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8980942 Prodrugs of tetrahydrocannabinol, compositions comprising prodrugs of tetrahydrocannabinol and methods of using the same  
Described herein are Δ9-THC prodrugs, methods of making Δ9-THC prodrugs, formulations comprising Δ9-THC prodrugs and methods of using Δ9-THC. One embodiment described herein relates to the...
8664411 Tetrahydropyranochromene gamma secretase inhibitors  
Disclosed are novel gamma secretase inhibitors of the formula. Also disclosed are methods of inhibiting gamma-secretase, methods of treating neurodegenerative diseases, and methods of treating...
8586767 Method for treatment of HIV and diseases of immune dysregulation  
This invention discloses cannabinoid derivatives and pharmaceutical uses thereof.
8575230 Environment-friendly antifoulants for the prevention of biofouling  
Environmentally-friendly alternatives to organometallic antifoulants that are efficacious at preventing biofouling by organisms such as the zebra mussel. Preferred antifoulant compositions utilize...
8530679 Delta 9—tetrahydrocannabinol processing  
The present invention provides a process for handling Δ9-THC, which comprises preparing a solution of Δ9-THC in a solvent which exists as a gas at room temperature and atmospheric pressure. The...
8500807 Photochromic intraocular lens  
The invention relates to an intraocular lens comprising at least one pharmaceutically-acceptable photochromic polymer that enables all or part of the intraocular lens to change colour reversibly...
8383842 Methods for purifying trans-(−)-Δ9-tetrahydrocannabinol and trans-(+)-Δ9-tetrahydrocannabinol  
Methods for making trans-(−)-Δ9-tetrahydrocannabinol and trans-(+)-Δ9-tetrahydrocannabinol are disclosed herein. In one embodiment, a trans-(−)-Δ9-tetrahydrocannabinol composition is prepared by...
8350065 5,6-dimethyl xanthone-4-acetic acid derivatives and method of preparing the same  
A method of preparation of 5,6-dimethylxanthone-4-acetic acid (DMXAA) and derivatives thereof. The derivatives are represented by formula (I), wherein R represents totally 1 to 2 substitutes at 1,...
8323750 Method of ultraviolet light assisted surface modification and product having a surface formed by this method  
The present invention relates to a UV irradiation assisted method of surface modification, which comprises: introducing a functional group L onto the surface of a polymer material P through the...
8324408 Method for the preparation of dronabinol  
The present invention relates to a method for the preparation of dronabinol ((6aR-trans)-6a,7,8,10a-tetrahydro-6,6,9-trimethyl-3-pentyl- 6H-dibenzo[b,d]pyran-1-ol, Δ9-tetrahydrocannabinol...
8303844 Benzo[f]chrome any pyrano[3,2-f]chrome derivatives for use in liquid crystal media  
The present invention relates to benzo[f]chromene and pyrano[3,2-f]-chromene derivatives of the formula I in which L1, L2, R1, R2, A1, A2, Z1, Z2, m and n are as defined in claim 1, to the...
8257981 Lanthanide chelates and use thereof in bioanalysis  
Novel chemical compounds, with application in fluorometric analytical methods, for qualitative and quantitative determination of biomolecules. The aim of the invention is to identify and prove the...
8227627 Prodrugs of tetrahydrocannabinol, compositions comprising prodrugs of tetrahydrocannabinol and methods of using the same  
Described herein are Δ9-THC prodrugs, methods of making Δ9-THC prodrugs, formulations comprising Δ9-THC prodrugs and methods of using Δ9-THC. One embodiment described herein relates to the...
8148551 Tricyclic aromatics and liquid-crystalline medium  
The invention relates to tricyclic aromatics of the general formula I in which A1, A2, A3, A4, Q1-Q2, R1, R2, X1, X2, X3, Z1, Z2, Z3, Z4, q, r, s, t and u have the meaning indicated, and to the...
8133887 Oxaphenanthrene derivatives  
The invention relates to compounds of the formula (I), in which R1, R2, R3, R4, Y and A have the meanings indicated, and to processes for the preparation thereof and to the use thereof for the...
7998541 Benzochromene derivatives for use in liquid crystal media and as therapeutic active substances  
The present invention relates to benzochromene derivatives of the formula I where the various parameters have the meaning indicated in the text, and to liquid-crystal media which comprise these...
7932014 Photosensitive compound, photosensitive composition, resist pattern forming method, and device production process  
A photosensitive compound has two or more structural units, in a molecule, represented by the following general formula (1): wherein R1 to R8 are selected from the group consisting of a hydrogen...
7923558 Method for obtaining pure tetrahydrocannabinol  
The invention relates to a method for obtaining pure tetrahydrocannabinol from reaction mixtures containing tetrahydrocannabinol compounds or from raw products containing tetrahydrocannabinol...
7824745 Benzochromene derivatives  
The present invention relates to benzochromene derivatives of the formula I where the various parameters have the meaning indicated in the text, and to liquid-crystal media which comprise these...
7674922 Process for production of delta-9-tetrahydrocannabinol  
The present invention relates to a process for preparation of a delta-9-tetrahydrocannabinol compound or derivative thereof involving treating a first intermediate compound with an...
7638554 Flavanoids as chemotherapeutic, chemopreventive, and antiangiogenic agents  
Compounds useful as chemotherapeutic, chemopreventive, and antiangiogenic agents are provided. The compounds are flavanoids, including flavanones, flavanols, and chalcones. The compounds have the...
7495029 Prodrugs of (2R)-2-propyloctanoic acid for the treatment of stroke  
Disclosed are prodrugs of (2R)-2-propyloctanoic acid, and pharmaceutical compositions comprising them, which may be effective in modulating multiple events in the biochemical cascade of stroke....
7449589 Process for purifying (-)-Δ9-trans-tetrahydrocannabinol  
A process for separating (−)-Δ9-trans-tetrahydrocannabinol from a mixture of cannabinoids is disclosed. The process comprises at least one chromatographic step wherein a mobile phase passes trough...
7402686 Cannabinoid crystalline derivatives and process of cannabinoid purification  
Δ9 tetrahydrocannabinol (THC) esters comprising the reaction product of THC with at least one aryl sulfonyl chloride in the presence of at least one tertiary amine. The resulting aryl sulfonic THC...
7399872 Conversion of CBD to Δ8-THC and Δ9-THC  
Methods of converting cannabidiol to Δ8-tetrahydrocannabinol or Δ9-tetrahydrocannabinol are described. The described methods produce higher yields and higher purity compared to prior art methods.
7344736 Extraction of pharmaceutically active components from plant materials  
The invention relates to the extraction of pharmaceutically active components from plant materials, and more particularly to the preparation of a botanical drug substance (BDS) for incorporation...
7326447 Benzochromene derivatives  
The present invention relates to benzochromene derivatives of the formula I in which the various parameters are as defined in the text, and to liquid-crystal media which comprise these compounds,...
7323576 Synthetic route to dronabinol  
Dronabinol, the tetrahydrocannabinol compound which comprises the active constituent of marijuana and is pharmaceutically useful as an antiemetic, is prepared by a process involving reaction of...
7321047 Separation of tetrahydrocannabinols  
An individual tetrahydrocannabinol isomer of interest is separated from a mixture containing two or more such isomers, by treating the mixture with an isocyanate or isothiocyanate of formula I:...
7279500 Sulfonamide cannabinoid agonists and antagonists  
Cannabinoid agonists and antagonists are provided for use in the treatment of disorders such as acute and chronic pain, inflammation, loss of appetite, convulsions, multiple sclerosis, nausea and...
7279499 Substituted benzopyrans as selective estrogen receptor-beta agonists  
The present invention relates to substituted benzopyran derivatives, stereoisomers, and pharmaceutical acceptable salts thereof and processes for the preparation of the same. The compounds of the...
7235584 Non-psychotropic cannabinoids  
Novel non-psychotropic cannabinoids are disclosed and pharmaceutical compositions comprising these novel compounds are described for preventing neurotoxicity, neuroinflammation, immune or...
7217734 Substituted benzopyrans as selective estrogen receptor-beta agonists  
The present invention relates to substituted benzopyran derivatives, stereoisomers, and pharmaceutical acceptable salts thereof and processes for the preparation of the same. The compounds of the...
7169942 Cannabinoid derivatives, methods of making, and use thereof  
1′-substituted cannabinoid derivatives of delta-8-tetrahydrocannabinol, delta-9-tetrahydrocannabinol, and delta-6a-10a-tetrahydrocannabinol that have affinity for the cannabinoid receptor type-1...
7105685 Cannabinol derivatives  
The invention provides cannabinol derivatives and pharmaceutical preparations thereof.
7019024 Pharmaceutical for treatment of neurological and neuropsychiatric disorders  
The invention provides a pharmaceutical for treatment of neurological and neuropsychiatric disorders comprising a compound of the formula: or a pharmaceutically acceptable salt thereof.
6939977 Analgesic and immunomodulatory cannabinoids  
Disclosed are novel compounds represented by the following structural formula: R-X-Y; and physiologically acceptable salts thereof. R is a tricyclic core of a cannabinoid or substituted...
6803381 Carbamic acid derivatives  
The present invention relates to compounds of formula whereinR1 is hydrogen or lower alkyl;R2, R2′ are each independently hydrogen, lower alkyl, lower alkoxy, halogen or trifluoromethyl;X is O, S...
6608216 Process for the preparation of chiral glucocorticoid receptor agents  
The present invention relates to the preparation of chiral glucocorticoid receptor agents via biaryl atropisomers.
6593480 Glucocorticoid receptor antagonists for treatment of diabetes  
Compounds of formula I are useful for treating type II diabetes, obesity, hyperglycemia, inadequate glucose clearance, hyperinsulinemia, hypertriglyceridemia, and high-circulating glucocorticoid...
6576595 Xanthone derivatives, processes for their preparation and their use for controlling harmful fungi, and compositions comprising these derivatives  
Xanthone derivatives of the formula I where the index and the variables are as defined below:n is 0, 1 or 2;R1 is alkyl or haloalkyl;R2,R3 are alkoxy, alkenyloxy or alkynyloxy, or R2 and R3...
6458974 Synthesis of β-lapachone and its intermediates  
A novel process for synthesizing β-lapachone (beta-lapachone), an agent that has demonstrated significant antineoplastic activity against human cancer lines. The process comprises the conversion...
6403126 Cannabinoid extraction method  
A method of extracting cannabinoids, cannflavins, and/or essential oils from hemp and/or of producing a whole hemp extract lacking Δ9-THC is herein described. The industrial hemp is harvested and...
6403521 Catalyst comprising nitrogen-containing heterocyclic compound, and process for producing organic compound using the catalyst  
A catalyst is for use in a reaction using an oxygen-atom-containing reactant and includes a nitrogen-containing heterocyclic compound of the following formula (1): wherein each of R1 and R2 is,...
6245807 Treatment of human prostate disease  
We have now discovered that unexpectedly compounds of the following formulae I or 11 can be used to selectively stimulate the death of mammalian prostate cells, including both epithelial cell and...
6008383 Method of preparing delta-9-tetrahydrocannabinol esters  
The present invention provides an economical and efficient process for converting delta-9-tetrahydrocannabinol to a variety of ester analogs. Delta-9-tetrahydrocannabinol is esterified by reaction...
5977077 Xanthone analogs for the treatment of infectious diseases  
Therapeutic compositions for the treatment of infectious diseases are disclosed. These compositions comprise xanthones and xanthone derivatives, such as 2,3,4,5,6-pentahydroxyxanthone. Also...
5872148 Compositions useful as a cannabinoid receptor probe  
A composition of matter, comprising a cannabinol compound having the structure ##STR1## wherein, Q is --C(R1)(Y1)--(CH2)n --Z1 ; R1 is --H or --CH3 ; Y1 is --CH3 or Y2 ; Y2 is --N3 or --NCS; n is...
5792389 Water soluble laser dyes  
Novel water soluble dyes of the formula I are provided ##STR1## wherein R1 and R4 are alkyl of 1 to 4 carbon atoms or hydrogen; or R1 -R2 or R2 -R4 form part of aliphatic heterocyclic rings; R2 is...
5763625 Synthesis and use of β-lapachone analogs  
3-Substituted-β-lapachone analogs and their use either alone or to augment chemotherapy or radiotherapy to induce programmed neoplastic cell death without exhibiting toxicity to surrounding normal...

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