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7592337 |
Di-aryl substituted tetrazole modulators of metabotropic glutamate receptor-5
Tetrazole compounds substituted directly, or by a bridge, with i) a heteroaryl moiety containing N adjacent to the point of connection of the heteroaryl and ii) another heteroaryl or aryl ring,...
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7589219 |
2,5-bis-diamine-[1,4]benzoquinonic derivatives, useful for the treatment of alzheimer's disease, method for preparing them and intermediates of said method
2,5-bis-diamine-[1,4]benzoquinonic derivatives, having a general formula (I) have proved useful for the treatment of Alzheimer's disease; a method for preparing them and intermediates used in said...
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7585882 |
Phosphodiesterase 4 inhibitors
Selective PDE4 inhibition is achieved by novel compounds, e.g., 4-(substituted-phenyl)-2-pyrrolidinone compounds. The compounds of the present invention are of formula I:
wherein R 1 , R 2 ,...
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7517893 |
Bichalcophenes and their prodrugs as antiprotozoal agents
Novel dicationic bichalcophene compounds are described. The presently disclosed novel dicationic bichalcophene compounds exhibit in vitro activity versus Trypanosoma brucei rhodesiense, Plasmodium...
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7517471 |
As-indacen derivatives
The present invention relates to compounds of the formula I
where
X 1 , X 2 , R 1 , R 2 , A 1 , A 2 , Z 1 , Z 2 , m, n and rings B and B′ are as defined in claim 1.
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7456249 |
Catalyst, its preparation and the polymerization of cyclic ethers over this catalyst
The present invention relates to a solid, acid catalyst for the preparation of polytetrahydrofuran, polytetrahydrofuran copolymers, diesters or monoesters of these polymers by polymerization of...
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7365089 |
Triazolo-quinolin derivatives useful as adenosine receptor ligands
The present invention relates to adenosine A 3? receptor ligands of the general formula (I), within those preferably antagonists, as well as their salts, solvates and isomers, and the...
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7282519 |
Nitrosated and nitrosylated diuretic compounds, compositions and methods of use
The invention describes novel nitrosated and/or nitrosylated diuretic compounds or pharmaceutically acceptable salts thereof, and novel compositions comprising at least one nitrosated and/or...
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7276573 |
Method for producing monoesters and diesters of polytetrahydrofuran and of tetrahydrofuran copolymers
The present invention provides a process for preparing mono- or diesters of polytetrahydrofuran or of tetrahydrofuran copolymers by polymerizing tetrahydrofuran in the presence of at least one...
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7153884 |
C-2′ methylated derivatives of paclitaxel for use as antitumour agents
Taxane derivatives of formula (I) in which: R is trifluoromethyl, phenyl, 2-furyl, 2-thienyl; R 1 is t-butoxycarbonyl or benzoyl; R 2 is hydroxy; R 3 is hydrogen or, together with R 2 , it forms...
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7128983 |
Furan-containing hole transporting materials
A furan-containing compound of formula (I):
Ar is aryl, heteroaryl, or oligoaryl; A is furyl; B is aryl or heteroaryl; R 1 is hydrogen, alkenyl, alkynyl, aryl, heteroaryl, cyclyl,...
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7078542 |
Nonlinear optical compounds and methods for their preparation
Nonlinear optically active compounds, methods for making nonlinear optically active compounds, compounds useful for making nonlinear optically active compounds, methods for making compounds useful...
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7019024 |
Pharmaceutical for treatment of neurological and neuropsychiatric disorders
The invention provides a pharmaceutical for treatment of neurological and neuropsychiatric disorders comprising a compound of the formula:
or a pharmaceutically acceptable salt thereof.
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7018430 |
Method of mass-coloring synthetic materials
The present invention relates to a method of mass-coloring synthetic materials, which comprises using at least one pigment dye of formula (1) wherein R and R 1 together form a phenyl or heteroaryl...
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6965041 |
N-acylphosphoramidites and their use in oligonucleotide synthesis
The present invention provides a compound of formula (I), (II), or (III), wherein R 1 , R 2 , R 2′ , R 3 , and R 3′ are the same or different and each is H an alkyl, an alkenyl, an alkynyl, a...
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6933091 |
Photoconductor for electrophotography and quinomethane compound
A highly sensitive positively charged type electrophotographic photoconductor includes an organic compound that transports electrons efficiently, improving light emission efficiency. The...
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6887737 |
Epoxidized acetals and thioacetals, episulfidized acetals and thioacetals, and reworkable thermosetting resin compositions formulated therefrom
This invention relates to epoxidized acetals and thioacetals, episulfidized acetals and thioacetals, thermosetting resin compositions based on such epoxidized acetals and thioacetals, episulfidized...
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6869967 |
Peroxisome proliferator-activated receptor (PPAR) active vinyl carboxylic acid derivatives
Novel compounds of the general formula (I), the use of these compounds as pharmaceutical compositions, pharmaceutical compositions comprising the compounds and methods of treatment employing these...
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6693201 |
Fluorescent photochromic fulgides, particularly for optical memories
Photochromic chemicals consisting essentially of colored fluorescent heterocyclic fulgides are particularly suitable for optical memories. The preferred heterocyclic photochromic fulgides consist...
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6677341 |
(R)-Chiral halogenated substituted heteroaryl benzyl aminoalcohol compounds useful for inhibiting cholesteryl ester transfer protein activity
The invention relates to substituted aryl and heteroaryl (R)-Chiral Halogenated 1-Substitutedamino-(n+1)-Alkanol compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma...
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6599648 |
Heterarylbenzene compounds
A method of preparing a compound of formula I is described. In this compound, each of R 1 -R 6 is, independently, in which Y is O, S, NH, or C(R 7 )═C(R 8 ). Each of R 7 -R 11 is,...
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6521660 |
3′-alkyl substituted taxanes and pharmaceutical compositions containing them
Taxane derivatives having an alkyl substituted C13 side chain.
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6512122 |
Hetarylbenzene compounds
A method of preparing a compound of formula I is described. In this compound, each of R 1 -R 6 is, independently, in which Y is O, S, NH, or C(R 7 )═C(R 8 ). Each of R 7 -R 11 is,...
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6492416 |
4,5-diaryl-3(2H)-furanone derivatives as cyclooxygenase-2 inhibitors
The present invention provides a novel class of 4,5-diaryl-3(2H)-furanone derivatives, which inhibit strongly and selectively COX-2 over COX-1. They are useful to treat inflammation,...
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6455711 |
Method for producing polytetrahydrofuran
A process for preparing polytetrahydrofuran, polytetrahydrofuran copolymers or diesters or monoesters of these polymers comprises polymerizing tetrahydrofuran in the presence of at least one...
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6410754 |
Photochromic spiropyrans, and compositions and articles containing same
Novel spiropyran compounds, particularly with photochromic properties, are disclosed, as well as photochromic compositions and ophthalmic articles containing said compounds. The photochromes have...
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6399786 |
Nonacyclic nodulisporic acid derivatives
The present invention relates to novel nodulosporic acid derivatives, which are acaricidal, antiparasitic, insecticidal and anthelmintic agents.
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6359150 |
Photochromic compound and optical function device using the same
A novel diarylethene photochromic compound is provided. The photochromic compound is capable of forming an amorphous thin film by itself through a coating method and has an excellent...
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6284785 |
1-arenesulfonyl-2-aryl-pyrrolidine and pyridine derivatives
1-Arenesulfonyl-2-Aryl-pyrrolidine and pyridine derivatives having activity as ligands of metabotropic glutamate receptors of the formula ##STR1## are disclosed.
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6265428 |
Substituted phenyl compounds and derivatives thereof that modulate the activity of endothelin
Methods, compositions, and compounds for modulating the activity of an endothelin peptide are provided. The methods use compositions that contain compounds of formula (1): ##STR1## where X and Y...
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6258839 |
Isolation of naturally occuring isoflavanone and some clinical uses thereof
A compound of general formula I ##STR1## in which the 2-3 bond in ring C could be double or single bond. Ring B and its substituents may be attached at position 2 (at J) in ring C. The key...
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6235956 |
Acetals, their preparation and their use
An acetal, wherein the acetal is 2,2-di(tetrahydrofurfuryloxy)propane as well as processed for producing the acetal and methods of using the acetal.
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6201140 |
7-0-ethers of taxane derivatives
The present invention concerns novel 7-ethers of taxane derivatives, their use as antitumor agents and pharmaceutical compositions containing the novel compounds.
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6197979 |
Method for producing polytetrahydrofuran with low color index
In a process for preparing polytetrahydrofuran, tetrahydrofuran copolymers, diesters or monoesters of these polymers having a low color number by polymerization of tetrahydrofuran in the presence...
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6180651 |
Diarylmethylidenefuran derivatives, processes for their preparation and their uses in therapeutics
The present invention relates to derivatives of the formula ##STR1## the process for their preparation, and to their uses in therapeutics, especially as drugs with anti-inflammatory, analgesic and...
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6150540 |
Versatile intermediate for annonaceous acetogenins
A tetrahydrofuran (THF) epoxide and method of its preparation according to a novel stereoselective synthetic method. The compounds of the invention are used to prepare therapeutically active...
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6136847 |
Water-soluble trioxanes as potent and safe antimalarial agents
Biologically-active, water soluble, 3-substituted trioxanes of the formula ##STR1## wherein R represents a COOH-- substituted aryl group, a substituted or unsubstituted heteroaryl group or an alkyl...
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6120859 |
Polymerisable, optically active dioxolane diesters
Polymerisable optically active compounds have the general formula: ##STR1## where: W 1 denotes a polymerisable residue, S 1 denotes a spacer unit, Y 1 denotes a single bond, or one of the...
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6072021 |
Copolymerization of formaldehyde and cyclic ethers using initiators based upon tetraphenyl borates
This invention concerns a process for the copolymerization of formaldehyde with cyclic ethers, the process comprising combining in a hydrocarbon solvent a cyclic ether, a cationic initiator...
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6063928 |
5-lipoxygenase inhibitors
Novel compounds having the ability to inhibit 5-lipoxygenase enzyme and having the following formula I: ##STR1## and the pharmaceutically acceptable salts thereof, wherein Ar 1 is a heterocyclic...
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6060575 |
1,4-bis(3,4-dicarboxyphenoxy)-2-tert-butylbenzene dianhydride and method of using the same
The present invention provides a series of easily processable poly(ether-imide)s that are organic-soluble and can afford colorless films, their organic solutions and their manufacturing process....
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6057342 |
Amidinophenyl-pyrrolidines, -pyrrolines, and -isoxazolidines and derivatives thereof
The present application describes amidinophenyl-pyrrolidines, -pyrrolines, and -isoxazolidines and derivatives thereof of formula I: ##STR1## or pharmaceutically acceptable salt forms thereof,...
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6017947 |
Heterocyclic carbodithioperoxyimidic compounds useful for the inhibition of the replication of HIV
useful for the inhibition of the replication of HIV-1, in vitro and in vivo.
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6013666 |
Oxirane carboxylic acid derivative and its manufacturing method
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6011161 |
Process for the preparation of 2-aryl-5-(perfluoroalkyl)pyrrole compounds from N-(perfluoro-alkylmethyl)arylimidoyl chloride compounds
There is provided a process for the preparation of 2-aryl-5-(perfluoroalkyl)pyrrole compounds from N-(perfluoroalkylmethyl)arylimidoyl chloride compounds. The 2-aryl-5-(perfluoroalkyl)pyrrole...
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5994394 |
Polyheterocyclic compounds
The present invention relates to a group of polyheterocyclic compounds covered by the following formula: ##STR1## wherein each of X 1 , X 2 , X 3 , and X 4 , independently, is O, S, NH, or N(C 1 -6...
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5990313 |
Preparation of 3-alkyltetrahydrofurans
Disclosed is a process for the preparation of 3-alkyltetrahydrofurans by a two-step process wherein 2,3-dihydrofuran is reacted with an acetal to form an intermediate compound which may be...
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5914410 |
Intermediates for annonaceous acetogenins
Novel tetrahydrofuran-epoxide compounds are described as intermediates for the preparation of non-adjacent bis-THF-acetogenins of pharmaceutical interest. Also described is a novel stereocontrolled...
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5869658 |
Photochromic indeno-fused naptho 2,1-b!pyrans
Described are novel photochromic indeno-fused naphthopyran compounds having certain substituents at the 2-position of the pyran ring and an alkoxy group at the number 6 carbon atom. Certain other...
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5821373 |
Solid sloutions of 1,4-diketopyrrolopyrroles
Solid solutions consisting of 3,6-bis(biphenyl-4-yl)- 2,5-dihydropyrrolo 3,4-c!pyrrole-1,4-dione and either a) a second 1,4-diketopyrrolopyrrole or b) a quinacridone, which are further defined...
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