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7285671 |
Materials and methods for treating coagulation disorders
The subject invention provides anticoagulant compounds of formula I: and pharmaceutically acceptable salts thereof, wherein R1, R3, n and Ar are as defined herein. The compounds of the subject...
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7259185 |
Stable warfarin sodium liquid formulation and method of making same
A stable liquid composition comprising warfarin sodium, glycerin, an alcohol such as ethanol, and a pH buffer such as a phosphate buffer providing a pH above 7 is provided. The stability of the...
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7179838 |
Coumarin analog compounds for safer anticoagulant treatment
The present invention relates to the albumin-guided development of coumarin analogs and the analogs developed thereby. The coumarin analogs of the present invention are identified and isolated by...
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6673944 |
Preparation of warfarin sodium from warfarin acid
The invention provides a method for the direct preparation of pure warfarin sodium from warfarin acid. The reaction is conducted in a polar organic solvent, preferably ethanol, using a...
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6512005 |
Process for synthesis of pure warfarin acid, warfarin alkali metal salts and corresponding clathrates
An improved procedure for the purification of warfarin acid. Sodium, potassium and lithium warfarin salts and the corresponding clathrates are prepared in high, pharnacopeial grade purity and good...
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6291518 |
Hydroxy and polyhydroxy derivatives of coumarin, preparation thereof and antiviral action thereof
The present invention relates to novel hydroxy and polyhydroxy derivatives of coumarin fused with dialdehydes and aldehyde acids of the general formulae I, II, III and IV: ##STR1##wherein R1 =R2...
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5856525 |
Asymmetric R and S warfarin and its analogs
The present invention provides a novel process for making compounds of formula 2a or 2b or pharmaceutically acceptable salts thereof, ##STR1## wherein R1 is selected from the group consisting of...
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5696274 |
Syntheses based on 2-hydroxyacetophenone
The present invention provides processes which are flexible, cost effective, and commercially viable methods of manufacturing or producing products from 2-hydroxyacetophenone (2-HAP).Of particular...
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5616719 |
Photoactive indicator compounds
Photoactive indicator compounds of the formula ##STR1##
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5580552 |
7-glycosyloxybenzopyran derivative and antiallergic agent containing the derivative as active ingredient
A 7-glycosyloxybenzopyran derivative represented by the following formula (I) ##STR1## wherein, R is a hydrogen atom, an acyl group, an alkyl group, a cycloalkyl group, an alkenyl group or an...
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5418254 |
Substituted cyclopentadienyl compounds for the treatment of inflammation
A class of 2,3-substituted cyclopenta-2,4-dienyl compounds is described for use in treating inflammation and inflammation-related disorders. Compounds of particular interest are defined by Formula...
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H000852 |
Rodenticidal composition
A method for stabilizing a rodenticidally active material selected from certain (i) indane dione derivatives, (ii) hydroxycoumarin derivatives and (iii) thiocoumarin analogs of (ii), comprising...
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4788297 |
Separation of isomers
Process for selective removal of the cis-isomer and consequent enrichment of a solution with respect to the trans-isomer of a 1-(4-hydroxycoumarin-3-yl)-3-substituted phenyl)tetrahydronaphthalene...
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4659657 |
Chromogenic and fluorogenic esters for photometric or fluorimetric determination of phosphatases or sulphatases
Compounds of the formula ##STR1## wherein Y is ##STR2## M is hydrogen, or an alkali metal or ammonium ion, X is --O-- or an amino group, R is H, Cl, Br, CN or carbamoyl, R1 is H or --SO3 H, and A...
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4113744 |
Microcrystalline 3-(alpha-acetonylbenzyl)-4-hydroxycoumarin (warfarin) and methods of making
Microcrystalline 3-(alpha-acetonylbenzyl)-4-hydroxy coumarin (warfarin), having a crystal size not greater than 4.0 microns, is stable for long periods of time, is advantageous in that it is...
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4078936 |
Silver halide emulsion containing two-equivalent yellow coupler
The two-equivalent yellow coupler having the following formula has an extremely high reactivity, produces an image of high density in color development and causes little fogging and no ground...
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3862239 |
ARYL SUBSTITUTED CYCLOHEXENECARBINOLS
Compounds of the formula: ##SPC1## Wherein R is carboxy, lower carbalkoxy, methylol, carboxamide or carboxylic alkali metal salts, R' is lower alkyl and Ar is substituted aryl are active agents for...
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3835161 |
3-SUBSTITUTED-4-HYDROXY-COUMARINS
New 3-substituted-4-hydroxy-coumarins of the formula: ##SPC1## Wherein R1 represents a lower alkyl radical containing 1 to 3 carbon atoms and X represents chlorine, bromine or iodine;...
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3764693 |
A RODENTICIDAL COMPOSITIONS CONTAINING 4-HYDROXY COUMARINS
The 4-hydroxy coumarins are represented by the formula ##SPC1## In which R is a member of the group formed by hydrogen, the phenyl, halophenyl, dihalophenyl, nitrophenyl, methoxyphenyl, tolyl,...
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3651091 |
DERIVATIVES OF 4-HYDROXY COUMARIN AND THE PREPARATION THEREOF
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3812181 |
O-(ALPHA-HYDROXYCINNAMOYL)BENZOIC ACID AND RELATED COMPOUNDS
A novel class of reagents react with primary amine-containing compounds, preferably polypeptides and amino acids to form highly fluorescent products. This reaction serves as a basis for a rapid and...
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3585214 |
HYDROXYL DERIVATIVES OF COUMARINE AND PROCESSES FOR THE PREPARATION THEREOF
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3485922 |
INJECTABLE SOLUTIONS OF THE TRI-(HYDROXYMETHYL)-AMINOMETHANE DERIVATIVE OF 3-(ALPHA-ACETONYLBENZYL)-4-HYDROXYCOUMARIN AND PROCESSES FOR PREPARING THE SAME
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3325515 |
Coumarin derivatives and their preparation
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3288809 |
3-(1-phenyl-2-propynyl)-4-hydroxycoumarin and method of preparing the same
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3246013 |
Preparation of crystalline warfarin sodium-isopropyl alcohol complex
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3239529 |
Resolution of warfarin and marcoumar
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3192232 |
Warfarin alkali metal derivative process
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3097213 |
Warfarin intermediates
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3077481 |
Warfarin sodium
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3022317 |
3-benzyl-4-hydroxycoumarin and a process for the preparation of derivatives of 3-benzyl-4-hydroxycoumarin
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2952689 |
Coumarin derivatives and their production
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2938039 |
Method of preparing 1-(chromonyl-3)-1-(4-hydroxycoumarinyl-3)-methane and its derivatives
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2932652 |
3-(1'-(alpha-naphthyl) 3'-oxo-butyl) 4-hydroxy coumarin and salts thereof
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2872457 |
Process for the preparation of 4-hydroxycoumarin derivatives
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2871257 |
Production of acid chlorides
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2816899 |
3-benzhydryl-4-hydroxycoumarins and their preparation
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