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7435722 |
Non-toxic crosslinking reagents to resist curve progression in scoliosis and increase disc permeability
A method of improving the resistance of collagenous tissue to mechanical degradation in accordance with the present invention comprises the step of contacting at least a portion of a collagenous...
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7417067 |
Composition and method for stabilizing the same
Disclosed is a novel composition comprising a novel bi-cyclic compound, which is expected to be pharmaceutically active, and a glyceride. The stability of the bi-cyclic compound can be improved...
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7326797 |
Manufacture of isoflavones
A process for manufacturing a hydroxylated isoflavone of the formula (I) given in the description comprises re-acting an appropriately substituted 2-hydroxydeoxybenzoin of the formula (II), also...
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7241906 |
Bycyclic tetrahydrofuran derivatives and process for the preparation thereof
The present invention relates to bicyclic tetrahydrofuran derivatives of Formula (1) and a preparation method thereof, and particularly it relates to a process of preparing compounds of Formula (1)...
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7196108 |
Bicyclic heterocycles for the treatment of diabetes and other diseases
The invention relates to certain bicyclic heterocycles havng the structure shown below which are useful in the treatment of diseases related to lipid and carbohydrate metabolism, such as type 2...
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7157589 |
One step process for the preparation of anticonvulsant derivatives
The present invention is directed to a one-step process for the preparation of fructopyranose sulfamate derivatives of the general formula (I)
wherein X, R 1 , R 3 , R 4 , R 5 and R 6 ...
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7122573 |
Analogs of green tea polyphenols as chemotherapeutic and chemopreventive agents
Novel compounds useful as chemotherapeutic and chemopreventive agents are provided. The compounds are analogs of polyphenol catechins that occur in green tea, such as epigallocatichin-3-gallate...
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7109236 |
Analogs of green tea polyphenols as chemotherapeutic and chemopreventive agents
Novel compounds useful as chemotherapeutic and chemopreventive agents are provided. The compounds are analogs of polyphenol catechins that occur in green tea, such as epigallocatichin-3-gallate...
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7098347 |
Process for the preparation of 1-hydroperoxy-16-oxabicyclo[10.4.0]hexadecane
Process for the preparation of 1-hydroperoxy-16-oxabicyclo[10.4.0]hexadecane (DDP-OOH), wherein 13-oxabicyclo[10.4.0]hexadec-1(12)-ene (DDP) and hydrogen peroxide are reacted in a diluent in the...
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7045514 |
Therapeutic heterocyclic compounds
Provided herein is a compound having the formula (I):
Wherein said compounds are useful for the treatment of psychiatric disorders including but not limited to depression, generalized anxiety,...
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7034015 |
Aminobenzoephenones
The invention relates to a novel class of aminobenzophenones derivatives, to pharmaceutical preparations comprising said compounds, to dosage units of such preparations, to methods of treating...
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6936726 |
Flavanol and cysteamine conjugates
The present invention refers to new products generated by the conjugation of flavanols with molecules that contain the thiol group. New molecules are obtained from polyphenolic plant extracts rich...
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6914109 |
Process for the preparation of 15-pentadecanolide
The invention relates to a process for the preparation of 15-pentadecanolide by hydrogenating 15-pentadecenolide and to its use.
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6911469 |
Sulfonamide compounds and pharmaceutical use thereof
A sulfonamide compound of the formula (I):
R 1 —SO 2 NHCO—A—X—R 2 (I)
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6869696 |
Organic red electro-luminescent device including a heterocyclic emitter
The invention concerns an electro-luminescent device in which the luminescent layer contains a compound of general formula I as doping agent or as luminescent compound, whereby the radicals R 1 to...
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6864278 |
Antifungal agents of sordarin derivatives
Sordarin derivatives prepared from C-11-hydroxysordarin are antifungal agents useful in the treatment and/or prevention of human and animal fungal infections, as well as in the control of...
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6861418 |
4-aryl substituted indolinones
The present invention relates to 4-arylindolinones, as well as pharmaceutical compositions thereof, capable of modulating protein kinase signal transduction in order to regulate, modulate and/or...
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6835845 |
Methine compound, material for organic luminescence element, and organic luminescence element using the same
A is a novel methine compound, for example, which is represented by the following formula (I): wherein R 1 , R 2 , R 3 , R 4 and R 5 each represents a hydrogen atom or a substituent; X...
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6790966 |
Cocoa extracts containing solvent-derived cocoa polyphenols from defatted cocoa beans
Disclosed and claimed are cocoa extracts such as polyphenols or procyanidins, methods for preparing such extracts, as well as uses for them, especially as antineoplastic agents and antioxidants....
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6727239 |
Derivatives of 2-aminopyridines, their use as medicaments and pharmaceutical compositions containing them
A compound of the formula wherein the substituents are defined as in the specification and their pharmaceutically acceptable salts having NOS and ROS activity.
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6723860 |
7a-alkoxy-4H-pyrano&lsqb 3,2-d&rsqb -oxazol-2(3H)-one and process for producing the same
The present invention provides a novel 7a-alkoxy-4H-pyrano-[3,2-d]-oxazol-2(3H)-one represented by the formula (I): wherein R 1 and R 2 each represent a hydrogen atom, an alkyl group, an...
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6649085 |
Cyclic sugar ketones as catalysts for peroxygen compounds
The use of cyclic sugar ketones of the formula in which R 1 and R 2 are hydrogen, C 1 -C 22 -alkyl, C 2 -C 22 -alkenyl or phenyl, R 3 is C 1 -C 4 -alkoxy, phenyl-CH 2 —O— or a group of...
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6624138 |
Drug-loaded biological material chemically treated with genipin
A method for treating tissue of a patient comprising, in combination, mixing a drug with a solidifiable biological material, chemically treating the drug with the biological material with a...
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6469182 |
Intermediates in the preparation of macrocyclic analogs
Novel intermediates of the formula They are used in the preparation of macrocyclic analogs.
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6444709 |
Heteroethylene compounds and pharmaceutical and cosmetic compositions containing same
The invention relates to novel heteroethynylenic compounds having the general formula (I): as well as to the use of these compounds in pharmaceutical compositions intended for use in human or...
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6420334 |
Tetracyclic acetals
2-Alkoxydecahydro-2,3a,4,4,7-pentamethyl-3,7a-methano-7aH-in
deno[5,6-b]furans are valuable novel woody fragrances for the preparation of perfume oils.
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6410586 |
Modulators of protein tyrosine phosphatases (PTPases)
The present invention provides novel compounds, novel compositions, methods of their use, and methods of their manufacture, where such compounds are pharmacologically useful inhibitors of Protein...
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6365759 |
Intermediate compounds for preparing macrocylcic analogs
Intermediate compounds of the formulas for use in the preparation of macrocyclic analogs.
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6262083 |
Genipin derivative having liver protection activity
The present invention relates to novel genipin derivatives which have an excellent liver protection activity with little cytotoxicity, and these compounds are so stable in vivo that they do not...
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6228653 |
1,2-dioxetane derivative fused to pyran ring and use thereof
A 1,2-dioxetane derivative represented by the general formula: ##STR1## wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 and R 7 each independently represents hydrogen atom, an alkyl group, or an aryl...
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6162826 |
Genipin derivative having anti hepatitis B virus activity
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6147230 |
Amino acid dysiherbaine
The present invention provides a novel amino acid dysiherbaine which is a non-NMDA type glutamate receptor agonist as well as salts and biological precursors thereof, which are useful as...
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6107254 |
5-(Dioxabicyclohept-6-yl)-cyclohexenone oxime ethers, and the preparation and thereof use
5-(Dioxabicyclohept-6-yl)cyclohexenone oxime ethers of the formula I ##STR1## where: R 1 is hydrogen, the equivalent of an agriculturally useful cation, C 1 -C 10 -alkylcarbonyl, C 1 -C 10 ...
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6008219 |
Bicyclic amine derivatives and their use as anti-psychotic agents
This invention relates to compounds of formula (I) ##STR1## which are useful as modulators of D 3 receptors, in particular as antipsychotic agents.
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5998408 |
Triterpene derivatives with immunosuppressant activity
The compounds of Formula I ##STR1## are useful as immunosuppressive agents.
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5990155 |
Oxygenated-heterocycle containing sulfonamide inhibitors of aspartyl protease
The present invention relates to a novel class of sulfonamides which are aspartyl protease inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds. The...
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5981572 |
Benzofurans and benzopyrans as chronobiological agents
The invention thus provides compounds of Formula (I) ##STR1## wherein R 1 and R 2 which may be the same or different represent H, C 1 -6 alkyl or substituted alkyl or C 3 -7 cycloalkyl; or aryl; ...
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5972996 |
4-cyano-4-deformylsordarin derivatives
4-Cyano-4-deformylsordarin derivatives are antifungal agents useful in the treatment and/or prevention of human and animal fungal infections, as well as in the control of phytopathogenic fungi in...
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5972957 |
Dihydrobenzopyran compounds and related compounds useful as anti-inflammatory agents
A compound having the structure: ##STR1## wherein (a) n is from about 1 to about 3; (b) X is selected from the group consisting of O, S, SO, or SO 2 ; (c) Y is independently hydrogen or...
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5908581 |
Red organic electroluminescent materials
A red fluorescent material includes a compound of the formula: ##STR1## wherein: R 1 , and R 2 are individually alkyl of from 1 to 20 carbon atoms, aryl, carbocyclic and other heterocyclic...
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5811427 |
Heterocyclic N-acetonylbenzamides
Certain N-acetonylbenzamides and their use as fungicides are disclosed. The N-acetonylbenzamides disclosed contain a heterocyclic ring fused to an aromatic ring. These compounds are particularly...
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5719291 |
Cyclohexane derivatives
Compounds of the formula ##STR1## which have antifungal activity.
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5718845 |
Tricyanovinyl substitution process for NLO polymers
Nonlinear optical compounds which contain a heteroaromatic ring and may further comprise a tricyanovinyl group attached to the heteroaromatic ring.
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5596100 |
Palladium catalyzed annulation of internal alkynes
A method is provided for the regioselective, palladium catalyzed carbo- or heteroannulation of internal alkynes by aryl iodides containing o-substituted side chains to yield aromatic carbocyclic...
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5502220 |
Process for the preparation of intermediates useful in the preparation of pyranyl cyanoguanidine derivatives
A process for preparing compounds of the formula ##STR1## where a, b d, R 1 , R 2 , R 3 and R 4 are as defined herein including condensation of a phenol of formula ##STR2## with an acetal of...
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5387700 |
Process for the preparation of chlorosulfate and sulfamate derivatives of 2,3:4,5-bis-O-(1-methylethylidene)-β-D-fructopyranose and (1-methylcyclohexyl)methanol
A process for producing chlorosulfate and sulfamate esters of 2,3:4,5-bis-O-(1-methylethylidene)-β-D-fructopyranose and (1-methylcyclohexyl)methanol is disclosed. The process involves a two step...
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5384327 |
Anticonvulsant sorbopyranose sulfamates
Sulfamate derivatives having the following formula (I): ##STR1## wherein R 1 , R 2 , R 3 , R 4 , R 5 , and R 6 are as herein defined, have been found to exhibit anticonvulsant activity and are...
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5380748 |
Trialkylamine derivative and ameliorant for digestive tract movement containing the same
A trialkylamine derivative represented by the formula (1) or a pharmaceutically acceptable salt thereof: ##STR1## wherein R 1 and R 2 may be the same or different from each other and each...
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5292899 |
Synthesis of 11-nor-Δ-9-tetrahydrocannabinol-9-carboxylic acid glucuronide
A method of producing a deuterated or undeuterated 11-nor-Δ 8 -tetrahydrocannabinol (THC) glucuronide or deuterated or undeuterated 11-nor-Δ 9 -THC glucuronide by reacting a blocked THC...
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5274130 |
Process for production of prostaglandin intermediates
The isomer ratio of a cis-isomer against the corresponding trans-isomer with respect to the 5-6 double bond is improved in the production of prostaglandins, when a lactol is reacted with an ylide...
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