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8163795 |
Chroman derivatives, medicaments and use in therapy
Novel chroman derivatives and intermediate compounds, compositions containing same, methods for their preparation and uses thereof as therapeutic agents particularly as anti-cancer and...
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8153828 |
Optical molecular sensors for cytochrome P450 activity
The invention provides a compound, useful as an optical probe or sensor of the activity of at least one cytochrome P450 enzyme, and methods of using the compound to screen candidate drugs, and...
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8143308 |
Synthesis of oligo/poly(catechins) and methods of use
A method for synthesizing a biocompatible, water-soluble oligo/polyflavanoid, includes polymerizing an optionally substituted flavanoid with a polymerization agent in the presence of a...
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8138359 |
Stabilized 3-hydroxyflavan compositions and methods therefor
Compositions and methods are directed to covalent adducts between reducing agents and optionally substituted 3-hydroxyflavans, wherein the reducing agent is covalently bound to the B-ring of the...
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8138223 |
Diosmetin compounds, a process for their preparation and pharmaceutical composition containing them
Compounds of formula (I): wherein R1, R2 and R3, which may be the same or different, each represent a hydrogen atom or the group of formula (A): Medicinal products containing the same which are...
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8080664 |
Use of compounds as inhibitors for Helicobacter flavodoxin
Use of the general formula compound (I), or any salt thereof, for preparation of a pharmaceutical compound for the treatment of infections illnesses, in particular for the treatment of...
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8080675 |
Chroman derivatives, medicaments and use in therapy
Novel chroman derivatives and intermediate compounds, compositions containing same, methods for their preparation and uses thereof as therapeutic agents particularly as anti-cancer and...
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8067594 |
Process for the production of benzopyran-2-ol derivatives
The invention provides a process for producing a compound of formula (I), wherein Y is selected from the group consisting of CH3, CH2OH, CH2CH2OH, CH2Br and Br; comprising the steps of: (i)...
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8048913 |
Compositions and products containing S-equol, and methods for their making
A composition for use in making commercial food and skin products comprising S-equol or mixtures, including both a non-racemic mixture and a racemic mixture, of S-equol and R-equol. The composition...
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8022101 |
Method of treating a knee meniscus with a cross-linking reagent to increase resistance to tearing or rupturing
A method of treatment of native, non-denatured tissue to increase resistance to tearing, fissuring, rupturing, and/or delamination, comprising the step of: contacting at least a portion of the...
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8017789 |
Process for production of 3-[5-[4-(cyclopentyloxy)-2-hydroxybenzoyl]-2-[(3-OXO-2-substituted-2,3-dihydro-1,2-benzisoxazol-6-yl]methoxy]phenyl]proprionate ester and intermediate for the process
A preparation method using as an intermediate 6-(halomethyl)-1,2-benzisoxazol-3(2H)-one derivative represented by general formula wherein R5 is a methyl group that is substituted with one or more...
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8008344 |
Compounds for the inhibition of histone deacetylase
The invention relates to a compound represented by the following formula (I): and pharmaceutically acceptable salts, stereoisomers, enantiomers, prodrugs and solvates thereof. The compounds are...
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7982058 |
Chiral intermediate, process for producing the same and its use in the manufacture of tolterodine, fesoterodine, or the active metabolite thereof
The compound of formula (I): is provided. It may be produced by subjecting a compound of formula (IV) to a reduction reaction wherein R represents hydrogen, straight or branched C1-C6 alkyl. This...
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7960573 |
Method for enantioselective hydrogenation of chromenes
A method for preparing an enantiomeric chromane, by asymmetrically hydrogenating a chromene compound in the presence of an Ir catalyst having a chiral ligand. The method includes the...
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7960432 |
Compositions and products containing S-equol, and methods for their making
A composition for use in making commercial food and skin products comprising S-equol or mixtures, including both a non-racemic mixture and a racemic mixture, of S-equol and R-equol. The composition...
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7919490 |
6-substituted 2-(benzimidazolyl)purine and purinone derivatives for immunosuppression
The present invention provides novel purinones and purines useful for the prevention and treatment of autoimmune diseases, inflammatory disease, mast cell mediated disease and transplant rejection....
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7915301 |
Inhibitors of cyclin dependent kinases and their use
The present invention relates to novel compounds for the inhibition of cyclin-dependent kinases, and more particularly, to chromenone derivatives of formula (Ia), wherein R1, R2, R3, R4, R5, R6, R7...
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7915298 |
Compounds and methods for leukotriene biosynthesis inhibition
This invention provides novel salt and crystalline forms thereof of (−)4-(4-fluorophenyl)-7-[({5-[1-hydroxy-1-(trifluoromethyl
)propyl]-1,3,4-oxadiazol-2-yl}amino)-methyl]-2H-chromen-2-on
e. The c...
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7915268 |
8-substituted 2-(benzimidazolyl)purine derivatives for immunosuppression
The present invention provides novel purines useful for the prevention and treatment of autoimmune diseases, inflammatory diseases, mast cell mediated disease and transplant rejection. The...
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7906660 |
Production of isoflavone derivatives
Methods for the hydrogenation of isoflavones are described which provide access to workable quantities of isoflavan-4-ols, isoflav-3-enes, and isoflavans. The isoflavone derivatives can be obtained...
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7902187 |
6-substituted 2-(benzimidazolyl)purine and purinone derivatives for immunosuppression
The present invention provides novel purinones and purines useful for the prevention and treatment of autoimmune diseases, inflammatory disease, mast cell mediated disease and transplant rejection....
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7884127 |
Inhibitors of cyclin dependent kinases and their use
The present invention relates to novel compounds for the inhibition of cyclin-dependent kinases, and more particularly, to chromenone derivatives of formula (Ic) wherein R1, R2, R3, R4, R5, R6, R7...
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7863466 |
Method of producing proanthocyanidin-containing material
The method for producing proanthocyanidin-containing product of the present invention comprises the steps of providing a pine bark as a starting material, extracting the pine bark with at least one...
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7846966 |
Chroman derivatives as estrogenic compounds
The invention provides chroman compounds having formula 1 wherein R1 is (1C-4C)alkyl, (2C-4C)alkenyl or (2C-4C)alkynyl, and independently R1 has a cis-orientation in relation to the exocyclic...
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7838553 |
Benzopyran derivatives as potassium channel openers
The present invention is directed to novel benzopyran derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders related to potassium channel.
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7820835 |
Method for producing flavan derivatives
The present invention provides a method for producing flavan derivatives having various substituent groups with controlling the stereochemistry. The method of the present invention includes the...
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7786315 |
Process for selectively extracting procyanidins
A process is described for selectively extracting cocoa procyanidins from an aqueous mixture of cocoa polyphenols by using a particular sequence of solvents to extract selected procyanidin monomers...
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7781483 |
Benzopyran compound
This invention relates to benzopyran compounds of formula (I) wherein X is NR6, Y is a bond, SO or SO2, Z is C1-4alkyl group or phenyl group, W is hydrogen atom, hydroxy group, C1-6 alkoxy group, a...
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RE41366 |
Total synthesis of galanthamine, analogues and derivatives thereof
The invention relates to a method for the synthesis of galanthamine, the derivatives and analogues thereof of formula (1) where R1=a hydrogen atom, R2=a hydroxy group, R1 and R2 together form ═O, R...
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7714150 |
Aminoalkyl-amidomethyl-substituted 2-(4-sulphonylamino)-3-hydroxy-3,4-dihydro-2H-chroman-6-yl derivatives
Compounds corresponding to formula I, wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10 and n have the meanings given in the description, and also a process for the preparation of these compounds and...
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7700646 |
Compounds for use in the treatment of infection
There is provided a novel compound of the general formula I in which each of R8 to R10 is hydrogen, aryl, C1-6 alkyl, trialkylsilyl or acyl; R1 to R5 are individually selected from hydrogen,...
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7696363 |
Preparation of flavonoid compounds
Disclosed is an improved method for preparing the isoflavonoid compound (+/−)-equol, the method comprising reducing an organic diester of the isoflavone daidzein under hydrogen-transfer c...
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7671220 |
Processes for the 3,3-dialkylation of 4-chromanones
The present invention relates to methods for the preparation of 3,3-dialky 4-chromanones, and particularly to the preparation of 6-fluoro-3,3-dimethyl-2,3-dihydro-4H-chromen-4-one and...
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7622499 |
β-Benzyloxyaspartate derivatives with photosensitive groups
The present invention relates to photosensitive derivatives of optically active L-threo-β-benzyloxyaspartate or its benzene ring-substituted analogs, represented by the following formula (1) or ...
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7615332 |
Photosensitive compound, photosensitive composition, resist pattern forming method, and device production process
A photosensitive compound has two or more structural units, in a molecule, represented by the following general formula (1): wherein R1 to R5 are selected from the group consisting of hydrogen...
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7547794 |
Compositions useful as inhibitors of protein kinases
The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of...
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7544816 |
(−)-Epigallocatechin gallate derivatives for inhibiting proteasome
(−)-EGCG, the most abundant catechin, was found to be chemopreventive and anticancer agent. However, (−)-EGCG has at least one limitation: it gives poor bioavailability. This invention provides com...
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7534903 |
Use of amidomethyl-substituted 2-(4-sulfonylamino)-3-hydroxy-3,4-dihydro-2H-chromen-6-yl-compounds in the treatment of cardiac arrhythmia and other disease states
The use of compounds corresponding to formula I: in which R1, R2, R3, R4, R5 and R6 have the meanings given in the description for treating cardiac arrhythmias and other disease states.
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7528267 |
Method for enantioselective hydrogenation of chromenes
A method for preparing an enantiomeric chromane, by asymmetrically hydrogenating a chromene compound in the presence of an Ir catalyst having a chiral ligand. The method includes the...
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7507831 |
Tetra- and penta-o-benzyl-protected, C-4 activated-epicatechin and -catechin monomers and processes for their preparation and use
Various processes are disclosed for preparing protected epicatechin oligomers having (4β,8)-interflavan linkages. In one process, a tetra-O-protected epicatechin monomer or oligomer is coupled ...
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7476741 |
Substituted 4H-chromens, 2H-chromenes, chromans and analogs as activators of caspases and inducers of apoptosis and the use thereof
The present invention is directed to substituted 4H-chromenes, 2H-chromenes, chromans and analogs thereof, represented by the general Formula (I) wherein R5, A, B, X, Y, Z and dotted lines are...
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7468445 |
Antigiardial agents and use thereof
The present invention provides a method of preventing or treating one or more of the following medical conditions, or treating symptoms of one or more of the following medical conditions: amebic...
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7435722 |
Non-toxic crosslinking reagents to resist curve progression in scoliosis and increase disc permeability
A method of improving the resistance of collagenous tissue to mechanical degradation in accordance with the present invention comprises the step of contacting at least a portion of a collagenous...
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7429411 |
Chroman compound, liquid crystal composition including the compound and liquid crystal display element including the liquid crystal composition
The compound (1) according to the invention has general solid-state properties necessary for a compound, stability against heat, light and the like, a suitable optical anisotropy, a suitable...
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7396855 |
Compositions and products containing S-equol, and methods for their making
A composition for use in making commercial food and skin products comprising S-equol or mixtures, including both a non-racemic mixture and a racemic mixture, of S-equol and R-equol. The composition...
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7361774 |
Chalcone compound
The present invention relates to a chalcone compound represented by the following general formula: wherein R1 and R2 are taken together with the carbon atom to which they are bound, respectively,...
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7329687 |
Flavanoid compounds as chemotherapeutic, chemopreventive, and antiangiogenic agents
Compounds useful as chemotherapeutic, chemopreventive, and antiangiogenic agents are provided. The compounds are flavanoids, including flavanones, flavanols, and chalcones. The compounds have the...
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7282598 |
Synthetic methods for preparing procyanidin oligomers
Processes are disclosed for the production of linear and branched procyanidin oligomers having “n” procyanidin monomeric units where n is 2 to 18. The processes include coupling protected, act...
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7271193 |
Inhibitors of cyclin-dependent kinases and their use
The present invention relates to novel compounds for the inhibition of cyclin-dependent kinases, and more particularly, to chromenone derivatives of formula (Ia), wherein R1, R2, R3, R4, R5, R6, R7...
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7268240 |
Synthetic methods for polyphenols
A process is disclosed for the production of polyphenol oligomers having n polyphenol monomeric units, n being an integer from 2-18. The process includes coupling of a protected polyphenol, having...
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