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8143375 Aziridine aldehydes, aziridine-conjugated amino derivatives, aziridine-conjugated biomolecules and processes for their preparation  
The present invention relates to unprotected amino aldehydes and applications for same. More particularly, the present invention relates to novel aziridine aldehydes and processes for preparing...
7838110 Aziridine-functional photoactive crosslinking compounds  
A photoactive compound that is the Michael addition reaction product of an aziridine compound and a photoinitiator-functional (meth)acrylate is described. The compound can be used to crosslink...
7186861 Z-substituted acrylamides, methods for production thereof and agents comprising the same  
Z-substituted acrylamides of formula (I), where the substituents have the following meanings: X═H, halogen, alkyl, haloalkyl, alkoxy, haloalkoxy, with X in the 3- or 4-position, n=1 or 2, where X c...
6573388 Ethylaziridine derivatives and their preparation methods  
This invention is related to new ethylaziridine derivatives of formula (I) and their preparation. The compounds are useful synthetic intermediates for the synthesis of HIV protease inhibitors and...
6559323 Process for the preparation of an oxirane, aziridine or cyclopropane  
A process for the preparation of an oxirane, aziridine or cyclopropane of formula (I), wherein X is oxygen, NR4 or CHR5; R1 is hydrogen, alkyl, aryl, heteroaromatic, heterocyclic or cycloalkyl; R2...
6559321 Synthesis of ethyleneimine dimer  
The invention provides a composition of greater than 90% pure ethyleneimine dimer and a method of synthesizing the same. This method of synthesis provides several advantages over previous methods:...
6517836 Nitrophenylaziridine compounds and their use as prodrugs  
A range of aziridin-1-yl nitrobenzamides are provided for use as prodrugs in conjunction with nitroreductase (NR) enzymes. The amides may have 1 or 2-substituents which may be bulky and polar. For...
6329523 Compounds having a plurality of nitrogenous substitutents  
Novel compounds having the formula: ##STR1##wherein the constituent variables are defined herein. The compounds are constructed to include a central aromatic, aliphatic, or heterocyclic ring...
6329359 Substituted benzyl oximino compounds  
The present invention relates to benzyloxyimino compounds of the formula I, ##STR1##where: R1 to R4, X, Y, and Z are as defined in the specification.
6323346 Process for producing aziridine compounds  
In the presence of an iridium compound, an imine of the following formula (1): ##STR1##wherein R1, R2 and R3 are each, identical to or different from one another, a hydrogen atom or a non-reactive...
6297230 Cyanoaziridines for treating cancer  
The present invention is directed to novel anti-cancer compounds of the formula. ##STR1##wherein X is CN, R4 is hydrogen or lower alkyl; and R5 is lower alkyl, lower cycloalkyl, alkenyl, alkynyl,...
6077954 Substituted heterocyclic compounds  
Novel compounds having the formula: ##STR1## wherein the constituent variables are defined herein. The compounds are constructed to include a central aromatic, aliphatic, or heterocyclic ring...
5972964 Aminomethylindans, -benzofurans and -benzothiophenes  
Compounds of formula I ##STR1## wherein R1(cyclo)alk(en)yl, aralkyl, alkyl(oxy)carbonyl, CONH2, etc.; R2H, (cyclo)alk(en)yl, aralkyl, etc.; R3-R5H, halo, alkyl, alkoxy, etc.; R6,R7H, alkyl; ...
5932745 Process for converting propargylic amine-N-oxides to enaminones  
This invention concerns the use of a hydroxylic solvent in the preparation of enaminones from the corresponding amine N-oxides or propargylic amines via the general process outlined below: ##STR1##
5886175 7-(substituted)-8-(substituted)-9-(substitued amino)-6-demethyl-6-deoxytetracyclines  
The invention provides compounds of the formulas ##STR1## which are useful as intermediates for the preparation of 6-demethyl-6-deotetracycline antibiotic agents.
5852205 Catalytic process  
Production of aziridines comprising reacting an ethylenically unsaturated compound, such as styrene or methyl cinnamate, with a nitrene donor, such as (N-(p-tolylsulphonyl) imino) phenyliodinane in...
5741543 Process for the production of an article coated with a crosslinked pressure sensitive adhesive  
This invention relates to a process in which a composition is coated onto a substrate and crosslinked so as to form a PSA by means of polymerizing free radically polymerizable monomers from...
5693825 Preparation of aziridines  
A process for the preparation of an aziridine, especially ethyleneimine but also its derivatives in which one or both of its carbon atoms may be substituted once or twice by C1 -C8 -alkyl, C3 -C8...
5616607 Hepoxilin analogs  
Compounds of the general structure ##STR1## are disclosed, wherein X is O, Cn, NH, or S, wherein n is 1, 2, 3 or 4; R1 is OH, CH3, CH2 OH, N3 or CH2 N3 ; R3 is H or CH3 ; R5 is Y-R2, wherein Y is a...
5521212 Cyclopropyl N-hydroxyurea and N-hydroxyacetamides which inhibit lipoxygenase  
Compounds of the formula ##STR1## wherein A is C1 to C3 alkylene, Ar is phenyl or styryl, R is halosubstituted C1 to C3 alkyl, NHR' or ##STR2## R' is hydrogen or C2 to C8 alkytthioalkyl, n is an...
5495018 7-(substituted-9-(substituted amino)-6-demethyl-6-deoxytetracyclines  
The invention provides compounds of the formulas ##STR1## which are useful as intermediates for the preparation of 6-demethyl-6-deotetracycline antibiotic agents.
5495031 Process for the production of 7-(substituted)-9-[(substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines  
The invention provides a process for the production of compounds of the formula: ##STR1## wherein R, R3, R4 and W are defined in the specification in which a compound of the following formula:...
5495032 Process for producing 7-(substituted)-8-(substituted-9-[(substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines  
The invention provides a process for the production of compounds of the formula: ##STR1## wherein, R, R3, R4, X and W are defined in the specification in which a compound of the following formula:...
5239084 Substituted aminoalkyl biphenyl compounds  
Antimycotically-active compounds of the formula ##STR1## wherein R1 and R2 each independently are hydrogen, C1-7 -alkyl or C2-7 -alkenyl or together are a straight chain C2-4 -alkylene; R3 and R4...
5231189 Process for producing N-substituted aziridine compound  
The present invention provides a novel process for producing an N-substituted aziridine compound by subjecting an N-substituted alkanolamine to a gas-phase catalytic dehydration reaction (the...
5177067 Substituted aminoalkyl biphenyl compounds and method of treating fungal infections  
Antimycotically-active compounds of the formula ##STR1## wherein R1 and R2 each independently are hydrogen, C1-7 -alkyl or C2-7 -alkenyl or together are a straight chain C2-4 -alkylene; R3 and R4...
5106993 Aziridine compounds  
Aziridine compounds having the following structural formula: ##STR1## wherein R1 represents an alkylidene group; R2 represents hydrogen or an alkyl radical; R3 represents an aromatic hydrocarbon...
5071853 Polycyclic amines useful as cerebrovascular agents  
A novel series of polycyclic amines, derivatives, methods of making the compounds, novel intermediates, compositions containing them, and methods for using them in the treatment and prevention of...
4996201 4-(N-substituted amino)-2-butynyl-1-carbamates and thiocarbamates and derivatives thereof as centrally acting muscarinic agents  
4-(N-Substituted amino)-2-butynyl-1-carbamates and thiocarbamates and derivatives thereof are described, as well as methods for the preparation and pharmaceutical compositions of same, which are...
4880821 α-nitroalkylnitrobenzenesulfonamides  
A compound of the formula ##STR1## wherein: R1 and R2 are defined as follows: R1 is hydrogen, an alkyl group, or an alkyl group having one or more hydroxy groups; R2 is an alkyl group having one or...
4853415 2-(substituted sulfamyl) derivatives of 4-nitrobenzamide as radiation sensitizers  
2-(Substituted sulfamyl) derivatives of 4-nitrobenzamide are disclosed as agents that increase the sensitivity of hypoxic cancer cells to x-rays and γ-radiation. Methods of preparing such ...
4652679 Aziridine and phenethanolamine derivatives having antiobesity and anti-hyperglycaemic acitivity  
Aziridine and phenethanolamine derivatives of formulae I and II-1 ##STR1## wherein R1 and R2 are hydrogen or lower-alkyl; Z1 is phenyl or a phenyl group substituted in a defined manner; Z2 and Z21...
4643849 Intermediates for urea and thiourea derivatives  
This invention relates to amine derivatives and salts thereof. These compounds have an anti-ulcer activity which is effective to human beings and animals. This disclosure relates to such compounds,...
4568747 Process for making 2-aminoethyl ether  
The invention is a process for obtaining pure BAEE from the crude reaction mixture of H2 SO4 and monoethanolamine. It consists of five major operations, which are: 1. Separation of 2-aminoethyl...
4460506 Nitrovinyl aziridine derivative  
The invention relates to a process for the preparation of ranitidine of formula (I) ##STR1## which comprises reacting a thiol of formula (II) ##STR2## with an alkylating agent of formula (III)...
4388238 Process for the preparation of N,O-disubstituted urethanes suitable as a starting material for the preparation of isocyanates  
A process for the preparation of N,O-disubstituted urethanes. Primary amines and alcohols are reacted with organic compounds having carbonyl groups at 120° to 350° C. Suitable carbonyl-containing c...
4337196 Method for producing 3,6-bis(carboethoxyamino)-2,5-diaziridinyl-1,4-benzoquinone  
A method is described of preparing a diaziridinyl diaminobenzoquinone-N, N'-dicarboxylate compound selected from dialkyl, di(arylalkyl), or diphenyl diaminobenzoquinone-N, N'-dicarboxylates, said...
4324724 Manufacture of polyalkylenepolyamines  
A process for the manufacture of polyalkylenepolyamines by reacting a primary or secondary amine with a compound of the formula ##STR1## where X is --Cl, --Br, or --OSO3 H and R1 and R2 are H or...
4276421 Cyano-guanidine geometrical isomers  
Particular Syn (--NHCH3) geometrical isomers of cyano-guanidines are disclosed as new compounds having activity as histamine antagonists useful in the treatment of gastric and duodenal ulcers.
4250092 Derivatives of N-cyano-azomethines and process for their preparation  
N-Cyano-azomethines, useful as intermediates for the production of antihistamines are described. They are produced by reaction of ##STR1## where R3 is a thiomethyl group, an alkylamino group or...
4170591 Aziridine complexes isomerize to form chelated dimers  
Metal salt complexes of aziridine and 2-alkylaziridines in solution isomerize at temperatures between 20°-70° C. to form aziridine dimer chelates. The chelates are biologically active compounds a...
4115384 N-cyanoaziridines  
N-Cyanoaziridines containing the grouping ##STR1## are obtained by reacting an ethylenically unsaturated compound with cyanogen azide (N3 CN). Exemplary is 3-cyanoazatricyclo[3.2.1.02.4 ] octane of...
4098895 Triazolylacetanilide compounds and microbicidal compositions  
Amino aceto anilides of the formula I shown hereinafter are effective microbicides. They may be used to control fungi on plants or parts of plants or to prevent them from fungi attack.
4087606 2-Cyano-3- or 4-(substituted amino)oxanilic acid derivatives  
The 2-cyano-3-or 4-(substituted amino) oxanilic acid derivatives of the formula: ##STR1## in which the group ##STR2## appears in the designated 3- or 4- position and R is --H; an alkali metal; +...
4070354 Polymers from N-(2-hydroxyethyl)aziridines  
Aziridinyl-terminated polymers containing the recurring unit ##STR1## wherein R1 is hydrogen or methyl and R2 is hydrogen or a side chain of like structure, are prepared by warming...
4062886 Fluorenone carboxyle acid esters  
Disclosed are monomers of the formula: ##STR1## WHEREIN R is ##STR2## R' is hydrogen or methyl; R" is alkyl of 1-10 carbon atoms; X and Y are independently selected from the group consisting of...
4062955 Analgesic basic naphthalene derivatives  
Compounds of the general formula: ##STR1## wherein the groups CHR1 NR2 R3 and CHR4 NR5 R6 may be the same or different and where the group CHR4 NR5 R6 is in either the 1 or the 3 position and R1...
4054591 2-Cyano-3-or 4-(substituted amino)oxanilic acid derivatives  
The 2-cyano-3-or 4-(substituted amino)oxanilic acid derivatives of the formula: ##STR1## in which the group ##STR2## appears in the designated 3- or 4- position and R is -H; an alkali metal; + NH4...
4046758 3-Halo-2,6-dinitro-4-trifluoromethylanilines  
3-Halo-2,6-dinitro-4-trifluoromethylanilines having hydrocarbon substituents on the nitrogen atom. The hydrocarbon substituents can be alkyl, alkenyl, alkynyl or a portion of a heterocyclic group....
4028402 Biguanide salts  
Biguanide salts of the formula ##STR1## wherein R1, R2, R3 and n are as hereinafter set forth, are described. The aforementioned biguanides are useful as hypoglycemic agents.
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