -C 18 ...
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6864285 |
Covalent derivatives of alkanolamides of monocarboxylic and dicarboxylic acids functionally active on the CB2 cannabinoid receptor
The present invention relates to novel covalent derivatives of alkanolamides of monocarboxylic and dicarboxylic acids with aminoalcohols of general formula (I) which can usefully be used as...
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6849733 |
Neuropeptide-Y ligands
There are disclosed novel neuropeptide Y ligands having the general formula I
Wherein the symbols W, A, D, R 1 , R 2 , R 3 , R 4 are further defined in the description. Compounds of formula I...
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6844452 |
Process for the co-production of aliphatic diols and cyclic ethers
A process for the co-production of a diol product (e.g. butane-1,4-diol) and a cyclic ether (e.g. tetrahydrofuran) by hydrogenation of an aliphatic diester or lactone feedstock (e.g. dimethyl or...
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6818664 |
Angiogenesis inhibitor
A compound represented by the following formula (I) or a salt thereof and a medicament such as an angiogenesis inhibitor and an antitumor agent which comprises said compound or a physiologically...
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6764829 |
Nucleoside hydrolase and nucleoside phosphorylase detection kits, dipsticks and substrates
The invention relates to a method of detecting and/or assaying nucleoside hydrolases or nucleoside phosphorylases using a chromogenic substrate. Preferred chromogenic substrates have formula (I)...
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6710078 |
5-Substituted-3(2H)-furanones useful for inhibition of farnesyl-protein transferase
Compounds of Formula (I): wherein R 1 , R 2 , R 3 , X, Y, Z and Q are as defined in the specification which compounds are inhibitors of Ras farnesyl-protein transferase enzyme (FPTase), and...
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6620947 |
Compounds for use in 11-oxa prostaglandin synthesis
Novel processes and intermediates useful in the preparation of 11-oxa prostaglandin analogs are disclosed.
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6593478 |
Stereospecific hydrolysis of optically active esters
A new, more efficient and highly stereospecific process is described for the preparation of compounds with general formula (R)-(I) and of absolute configuration (R), where the groups M, W, Q and Q...
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6566375 |
Elevation of HDL cholesterol by 4-&lsqb (aminothioxomethyl)-hydrazono&rsqb -N-(substituted)-4-arylbutanamides
Compounds of this invention increase plasma levels of high density lipoprotein or HDL, the “good” cholesterol and as such may be useful for treating diseases such as atherosclerosis. These...
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6548539 |
Agents for regulation of colon cancer gene expression
Compounds of the general structure according to Formula (I) wherein R 1 is selected from alkyl, alkenyl, alkynyl, heteroalkyl, haloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl,...
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6537527 |
Skin lightening compositions
This invention relates to compositions, compounds, and methods for lightening skin, using active compounds having the general structure: wherein each X is halo; m is 1 to 4; each R′ and R″...
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6441196 |
Processes and novel intermediates for 11-oxa prostaglandin synthesis
Novel processes and intermediates useful in the preparation of 11-oxa prostaglandin analogs are disclosed.
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6410748 |
Alicycli c group-containing monomer
A monomer represented by the following general formula (m-1): wherein R is a group having an alicyclic skeleton, R 2 s may be the same or different and are individually hydrogen atom, halogen...
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6403814 |
Method for synthesizing diaryl-substituted heterocyclic compounds, including tetrahydrofurans
A method is provided for synthesizing diaryl-substituted heterocyclic compounds, particularly 2,5-diaryl-substituted tetrahydrofurans and tetrahydrothiophenes. Methods for synthesizing starting...
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6388128 |
Stannane synthesis of prostanoids
The present invention is directed to novel methods of prostanoid synthesis. Specifically, the invention is directed to the addition of alpha chains to prostanoids using cis-alkenylstannane...
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6379911 |
Enzyme detection/assay method and substrates
The invention relates to a method of detecting and/or assaying nucleoside hydrolases or nucleoside phosphorylases using a chromogenic substrate. Preferred chromogenic substrates have formula (I)...
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6376502 |
Osteoporosis compounds
This invention relates to prostaglandin agonists, methods of using such prostaglandin agonists, pharmaceutical compositions containing such prostaglandin agonists and kits containing such...
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6369102 |
Substituted tetrahydrofuran analogs of prostaglandins as ocular hypotensives
Substituted tetrahydrofuran analogs of prostaglandins and methods of their use in treating glaucoma and ocular hypertension are disclosed.
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6359155 |
Process for the preparation of 3-hydroxytetrahydrofuran
An industrial advantage process for producing high-purity 3-hydroxytetrahydrofuran easily and simply, which comprises reducing a 4-halo-3-hydroxybutyric acid ester (1) with a boron hydride...
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6350909 |
Methoxymino-phenylacetamide derivatives and their utilization as pesticides
The invention relates to new imides, to a plurality of processes for their preparation and to their use as fungicides.
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6350761 |
Benzenamine derivatives as anti-coagulants
This invention is directed to benzenamine derivatives of formula (I): wherein A, W, m, n, R 1 , R 2 , R 3 , R 4 , R 5 and R 6 are defined herein. These compounds are useful as anti-coagulants.
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6281367 |
Process for the synthesis of HIV protease inhibitors
An improved process for the synthesis of (3S)-tetrahydro-3-furyl N-[(1S,2R)-3 -(4-amino-N-isobutylbenzenesulphonamido)-1-benzyl-2-hydroxyp
ropyl]carbamat e comprising four steps form the compound...
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