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7626046 |
Manufacture of α-tocopherol
A process for the manufacture of (all-rac)-α-tocopherol comprises submitting isolated, purified phytyltrimethylhydroquinone to acid catalysis, thereby promoting ring closure to...
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7615650 |
Process for producing chroman compound
The invention provides a process for producing a chroman compound represented by formula (1), characterized in that the process includes allowing a phenol, an unsaturated compound, and a...
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7608638 |
Tocopherols, tocotrienols, other chroman and side chain derivatives and uses thereof
The present invention provides an antiproliferative compound having the structural formula
wherein X is oxygen, nitrogen or sulfur; Y is selected from the group consisting of oxygen, nitrogen...
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7585891 |
Pesticidal (dihalopropenyl)phenylalkyl substituted benzodioxolane and benzodioxole derivatives
Certain novel (dihalopropenyl)phenylalkyl substituted benzodioxolane and benzodioxane derivatives have provided unexpected insecticidal activity. These compounds are represented by formula I: where...
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7579014 |
Mesoporous compositions for use in drug delivery
The present invention encompasses novel mesoporous compositions comprising vitamin E and alumina, and methods for their synthesis. The mesoporous compositions of the present invention have...
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7547794 |
Compositions useful as inhibitors of protein kinases
The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of...
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7528267 |
Method for enantioselective hydrogenation of chromenes
A method for preparing an enantiomeric chromane, by asymmetrically hydrogenating a chromene compound in the presence of an Ir catalyst having a chiral ligand. The method includes the...
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7429411 |
Chroman compound, liquid crystal composition including the compound and liquid crystal display element including the liquid crystal composition
The compound (1) according to the invention has general solid-state properties necessary for a compound, stability against heat, light and the like, a suitable optical anisotropy, a suitable...
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7410998 |
Inhibitors of NADH:ubiquinone oxidoreductase
Benzopyran-based inhibitors of NADH:ubiquinone oxidoreductase for inhibiting the growth of cancer cells.
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7396855 |
Compositions and products containing S-equol, and methods for their making
A composition for use in making commercial food and skin products comprising S-equol or mixtures, including both a non-racemic mixture and a racemic mixture, of S-equol and R-equol. The composition...
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7312232 |
Tocopherols, tocotrienols, other chroman and side chain derivatives and uses thereof
The present invention provides an antiproliferative compound having the structural formula
wherein X is oxygen, nitrogen or sulfur; Y is selected from the group consisting of oxygen, nitrogen...
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7309755 |
Method of producing polycarbonate articles by rotation molding and rotation molded articles made by the method
A method for making a polycarbonate article is described wherein the article is made by rotation molding a melt polycarbonate having a weight average molecular weight from 25,000 to about 36,000....
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7297715 |
PPAR alpha selective compounds for the treatment of dyslipidemia and other lipid disorders
A class of chromane and chromene compounds having the structure shown below and pharmaceutically acceptable salts thereof are useful as therapeutic compounds, particularly in the treatment and...
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7247355 |
Liquid crystal compound having chroman ring, liquid crystal composition comprising the compound and liquid crystal display device comprising the composition
The present invention relates to a compound having a chroman ring, which has good thermal and optical stability, adequate optical anisotropy, adequate dielectric anisotropy and superior...
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7226644 |
Chroman derivative and liquid-crystal composition containing the compound
The present invention relates to a liquid crystal compound which has negative dielectric anisotropy and a large absolute value thereof; and a liquid crystal display element which contains the...
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7148240 |
Aminoalkoxybenzoyl-benzofuran or benzothiophene derivatives, method for preparing same and compositions containing same
The invention relates to benzofuran or benzothiophene derivatives of general formula:
These compounds are of use as medicinal products, in particular in the treatment of pathological syndromes...
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7138532 |
Color-stable, low impurity tocopherol compositions and processes for preparing the same
Processes for preparing color-stable, low-impurity tocopherol compositions are described, wherein the processes comprise: (a) providing a protecting group-substituted tocopherol compound, for...
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7115657 |
Bifunctional agents possessing antioxidant and antiarrhythmic activity
The present invention relates to novel bifunctional agents possessing antioxidant and antiarrhytmic activity, methods for the synthesis of the same and their applications in treating...
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7105686 |
Manufacture of tocol, tocol derivatives and tocopherols
The present invention is concerned with a novel process for the manufacture of tocol, tocol derivatives and tocopherols, especially α-tocopherol, by the reaction of a hydroquinone featuring 0 to 3...
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6987194 |
Insecticidal (dihalopropenyl) phenylalkyl substituted dihydrobenzofuran and dihydrobenzopyran derivatives
Insecticidal (dihalopropenyl) phenylalkyl substituted dihydrobenzofuran and dihydrobenzopyran derivatives of Formula I are disclosed. These compounds provide unexpected insecticidal activity across...
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6867307 |
Intermediates for use in the preparation of vitamin E
Intermediate compounds which can be used in the preparation of phytone and Vitamin E, a process for the preparation thereof, and a process for the preparation of phytone and Vitamin E from these...
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6841536 |
Prodrugs and conjugates of thiol- and selenol-containing compounds and methods of use thereof
Disclosed is a prodrug of the formula:
where A is a sulfur or a selenium, and R is derived from a mono- di- or oligo- saccharide.
Also disclosed is a prodrug of the formula:
where A is...
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6818666 |
Bi-aromatic compounds linked via a heteroethylene radical, and pharmaceutical and cosmetic compositions using them
Bi-aromatic compounds linked via a heteroethynylene radical are provided along with pharmaceutical and cosmetic compositions containing these compounds and methods for their use.
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6790965 |
Combinatorial dihydrobenzopyran library
Combinatorial libraries are disclosed which are represented by Formula I: (T′—L) q —Ŝ—C(O)—L′—II′ I wherein: Ŝ is a solid support; T′—L— is an identifier residue; and...
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6784303 |
Method for continuously acylating chromanol ester derivatives
A process is described for continuously preparing chromanol ester derivatives, in particular for continuously preparing carboxylic esters of tocopherols and tocotrienols by continuous acylation...
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6706757 |
Chroman derivatives as 5-hydroxytryptamine-6 ligands
The present invention provides a compound of formula I and the use thereof for the therapeutic treatment of disorders relating to or affected by the 5-HT6 receptor.
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6599933 |
Tocotrienol derivative, process for producing the same and &ggr -CEHC delivering agent
The object of the present invention is to provide a tocotrienol derivative which is highly water-soluble and shows high bioavailability in the living body and γ-CEHC delivering agent. (A...
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6596758 |
Benzopyrans and benzoxepines, pharmaceutical compositions comprising them and preparation process
The present invention relates to benzopyrans and benzoxepines of formula (I), wherein X, A, R 1 , R 2 and (R) p have the meanings as given in claim 1, which can be used in the treatment of...
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6482961 |
Method of making (all-rac)-α-tocopherol
The present invention is a method of making (all-rac)-α-tocopherol in a reaction having the following steps: a) reacting trimethylhydroquinone and a phytol selected from the group consisting of...
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6471954 |
Method for the production and use of a cream containing vitamin-A
A method for the production of a vitamin-A containing cream comprising the following steps: a) a first mixture—consisting of a number of water-soluble substances such as glycerine and extracts...
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6452023 |
Process for preparing d,l-α-tocopherol
A process for the manufacture of d,l-α-tocopherol by the acid-catalyzed condensation of trimethylhydroquinone with isophytol or phytol in ethylene or propylene carbonate or a mixture of both...
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6441199 |
Process for the production of α-tocopherol acetate by condensation of trimethylhydroquinone with isophytol with recycling of an acetic catalyst solution
A process for the production of α-tocopherol acetate in a recirculating process by condensation of trimethylhydroquinone and isophytol in the presence of a catalyst system of a zinc halide and an...
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6429320 |
Processes for the purification of tocopherol and/or sterol compounds and compositions containing orthoborate ester mixtures
Processes for purifying compounds are disclosed which include reacting (i) a mixture of at least one tocopherol compound or sterol compound, and an alcohol having from about 10 to 30 carbons with...
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6423744 |
Method of diminishing the adverse effects of interleukin-2
A method and composition for preserving or enhancing the beneficial effects of interleukin-2 (IL-2) while simultaneously mitigating the adverse effects of IL-2 on a subject is disclosed. The method...
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6414166 |
Process for preparing tocopherol concentrates
This invention relates to a process for the preparation of tocopherol concentrates from a material containing tocopherols and free fatty acids. The free fatty acids in the tocopherol-containing...
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6410755 |
Method of vitamin production
The invention provides a method of producing α-tocopherol and α-tocopheryl esters. The method comprises using a biological system to produce farnesol or geranylgeraniol. Then, the farnesol or...
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6403638 |
2,4-pentadienoic acid derivatives having selective activity for retinoid X (RXR) receptors
Compounds having the formulas below, where R is H, lower alkyl, or a pharmaceutically acceptable salt, and where R 1 represents i-propyl, t-butyl or n-butyl groups, have selective RXR retionoid...
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6384245 |
Method for preparing DL-α-tocopherol with high yield
Disclosed is a method for preparing DL-α-tocopherol with a high yield through the condensation of isophytol or phytol derivatives with trimethylhydroquinone (TMHQ) in the presence of a Zn—Al...
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6380429 |
Preparation of sulfonyl imine compounds
Disclosed is a process for the oxidation of sulfonamides to sulfonyl imines using chromium (IV) dioxide as the oxidant.
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6369242 |
Tocopherol manufacture by tris(perfluorohydrocarbylsulphonyl) methane or metal methides thereof
A method of making (all-rac.)-α-tocopherol by the acid-catalyzed condensation of trimethylhydroquinone with isophytol or phytol wherein the condensation is carried out in the presence of a...
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6359132 |
Aminomethylation of tocopherols
A process for the production of a Mannich reagent comprises reacting formaldehyde, especially paraformaldehyde, with a secondary amine in the complete or almost complete absence of a solvent. An...
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6355811 |
Polyoxypropylenepolyethylene vitamin E and preparation thereof
Disclosed is polyoxypropylenepolyoxyethylene vitamin E, represented by formula (I). It is prepared by subjecting vitamin E to polyethoxylation and then, to polypropoxylation to a proper extent. The...
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6350453 |
Tocotrienols and geranylgeraniol from Bixa orellana byproducts
A source of material known as a byproduct solution of Bixa orellana seed components, which is obtained as an oily material after the bulk of annatto color, is removed from either the aqueous...
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6348605 |
Process for preparing 3-hydroxymethyl chromen-4-ones
3-(Hydroxymethyl)chromen-4-ones of formula (I) are described and a process for preparing said compounds. The process consists in reacting the compounds of general formula (II) wherein R is...
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6280752 |
Vitamin E acetate-based hydrophobic gel formulation for topical application
A formulation for topical use in hydrophobic gel form comprising, in weight percentages on the total weight of the formulation: 20 to 70% of vitamin E acetate, 20 to 70% of a volatile...
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6268170 |
α-Tocopherol transport protein: compositions and methods
The present invention provides an isolated and purified α-tocopherol transport protein polypeptide. Human recombinant α-tocopherol transport protein, polynucleotides encoding human α-tocopherol...
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6262279 |
Preparation of tocopherols
The invention provides methods for producing tocopherol compounds of the Vitamin E family by reduction of various 4-chromanone trienol materials. In preferred embodiments the invention provides...
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6239294 |
Process to produce α-tocopherol-acetate
Process for the production of α-tocopherol acetate in a recycling process by condensation of trimethylhydroquinone diesters and isophytol in the presence of a catalyst system consisting of a zinc...
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6239171 |
Tocotrienols and tocotrienol-like compounds and methods for their use
The present invention relates to novel tocotrienols and tocotrienol-like compounds displaying biological activity. The tocotrienols and tocotrienol-like compounds of this invention may be...
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6156913 |
Method of producing vitamin E
The invention provides processes for producing phytol, isophytol, and certain phytol derivatives by a method of oxidizing or epoxidizing geranylgeraniol or geranylgeraniol derivatives to form...
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