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7422908 |
Chemiluminescent 1,2-dioxetanes
A method of generating light through chemiluminescence involves providing a stable 1,2-dioxetane of the formula:
Wherein (a) R 1 and R 2 are each, individually, a chemical reactive site or...
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7351739 |
Bioactive compounds and methods of uses thereof
In one aspect, the present invention provides compounds having formula I or IV as shown below:
as further defined herein. In additional aspects, the present invention provides compositions and...
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7332523 |
TNP-470 polymer conjugates and use thereof
The present invention relates to conjugates of water-soluble polymers and o(chloracetyl-carbamoyl) fumagillol (TNP-470) and use of those conjugates as specific intracellular carriers of the TNP-470...
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7300766 |
Polymeric ammonium and or phosphonium salts having added π-electrons and higher molecular weight as enhancers for chemiluminescent systems
A compound for enhancing the light output of a chemiluminescent system and, in particular, a stabilized, triggerable 1,2-dioxetane, is obtained by reacting a polyvinylbenzyl halide and a bilinker...
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7223882 |
Process for producing triterpene derivative
A process for a preparation of Compound (V), a pharmaceutically acceptable salt or a solvate thereof, said process comprising the steps represented by the following formula:
wherein R 1 and R...
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6949584 |
TNP-470 species, polymer conjugates and use thereof
The present invention relates to conjugates of water-soluble polymers and o-(chloracetyl-carbamoyl) fumagillol (TNP-470) and use of those conjugates as specific intracellular carriers of the...
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6803382 |
Angiogenesis inhibitors and pharmaceutical and cosmetic use thereof
The invention relates to novel 1-oxaspiro[2,5]octan-6-ol derivatives of general formula (I): and also to a method for preparing them, and to their use in pharmaceutical compositions for use in...
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6756502 |
Intermediate and processes for its preparation and conversion into a pharmacologically-active agent
Processes for the preparation of Venlafaxine (IX) via the novel epoxy-nitrile intermediate (I), which when subjected to hydrogenation forms compound (X), and may subsequently be reduced to yield...
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6736998 |
Indeno-fused photochromic naphthopyrans
Described are novel reversible photochromic indenonaphthopyran compounds, examples of which are 2H-naphtho[1,2-b]pyrans characterized by having a substituted or unsubstituted indeno group fused at...
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6723859 |
Chromene compound
Novel chromene compounds having various substituents to exhibit a high color-developing sensitivity and a high density even when dispersed in a high-molecular matrix, and exhibiting a large fading...
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6686389 |
2,3-dihydrobenzofuran derivatives
2,3-Dihydrobenzofuran derivatives of general formula (1): wherein R 1 represents a hydrogen atom or an acyl group; R 2 , R 3 and R 4 represent a hydrogen atom, a lower alkyl group or a lower...
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6645996 |
Physiologically active substances
The present invention provides a novel bioactive substance having an antiangiogenic effect. The chemical compound represented by the formula (1) (wherein, R 1 represents hydrogen atom, aldehyde...
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6521764 |
Process for the preparation of fumagillin
The invention relates to a process for the preparation of Fumagillin by liberation from its salt characterized by reacting Fumagillin dicyclohexylamine salt with an organic acid in alcoholic...
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6482960 |
Process for epoxidizing substituted cyclohexanones
This invention relates to a method for preparing 1-oxaspiro[2,5]-carbonitriles from ketones using spinning disc reactor technology.
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6452022 |
Method for preparing substituted 4-phenyl-4-cyanocyclohexanoic acids
This invention relates to a method of preparing a compound type where at least one of R′ or R″ is a carboxyl group (I) by treating a compound of formula (II) with a Group I(a) or Group II(a)...
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6407268 |
Substituted 4-benzoylpyrazoles
4-Benzoylpyrazoles of the formula I where: R 1 and R 2 are each hydrogen, mercapto, nitro, halogen, cyano, thiocyanato, C 1 -C 6 -alkyl, C 1 -C 6 -haloalkyl, C 1 -C 6 -alkoxy, C 2 -C 6...
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6337408 |
Compounds and method for preparing substituted 4-phenyl-4-cyanocyclohexanoic acids
This invention relates to a method of preparing a compound of the following type by treating a compound of formula (II) with lithium bromide, magnesium bromide and the like.
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6284899 |
Chemiluminescent dialkyl-substituted 1,2-dioxetane compounds, methods of synthesis and use
A chemiluminescent assay method and compositions are described which use a dialkyl-substituted dioxetane which is deprotected to trigger a chemiluminescent reaction. Chemiluminescent 1,2-dioxetane...
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6225478 |
Iridoid derivatives and neovascularization inhibitors containing the same as active ingredient
Novel iridoid derivatives represented by general formula (I): ##STR1## and a vascularization inhibitor having for its active ingredient said derivative are disclosed. This vascularization inhibitor...
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6139781 |
Chemiluminescent electron-rich aryl-substituted 1,2-dioxetanes
Chemiluminescent electron-rich aryl-substituted 1,2-dioxetane compounds are disclosed in which the aryl group is poly-substituted with suitable electron-donating groups such that the light-emitting...
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6133459 |
Method and compositions providing enhanced chemiluminescence from 1,2-dioxetanes
A method and compositions including a 1,2-dioxetane and a fluorescent compound is described. In particular, enzymatic triggering of a triggerable 1,2-dioxetane admixed with a surfactant and the...
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6124478 |
Methods of using 1,2-dioxetanes and kits therefore
Compounds having the formula: ##STR1## wherein T is a polycycloalkylidene group (e.g., adamant-2-ylidene); R is a C 1 -20 alkyl, aralkyl or cycloalkyl group; and Y is a fluorescent chromophore...
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6063812 |
Fumagillol derivatives and processes for preparing the same
Compounds useful as angiogenesis inhibiting agents and processes for their preparation are disclosed. In one embodiment, the compounds of the invention are represented by Formula 1: ##STR1## Also...
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6040461 |
Synthesis of 3-epi vitamin D.sub.3 metabolites and analogs
The invention relates to a process for the preparation of vitamin D 3 compounds of formula I. ##STR1## Wherein A is a single or a double bond; B is a single, cis-double, trans double or a triple...
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5981768 |
1,2 chemiluminescent dioxetanes of improved performance
A new class of stable dioxetanes bears a polycyclic stabilizing group and aryloxy moiety, the oxygen atom of which is provided with a protective group which can be removed by an enzymatic or...
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5936101 |
Process for the preparation of 1,2-dioxetane compounds and novel sulfur-substituted 1,2-dioxetane compounds as intermediates
A process for producing a stable triggerable dioxetane comprising; (a) reacting a vinyl sulfide compound containing a sulfur-substituent SR 4 , wherein R 4 is an organic group containing 1 to...
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5929254 |
1,2-dioxetane derivatives
A 1,2-dioxetane derivative of formula (I) for use as a chemiluminescent substrate for immunoassays: ##STR1## wherein R 1 is an alkyl group or an aryl group, R 2 a hydrogen atom, an alkyl group or...
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5919956 |
Process for the C.sub.1 -homologization of protected phorenol
A process for the manufacture of an optionally protected 4,8,8-trimethyl-1-oxaspiro 2.5!oct-4-en-6-ol (I) starting from protected 4-hydroxy-2,6,6-trimethyl-2-cyclohexen-1-one (II) comprises...
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5871938 |
Dioxetane compounds for the chemiluminescent detection of proteases, methods of use and kits therefore
1,2-dioxetane compounds bearing a proteolytic enzyme specific amino acid or peptide are provided, which amino acid or peptide can be removed by action of the corresponding protease. When the amino...
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5869698 |
1,2-dioxetane compounds as chemiluminescent labels for organic and biological molecules
Dioxetanes which couple with organic and biological molecules of the formula: ##STR1## wherein X is a leaving group which is removed by an `activating agent to produce light, wherein A is a...
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5856522 |
Method of using synthesis of 1,2-dioxetanes and kits therefore
Kits comprising 1,2-dioxetanes which can be cause to chemiluminesce by contact with an enzyme, and the enzyme, are provided for use in optically detectable assays. The assay calls for binding the...
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5854235 |
17-spiromethylene steroids
The invention relates to a steroid derivative which steroidal skeleton is bound at carbon atom 17 to a spiromethylene ring of the formula: ##STR1## wherein R a and R b are independently selected...
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5847161 |
1, 2 chemiluminescent dioxetanes of improved performance
A new class of stable dioxetanes bears a polycyclic stabilizing group and aryloxy moiety, the oxygen atom of which is provided with a protective group which can be removed by an enzymatic or...
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5846753 |
Chemiluminescence-based method for rapid and sensitive in-situ detection of organophosphorus compounds and metal ions
A method of detecting the presence of a substance being monitored in a medium, selected from the group of substances including organophosphorus compounds and the metal ions Zn, Be and Bi, including...
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5831102 |
Chemiluminescent 3-(substituted adamant-2'-ylidene) 1,2-dioxetanes
Enzymatically cleavable chemiluminescent 1,2-dioxetane compounds capable of producing light energy when decomposed, substantially stable at room temperature before a bond by which an enzymatically...
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5789604 |
Isolation, characterization and structures of new antibiotic components produced by fungal culture 07F275
New antibacterial agents produced by fungal culture 07F275, of which the compound designated 07F275 alpha having the following structure: ##STR1## is representative. Methods for the fermentation,...
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5789405 |
Oxaspiro(2,5)octane derivative
An oxaspiro 2,5!octane derivative of the formula: ##STR1## useful in inhibiting angiogenesis in solid tumors.
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5785887 |
Peroxygen bleach composition
A peroxygen bleaching composition which comprises approximately by weight a mixture of about 1 to about 75% of an inorganic peroxygen bleaching compound; and about 1 to about 75% peroxygen...
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5777133 |
Synthesis of 1, 2-dioxetanes and intermediates therefor
Compounds having the formula: ##STR1## wherein T is a polycycloalkylidene group (e.g., adamant-2-ylidene); R is a C 1 -20 alkyl, aralkyl or cycloalkyl group; and Y is a fluorescent chromophore...
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5773628 |
1,2-dioxetane compounds with haloalkoxy groups, methods preparation and use
A chemiluminescent assay method and compositions are described which use a haloalkoxy group-substituted dioxetane which is deprotected by a hydrolytic enzyme to undergo a chemiluminescent reaction....
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5719291 |
Cyclohexane derivatives
Compounds of the formula ##STR1## which have antifungal activity.
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5707559 |
Chemiluminescent 1,2-dioxetane compounds
Novel light producing 1,2-dioxetanes are described of the formula ##STR1## wherein ArOX is an aryl ring substituted with an X oxy group and A are passive organic groups which allow the...
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5698714 |
Process for the preparation of 9, 10-secocholesta-5,7,10 (19)-trienes
The invention recites a process for preparing 9,10-secocholesta-5,7,10(19)-trienes of formula (I) ##STR1## where R 1 is hydrogen or a hydroxy-protecting group and R 2 and R 3 are independently...
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5698586 |
Angiogenesis inhibitory agent
O-substituted fumagillol derivatives and its salts have an angiogenesis inhibiting activity and are useful for prophylaxis and treatment of diseases induced by abnormally stimulated...
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5679802 |
1,2-dioxetanes useful in chemiluminescent immunoassays
A compound of the formula ##STR1## where n, Q, and Z are as defined useful in chemiluminescent immunoassays.
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5663373 |
4-alkoxy-2, 6-di-t-butylphenol derivatives
Compounds represented by the general formula (I), as well as intermediates for the synthesis of thereof: ##STR1## where R 1 is a hydrogen atom or an acyl group; R 2 is a lower alkyl group; R 3 ...
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5652345 |
1,2-dioxetane compound
4-(3-beta-D-galactopyranosylphenyl)-4-methoxyspiro[1,2-dioxe
tane-3,2'-adama ntane] which is useful in various chemiluminescent assays.
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5648382 |
Cyclohexane compounds
Compounds of formula (I): ##STR1## wherein: R is selected from the radicals: ##STR2## Y is selected from ##STR3## R 1 represents the radical ##STR4## and A, B, C, D, R 2 , R 3 and R 4 are as...
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5639918 |
Intermediate compounds useful in the preparation of fungicidal compositions containing (benzylidene)-azolylmethyclycloalkane
(Benzylidene)-azolylmethylcycloalkane or -alkene of formula ##STR1## in which: A and A 1 are hydrocarbon chains of 1 to 3 carbon atoms, R 1 , R 2 , R 3 , R 4 and R 5 are hydrocarbon radicals,...
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5631353 |
Alkene adamantane intermediates and the corresponding 1,2-dioxetanes
Alkene adamantane compounds useful as intermediates for producing the corresponding 1,2-dioxetanes which are useful in chemiluminescent assays.
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