Matches 1 - 50 out of 205 1 2 3 4 5 >
Match Document Document Title
7576124 Anti-first-pass effect compounds  
Safe, effective first-pass inhibiting compounds and citrus-derived substances are provided. Formulations containing the compounds are also provided as are methods for their preparation and for...
7576123 Anti-first-pass effect compounds  
Compositions, methods, etc. for addressing the first-pass effect.
7316884 5-methylene-1,3-dioxolan-4-one derivatives, process for their production, polymers of the derivatives, resist compositions, and pattern formation process  
A 5-methylene-1,3-dioxolan-4-one derivative and a monomer and copolymer thereof and a resist composition containing the polymer or copolymer where the 5-methylene-1,3 -dioxolan-4-one derivative is...
7314942 Methylenelactones syntheses in supercritical fluids  
Alpha-methylenelactone is produced from butyrolactone and valerolactone by the addition of formaldehyde in a supercritical fluid.
7232915 Process for the synthesis of 1,3-diols  
An improved process for the preparation of cis-1,3-diols is described where a beta hydroxy ketone is treated with a trialkylborane or dialkylalkoxyborane or a mixture of a trialkylborane and a...
6808724 Artemisolide compound isolated from the aerial parts of Artemisia sylvatica, isolation method, and use thereof  
The present invention relates to a novel compound isolated from Artemisia Sylvatica , expressed by the formula 1, a method of isolation, and its use thereof, and more particularly to a novel...
6486195 Thermodynamically stable crystal form of 4″-deoxy-4″-epi-methylamino avermectin B1a/B1b benzoic acid salt and processes for its preparation  
The most thermodynamically stable crystalline form of the benzoic acid salt of 4″-deoxy-4″-epi-methylamino avermectin B1a/B1b as the hemihydrate is obtained by crystallization from organic...
6410590 Compounds having antitumor activity: process for their preparation and pharmaceutical compositions containing them  
The present invention relates to novel derivatives of Andrographolide, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, and their pharmaceutically acceptable...
6388099 Production of 8,8a-dihydroxy-6-deoxyerythronolide B  
The heterologous expression of the OlePKS in Streptomyces lividans , produces 8,8a-deoxyoleandolide, an aglycone precursor of oleandomycin. The co-expression with DEBS in S. lividans of the P450...
6387948 8-Acetylarteminolide and process for preparing same  
8-Acetylarteminolide of the formula (I) having inhibitory activities against farnesyl-protein transferase(FPTase), a progression of the cell cycle and angiogenesis may be useful for the prevention...
6372781 Compounds for treating gastroduodenal diseases  
Spirolaxine, the compound of formula (I) wherein R is H, and the novel compounds of formula (I) wherein R is (C 1 -C 5 ) alkyl or CH 3 (CH 2 ) n CO and n is 1, 2, 3 or 4 are useful in treating...
6362168 Antiparasitic agents  
Compounds of the formula: wherein X represents a single or a double bond; R 1 is H or OH; provided that when X is a single bond, R 1 is H or OH, and when X is a double bond, R 1 is absent; R...
6355810 Multibinding inhibitors of HMG-CoA reductase  
Disclosed are multibinding compounds which inhibit 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMG-COA reductase), the rate limiting enzyme in cholesterol biosynthesis. The multibinding...
6255337 Anti-first-pass effect compounds and citrus extract  
First-pass effective substances derived from citrus.
6239073 Brassinosteroid analogs useful as plant growth regulators  
Disclosed are compositions and methods for promoting plant growth. The compounds are cyclopropyl-, cyclobutyl-, and cyclopentyl-substituted brassinosteroids having high growth promoting ability....
6174710 Spirolaxine derivatives for treating gastrobuodenal diseases  
Spirolaxine, the compound of formula (I) ##STR1## wherein R is H, and the novel compounds of formula (I) wherein R is (C 1 -C 6 )alkyl or CH 3 (CH 2 ) n CO and n is 1, 2, 3 or 4 are useful in...
5962659 Anthelmintic milbemycins and avermectins  
Novel compounds of formula (I): ##STR1## wherein R 1 is hydrogen or optionally protected hydroxy; R 2 is alkoxy, optionally protected hydroxy, oxo or optionally O-substituted oximino; R 3 is...
5883080 Antiparastic auermectin derivatives  
Antiparasitic avermectin derivatives of formula (I), where the broken line represents an optional bond, R 1 and R 4 are independently H, OH, halo, oximino, or an organic radical, R 2 , R 6 and R...
5871938 Dioxetane compounds for the chemiluminescent detection of proteases, methods of use and kits therefore  
1,2-dioxetane compounds bearing a proteolytic enzyme specific amino acid or peptide are provided, which amino acid or peptide can be removed by action of the corresponding protease. When the amino...
5861518 Phthalide compounds and their production process  
This invention provides processes for producing phthalide compounds which comprise cultivating Phanerochaete avelutina FERM BP-4787 and then isolating phthalide compounds from the fermentation broth.
5861429 13-substituted milbemycin 5-oxime derivatives, their preparation and their use against insects and other pests  
Compounds of formula (I): ##STR1## wherein: R 1 is methyl, ethyl, isopropyl or sec-butyl; X is carbonyl or methylene; Z is C(R 2 ) 2 or C(CH 2 ) m , in which R 2 is alkyl, and m is...
5840728 Conformationally locked nucleoside analogs as antiherpetic agents  
A method for treatment of herpes virus infection by administering an effective virus-inhibiting amount of a cyclopropanated carbocyclic 2'-deoxynucleoside to an individual in need thereof. The...
5840704 Antiparasitic agents and process for their preparation  
The invention provides novel compounds having the formula: ##STR1## wherein R when taken individually is H; R 1 when taken individually is H or OH; R and R 1 when taken together represent a...
5830875 24-and 25-substituted avermectin and milbemycin derivatives  
Novel avermectin and milbemycin derivatives are disclosed, where the C-24 and C-25 carbon atoms are substituted by hydrogen, alkyl, alkenyl, substituted alkyl or substituted alkenyl groups. These...
5811034 7-methylidene-5-oxo-furo fused naphthopyrans  
Described are novel 7-methylidene-5-oxo-furo fused naphthopyran compounds having certain substituents at the 2 position of the pyran ring. Also described are polymeric organic host materials that...
5728719 Systemic control of parasites  
The present invention is a method for controlling ectoparasites. More particularly, the invention relates to a method of treatment in which the warm blooded animal is dosed with an ovicidally...
5721271 Parasiticidal milbemycin derivatives  
Compounds of formula (I): ##STR1## wherein R 1 is hydrogen or methyl, R 2 is hydrogen or (E)-2-methyl 2-butenoyloxy, and R 3 is hydrogen or hydroxy, with the proviso that when R 3 is hydrogen,...
5686484 Milbemycin derivatives, their preparation and their use  
Compounds of formula (I): ##STR1## and of formula (I) w : ##STR2## in which: A represents group having one of the following formulae: ##STR3## wherein R 2 , R 3 and R 4 are independently...
5677332 Antiparasitic agents  
This invention is directed to novel antiparasitic compounds of formula (I), wherein the broken line represents an optional bond, R 1 and R 4 being absent when this bond is present, R 1 , R 3 , R...
5656748 Process for the preparation of ivermectin  
The invention relates to a process for the selective hydrogenation of avermectins with the aid of a rhodium-phosphine complex based on a hydrazine.
5625078 Processes for the production of 13-ether derivatives of milbemycins and novel intermediates therefor  
An intermediate useful in the synthesis of milbemycin derivatives having an ether bond at the 13-position and which is represented by the general formula (IIId): ##STR1## wherein R represents a...
5616729 Enhanced chemiluminescence from 1,2-dioxetanes through energy transfer to tethered fluorescers  
Triggerable dioxetanes with a fluorescent substituent bonded or tethered in the dioxetane so as to produce fluorescence from the group are described. The compounds are of the formula: ##STR1##...
5614470 13-substituted milbemycin derivatives, their preparation and their use  
13-Substituted milbemycin derivatives having the formula (I): ##STR1## wherein: R 1 is methyl, ethyl, isopropyl or sec-butyl; R 2 is hydrogen or alkyl; X is (α-hydroxyimino- or...
5604182 Milbemycin ether derivatives, their preparation and their therapeutic and agrochemical uses  
Compounds of formula (I): ##STR1## and salts and esters thereof have valuable anthelmintic, acaricidal and insecticidal activities. Methods of preparing the compounds are also provided.
5559249 7'-amino-naphthazarin antibiotic derivatives  
Compound of general formula V ##STR1## wherein Hal is a chlorine or bromine atom. The compounds are useful as starting materials in preparing gamma-rubromicin amino derivatives.
5556868 Antiparasitic avermectin and milbemycin derivatives  
Avermectin and milbemycin derivatives of formula (I) ##STR1## having a double bond at the 3-4 position and a cyano substituent at the 3-position have outstanding anthelmintic properties. They may...
5539089 A83543 aglycones and pseudoglycones  
A83543 Aglycones A83543AgA, A83543AgD, A83543AgE, and A83543AgF, and A83543 pseudoaglycones A83543PsaA2, A83543PsaB2, A83543PsaD2, and A83543PsaN2 are intermediates useful in preparation of known...
5519050 Isolation and structural elucidation of halistatin 3  
The Micronesian marine sponge Phakellia sp. has been found to contain cern key members of the antineoplastic halichondrin/halistatin family. These compounds include halichondrin B, homohalichondrin...
5510372 Antiparasitic macrolide antiobiotics  
The present invention relates to certain antibiotic compounds, designated N787-182 compounds herein and derivatives thereof, which are antiparasitic agents, active against insect pest, acari,...
5478951 Method for the purification of 23-E isomers of 23-imino derivatives of LL-F28249 compounds  
The present invention provides a method for the purification of a 23-E isomer of a 23-imino derivative of a LL-F28249 compound having the structural formula I ##STR1##
5436355 Process for making avermectin/zein compositions  
Their is disclosed a novel solvent-depletion process for making an avermectin/zein composition and the composition itself, which has excellent photostability and unexpected bioavailability to...
5420260 Process for 4"-epi-acetylamino-4"-deoxy-5-oximinoavermectin B.sub.1  
An improved process for formation of a 5-oxime on avermectin derivatives comprises the treatment of the oxo-compound with hydroxylamine in aqueous isopropanol at pH 1.8-2.1.
5411946 Avermectin derivatives  
Avermectin derivatives, wherein the C-17-21-25-dioxaspirane substructure has been modified to include substitutions of heteratomic nucleophilic thiols at the 23,24-α-epoxide. These compounds can...
5405867 Macrolide compounds, their preparation and their use  
Compounds having a 16-membered macrolide ring, and related to the milbemycins and avermectins, with substituents at positions 5.13, 25 and optionally also 23, have acaricidal, insecticidal and...
5399717 Glycosidation route to 4"-epi-methylamino-4"-deoxyavermectin B.sub.1  
A stereocontrolled glycosidation with thiophenyl 4-(N-allyloxycarbonyl)-epi-methylamino-4-deoxyoleandrose and 5-O-allyloxycarbonyl avermectin B 1 monosaccharide using N-iodosuccinimide produces...
5384078 Soluble highly reactive form of calcium and reagents thereof  
A soluble highly reactive form of calcium, prepared from Ca(II) salts and a reducing agent in ethereal, polyethereal, or hydrocarbon solvents, is presented. This form of calcium can be used in the...
5380838 Stable solvates of avermectin compounds  
There is disclosed a novel form of avermectin compounds wherein the avermectin compounds are crystallized as alcohol solvates to greatly enhance stability of the avermectin drug during long-term...
5376678 Active principle based on avermectins, related strain and process for the preparation thereof, as well as veterinary compositions containing it  
By carrying out the fermentation of Streptomyces avermitilis ATCC 55278, a dried mycelium is obtained which, orally administered to animals, particularly to ovines, has an antiparasitic activity.
5360917 Process for producing macrolide compounds  
A process for recovering at least one Antibiotics S541 compound or chemical derivative thereof from solution in an organic solvent, which comprises the steps of contacting the said solution with...
5352804 Isolation and structure of Halistatin 2  
An intensive long-term investigation of marine organisms as sources of new anticancer drugs has led to the isolation and structural elucidation (primarily by high field NMR and mass spectrometry)...
Matches 1 - 50 out of 205 1 2 3 4 5 >