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5856531 |
Preparation of 3-methytetra-hydrofuran from 2,3-dihydrofuran
Disclosed is a two-step process wherein (1) 2,3-dihydrofuran is reacted with a trialkyl orthoformate in the presence of an acidic catalyst to produce a 2-alkoxy-3-(dialkoxymethyl)tetrahydrofuran...
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5852027 |
Antiviral 1,3-dioxolane nucleoside analogues
This invention includes the compounds 2'-deoxy-5-fluoro-3'-oxacytidine, (-)-2'-deoxy-5-fluoro-3'-oxacytidine, and (+)-2'-deoxy-5-fluoro-3+-oxacytidine, and pharmaceutically acceptable salts thereof...
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5808124 |
O- or S-substituted dihydronaphthalene derivatives having retinoid and/or retinoid antagonist-like biological activity
Compounds of the formula ##STR1## where the symbols have the meaning described in the application, have retinoid-like or retinoid antagonist-like biological activity.
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5718845 |
Tricyanovinyl substitution process for NLO polymers
Nonlinear optical compounds which contain a heteroaromatic ring and may further comprise a tricyanovinyl group attached to the heteroaromatic ring.
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5646158 |
1,3,3-(trisubstituted)cyclohex-1-ene monomers and related compounds
This invention relates to certain 1,3,3-(trisubstituted)cyclohex-1-ene monomers and related compounds which are useful in treating allergic and inflammatory diseases and for inhibiting the...
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5633367 |
Process for the preparation of a 2-substituted 3,3-difluorofuran
A process for the preparation of a 2-substituted-3,3-difluorofuran using diethyl ammonium sulfur trifluoride (DAST) and pyridine hydrogen fluoride. The process is particularly useful for producing...
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5618931 |
Acetylenes disubstituted with a 5 substituted dihydronaphthyl group and with an aryl or heteroaryl group having retinoid-like biological activity
Compounds of the formula ##STR1## wherein the symbols have the meaning described in the specification have retinoid-like biological activity.
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5614644 |
Process for the removal of organic chlorides from furan and hydrogenated furans
Disclosed is a process for the removal of organic chlorides from furan and hydrogenated furans by contacting a crude product stream comprising (i) furan, 2,3-DHF, 2,5-DHF, THF or a mixture thereof...
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5597932 |
Intermediate for the preparation of 19-nor vitamin D compounds
The invention is drawn to a compound having the following formula ##STR1## in which X 1 and X 2 , which may be the same or different, represent hydrogen or a hydroxy-protecting group, X 4 is...
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5559254 |
Separation of a mixture of methanol and tetrahydrofuran into its constituents
A process is disclosed for separating a mixture of methanol and tetrahydrofuran into its components. The separation is carried out in the liquid or gaseous phase through an organophilic membrane,...
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5536851 |
Preparation of 2,3-dihydrofurans
Disclosed is a process for the preparation of 2,3-dihydrofurans from the corresponding isomeric 2,5-dihydrofurans wherein a feed mixture comprising a 2,5-dihydrofuran compound and an aldehyde...
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5532228 |
Side-chain homologous vitamin D derivatives, process for their production, pharmaceutical preparations containing these derivatives and their use as pharmaceutical agents
The invention discloses side-chain homologous vitamin D derivatives of formula I ##STR1## in which R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , B, and D have the meanings defined in the specification and...
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5525745 |
Intermediates in the preparation of 19-nor vitamin D compounds
The invention describes intermediates for use in the synthesis of 1α-hydroxy-19-nor-vitamin D compounds. The intermediates have the following formula: ##STR1## The disclosed process includes (a)...
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5514683 |
Bicyclo 2,2,2!octane derivatives
The compounds of the formula I ##STR1## and their pharmaceutical acceptable salts, which are defined herein, are ligands for cholecystokinin and/or gastrin receptors.
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5510326 |
Multi-substituted tetrahydrofurans
Novel odorant compositions which are characterized by a content of one or more compounds selected from the group consisting of tetrahydrofurans of structures 1 or 2, or tetrahydropyrans of...
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5508435 |
Asymmetric hydrogenation of beta- or gamma-ketoesters and beta- or gamma-ketoamides
β- or γ-Ketoesters and β- or γ-ketoamides are asymmetrically reduced with a Ru(II)-BINAP derived catalyst at about 40° C. and about 50N/mm 2 of hydrogen in the presence of a strong acid.
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5451605 |
1,2-epoxycyclohexanyl and bicyclic aromatic substituted ethyne compounds having retinoid-like biological activity
Compounds of the formula ##STR1## where R 1 -R 5 are hydrogen, lower alkyl of 1-6 carbons, or halogen; A is (CH 2 ) n where n is 0-5, lower branched chain alkyl having 3-6 carbons, cycloalkyl...
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5425854 |
Separation of methylene chloride from tetrahydrofuran by extractive distillation
Methylene chloride is difficult to separate from tetrahydrofuran by conventional distillation or rectification because of the proximity of their vapor pressures. Methylene chloride can be readily...
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5424441 |
N-aralkyl-and N-heteroaralkyl-aminoalkanephosphinic acids
N-aralkyl- and N-heteroaralkyl-aminoalkanephosphinic acids of formula I ##STR1## wherein R is an aliphatic, cycloaliphatic, cycloaliphatic-aliphatic, araliphatic or heteroarylaliphatic radical...
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5414122 |
Process for producing alpha-ketoamide derivative
There is disclosed an efficient process for producing α-ketoacetamide of the formula: ##STR1## which is useful as an intermediate for the production of various alkoxyiminoacetamide compounds to be...
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5393923 |
3,5-di-t-butyl-4-hydroxyphenylmethylhydroxylamines and their derivatives, pharmaceutical compositions, and methods of use therefor
The present invention is a novel compound which is a 3,5-di-t-butyl-4-hydroxyphenylmethylhydroxylamine or derivative thereof and a pharmaceutically acceptable acid addition or base salt thereof,...
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5387681 |
Synthesis of bicyclic aromatic sulfonic acids sulfonyl chlorides and sulfonamides
This invention provides a novel process for the synthesis of bicyclic aromatic sulfonic acids employing reacting a bicyclic aromatic compound with sulfur trioxide-N,N-dimethylformamide complex in...
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5371242 |
Preparation of products of the reduction of 4-hydroxybutyric acid derivatives
Abstract of the Disclosure: Products of the reduction of 4-hydroxybutyric acid derivatives of the formula IIa ##STR1## where one of A and B is methylene and the other is cyclopropylidene, or of C 1...
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5359099 |
Controlled catalytic and thermal sequential pyrolysis and hydrolysis of mixed polymer waste streams to sequentially recover monomers or other high value products
A process of using fast pyrolysis in a carrier gas to convert a plastic waste feedstream having a mixed polymeric composition in a manner such that pyrolysis of a given polymer to its high value...
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5334333 |
Electroactive compounds, compositions and devices and methods of making the same
The present invention relates to electroactive compounds capable of undergoing a change in light absorption and refraction due to an applied electric field and a permanent change in refraction due...
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5310954 |
Process for preparing tetrahydrofuran
Separation of tetrahydrofuran (THF) from a mixture containing water, THF and a lower alkanol such as ethanol or methanol, is achieved by distillation in two zones, the vaporous mixture from the...
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5306821 |
Process for the preparation of tertiary carbinamines
This invention relates to a novel process for the preparation of tertiary carbinamines by double addition of organolanthanide reagents, especially organocerium reagents, to nitriles. It further...
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5290773 |
Sulfonyl derivatives
A sulfonyl compound of the formula ##STR1## The above illuminated formula (I) undergo bimolecular condensation by the condensing agents and easily form simple metal salts especially metal complexes...
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5286889 |
Transmetalations from zirconium to copper intermediates
Higher order cuprate complexes are prepared by means of a transmetalation from a corresponding zirconate intermediate. This process is particularly valuable with respect to the preparation of...
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5284980 |
Block copolyethers via oxonium coupling of poly(tetramethylene ether) glycols
Treatment of poly(tetramethylene ether) glycols with acid catalysts at elevated temperatures leads to a chain coupling with rapid increase in molecular weight. Various alcohols including diols and...
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5283355 |
Benzoquinone compounds
Compounds of the Formula (5) and processes for their preparation and use, particularly in the manufacture of unsymmetrical triphenodioxazine dyes: ##STR1## wherein: Y is H, alkyl, substituted...
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5266708 |
New intermediates, process for their preparation, and their use for the synthesis of vitamins A and E
New intermediates and processes for the preparation of vitamins A and E, which are the acetals of 5,6-dihalo-3-methyl-3-hydroxyhexanal or of 6-halo-3-hydroxy-3-methyl-5-hexenal or...
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5258551 |
Process for producing α-ketoamide derivative
There is disclosed an efficient process for producing α-ketoacetamide of the formula: ##STR1## which is useful as an intermediate for the production of various alkoxyiminoacetamide compounds to be...
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5209825 |
Preparation of purified concentrated BDO
A distillation process for the preparation of purified concentrated BDO. High boiling impurities, including color formers, precursors of color formers and tar formers are removed from the BDO early...
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5206394 |
Lewis base complexes of alkali metal salts
Disclosed is a process for the manufacture of alkali metal salt complexes of the formula (M x X.nL) y , where M is an alkali metal, e.g. lithium, X is an anion, e.g. halide or thiocyanate, L is an...
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5166382 |
Transmetalations from zirconium to copper intermediates
Higher order cuprate complexes are prepared by means of a transmetalation from a corresponding zirconate intermediate. This process is particularly valuable with respect to the preparation of...
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5144047 |
Process for the production of tetronic acid alkyl esters
Tetronic acid alkyl esters are produced at a higher temperature by a ring closure of 4-halo-3-alkoxy-2-butene carboxylic acids. The tetronic acid alkyl esters are reacted by in acid hydrolysis in...
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5128370 |
Furans and lactones from sterptomycetes and the use thereof
New furans and lactones from streptomycetes, a process for the preparation thereof, and the use thereof. It is possible with the aid of various streptomycetes species to prepared new compounds...
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5104995 |
4-(3,3-ethylenedioxo- cyclohexyl) acetophenone and derivatives thereof, processes for preparing them and use of these compounds
The invention is concerned with the preparation of 2-[4-(3-oxo- cyclohexyl)phenyl] propionic acid and of its derivatives. This preparation consists in transforming 4-(3,3-ethylenedioxo- cyclohexyl)...
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5103056 |
Amidoamines derived from amines with aminopropyl and secondary amine termini
Disclosed is a method for selective formation of amidoamines which comprises reacting a carboxylic acid group, such as, for example, a diacid or an aliphatic acid terminated amide with an...
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5087726 |
Carbamate ACAT inhibitors
This invention relates to novel compounds which are ACAT inhibitors rendering them useful in lowering blood cholesterol levels. The compounds are carbamates represented by the general formula...
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5055599 |
Process for the hydrogenation of maleic anhydride to tetrahydrofuran and gamma-butyrolactone
Tetrahydrofuran and gamma-butyrolactone are prepared from at least one of maleic anhydride or succinic anhydride by catalytically hydrogenating vaporous maleic anhydride or vaporous succinic...
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5008408 |
Preparation of 1,4-butanediol and tetrahydrofuran
Mixtures which contain 1,4-butanediol and tetrahydrofuran are prepared by heating 4-hydroxybutyraldehyde of the formula ##STR1## at 20°-300° C. in the presence or absence of 1,4-butanediol and...
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4978430 |
Method for dehydration and concentration of aqueous solution containing organic compound
An improved method for dehydration and concentration of an aqueous solution containing an organic compound is disclosed. The solution is evaporated to produce a gaseous mixture comprising an...
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4978653 |
Derivative of 2-cyclohexylpropanal and perfumery composition comprising the same
2-Cyclohexylpropanal derivatives are disclosed. The derivatives are represented by the following formula (I): ##STR1## wherein P is a hydrogen atom and Q represents a group --CHN--OH or a group...
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4962210 |
Process for the preparation of high-purity tetrahydrofuran
Disclosed is a process for the preparation of high-purity tetrahydrofuran from a mixture of 2,5-dihydrofuran and 3,4-epoxy-1-butene and/or crotonaldehyde wherein the mixture is hydrogenated in the...
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4919765 |
Process for the purification of tetrahydrofuran
Tetrahydrofuran is recovered by a two stage distillation procedure from a crude hydrogenation product resulting from vapor phase hydrogenation of diethyl maleate and containing water, ethanol and a...
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4918204 |
Tetrahydrofuran purification
Purification of tetrahydrofuran from the dehydrocyclization of 1,4-butanediol in the presence of an organic acid catalyst has been accomplished by the extractive distillation of crude...
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4912236 |
Purification of tetrahydrofuran by distillation
Crude water-containing tetrahydrofuran is purified by distillation by a process in which the crude tetrahydrofuran is passed through three distillation columns, water being removed from the bottom...
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4875980 |
Method for separating and concentrating an organic component from an aqueous solution containing same
Disclosed is a method for separating and concentrating an organic component having a lower boiling point than water from an aqueous solution containing the organic component which comprises the...
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