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6680391 |
Treatment of skin conditions
The present invention provides piperine and analogues or derivatives thereof for the treatment of skin conditions treatable by stimulation of melanocyte proliferation, such as vitiligo, and also...
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6660728 |
Thienyl substituted acylguanidines as inhibitors of bone resorption and vitronectin receptor antagonists
The present invention relates to thienyl substituted acylguanidine derivatives, such as compounds of formula (I) in which R 1 , R 2 , R 4 , R 6 , A, B and D have the meanings indicated in the...
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6620841 |
Aromatic heterocycle compounds having HIV integrase inhibiting activities
A compound of the formula (I): wherein X is hydroxy, protected hydroxy or optionally substituted amino; Y is —COOR A wherein R A is hydrogen or ester residue, —CONR B R C wherein R B and...
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6566381 |
Hetero-substituted metalloprotease inhibitors
Heterocyclic substituted compounds having the general structure: which are inhibitors of metalloproteases and which are effective in treating conditions characterized by excess activity of these...
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6548524 |
Preparation and use of ortho-sulfonamido bicyclic heteroaryl hydroxamic acids as matrix metalloproteinase and TACE inhibitors
This invention provides, non-peptide inhibitors of matrix metalloproteinases (e.g. gelatinases, stromelysins and collagenases) and TNF-α converting enzyme (TACE. tumor necrosis factor-α...
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6541676 |
Integrated palladium-based micromembranes for hydrogen separation and hydrogenation/dehydrogenation reactions
The present invention relates to gas separation membranes including a metal-based layer having sub-micron scale thicknesses. The metal-based layer can be a palladium alloy supported by ceramic...
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6521765 |
Process for the preparation of 3-methyltetrahydrofuran
Disclosed is a process for the preparation of 3-methyltetrahydrofuran (MeTHF) from 3-(hydroxymethyl)tetrahydrofuran (HOMeTHF) by contacting HOMeTHF with hydrogen in the presence of an acidic,...
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6514996 |
Derivatives of benzofuran or benzodioxole
An oxygen-containing heterocyclic compound represented by following Formula (I): wherein R 1 and R 2 independently represent hydrogen, lower alkyl, cyano, —(CH 2 ) n —E 1 —CO—G 1 ...
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6509474 |
Method of lithiating five membered heterocycles
The invention relates to a method of lithiating CH-acidic five-membered heterocycles whereby the five-membered heterocycle is reacted with metallic lithium in an ether-containing solvent in the...
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6509481 |
Tetrahydrofuran compounds having alicyclic structure
Tetrahydrofuran compounds of formula (1) wherein the broken line represents a single bond, a divalent organic group, or a structure in which the alicyclic structure in the form of norbornene or...
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6492338 |
Therapeutic agents
Therapeutic or preventive agents for diseases due to the action of aldose reductase; and aldose reductase inhibitors, characterized by containing at least one compound having an aldose reductase...
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6462207 |
Polyethylene glycol diene derivatives
A series of polyethylene glycol derivatives possessing a diene moiety has been prepared and characterized. The reactivities of these derivatives in various Diels-Alder reactions have been...
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6452013 |
Gastrokinetic monocyclic benzamides of 3- or 4-substituted 4-(aminomethyl)-piperidine derivatives
The present invention of compounds of formula (I) a stereochemically isomeric form thereof, an N-oxide form thereof or a pharmaceutically acceptable acid addition salt thereof, R 1 is C 1-6...
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6433193 |
Process to afford gamma butyrolactone and tetrahydrofuran
A process for production of tetrahydrofuran and gamma butyrolactone by hydrogenation of maleic anhydride recovered from a process of conversion of a n-butane. The process consists essentially of...
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6433192 |
Method for producing mixtures of 1,4-butanediol, tetrahydrofuran and &ggr -butyrolactone
In a process for preparing 1,4-butanediol, tetrahydrofuran and γ-butyrolactone by oxidation of butane to give a product stream comprising maleic anhydride, absorption of maleic anhydride from the...
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6429321 |
Depolymerization of polytetrahydrofuran derivatives
The invention discloses a method for depolymerization of a mixture containing polytetrahydrofuran derivatives, including heating the mixture comprising polytetrahydrofuran derivatives at 100-250°...
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6423852 |
Process for the preparation of trifluorothymidine derivatives
5-trifluoromethyl-2,4-bis(trimethylsilyloxy)pyrimidine is reacted with a 2-deoxy-α-D-erythro-pentofuranosyl chloride derivative reacted in the absence or presence of a small amount of solvent to...
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6379911 |
Enzyme detection/assay method and substrates
The invention relates to a method of detecting and/or assaying nucleoside hydrolases or nucleoside phosphorylases using a chromogenic substrate. Preferred chromogenic substrates have formula (I)...
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6369101 |
Therapeutic method to treat herpes virus infection
A therapeutic method is provided for treating a mammal afflicted with a herpesvirus infection, comprising administering an effective amount of a compound of formula I: wherein R 1 -R 11 , have...
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6369099 |
Method of locking 1 α-OH of vitamin D compounds in axial orientation
A method of modifying or altering the structure of a 1α-hydroxylated vitamin D compound to increase its biological activity by altering the conformational equilibrium of the A-ring to favor a...
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6358960 |
Amidino derivatives and drugs containing the same as the active ingredient
The novel amidino derivatives of the formula (I): wherein all the symbols are as in specification defined; have an inhibitory activity of a blood coagulation factor VIIa and are useful for...
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6353000 |
11-halo prostaglandins for the treatment of glaucoma or ocular hypertension
A method of treating glaucoma or ocular hypertension in a patient, which comprises administering to the patient a pharmaceutically effective amount of a compound of formula I:
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6346652 |
Asymmetric ring-closing metathesis reactions involving achiral and meso substrates
A composition and method for the catalytic conversion of a racemic mixture of dienes to a cyclic olefin by a ring-closing metathesis (RCM) reaction are disclosed. The composition, a transition...
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6316640 |
Preparation of tetrahydrofuran
In a process for preparing THF (tetrahydrofuran) by reaction of a 1,4-butanediol-containing reaction mixture over an acid catalyst, the reaction mixture comprises further alcohols different from...
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6288244 |
Process for the preparation of 3, 4-dihydroxybutanoic acid and derivatives thereof from substituted pentose sugars
A process for the preparation of 3,4-dihydroxybutanoic acid (I) and 3-hydroxy-γ-butyrolactone (V) thereof from a 3-leaving group substituted pentose source is described. In particular, the process...
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6274743 |
Process for the preparation of butanediol, butyrolactone and tetrahydrofuran
Butane-1,4-diol, gamma-butyrolactone or tetrahydrofuran are prepared by vapor phase hydrogenation of a C4-dicarboxylic acid derivative. A maleic anhydride containing vapor stream is contacted in an...
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6235930 |
Process for the preparation of 3,4-dihydroxybutanoic acid and derivatives thereof from substituted pentose sugars
A process for the preparation of 3,4-dihydroxybutanoic acid (I) and 3-hydroxy-γ-butyrolactone (V) thereof from a 3-leaving group substituted pentose source is described. In particular, the process...
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6211203 |
Benzofuran-4-carboxamides
Compounds of formula I ##STR1## wherein R1 is 1-2C-alkoxy optionally substituted by flourine, R2 is methyl, 1-methylethyl, 3-7C-cycloalkyl or 3-7Ccycloalkylmethyl and Ar is a pyridyl which is...
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6201137 |
Process for purifying tetrahydrofurans used as starting material for polyether polyols
Tetrahydrofurans suitable for use as starting materials in the synthesis of polyether polyols without causing coloration in the product polyether polyols can be obtained by contacting crude...
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6169189 |
Process for preparing tetrahydrofuran from dialkoxybutenes
A process for preparing tetrahydrofuran, which comprises reacting 1,4-butenediol diethers of the formulae I and/or II RO--CH 2 --CHCH--CH 2 --OR I RO--CH 2 --CH 2 CH--CH 2 --OR II,...
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6150532 |
Modulators of proteins with phosphotyrosine recognition units
The present invention relates to novel protein tyrosine phosphatase modulating compounds having the general structure shown in Formula (A1), to methods for their preparation, to compositions...
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6140505 |
Synthesis of benzo fused heterocyclic sulfonyl chlorides
A process for preparing a benzo fused heterocyclic sulfonyl halide comprising reacting a benzo fused heterocyclic compound with an SO 3 complex in the presence of a water immiscible, non-reactive...
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6133238 |
Tetrahydrofurans
2,5-dihydroxytetrahydro-2-furancarboxylic acid represented by the following formula [I], its optically active substance or salt thereof. ##STR1##
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6077964 |
Process for preparing gamma-butyrolactone, butane-1, 4-diol and tetrahydrofuran
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6066746 |
Radiation curing of dihydrofuran derivatives
Process for producing coatings or moldings by radiation curing, which involves using high-energy light to irradiate radiation-curable compositions containing 1-100% by weight, based on the total...
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6054611 |
Method for the production of levulinic acid and its derivatives
A method of producing dehydration products from one more 5-carbon or 6-carbon sugars includes reacting said one or more sugars at 40-240° C. for 1 to 96 hours in the presence of 5-90% sulfuric...
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6048989 |
Furyl containing fatty acids, glycosyl phosphatidylinositol (GPI) analogues used for inhibiting parasitic activity
A method of inhibiting parasitic activity is disclosed in which the biosynthesis, structure and/or function of the glycosyl phosphatidylinositol (GPI) anchor of said parasite may be affected by...
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6013813 |
Guerbet based sorbitan esters
The present invention deals with the composition of matter and the utilization of certain novel sorbitol guerbet esters which are prepared by the reaction of a guerbet acid and a sorbitol as...
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5990171 |
Hydrazonoacetic acid amides and the use thereof as pesticides
The invention concerns hydrazonoacetic acid amides of general formula (I), a process for producing them, and the use of the said amides as pesticides. In the formula shown, the following meanings...
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5981755 |
Tachykinin antagonists
The invention concerns tachykinin antagonists. The compounds are nonpeptides which have utility in treating disorders mediated by tachykinins. Such disorders are respiratory, inflammatory,...
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5965751 |
Process for hydrogenation of dihydrofurans to give tetrahydrofurans
In a process for the catalytic hydrogenation of 2,5- and 2,3-dihydrofuran with hydrogen to give tetrahydrofuran, use is made of a catalyst in which a metal or a plurality of metals have been...
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5932591 |
C.sub.3 substituted trioxanes useful as antiparasitic drugs
Novel biologically-active 3-substituted trioxanes of the formula ##STR1## wherein R represents a substituted alkyl or aryl group of 1-20, preferably 1-12, carbon atoms, and methods for the use of...
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5919829 |
Gastrin and cck receptor ligands
Compounds of formula (Ia), (Ib), or (Ic), wherein A represents a group having two fused rings, or a group of formula (Id), R 1 (m) represents up to 6 substituents, K represents --O--, --S--, --CH 2...
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5905159 |
Method of producing 1,4-butanediol and tetrahydrofuran from furan
1,4-butanediol and THF are prepared from furan by a process which comprises converting furan in the presence of water and hydrogen but in the absence of a water-soluble acid in a single stage over...
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5886233 |
Cyclohexanone derivatives, process for their production and intermediate products of the process
Described are cyclohexanone derivatives of the formula (I), a method of preparing them and intermediates used in their preparation. ##STR1##
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5883266 |
Hydrogenated 5-carbon compound and method of making
The present invention is based upon the surprising discovery that a 5-carbon compound selected from the group of 4-oxopentanoic acid, at least one lactone of 4-oxopentanoic acid, and combinations...
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5872266 |
Process for producing 3-methyltetrahydrofuran
There is disclosed a process for producing 3-methyltetrahydrofuran substantially free from any of an alcohol and water which comprises adding an organic solvent capable of forming an azeotropic...
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5856531 |
Preparation of 3-methytetra-hydrofuran from 2,3-dihydrofuran
Disclosed is a two-step process wherein (1) 2,3-dihydrofuran is reacted with a trialkyl orthoformate in the presence of an acidic catalyst to produce a 2-alkoxy-3-(dialkoxymethyl)tetrahydrofuran...
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5852027 |
Antiviral 1,3-dioxolane nucleoside analogues
This invention includes the compounds 2'-deoxy-5-fluoro-3'-oxacytidine, (-)-2'-deoxy-5-fluoro-3'-oxacytidine, and (+)-2'-deoxy-5-fluoro-3+-oxacytidine, and pharmaceutically acceptable salts thereof...
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5808124 |
O- or S-substituted dihydronaphthalene derivatives having retinoid and/or retinoid antagonist-like biological activity
Compounds of the formula ##STR1## where the symbols have the meaning described in the application, have retinoid-like or retinoid antagonist-like biological activity.
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