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7601856 |
Benzofurans as potassium ion channel modulators
The present invention is directed to compounds of Formula I:
that are potassium channel modulators and pharmaceutical compositions thereof. The present invention is further directed to methods...
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7563900 |
Process for the preparation N-(3,5-dichloropyrid-4-yl)-4-difluoromethoxy-8-methane sulfonamido-dibenzo[b,d]furan-1-carboxamide
The present invention relates to a method of preparing N-(3,5-dichloropyrid-4-yl)-4-difluoromethoxy-8-methanesulfon
amido-dibenzo[b,d]furan-1-carboxamide and pharmaceutically acceptable salts...
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7524878 |
Phenyl substituted carboxylic acids
Disclosed are compounds and pharmaceutically acceptable salts of formula (A):
which are useful in the treatment of metabolic disorders related to insulin resistance, leptin resistance, or...
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7498356 |
Substituted amino carboxylic acids
Disclosed are compound and pharmaceutically acceptable salts of formula (I):
which are useful in the treatment of metabolic disorders related to insulin resistance, leptin resistance, or...
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7465825 |
Phenyl substituted carboxylic acids
Disclosed are compounds and pharmaceutically acceptable salts of formula (A):
which are useful in the treatment of metabolic disorders related to insulin resistance, leptin resistance, or...
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7417157 |
Hexahydrodibenzofuran derivatives
Disclosed are hexahydrodibenzofuran compounds of formula I,
the preparation thereof, the use thereof as components in liquid-crystalline media, and to electro-optical display elements which...
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7393846 |
Heterocyclic compounds useful for the treatment of inflammatory and allergic disorders
The present invention relates to novel heterocyclic compounds, their analogs, their tautomers, their regioisomers, their stereoisomers, their enantiomers, their diastereomers, their polymorphs,...
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7351825 |
Cyclopropane compounds and pharmaceutical use thereof
The present invention provides a compound having aggrecanase inhibitory activity and MMP-13 inhibitory activity, and useful as a therapeutic agent for osteoarthritis, rheumatoid arthritis and the...
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7288543 |
Opioid receptor antagonists
A compound of the formula (I) (I) wherein the variables X1 to X6, Ra, Rb, R1 to R7 including R3′, E, p, j, y, z, A, B and C are as described or a pharmaceutically acceptable salt, solvate,...
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7238725 |
Tricyclic compounds useful for the treatment of inflammatory and allergic disorders: process for their preparation and pharmaceutical compositions containing them
The present invention relates to novel tricyclic compounds useful for the treatment of inflammatory conditions, diseases of the central nervous and insulin resistant diabetes.
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7196089 |
EP4 receptor antagonists
Compounds of formula (I):
wherein: R 2 is H or an optionally substituted C 1-4 alkyl group; Y is either —(CH 2 ) n —X—, where n is 1 or 2 and X is O, S, S(═O), S(═O) 2 , or NR N1 ,...
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7186752 |
Derivatives of N-(iminomethyl)amines, their preparation, their use as medicaments and the pharmaceutical compositions containing them
N-(imino)amines and their preparation and their use as NO synthase inhibitors and selective or non-selective traps for a reactive oxygen species.
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6624177 |
Matrix metalloproteinase inhibitors and their therapeutic uses
The present invention relates to a method of inhibiting matrix metalloproteinases using compounds that are dibenzofuran sulfonamide derivatives having the Formula I More particularly, the...
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6562842 |
Protease inhibitors
The present invention provides compounds which inhibit proteases, including cathepsin K, pharmaceutical compositions of such compounds, and methods for treating diseases of excessive bone loss or...
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6472545 |
Protein tyrosine phosphatase inhibitors
Compounds of formula (I) or therapeutically acceptable salts thereof, are protein tyrosine kinase PTP1B inhibitors. Preparation of the compounds, compositions containing the compounds, and...
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6407100 |
Fungicidal aromatic oximes
The invention relates to novel compounds of the formula in which R 1 is C 1-4 alkyl and (Y—X) is CH 2 , C 1-2 alkylthio-CH═ or C 1-2 alkyl-ON═ and Z is an aldimino or ketimino group, and...
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6350885 |
Tricyclic heteroaromatics and their derivatives as inhibitors of matrix metalloproteinases
Tricyclic heteroaromatic compounds and derivatives are described as well as methods for the preparation and pharmaceutical compositions of same, which are useful as inhibitors of matrix...
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6172104 |
Dicationic dibenzofuran and dibenzothiophene compounds and methods of use thereof
Methods of treating Pneumocystis carinii pneumonia comprise administering a therapeutically effective amount of a dicationic dibenzofuran compound described by Formula (I). Methods of treating...
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6069166 |
Fused heterocyclic benzenecarboxamide derivatives and PGD.sub.2 antagonists comprising them
A compound, pharmaceutically acceptable salt thereof, or hydrate thereof having a PGD 2 -antagonistic activity, and an inhibitory activity against infiltration of eosinophils, useful for treating...
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6037367 |
Substituted-pent-4-ynoic acids
Compounds of formula (I) wherein: R 1 is --(CR 4 R 5 ) n C(O)O(CR 4 R 5 ) m R 6 , --(CR 4 R 5 ) n C(O)NR 4 (CR 4 R 5 ) m R 6 , (CR 4 R 5 ) n O(CR 4 R 5 ) m R 6 , or --(CR 4 R 5 ) r ...
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6037361 |
Fluorinated butyric acids and their derivatives as inhibitors of matrix metalloproteinases
Fluorinated butyric acid compounds and derivatives are described as well as acid methods for the preparation and pharmaceutical compositions of same, which are useful as inhibitors of matrix...
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6020366 |
Butyric acid matrix metalloproteinase inhibitors
Compounds of the formula ##STR1## wherein R 1 and R 2 include hydrogen, alkyl, substituted alkyl, halo, and arylalkyl; R 3 is hydroxy, alkoxy, or hydroxyamino; X is O, S, or NOH; and R 4 and R...
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5969163 |
Ortho-quinone derivatives, novel synthesis therefor, and their use in the inhibition of neoplastic cell growth
A process for the preparation of β-lapachone and dunnione derivatives of formulae I and II ##STR1## wherein, the a solution of lawsone in dimethylsufoxide at a temperature of -78° C. or less is...
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5846995 |
Substituted 1, 2, 3, 4-tetrahydro-2-dibenzofuranamines and 2-amino-cyclohepta (6, 7-B) Benzofurans
The invention provides substituted-2-amino-1,2,3,4-tetrahydrodibenzofurans and 2-aminocyclohepta b!benzo-furans useful as 5-HT 1F agonists.
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5843997 |
Excitatory amino acid receptor antagonists
The present invention provides novel compounds that affect excitatory amino acid receptors and are useful in the treatment of neurological disorders. This invention also provides synthetic methods...
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5840927 |
Sesquiterpene compounds
Novel anti-microbial sesquiterpene compounds isolated from the fruit bodies of Roseofomes subflexibilis (Hounen-take) having the general formula ##STR1##
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5716986 |
Oxaindene derivatives and process for the preparation thereof
This invention relates to new oxaindene derivatives, a process for the preparation thereof and pharmaceutical compositions comprising the same. The compounds according to the invention are...
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5627206 |
Tricyclic inhibitor of matrix metalloproteinases
A tricyclic compound is described as well as pharmaceutical compositions of same, which is useful as an inhibitor of matrix metalloproteinases, particularly gelatinase A (72 kD gelatinase) for the...
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5543433 |
Azine-substituted phenylacetic acid derivatives and fungicides containing these
Compounds of the formula I ##STR1## where X is hydrogen, halogen, alkyl, alkoxy, trifluoromethyl, cyano or nitro, Y is an amino, methylamino or dimethylamino group, Z is a group CHCH 3 ,...
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5541333 |
Carbazole derivatives
Novel tethered hapten intermediates and related conjugates based on carbazole and/or dibenzofuran, as well as methods for making and using such conjugates. Haptens based on the above core...
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5536746 |
Insecticidal phenylhydrazine derivatives
Compounds having the structural formula ##STR1## where X, Y, R and Z are defined in the specification are disclosed. The compounds of this invention are effective for controlling mites, nematodes,...
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5496849 |
Sulfonic acid derivative and its pharmaceutical application
The present invention discloses sulfonamide derivative represented by the following general formula: ##STR1## [wherein, R 1 is (i) --COOR 2 (where, R 2 is (1) hydrogen, (2) a...
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5457237 |
Dihydroxyindanone tyrosine kinase inhibitors
Certain dihydroxyindanone compounds, and their pharmaceutically-acceptable salts, are inhibitors of tyrosine kinase enzymes, and so are useful for the control of tyrosine kinase dependent diseases...
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5401769 |
Dibenzofuranyl N-alkyl carbamates
A compound of formula A: ##STR1## wherein R 1 and R 2 are, independently, hydrogen, fluorine, chlorine, bromine, iodine, trifluoromethyl, cyano, nitro, alkyl, alkoxy, --CO 2 H, alkylcarbonyl,...
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H001406 |
Process for preparing dibenzofurans via catalytic heteroannulation
The present invention is directed to the synthesis of 2-chloro-cis-[5a(S)-9a(S)-(5a,6,7,8,9,9a-hexahydro)]dibenzof
uran-4-carboxy lic acid by a stereospecific catalytic heteroannulation synthesis...
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5278323 |
Process for preparing chiral dibenzofurans via intramolecular heck reaction
The present invention is directed to the synthesis of 2-chloro-cis-[5a(S)-9a(S)-(5a,6,7,8,9,9a-hexahydro)]dibenzof
uran-4-carboxy lic acid by an intramolecular Heck stereospecific synthesis...
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5276053 |
Polycyclic amines useful as cerebrovascular agents
A novel series of polycyclic amines, derivatives, methods of making the compounds, novel intermediates, compositions containing them, and methods for using them in the treatment and prevention of...
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5231198 |
Asymmetric synthesis of hexahydrodibenzofurans by stereospecific inversion of ortho substituted 2-phenylcyclohexanols
This invention relates to the stereospecific process for the preparation, separation and purification of hexahydrodibenzofurans which are used in the preparation of the 5HT 3 compounds. More...
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5219879 |
Heterocyclic steroid compounds
The present invention relates to novel substituted 15-oxa-, 15-thia-, and 15-aza- dihydrolanosterols, to pharmaceutical compositions containing such compounds, and to methods of using these...
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5145954 |
Derivatives of alphaphenylacrylic acid and their use in agriculture
Compounds of formula: ##STR1## and stereoisomers thereof, wherein R 1 and R 2 , which are the same or different, are optionally substituted alkyl; W, X, Y and Z, which are the same or different,...
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5019573 |
Substituted dibenzofurans and methods of using same
Novel substituted dibenzofuran compounds are disclosed. The compounds exhibit activity in antagonizing the effects of leukotriene B 4 (LTB 4 ). Pharmaceutical compositions containing the novel...
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4990630 |
2,3-diaminoacrylonitrile derivatives and process for making the same
The present invention relates to a 2,3-diaminoacrylonitrile derivative or salts thereof, having the formula ##STR1## wherein R represents an alkyl group (which may be substituted by unsubstituted...
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4983587 |
Dihydrodibenzofuran derivatives and fungicides containing these compounds
Substituted benzofuran derivatives of the formula ##STR1## where R 1 , R 2 and R 3 are hydrogen, an alkali or alkaline earth metal, alkyl, aralkyl, alkanoyl, halogen-substituted alkanoyl, benzoyl...
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4959485 |
Hexahydrodibenzofuran carboxylic acid derivatives
This invention is directed to certain dibenzofurancarboxamides and their use as 5HT 3 antagonists having unique CNS, anti-emetic and gastric prokinetic activity void of any significant D 2 ...
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4866070 |
Acenaphtho[1,2b]quinolinylmethylamino derivatives and pharmaceutical compositions containing them
The present invention relates to compounds of formula (I) ArCH 2 R 1 (I) or a monomethyl or monoethyl ether thereof (the compound of formula (I)...
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4866073 |
Acridinylmethylamino derivatives and pharmaceutical compositions containing them
The present invention relates to compounds of formula (I) ArCH 2 R 1 (I) or a monomethyl or monoethyl ether thereof (the compound of formula (I)...
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4855446 |
Process for the resolution of racemates using lactone esters
Racemic carboxylic acids are resolved into their enantiomers using optically active enantiomers of four lactones as resolving agents. The four lactones are 2,3-isopropylidene-ribonic...
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4831168 |
Process for preparing 2-hydroxydibenzofuran-3-carboxylic acid and alkali metal salts thereof
2-Hydroxydibenzofuran-3-carboxylic acid and its alkali metal salts are prepared by reacting an alkali metal salt of 2-hydroxydibenzofuran with carbon dioxide, where appropriate under pressure, at a...
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4769387 |
Dibenzofuran lipoxygenase inhibiting compounds, compositions and use
Compounds of the formula: ##STR1## wherein R 1 is (1) hydrogen, (2) C 1 to C 4 alkyl, (3) C 2 to C 4 alkenyl, or (4) NR 2 R 3 , wherein R 2 and R 3 are independently selected from hydrogen,...
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4501908 |
2,3-Isopropylidene ribonic acid, 1,4-lactones
Racemic carboxylic acids are resolved into their enantiomers using optically active enantiomers of four lactones as resolving agents. The four lactones are 2,3-isopropylidene-ribonic...
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