Patents in Class 549/218

Matches 1 - 50 out of 261

1 2 3 4 5 6 >

Match	Document	Document Title
1	8052963	[(4-oxo-4H-chromen-3-yl)hydroxymethyl]- or [(4-oxo-4H-chromen-3-yl)methyl]phosphonic acid derivatives The present invention relates to compounds of the formula (I), where R1 to R3 each, independently of one another, denote H, hydroxyl or alkoxy having 1 to 8 C atoms, R4 denotes alkyl having 1 to 4...
2	8003625	Phosphoramidate alkylator prodrugs Phosphoramidate alkylator prodrugs can be used to treat cancer when administered alone or in combination with one or more anti-neoplastic agents.
3	7629379	Substituted phosphonate fluorescent sensors and use thereof The invention relates to new compounds of formula (1) wherein R is hydrogen or a linear or branched C1-40alkyl; where X is O, S, or NR1 where R1 is a hydrogen, a linear or branched C1-40 alkyl,...
4	7626044	Triptolide derivatives and their uses Triptolide derivatives of Formula (I), their pharmaceutically acceptable salts and optical isomers, Formula (I): wherein, C5 and C6 are connect with each other by a C-C single bond or double bond;...
5	7479502	2-(2-hydroxybiphenyl-3-yl)-1H-benzoimidazole-5-carboxamidine derivatives as factor VIIA inhibitors The present invention relates to novel inhibitors of Factors VIIa, IXa, Xa, XIa, in particular Factor VIIa, pharmaceutical compositions comprising these inhibitors, and methods for using these...
6	7420000	Amino phosphonate and amino bis-phosphonate derivatives Aminophosphonate and amino bisphosphonate compounds and methods for their preparation are provided. Also provided are pharmaceutical and agricultural compositions containing the compounds. The...
7	7087626	Pyrrole derivatives as pharmaceutical agents Novel pyrrazole derivative compounds and their use as pharmaceutical agents, in particular their use as TGF-beta signal transduction inhibitors. The disclosed invention relates to compounds of the...
8	7019024	Pharmaceutical for treatment of neurological and neuropsychiatric disorders The invention provides a pharmaceutical for treatment of neurological and neuropsychiatric disorders comprising a compound of the formula: or a pharmaceutically acceptable salt thereof.
9	6916831	Flavone acetic acid analogs and methods of use thereof Compounds are described having a structure according to Formula I or Formula II: wherein: X is selected from the group consisting of O, NH, and S; Y is selected from the group consisting of O and...
10	6906007	Phenyl-substituted 5,6-dihydropyrone derivatives for use as pesticides and herbicides The present invention relates to novel phenyl-substituted 5,6-dihydro-pyrone derivatives of the formula (I) in which W, X, Y, Z, G, A, B, Q1 and Q2 are each as defined in the description, to a...
11	6864283	Oxy-and amino-substituted tetrahydrofuryl derivatives with antitumour activity Compounds of formula (I) wherein R1is selected from H, C(═O)R′, P(═O)R′R″, S(═O)R′R″, substituted or unsubstituted C1-C18 alkyl, substituted or unsubstituted C2-C18 alkenyl, substituted or ...
12	6737416	Phosphonic acid derivative having inhibitory activity against carboxypeptidase B A compound represented by the following general formula (I) and a pharmacologically acceptable salt thereof: wherein R1 represents hydrogen atom, an alkyl group, a substituted alkyl group and the...
13	6677461	Ligands and asymmetric catalysts made by using the same A ligand expressed by a general formula (1) in claim 1, wherein R1, R2 and R3 denote substituting groups on aromatic rings, X is P or As, and n is 1 to 3.
14	6590107	Synthesis, anti-human immunodeficiency virus, and anti-hepatitis B virus activities of 1,3-oxaselenolane nucleosides A method and composition for the treatment of HIV infection, HBV infection, or abnormal cellular proliferation in humans and other host animals is disclosed that includes the administration of an...
15	6566508	Fluorogenic compounds and uses therefor Disclosed are novel coumarin based fluorogenic compounds useful in assaying for biological activity. Specifically, these fluorogenic compounds exhibit fluorescence at particular wavelengths when...
16	6514953	Calcium (3S) tetrahydro-3-furanyl(1S,2R)-3-&lsqb &lsqb (4-aminophenyl)sulfonyl&rsqb (isobutyl)amino&rsqb -1-benzyl-2-(phosphonooxy)propylcarbamate The invention relates to calcium (3S) tetrahydro-3-furanyl(1S,2R)-3-[[(4-aminophenyl)sulfonyl](iso butyl)amino]-1-benzyl-2-(phosphonooxy)propylcarbamate, to processes for its preparation, and to...
17	6515183	Chiral diphenyldiphosphines and d-8 metal complexes thereof Compounds of formula III, wherein R6 und R7 signify identical or different secondary phosphino; R8 is —CH2—OH, —CH2—NH2, —CH2—O—B—FU, —CH2—NH2—B—FU, or —O—B—FU; R9 has the same significance as R8 o...
18	6500811	Sulfonylaminophosphinic and sulfonylaminophosphonic acid derivatives, methods for their preparation and use Compounds of the formula I are suitable for the production of pharmaceuticals for the prophylaxis and therapy of disorders in the course of which an increased activity of matrix-degrading enzymes...
19	6479471	NAALADase inhibitors The present disclosure relates to dipeptidase inhibitors, and more particularly, to novel phosphonate derivatives, hydroxyphosphinyl derivatives, and phosphoramidate derivatives that inhibit...
20	6472414	Conformationally restricted aromatic inhibitors of microsomal triglyceride transfer protein and method Novel compounds are provided which are inhibitors of MTP and thus are useful for lowering serum lipids and treating atherosclerosis and related diseases, and have the structure including...
21	6410751	Water soluble tri-substituted 1, 2-dioxetane compounds having increased storage stability, synthetic processes and intermediates Stable, enzymatically triggered chemiluminescent 1,2-dioxetanes with improved water solubility and storage stability are provided as well as synthetic processes and intermediates used in their...
22	6372895	Fluorogenic compounds Disclosed are novel coumarin based fluorogenic compounds useful in assaying for biological activity. Specifically, these fluorogenic compounds exhibit fluorescence at particular wavelengths when...
23	6365592	Phosphonic and carboxylic acid derivatives as inhibitors of protein tyrosine phosphatase-1B (PTP-1B) The invention encompasses compounds represented by formula I: as well as compositions and methods of treatment. The compounds are inhibitors of the PTP-1B enzyme.
24	6362348	Additive for inkjet printing, recording solution, method for preventing discoloration and fading of image, and recording sheet An additive for inkjet printing, comprising a stabilized ascorbic acid derivative. Also disclosed are a recording solution, a method for preventing discoloration and fading of an image, and a...
25	6346615	Chemiluminescent 1,2-dioxetanes Spiroadamantyl dioxetanes bearing an alkoxy substituent, and an aromatic substituent of phenyl or naphthyl on the dioxetane ring can be activated to chemiluminesce if the aromatic substituent bears...
26	6333291	Optically active diphosphine compound, production intermediate thereof, transition metal complex containing the compound as ligand and asymmetric hydrogenation catalyst containing the complex This invention provides a novel diphosphine compound which is useful as a ligand of catalysts for asymmetric synthesis reactions, particularly asymmetric hydrogenation reaction. Particularly, it...
27	6313159	Metabotropic glutamate receptor ligand derivatives as naaladase inhibitors The present invention relates to metabotropic glutamate receptor ligand derivatives and methods of using the same to inhibit NAALADase enzyme activity, to effect neuronal activities, to inhibit...
28	6288280	Racemization of atropisomeric bis(phosphine oxide) compounds A process for the racemization of atropisomeric bis(phosphine oxide) compounds of formula I: ##STR1##in their (S) or (R) or non-racemic form, is useful for preparing optical active bisphosphine...
29	6277833	Substituted triols Substituted triols are prepared by reducing appropriately substituted carboxylic esters. The substituted triols can be used as active substances in medicaments.
30	6271397	L-ascorbic acid-2-phosphoric acid potassium crystal and method for producing the same A high-purity L-ascorbic acid-2-phosphoric acid potassium crystal having excellent stability, and a method for simply producing the high-purity L-ascorbic acid-2-phosphoric acid potassium in a high...
31	6248848	Optically active phosphine derivative having at least two vinyl groups, polymer produced using the same as monomer, and transition metal complexes of these A 2'-diarylphosphino-1,1'-biphenylen-2-yloxy(6,6'-divinyl-1,1' -binaphthalene -2,2'-diyloxy)phosphine derivative is disclosed, which is represented by general formula (I): ##STR1##wherein Ar is an...
32	6150539	Triptolide prodrugs having high aqueous solubility Compounds useful in immunosuppressive and anti-inflammatory treatment are described. The compounds are hydrolyzable triptolide analogs with improved water solubility and generally lower toxicity...
33	6133459	Method and compositions providing enhanced chemiluminescence from 1,2-dioxetanes A method and compositions including a 1,2-dioxetane and a fluorescent compound is described. In particular, enzymatic triggering of a triggerable 1,2-dioxetane admixed with a surfactant and the...
34	6087513	Epoxidation process for aryl allyl ethers A process for making an aromatic glycidyl ether epoxy compound by contacting an allyl ether made from the hydroxy moiety of a hydroxy-containing aromatic compound with an inorganic or organic...
35	6075152	Process for preparing isochroman-3-ones The present invention relates to a process for preparing an isochroman-3-one of the formula (I) by reacting a 1,2-bishalomethylbenzene of the formula (II) ##STR1## in which X is chlorine, bromine...
36	6063937	Method of making ascorbyl monophosphates The present invention provides a method of making alkali metal and alkaline earth metal salts of L-ascorbic acid 2-monophosphate comprising reacting a L-ascorbic acid 2-polyphosphate under alkaline...
37	6030996	Mur D inhibiting compounds, compositions containing such compounds and methods of use The present invention addresses compounds which inhibit Mur D. The compounds are represented by structural formula 1: ##STR1## wherein: X represents OH, OC1-6 alkyl, O-aryl, O-Har, uridinyl,...
38	6028216	Asymmetric syntheses and intermediates for preparing enantiomer-enriched hydroxyphosphinyl derivatives The present invention relates to asymmetric syntheses and intermediates for preparing enantiomer-enriched hydroxyphosphinyl derivatives.
39	6025344	Certain dioic acid derivatives useful as NAALADase inhibitors The present disclosure relates to dipeptidase inhibitors, and more particularly, to novel phosphonate derivatives, hydroxyphosphinyl derivatives, and phosphoramidate derivatives that inhibit...
40	6025345	Inhibitors of NAALADase enzyme activity The present disclosure relates to dipeptidase inhibitors, and more particularly, to novel methods of using phosphonate derivatives, hydroxyphosphinyl derivatives, and phosphoramidate derivatives to...
41	6008379	Aromatic-substituted xanthene dyes A class of aromatic-substituted xanthene compounds useful as fluorescent dyes is disclosed, the compounds having the general structure where Y1 and Y2 taken separately are selected from the group...
42	5990320	Optically active diphosphine ligands Optically active diphosphine ligands of the formula I, ##STR1## where: R1 is hydrogen, C1 -C10 -acyl, C1 -C10 -alkyl, C2 -C10 -alkenyl, each of which may be linear or branched, aryl, arylalkyl, in...
43	5965750	High- purity tocopherol phosphates, process for the preparation thereof, methods for analysis thereof, and cosmetics Disclosed herein are a highly purified tocopheryl phosphate and/or a salt thereof (tocopheryl phosphates) wherein a P,P'-bistocopheryl hypophosphate and/or a salt thereof (P,P'-bistocopheryl...
44	5962701	Chromanylascorbic acid derivatives their preparation and use Chromanylascorbic acid derivatives of the general formula I ##STR1## where R1 is an organic radical having 1 to 12 C atoms, in particular a methyl group, R2 is an organic radical having 8 to 30 C...
45	5929254	1,2-dioxetane derivatives A 1,2-dioxetane derivative of formula (I) for use as a chemiluminescent substrate for immunoassays: ##STR1## wherein R1 is an alkyl group or an aryl group, R2 a hydrogen atom, an alkyl group or an...
46	5895819	Enzyme substrate An enzyme substrate is disclosed which comprises a phosphoric ester and an organic acid or a salt thereof having a zinc chelating stability factor constant (log K) of from 8 to 14 in an aqueous...
47	5892064	Chemiluminescent dialkyl-substituted 1,2-dioxetanes, methods of synthesis and use A chemiluminescent assay method and compositions are described which use a dialkyl-substituted dioxetane which is deprotected to trigger a chemiluminescent reaction. Chemiluminescent 1,2-dioxetane...
48	5886217	Method of producing aryl-substituted, amino-acylated phosphonic-acid derivatives with the aid of metal complexes of chiral, amphiphilic ligands The invention is relates to a method of producing aryl-substituted, amino-acylated phosphonic-acid derivatives with the aid of metal complexes of chiral amphiphilic ligands in that according to the...
49	5856522	Method of using synthesis of 1,2-dioxetanes and kits therefore Kits comprising 1,2-dioxetanes which can be cause to chemiluminesce by contact with an enzyme, and the enzyme, are provided for use in optically detectable assays. The assay calls for binding the...
50	5856314	Thio-substituted, Nitrogen-containing, heterocyclic phosphonate compounds, pharmaceutical compositions, and methods of treating abnormal calcium and phosphate metabolism The present invention relates to thio-substituted, nitrogen-containing heterocyclic phosphonate compounds, including bisphosphonates, phosphonoalkylphosphinates, phosphonocarboxylates, and...

Matches 1 - 50 out of 261

1 2 3 4 5 6 >