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4619944 |
Antihypertensive compounds
Provided are antihypertensive compounds of the formula ##STR1## wherein R 1 , R 2 , R 3 , R 4 , R 5 , and R 6 are hydrogen, alkyl, alkenyl, alkynyl, phenyl-alkyl, or cycloalkyl, and may be the...
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4578390 |
Hydroxybenzylamino derivatives as anti-inflammatory agents
Hydroxybenzylamino derivatives have been prepared from an appropriate hydroxybenzaldehyde and an amine followed by reduction. These compounds are found to be active topical anti-inflammatory agents.
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4576940 |
Anti-allergic 3-indolecarboxamides
3-Indolecarboxamide compounds of the formula: ##STR1## inclusive of pharmaceutically acceptable acid addition salt and/or hydrate forms thereof, wherein R 1 is C 1 -8 alkyl, C 3 -8 cycloalkyl, C 3...
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4564677 |
Preparation of N-amino compounds
Disclosed is a method of preparing N-amino compounds from corresponding secondary amines by reacting a secondary amine with nitrous acid and zinc in a neutral pH reaction media to form the...
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4560684 |
1,4-Benzodiazepine derivatives
1,4-Benzodiazepine derivatives of the formula: ##STR1## (in which R 1 is pyrrolidinyl or piperidinyl each optionally substituted by C 1 -3 alkyl, phenyl-C 1 -3 alkyl, C 1 -5 alkanoyl, or C 2 -5...
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4517195 |
Pyrrolo[1,2-b][1,2,5]triazepines and pharmaceutical compositions thereof
There are described novel pyrrolo[1,2-b][1,2,5]triazepines of the general formula ##STR1## where R is hydrogen, loweralkyl, loweralkylaminoloweralkyl or diloweralkylaminoloweralkyl; X is hydrogen,...
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T105001 |
Adsorbable alkynyl substituted heterocyclic quaternary ammonium salts and applications thereof to silver halide photography
The use of thioamido and alkynyl substituted heterocyclic ammonium salts in producing images in silver halide photographic elements is disclosed. The thioamido and alkynyl substituted heterocyclic...
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4491584 |
Ethoxyphenyl piperidines and uses thereof
Certain compounds in which a carbon atom of a pyrrolidine or piperidine ring is bonded directly or through a methylene group to the nitrogen of a phenyl-substituted urea, and their pharmaceutically...
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4473394 |
Pyrrole sulfonamides
This invention relates to pyrrole sulfonamides which are useful as herbicides. Typical of the pyrrole sulfonamides of the instant application in...
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4393006 |
Diazidosulfonyl-N-substituted aniline
Novel diazidosulfonyl-N-substituted aniline compounds are disclosed. These compounds are useful in pretreating cellulosic materials to thereby photolytically develop colored images on said materials.
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4383112 |
Chiral amino-alcohol complexes
Chiral Schiff bases according to the general formula: ##STR1## and transition metal complexes thereof, wherein C * is an asymmetric carbon atom, R 1 and R 2 , which may be the same or different...
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4376778 |
Antibiotic substances and processes for production thereof
Antibiotics, designated as SF-2080A substance and SF-2080B substance, are described, and are obtained by cultivating an SF-2080 substance-producing strain belonging to the genus Streptomyces, for...
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4362667 |
Optical isomers of 4-amino-N-(1-cyclohexyl-3-pyrrolidinyl)-N-methylbenzamide
The resolution of racemic 4-amino-N-(1-cyclohexyl-3-pyrrolidinyl)-N-methylbenzamide into the optically active (+) and (-) isomers is disclosed.
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4344893 |
Pesticide compounds
Novel compounds are described which are substituted benzophenone hydrazones. They have pesticidal activity, especially against insects and acarids, and pesticidal compositions and methods are...
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4332822 |
Guanidine derivatives
Novel cyanoguanidine derivatives having the formula ##STR1## wherein Ar is a phenyl or pyrrol-1-yl group substituted by one or more substituents selected from halogen, trifluoromethyl, lower alkyl,...
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4331680 |
Pesticidal compounds, compositions and methods
Novel compounds are described which are substituted benzophenone hydrazones. They have pesticidal activity, especially against insects and acarids, and pesticidal compositions and methods are...
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4321373 |
2-Hydroxy-3-naphthoic acid amides
This invention relates to 2-hydroxy-3-naphthoic acid amides of the general formula: ##STR1## wherein R 1 is hydrogen, a substituted or unsubstituted alkyl, cycloalkyl, aralkyl, or aryl group, and...
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4279822 |
N-(1-Substituted-3-pyrrolidinyl)benzamides
N-(1-Substituted-3-pyrrolidinyl)benzamides of the formula ##STR1## wherein R is cycloalkyl or phenyllower-alkyl; R 1 is hydrogen or lower alkyl of 1 to 8 carbon atoms; R 2 is acetamido, amino,...
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4260410 |
Herbicidal and plant-growth-regulating N-haloacetylphenylamino carbonyl oximes
Novel N-haloacetylphenylamino carbonyl oximes represented by the formula ##STR1## wherein Ar is phenyl or substituted phenyl; R 1 is halomethyl; R 2 and R 3 are each independently hydrogen,...
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4247550 |
Compositions and methods for the treatment of hypertension or oedemas
The invention relates to a series of new compounds, salts thereof and to methods for the preparation of the compounds which have the general formula ##STR1## in which R 1 stands for an...
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4234580 |
Carbamate thiosulfenylcarbamoyl fluoride compounds
Carbamate thiosulfenylcarbamoyl fluoride compounds are insecticidal and miticidal compounds and are also useful intermediates in the preparation of pesticidally active bis-carbamate disulfide...
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4210660 |
Benzamide derivatives
Benzamide derivatives represented by the formula ##STR1## wherein X represents a lower alkoxy group; Y represents a mono- or di-lower alkylamino group; Z represents a halogen atom; R 1 represents...
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4197243 |
N-1-Benzyl-3-pyrrolidinyl-4-dimethylamino benzamide derivatives
The compounds of this invention are strong central nervous system depressants, in particular strong antipsychotics.
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4172835 |
1-(Phenylamino)pyrrole
1-(Phenylamino)pyrrole, useful as a urinary antiseptic, hypotensive and hypoglycemic agent, is prepared by reaction of an N-benzoylphenylhydrazine or N-lower-alkanoylphenylhydrazine or a...
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4163015 |
1-(Arylamino)pyrroles
1-(Arylamino)pyrroles and 1-(arylimino)pyrroles, useful as antibacterial agents, are prepared by reaction of an arylhydrazine or arylhydrazone with a 2,5-di-lower-alkoxytetrahydrofuran or with an...
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4161590 |
Fluorinated amphoteric and cationic surfactants
The invention is directed to fluorinated compounds of the formula ##STR1## wherein R f is a perfluoroalkyl or perfluoroalkoxy-perfluoroalkyl group, R 1 is a branched or straight chain alkylene,...
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4143150 |
Derivatives of oxanilic acid
Oxanilic acid derivatives having the formula: ##STR1## are disclosed wherein R is lower-alkyl, cycloalkyl, phenylalkyl or phenyl; R 1 is hydrogen, lower-alkyl or phenyl; R 2 is hydrogen,...
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4138405 |
1-(Arylamino)-and 1-(arylimino)pyrroles
1-(Arylamino)pyrroles and 1-(arylimino)pyrroles, useful as antibacterial agents, are prepared by reaction of an arylhydrazine or arylhydrazone with a 2,5-di-lower-alkoxytetrahydrofuran or with an...
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4134889 |
Manufacture of glycinonitriles
Manufacture of glycinonitriles by reacting amines with carbonyl compounds and hydrogen cyanide under specific reaction conditions in respect of the temperature, reaction time and hydrogen cyanide...
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4125724 |
Hydrogenation process
An improved and novel process is provided for the reduction of isocyanate groups in organic compounds to formamide groups by catalytic hydrogenation with a noble metal catalyst. The process allows...
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RE29828 |
1-Substituted-3-amidopyrrolidines
1-Substituted-3-amidopyrrolidines useful as analgetics and anti-depressants are disclosed. The compounds are prepared by acylation of 1-substituted-3-aminopyrrolidines.
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4108854 |
Process for preparing substituted glycines
A new process is disclosed for the preparation of N-acyl-α-aromatic and N-acyl-α-heteroaromatic glycines by reaction of an α-ester or ether of an N-acylglycine ester or acid with an aromatic or...
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4100192 |
Inter-phenylene-PG amides
The present invention relates to novel amido, cycloamido, carbonylamido, sulfonylamido, and hydrazino derivatives of inter-phenylene-PG-type compounds. These novel derivatives produce surprisingly...
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4097481 |
Tertiary amide derivatives of pyrrolidine and piperidine
Certain compounds in which a carbon atom of a pyrrolidine or piperidine ring is bonded directly or through a methylene group to the completely substituted nitrogen of a substituted benzamido group,...
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4097487 |
Pyrrolidinyl and piperidinyl benzamide derivatives
The compounds of this invention are strong central nervous system depressants, in particular strong antipsychotics.
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4073796 |
N-(1-substituted-3-pyrrolidinyl)-1-naphthalene carboxamides
Novel N-(1-substituted-3-pyrrolidinyl)-1-naphthalene- and 4-quinolinecarboxamides of the formula: ##STR1## wherein R is lower cycloalkyl, R 1 is hydrogen, lower alkyl or aryl, R 2 is hydrogen,...
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4071524 |
Derivatives of urea
Certain compounds in which a carbon atom of a pyrrolidine or piperidine ring is bonded directly or through a methylene group to the nitrogen of a phenyl-substituted urea, and their pharmaceutically...
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4066639 |
Benzene-sulfonyl semicarbazides and process for preparing them
A benzene-sulfonyl semicarbazide of the formula ##STR1## wherein R is such as phenyl and substituted phenyl, cyclohexyl or alkyl, Y is -CH 2 CH 2 - or ##STR2## is alkylene-imino of 3 to carbon...
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4064151 |
Halosilyl carbamates
Isocyanates are prepared directly from amines in a facile process which involves the reaction with halosilyl compounds to form novel halosilyl carbamates. The isocyanate may then be derived from...
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4056535 |
N-substituted 3-aminopyrrolidines
The compounds 3-(N-diethylcarbamyl)amino-1-methyl pyrrolidine, 3-(N-carbethoxy-N-methyl)amino-1-methyl pyrrolidine, 1-diethylcarbamyl-3-(N-methyl)amino pyrrolidine and...
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4056536 |
Pyrrolo[2,1-b][3]benzazepines
11H-Pyrrolo[2,1-b][3]benzazepin-11-one and derivatives thereof are generally prepared by Friedel-Crafts ring closure of a N-styrylpyrrole-2-carboxylic acid derivative. They are useful intermediates...
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4054441 |
Substituted (α,α,α-trifluoro-2,6-dinitro-p-tolyl)hydrazines
Novel substituted (α,α,α-trifluoro-2,6-dinitro-p-tolyl)hydrazines, active as herbicides, together with herbicidal methods and compositions employing said novel compounds.
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4002757 |
N-(1-substituted-3-pyrrolidinyl)-4-quinolinecarboxamides
Novel N-(1-substituted-3-pyrrolidinyl)-1-naphthalene and 4-quinolinecarboxamides of the formula: ##STR1## wherein R is lower cycloalkyl, R 1 is hydrogen, lower alkyl or aryl, R 2 is hydrogen,...
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3979431 |
Process for preparing nitroaromatic nitriles
A process for preparing nitroaromatic nitriles which comprises reacting an aromatic carbocyclic nitrile with a mixture of nitric acid and sulfuric acid at a temperature of at least 35°C and an...
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3978049 |
Process for the preparation of hydrazine compounds
This invention relates to a method for preparing an azine of the formula ##EQU1## wherein R 1 and R 2 , which may be the same or different, represent a hydrogen atom or a straight alkyl radical of...
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3965119 |
Carbamates and their use as pharmaceuticals
Carbamates derived from polycyclic γ-hydroxylactones and their production. The compounds may be used as pharmaceuticals by virtue of their analgesic properties.
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3957823 |
Electrophilic substitution of nitrosamines
The invention relates to a process for the electrophilic substitution of nitrosamines on the carbon atom in the α-position to the amino nitrogen by metallizing the nitrosamine of a secondary amine...
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3957820 |
Pyrrolidines containing two primary amino groups and process for their manufacture
The invention relates to 3-amino-4-aminomethyl-pyrrolidines which contain, in the 1-position of the heterocyclic ring, organic radicals as substituents, and in which also the H-atom in the...
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3950332 |
α-(N-Substituted amino-N-nitrosoamino)acetamides
N-substituted amino-N-nitroso-aminoacetamides, e.g., α-(N-morpholino-N-nitrosoamino)acetamide, are prepared by hydrolyzing the corresponding 3-N-substituted amino-sydnonimines and have been found...
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3943132 |
Process for the preparation of hydrazones
This invention relates to a method of preparing hydrazones of the formula ##EQU1## in which R 1 and R 2 , which may be identical or different, represent a linear alkyl radical of from 1 to 12...
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