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7538124 |
Biphenylcarboxamides useful as lipid lowering agents
Biphenylcarboxamide compounds of formula (I)
methods for preparing such compounds, pharmaceutical compositions comprising said compounds as well as the use of said compounds as a medicine for...
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7534882 |
Method for preparing pyrrolotriazine compounds via in situ amination of pyrroles
A method for aminating pyrrole derivatives via in situ generated chloramines and for preparing pyrrolotriazine compounds having the formula III,
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7534881 |
Method for preparing pyrrolotriazine compounds
A method for aminating pyrrole derivatives and for preparing pyrrolotriazine compounds having the formula V,
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7531676 |
Lipids
Bipolar lipids are described which are able to form complexes with polyanions. The lipids comprise a cationic head linked to a hydrophobic backbone and a hydrophilic tail and are capable of self...
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7504521 |
Methods for the preparation of pyrrolotriazine compounds
A method for preparing a compound having the formula:
including the steps of: (a) cyclizing a compound of formula II:
to form a compound of formula I:
(b) deprotecting...
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7485665 |
Medicinal composition
The present invention relates to an ameliorant for improving the movement of the digestive tract comprising, as an active ingredient,...
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7479357 |
Electrophotographic organophotoreceptors with novel charge transport materials
An organophotoreceptor that includes:
(a) a charge transport material having the formula
wherein A is selected from heterocyclic groups, naphthyl group, alkylsulfonylphenyl,...
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7446115 |
Peptidomimetic ligands for cellular receptors and ion channels
One aspect of the present invention relates to novel peptidomometic compounds. A second aspect of the present invention relates to the use of the novel peptidomimetic compounds as...
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7425631 |
Compounds and methods of use
Selected compounds are effective for treatment of pain and diseases, such as inflammation mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically...
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7388112 |
Immunomodulation with novel pharmaceutical compositions
The synthesis and use of a novel class of tumor necrosis factor (TNFα) inhibitors and immunomodulators are provided. Examples are those having the structures:
wherein a, b and c are integers...
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7381741 |
3-amino-2-phenylpyrrolidine derivatives
3-amino-2-phenylpyrrolidine compounds useful as NK-1 antagonists, with pharmaceutical compositions and methods of treatment comprising same, are disclosed.
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7378436 |
Compounds
A compound of Formula (I)
and pharmaceutically and/or veterinarily acceptable derivatives thereof, wherein R 1 is H, C 1-6 alkyl, —C(X)Y, C 3-8 cycloalkyl, aryl, het, aryl-C 1-4 alkyl or...
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7368572 |
Acetylene derivatives as inhibitors of histone deacetylase
The present invention is directed to certain hydroxamate derivatives that are inhibitors of histone deacetylase and are therefore useful in the treatment of diseases associated with histone...
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7329685 |
1-Phenyl-2-oxo-3-sulfonylamino-pyrrolidine derivatives and related compounds as factor Xa inhibitors for the treatment of acute vascular diseases
The invention relates to compounds of formula (I):
wherein substituents are as defined.
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7326729 |
CXCR1 and CXCR2 chemokine antagonists
The present invention is directed to a compound having the general structure of formula (1):
useful for the treatment, prevention or amelioration of a CXCR1 or CXCR2 chemokine-mediated disease.
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7300934 |
Benzamide nitriles
Compounds of the formula (I)
wherein m, n, A, R 1 , R 2 , R 3 , R 4 , R 5 and R 6 are as described herein, together with methods for making the compounds and using the compounds for treatment...
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7291621 |
Substituted biaryl amides C5a receptor modulators
Substituted biaryl amides of Formula I are provided. Such compounds are ligands that may be used to modulate C 5 a receptor activity in vivo or in vitro, and are particularly useful in the...
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7271272 |
Process for preparing 4-aminomethyl-3-alkoxyiminopyrrolidine methanesulfonate
The present invention relates to a process for the preparation of 4-aminomethyl-3-alkoxyiminopyrrolidine methane-sulfonate, a key intermediate of quinolone antibiotics. According to the process of...
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7268236 |
Method of heightening optical purity of 1-benzyl-3-aminopyrrolidine and salt for used therein
The present invention provides a method to improve the optical purity of 1-benzyl-3-aminopyrrolidine having a low optical purity using an inexpensive agent via a simple procedure. The present...
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7250443 |
Pyrrole based inhibitors of glycogen synthase kinase 3
New pyrrole based compounds, compositions and methods of inhibiting the activity of glycogen synthase kinase (GSK3) in vitro and of treatment of GSK3 mediated disorders in vivo are provided. The...
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7223788 |
Substituted N-aryl heterocycles, process for their preparation and their use as medicaments
The invention relates to substituted N-aryl heterocycles and to the physiologically tolerated salts and physiologically functional derivatives thereof. Compounds of the formula I
in which the...
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7183298 |
Carbamic acid compounds comprising a sulfonamide linkage as HDAC inhibitors
This invention pertains to certain active carbamic acid compounds which inhibit HDAC activity and which have the following formula: (I) A is an aryl group; Q 1 is a covalent bond or an aryl leader...
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7176312 |
Kinase inhibitor scaffolds and methods for their preparation
General methods for the solution phase as well as solid phase synthesis of various substituted heteroaryls has been demonstrated. These substituted heteroaryls can be further elaborated by aromatic...
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7132543 |
Para-phenylenediamine derivatives containing a disubstituted pyrrolidinyl group bearing a cationic radical, and use of the same for dyeing keratin fibers
The present disclosure relates to a novel a para-phenylenediamine derivative substituted with a pyrrolidinyl group of formula (I) and the addition salts thereof. The present disclosure also relates...
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7132534 |
Para-phenylenediamine derivatives containing a pyrrolidyl group, and use of these derivatives for coloring keratin fibers
The invention relates to novel pyrrolidyl-substituted para-phenylenediamine derivatives, to dye compositions containing them and to the process for dyeing keratin fibers using these compositions. ...
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7126010 |
Benzylcycloalkyl amines as modulators of chemokine receptor activity
The present application describes modulators of CCR3 of formula (I):
or pharmaceutically acceptable salt forms thereof, useful for the prevention of inflammatory diseases such as asthma and...
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7126007 |
Process for preparing pyrrolidinyl-functional para-phenylenediamine derivatives substituted by a nitrogenous radical, and intermediate compounds
A process for synthesizing para-phenylenediamine derivative compounds containing a pyrolidinyl group, and substituted by a nitrogenous radical, wherein the para-phenylenediamine derivative...
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7122683 |
Amides useful as monoamine re-uptake inhibitors
A compound of Formula (I)
and pharmaceutically and/or veterinarily acceptable derivatives thereof, wherein:
R 1 , R 2 , R 3 and R 20 are each independently H, Cl, Br, F, I, CF 3 , OCF...
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7115754 |
Pyrrolidine derivatives as oxytocin antagonists
The present invention relates to novel pyrrolidine derivative of formula (I), its geometrical isomers, its optically active forms as enantiomers, diastereomers, mixtures of these and its racemate...
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7105546 |
Acyclic and cyclic amine derivatives
The present invention relates to acyclic and cyclic amine derivatives for treating or preventing neuronal damage associated with neurological diseases. The invention also provides compositions...
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7064218 |
Aromatic compounds and poly(oxyalkylene) containing aromatic compounds possessing antibacterial, antifungal or antitumor activity
The present invention provides novel compounds possessing one or more of the following activities: antibacterial, antifungal and antitumor activity. The compounds are of Formula (I):
...
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7045532 |
ACE-2 modulating compounds and methods of use thereof
ACE-2 inhibitors for the treatment of body weight and related disorders are disclosed. ACE-2 inhibitors include peptides and small molecules. Examples of small molecule ACE-2 inhibitors include...
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7045521 |
Cyclic derivatives as modulators of chemokine receptor activity
The present application describes modulators of MCP-1 of formula (I):
or pharmaceutically acceptable salt forms thereof, useful for the prevention of rheumatoid arthritis, multiple sclerosis,...
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7019006 |
Compounds useful as anti-inflammatory agents
Disclosed are novel aromatic compounds which are useful for treating diseases or pathological conditions involving inflammation such as chronic inflammatory diseases. Also disclosed are...
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6982263 |
Nitriles useful as reversible inhibitors of cysteine proteases
Disclosed are novel nitrile compounds of formula (I) further defined herein, which compounds are useful as reversible inhibitors of cysteine proteases such as cathepsin K, S, F, L and B. These...
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6974825 |
Compounds with analgesic effect
Compounds of general formula (I)
wherein m is 0 or 1, and n is 1 or 2;
are disclosed and claimed in the present application, as well as their pharmaceutically acceptable salts, pharmaceutical...
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6962633 |
Amine azide propellant
A novel family of amine azides having a cyclic structure therein is disclosed. These compounds have attractive properties as rocket propellants.
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6949553 |
Aliphatic compounds, their synthesis method, and utilization of the same
The present invention relates to aliphatic compounds of the formula I, or stereoisomers thereof, or their pharmaceutically acceptable salts:
wherein A represents an optionally substituted CH 3...
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6946005 |
Pyrrolidinyl-substituted para-phenylenediamine derivatives substituted with a cationic radical, and use of these derivatives for dyeing keratin fibers
Novel pyrrolidinyl-substituted para-phenylenediamine derivatives comprising a cationic radical, the dye compositions comprising them and the process for dyeing keratin fibers using these...
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6939891 |
Heterocyclic ureas, their preparation and their use as vanilloid receptor antagonists
The invention relates to certain novel compounds having Vanilloid Receptor (VR1) antagonist activity, processes for their preparation, to compositions containing them and to their use in the...
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6900322 |
Method for stereochemically controlled production of isomerically pure highly substituted azacyclic compounds
A method for stereochemically controlled production of azacyclic compounds of general formula (I)
in which the substituents have the meanings given in the specification. The invention also...
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6872836 |
Process for the manufacture of 3-amino-pyrrolidine derivatives
The invention is concerned with a process for the manufacture of 3-amino-pyrrolidine derivatives of the formula
wherein
R 1 signifies hydrogen or an amino protecting group; Z signifies...
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6867221 |
Cyclic amine compounds and pharmaceutical composition containing the same
A cyclic amine compound represented by the following general formula (1):
wherein,
R 1 , R 2 and R 3 each independently represent a hydrogen atom or an alkoxy group; W 1 and W 2 ...
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6864380 |
Benzylcycloalkyl amines as modulators of chemokine receptor activity
The present application describes modulators of CCR3 of formula (I):
or pharmaceutically acceptable salt forms thereof, useful for the prevention of inflammatory diseases such as asthma and...
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6849733 |
Neuropeptide-Y ligands
There are disclosed novel neuropeptide Y ligands having the general formula I
Wherein the symbols W, A, D, R 1 , R 2 , R 3 , R 4 are further defined in the description. Compounds of formula I...
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6835727 |
Cathepsin cysteine protease inhibitors
This invention relates to a novel class of compounds which are cysteine protease inhibitors, including but not limited to, inhibitors of Cathepsins K and L. These compounds are useful for treating...
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6743787 |
N-(4-sulfonylaryl)cyclylamine-2-hydroxyethylamines as beta-3 adrenergic receptor agonists
This invention provides compounds of Formula I having the structure wherein R 1 , R 2 , R 3 , R 4 , W, X, and Y are as defined hereinbefore or a pharmaceutically acceptable salt thereof, which...
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6709824 |
Parallel combinatorial approach to the discovery and optimization of catalysts and uses thereof
The present invention provides methods and compositions, i.e. synthetic libraries of candidate compounds, useful in the discovery and optimization of compounds which catalyze at least one chemical...
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6683189 |
Method for the synthesis of pyrrole and imidazole carboxamides on a solid support
The present invention describes a novel method for the solid phase synthesis of polyamides containing imidazole and pyrrole carboxamides. The polyamides are prepared on a solid support from...
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6677353 |
Substituted N-phenyl-N-heteroaralkyl aminoalcohol compounds useful for inhibiting cholesteryl ester transfer protein activity
The invention relates to substituted polycyclic aryl and heteroaryl tertiary-heteroalkylamine compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer...
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