|
Match
|
Document |
Document Title |
|
|
7642362 |
Compounds as semaphorin inhibitors
Compounds represented by the general formula (1)
wherein R 1 and R 3 are each independently hydrogen or a carboxyl group and R 2 and R 4 are each independently hydrogen or a hydroxyl group,...
|
|
|
7495111 |
Compounds useful as serotonin inhibitors and 5-HT1A agonists and antagonists
3-Amino chroman and 2-amino tetralin derivatives and compositions containing such compounds are disclosed. Such compounds are useful for modulating activity of a 5-HT 1A receptor (agonizing or...
|
|
|
7414126 |
Process for the preparation of topiramate
The present invention relates to a process for the preparation of topiramate, intermediates in this process and a process for the preparation of these intermediates.
|
|
|
7385067 |
Process for the preparation of compounds having a CF2O bridge
The invention relates to a process for the preparation of compounds containing at least one —CF 2 —O— bridge in the molecule, in which
a) an acid is added onto at least one ketene...
|
|
|
7196209 |
Continuous process for the preparation of fructopyranose sulfamate derivatives
The present invention is directed to a continuous process for the preparation of fructopyranose sulfamate derivatives of the general formula (I)
wherein R 1 , R 3 , R 4 , R 5 , R 6 and X...
|
|
|
7157589 |
One step process for the preparation of anticonvulsant derivatives
The present invention is directed to a one-step process for the preparation of fructopyranose sulfamate derivatives of the general formula (I)
wherein X, R 1 , R 3 , R 4 , R 5 and R 6 ...
|
|
|
7144885 |
Fused tricyclic heterocycles useful for treating hyper-proliferative disorders
This invention relates to a novel fused tricyclic heterocycle of the formula (Ia, Ib) and its use for the treatment of hyper-proliferative disorders
|
|
|
6774142 |
Inhibition by 3-deoxyflavonoids of T-lymphocyte activation and therapies related thereto
3-Deoxyflavonoid compounds and methods for inhibiting T-cell activity and treating diseases and disorders (e.g., autoimmune disorders, inflammatory disorders, diabetes, ALS, MS, rheumatoid...
|
|
|
6737439 |
Aromatase inhibitors from Broussonetia papyrifera
A composition and method of cancer treatment is disclosed. The composition and method utilized the extract of B. papyrifera , or compounds included therein having aromatase inhibition properties,...
|
|
|
6696578 |
Difuropyrone derivatives
A novel cartilage-specific compound and methods of diagnosis in medical and veterinary contexts using the compound. Screening methods for therapeutic substances and methods of treatment are also...
|
|
|
6602903 |
Substituted heterocyclic compounds
The invention relates to compounds of formula (I): and medicinal products containing the same are useful in treating or in preventing melatoninergic disorders.
|
|
|
6465625 |
Taxol derivatives
Highly specific biocatalytic reactions have been used to create a population of taxol derivatives.
|
|
|
6399653 |
Ring fused dihydropyrans, process for preparation and use thereof
The invention relates to compounds of the formula I in which the radicals R 1 , R 2 , R 3 and A have the meaning mentioned in the description. The invention further relates to a process for the...
|
|
|
6384045 |
Tricyclic and tetracyclic pyrones
This invention provides cancer-active tricyclic and tetracyclic oxypyrones and a method of synthesizing these compounds. Preferred compounds have aryl groups at the 3-position of the oxypyrone...
|
|
|
6365610 |
Ozonide compounds with inhibitory activity for urokinase production and angiogenesis
The invention provides a urokinase production inhibitor or angiogenesis inhibitor comprising as an active component an ozonide derivative represented by the formula (1), and method of prevention or...
|
|
|
6262083 |
Genipin derivative having liver protection activity
The present invention relates to novel genipin derivatives which have an excellent liver protection activity with little cytotoxicity, and these compounds are so stable in vivo that they do not...
|
|
|
6255324 |
Amino-and mercurio-substituted 4',5'-dihydropsoralens and therapeutical uses thereof
5'-substituted, 4',5'-dihydropsoralen compounds (5) bearing tertiary amines (and salts thereof), quaternary ammonium moieties or organomercurial moieties are described. ##STR1## Also described are...
|
|
|
6225478 |
Iridoid derivatives and neovascularization inhibitors containing the same as active ingredient
Novel iridoid derivatives represented by general formula (I): ##STR1## and a vascularization inhibitor having for its active ingredient said derivative are disclosed. This vascularization inhibitor...
|
|
|
6136961 |
Biocatalytic methods for synthesizing and identifying biologically active compounds
Highly specific biocatalytic reactions have been used to create a population of derivatives from a single starting compound. Examples demonstrate synthesis of derivatives of taxol,...
|
|
|
6071946 |
Tricyclic urea compounds
A compound selected from those of formula (I): ##STR1## in which A, Y, R 1 , R 2 and R 3 are as defined in the Specification, and pharmaceutical compositions containing the same, which are useful...
|
|
|
6034120 |
Insect antifeedant for agriculture
The present invention provides an antifeedant and a contact insecticide using the components contained in Cyperaceae species. In particular, the present invention provides an insect antifeedant and...
|
|
|
5998461 |
Tricyclic amide compounds
This invention relates to benzofuran/pyran derivatives of a new tricyclic amide compound, their composition and method of use for treating disorders of the melatoninergic system.
|
|
|
5986114 |
Benzopyranol derivatives
The invention relates to benzopyranol derivatives which are intermediates in a process for stereoselectively forming N-substituted dihydro-2,3 benzodiazopines which are useful as AMPA receptor...
|
|
|
5856529 |
Benzofuran and dihydrobenzofuran melatonergic agents
Novel derivatives of benzofuran and dihydrobenzofuran are provided which are useful as melatonergic agents.
|
|
|
5773609 |
Photoactivatable compositions and to methods for the diagnosis and treating medical conditions
A broad class of photosensitive compounds having enhanced in vivo target tissue selectivity and versatility in photodynamic therapy. Many furocoumarin compounds, such as psoralens, exhibit...
|
|
|
5702645 |
Photochromic chromene derivatives
Described herein are photochromic compounds or a structural isomer of the photochromic compound, the photochromic compounds represented by the formula: ##STR1## wherein R 1 , R 2 , R 4 , R 5 , R 6...
|
|
|
5686485 |
Physiologically active EI-1941 compounds
The present invention relates to EI-1941 compounds having interleukin-1 production inhibitory activity which are represented by the formula: ##STR1## wherein either of R 1 and R 2 is hydrogen and...
|
|
|
5646175 |
Carbamoyloxylabdane compounds
Novel carbamoyloxylabdanes, intermediates and processes for the preparation thereof, and methods for reducing intraocular pressure and treating cardiac failure utilizing compounds and compositions...
|
|
|
5639889 |
Asymmetric epoxidation reaction
A process for producing an optically active benzopyran compound of the formula [I] or [II]: ##STR1## in which an olefin compound of the formula [V] or [VI]: ##STR2## is subjected to asymmetric...
|
|
|
5428027 |
Substituted semicarbazone arthropodicieds
Certain substituted semicarbazones, including all geometric and stereoisomers thereof, agricultural compositions containing them and their use as arthropodicides.
|
|
|
5418232 |
Diazabicycloalkene derivatives
A compound of formula (I) possesses excellent potassium channel opening activity and is effective on various diseases arising from contractions of blood vessels, bronchial smooth muscles, etc., for...
|
|
|
5409952 |
Heterocyclic compounds: 2-styryl-4H-1-benzopyran-4-ones
A compound of the formula (I) ##STR1## in which: R 1 represents a hydrogen atom, a lower alkyl group, a hydroxy group or a lower alkoxy group, R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 and R 11 ...
|
|
|
5391751 |
2,2-dimethylchromene derivatives, process for their preparation and pharmaceutical compositions in which they are present
The present invention relates to 2,2-dimethylchromene derivatives of the formula: ##STR1## in which Z represents a halogen atom or a cyano, nitro, acetyl, phosphono or dialkoxyphosohoryl group, the...
|
|
|
5387700 |
Process for the preparation of chlorosulfate and sulfamate derivatives of 2,3:4,5-bis-O-(1-methylethylidene)-β-D-fructopyranose and (1-methylcyclohexyl)methanol
A process for producing chlorosulfate and sulfamate esters of 2,3:4,5-bis-O-(1-methylethylidene)-β-D-fructopyranose and (1-methylcyclohexyl)methanol is disclosed. The process involves a two step...
|
|
|
5276054 |
Substituted hexahydrobenzopyran derivatives as angiotensin II antagonists
Substituted hexahydrobenzopyran derivatives of the Formulae A, B, or C are useful as angiotensin II antagonists: ##STR1##
|
|
|
5273998 |
Process for making an optically active 3,4-dihydro-3,4-epoxy-2H-1-benzopyran compound
The present invention provides an industrially valuable method for preparing an optically active 3,4-dihydro-3,4-epoxy-2H-1-benzopyran compound which is useful as a starting material for an...
|
|
|
5258402 |
Imidate derivatives of pharmaceutically useful anticonvulsant sulfamates
Imidate derivatives of sulfamates having the following formula (I): ##STR1## wherein R 1 , R 2 , R 3 , R 4 and X are as herein defined have been found to be useful prodrug and exhibit...
|
|
|
5254595 |
Aryloxypropanolaminotetralins, a process for their preparation and pharmaceutical compositions containing them
Aryloxypropanolaminotetralins with beta-antagonist activity of the formula ##STR1## wherein R is hydrogen, hydroxy or methoxy and Ar is an optionally substituted aromatic or heteroaromatic group,...
|
|
|
5189183 |
Aromatic amine derivatives
Novel aromatic amine derivatives of specific structure are useful intermediates for herbicides. The aromatic amine compounds have the structure shown by formula [I]: ##STR1## wherein Ar and A are...
|
|
|
5176919 |
Pharmaceutical compositions having activity on the cutaneous microcirculation
Pharmaceutical and cosmetic compositions comprising extracts of Ammi visnaga and Ammi majus or the vasoactive agents contained therein are described.
|
|
|
5103025 |
Process for the resolution of enantiomers of benzopyran derivatives
The invention relates to a process for the resolution of enantiomers of 3,4-epoxy-3,4-dihydro-2,2-dimethyl-3-R-2H-1-benzopyran-6-car
bonitriles (I), in which R is H or CH 3 , characterized in that...
|
|
|
5075460 |
Epoxybenzopyrans
A compound of the formula ##STR1## wherein: one of R 1 and R 2 is hydrogen or C 1 -4 alkyl and the other is C 1 -4 alkyl or R 1 and R 2 together are C 2 -5 polymethylene; and R' 4 is ethyl,...
|
|
|
4994584 |
Precursor of prostaglandin and production thereof
The present invention provides new compound, 10-substituted-5,9-dioxatricyclo[6.4.0.0 2 ,6 ]dodecane-4-one, which is very useful as an intermediate for prostaglandin synthesis.
|
|
|
4990668 |
Optically active aryloxypropanolamines and arylethanolamines
Described is a process for preparing a racemic or chiral aryloxypropanolamine (1) or arylethanolamine (2) of the formula ##STR1## wherein Ar is aryl, substituted aryl, heteroaryl, or aralkyl and R...
|
|
|
4963537 |
Labdane compounds, pharmaceutical compositions and use
Novel labdanes, intermediates and processes for the preparation thereof, and methods for reducing intraocular pressure utilizing compounds or compositions thereof are disclosed.
|
|
|
4822803 |
Benzofuran 2-carboxylic acid hydrazides useful as inhibitors of leukotriene biosynthesis
Compounds of the Formula I: ##STR1## and pharmaceutically acceptable salts thereof are inhibitors of leukotriene biosynthesis. These compounds inhibit the mammalian 5-lipoxygenase enzyme, thus...
|
|
|
4814346 |
Benzopyrans and use thereof in treating vascular diseases
Isoflavans of the formula I ##STR1## wherein the groups OR, R', R" and ring B are as defined in the specification, exhibit valuable pharmacological properties, especially for the treatment of...
|
|
|
4758677 |
Cyanobenzano [b] pyrans
2,2-Dimethyl-3,4-dihydro-2H-benzo[b]pyran-3-ols bearing an amino group in the 4-position and a cyano group in the benzo ring, their salts, esters and ethers, demonstrate excellent vasodilatory...
|
|
|
4745127 |
Benzyl esters of benzofuran-2-carboxylic acids useful as inhibitors of leukotriene biosynthesis
Compounds of the Formula I: ##STR1## and pharmaceutically acceptable salts thereof are inhibitors of leukotriene biosynthesis. These compounds inhibit the mammalian 5-lipoxygenase enzyme, thus...
|
|
|
4661595 |
Method for producing xanthone and thioxanthone compounds useful as photoinitiators
A method for preparing a compound of formula I ##STR1## in which X is O or S; both groups R together with the two carbon atoms to which they are attached form a fused aromatic group; R 1 is...
|